SG11202107282VA - Encapsulated rna polynucleotides and methods of use - Google Patents

Encapsulated rna polynucleotides and methods of use

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Publication number
SG11202107282VA
SG11202107282VA SG11202107282VA SG11202107282VA SG11202107282VA SG 11202107282V A SG11202107282V A SG 11202107282VA SG 11202107282V A SG11202107282V A SG 11202107282VA SG 11202107282V A SG11202107282V A SG 11202107282VA SG 11202107282V A SG11202107282V A SG 11202107282VA
Authority
SG
Singapore
Prior art keywords
methods
rna polynucleotides
encapsulated rna
encapsulated
polynucleotides
Prior art date
Application number
SG11202107