RU2018130673A3 - - Google Patents
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- RU2018130673A3 RU2018130673A3 RU2018130673A RU2018130673A RU2018130673A3 RU 2018130673 A3 RU2018130673 A3 RU 2018130673A3 RU 2018130673 A RU2018130673 A RU 2018130673A RU 2018130673 A RU2018130673 A RU 2018130673A RU 2018130673 A3 RU2018130673 A3 RU 2018130673A3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16621—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16661—Methods of inactivation or attenuation
- C12N2710/16662—Methods of inactivation or attenuation by genetic engineering
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662287619P | 2016-01-27 | 2016-01-27 | |
| US62/287,619 | 2016-01-27 | ||
| PCT/US2017/015417 WO2017132552A1 (en) | 2016-01-27 | 2017-01-27 | Oncolytic viral vectors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021114137A Division RU2021114137A (ru) | 2016-01-27 | 2017-01-27 | Онколитические вирусные векторы и их применение |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018130673A RU2018130673A (ru) | 2020-02-28 |
| RU2018130673A3 true RU2018130673A3 (enExample) | 2020-05-19 |
| RU2749050C2 RU2749050C2 (ru) | 2021-06-03 |
Family
ID=57995301
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021114137A RU2021114137A (ru) | 2016-01-27 | 2017-01-27 | Онколитические вирусные векторы и их применение |
| RU2018130673A RU2749050C2 (ru) | 2016-01-27 | 2017-01-27 | Онколитические вирусные векторы и их применение |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021114137A RU2021114137A (ru) | 2016-01-27 | 2017-01-27 | Онколитические вирусные векторы и их применение |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10391132B2 (enExample) |
| EP (2) | EP3408382B1 (enExample) |
| JP (4) | JP2019508063A (enExample) |
| KR (1) | KR20180136435A (enExample) |
| CN (2) | CN116904404A (enExample) |
| AR (1) | AR107469A1 (enExample) |
| AU (1) | AU2017212713B2 (enExample) |
| BR (1) | BR112018015390A2 (enExample) |
| CA (1) | CA3011933A1 (enExample) |
| DK (1) | DK3408382T3 (enExample) |
| ES (1) | ES2919953T3 (enExample) |
| IL (2) | IL260790B (enExample) |
| MX (1) | MX2018009126A (enExample) |
| PT (1) | PT3408382T (enExample) |
| RU (2) | RU2021114137A (enExample) |
| SG (2) | SG11201806134SA (enExample) |
| TW (1) | TWI798168B (enExample) |
| WO (1) | WO2017132552A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201806134SA (en) | 2016-01-27 | 2018-08-30 | Oncorus Inc | Oncolytic viral vectors and uses thereof |
| HUE049237T2 (hu) * | 2016-04-08 | 2020-09-28 | Krystal Biotech Inc | Készítmények a bõr sérülései, rendellenességei és betegségei kezelési eljárásaiban történõ alkalmazásra |
| CA3029426A1 (en) | 2016-06-30 | 2018-01-04 | Oncorus, Inc. | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| US10682425B2 (en) * | 2016-12-14 | 2020-06-16 | The Regents Of The University Of California | Engineered B lymphocytes and compositions having micro-RNA and methods for making and using them |
| US12121573B2 (en) | 2019-07-14 | 2024-10-22 | Tianxin Wang | Methods and agents including STING agonist to treat tumor |
| JP6832422B2 (ja) * | 2017-04-19 | 2021-02-24 | 国立大学法人 東京大学 | 遺伝子改変コクサッキーウイルス及び医薬組成物 |
| US10975444B2 (en) * | 2017-04-28 | 2021-04-13 | Toray Industries, Inc. | Kit, device, and method for detecting ovarian tumor |
| US11612625B2 (en) * | 2017-07-26 | 2023-03-28 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| GB201714430D0 (en) | 2017-09-07 | 2017-10-25 | Micol Romain | Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue |
| CA3074901A1 (en) | 2017-09-11 | 2019-03-14 | Imba - Institut Fur Molekulare Biotechnologie Gmbh | Tumor organoid model |
| TWI666321B (zh) * | 2017-10-23 | 2019-07-21 | 大陸商深圳市亦諾微醫藥科技有限公司 | 用於癌症治療的溶瘤性單純皰疹病毒（ｏＨＳＶ）專性載體及其建構體的建構 |
| CN107723367A (zh) * | 2017-10-27 | 2018-02-23 | 青岛大学 | miRNA‑885‑3p的应用和应用其的产品 |
| CN107674918A (zh) * | 2017-11-10 | 2018-02-09 | 上海交通大学医学院 | has‑mir‑195‑5p作为生物标志物在制备肺癌诊断试剂盒中的应用 |
| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス， インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
| AU2019221826A1 (en) * | 2018-02-19 | 2020-09-17 | Combined Therapeutics, Inc. | Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids |
| US11739350B2 (en) | 2018-04-10 | 2023-08-29 | Ottawa Hospital Research Institute | MicroRNA-based compositions and methods used in disease treatment |
| EP3781188A4 (en) * | 2018-04-13 | 2022-03-02 | 2seventy bio, Inc. | ADOPTIVE CELL THERAPY |
| CN108707625B (zh) * | 2018-07-03 | 2021-09-21 | 云笛生物科技有限公司 | mir-124和HER2-shRNA双基因表达盒病毒载体、构建方法、病毒、应用 |
| CN109091491A (zh) * | 2018-08-02 | 2018-12-28 | 广州安镝声生物医药科技有限公司 | lncRNA H19的靶miRNA miR19a-3p及其应用 |
| CN109091492A (zh) * | 2018-08-02 | 2018-12-28 | 广州安镝声生物医药科技有限公司 | lncRNA H19的靶miRNA miR-106b-5p及其应用 |
| CN111117973A (zh) * | 2018-10-30 | 2020-05-08 | 中国科学院武汉病毒研究所 | 一种受microRNA调控的重组溶瘤肠道病毒71型及应用 |
| SG11202104887UA (en) * | 2018-11-13 | 2021-06-29 | Oncorus Inc | Encapsulated polynucleotides and methods of use |
| TWI690597B (zh) * | 2018-11-14 | 2020-04-11 | 國立中央大學 | 泌尿上皮癌的檢測套組及檢測方法 |
| KR20210098483A (ko) * | 2018-11-29 | 2021-08-10 | 바이로진 바이오테크 캐나다 리미티드 | 신경독성이 감소된 hsv 벡터 |
| WO2020117003A1 (ko) * | 2018-12-06 | 2020-06-11 | 국립암센터 | Nc886을 포함하는 암살상 바이러스 활성 증진 또는 생산 증진용 조성물 |
| SG11202107282VA (en) * | 2019-01-04 | 2021-07-29 | Oncorus Inc | Encapsulated rna polynucleotides and methods of use |
| CN109762903B (zh) * | 2019-01-31 | 2022-02-01 | 山东大学齐鲁医院 | miR-1246和/或TERF2IP在诊治胶质瘤中的应用 |
| US12209250B2 (en) * | 2019-03-14 | 2025-01-28 | Massachusetts Institute Of Technology | Engineered Herpes Simplex Virus-1 (HSV-1) vectors and uses thereof |
| CN110283794B (zh) * | 2019-05-30 | 2021-04-23 | 伍泽堂 | 重组溶瘤病毒以及制备方法、应用和药物 |
| CN112011570B (zh) * | 2019-05-31 | 2023-04-18 | 北京合生基因科技有限公司 | 特异杀伤肿瘤细胞的溶瘤病毒系统及其应用 |
| JP2022541197A (ja) * | 2019-07-16 | 2022-09-22 | ユニヴェルシテ・コート・ダジュール | 腫瘍溶解性ウイルスに対する対象の感受性又は抵抗性を評価する方法、組換えウイルス、その調製、及び使用 |
| AU2020326774A1 (en) * | 2019-08-05 | 2022-03-03 | Virogin Biotech Canada Ltd | Genetically modified enterovirus vectors |
| CN110468132B (zh) * | 2019-08-15 | 2022-11-25 | 西南大学 | 一种sgRNA及转基因表达载体、表达品系、筛选方法 |
| CN110433171B (zh) * | 2019-08-20 | 2022-08-19 | 中山大学附属第六医院 | miRNA-1293在制备抗结直肠肿瘤药物中的应用 |
| CN114765990A (zh) | 2019-10-10 | 2022-07-19 | 昂克诺斯公司 | 双重病毒和双重溶瘤病毒以及治疗方法 |
| KR102320430B1 (ko) * | 2020-01-29 | 2021-11-03 | 서울대학교병원 | 수모세포종에 대한 miR-135b, miR-135a 및 이들의 표적 유전자 AMOTL2의 용도 |
| AU2021256845A1 (en) * | 2020-04-14 | 2022-11-24 | Eidgenössische Technische Hochschule Zürich | Cell classifier circuits and methods of use thereof |
| CN113583977B (zh) * | 2020-04-30 | 2025-06-06 | 杭州康万达医药科技有限公司 | 可受微小rna调控的分离的重组溶瘤痘病毒及其应用 |
| EP4162951A4 (en) * | 2020-06-05 | 2024-07-10 | Shanghai Bao Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMPOSITION OF ENZYMES AND VIRUSES AND ASSOCIATED APPLICATION |
| US20230242994A1 (en) * | 2020-07-10 | 2023-08-03 | Shanghai Miran Biotech Co., Ltd. | Fluorescent cross-linked rnase h mutant conjugate, mirna combination and application thereof |
| IL300247A (en) | 2020-07-31 | 2023-03-01 | Combined Therapeutics Inc | Compositions and methods for improving vaccination |
| WO2022100898A1 (en) * | 2020-11-13 | 2022-05-19 | Technische Universität Berlin | Mir-375- and mir-1-regulated coxsackievirus b3 has no pancreas and heart toxicity but strong antitumor efficiency in colorectal carcinomas |
| CN116744951A (zh) * | 2020-12-25 | 2023-09-12 | 苏州系统医学研究所 | 一种包含溶瘤病毒的组合物及其在肿瘤治疗中的应用 |
| JP2024512053A (ja) * | 2021-03-24 | 2024-03-18 | ヴァイロジン バイオテック カナダ リミテッド | 転写及び翻訳の二重調節を受ける腫瘍溶解性単純ヘルペスウイルスベクター |
| CN117412986A (zh) | 2021-04-02 | 2024-01-16 | 克里斯托生物技术股份有限公司 | 用于癌症疗法的病毒载体 |
| JP2024532622A (ja) * | 2021-08-31 | 2024-09-05 | ヴィロジェン バイオテック カナダ リミテッド | 操作された腫瘍溶解性ヘルペスウイルス |
| CN113637761B (zh) * | 2021-10-15 | 2025-01-24 | 北京百奥思科生物医学技术有限公司 | 用于黑色素瘤诊断和治疗的miRNA标志物及其相关产品 |
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| CN118634240A (zh) * | 2022-06-27 | 2024-09-13 | 浙江大学 | 抗口腔肿瘤药物活性成分及其用途 |
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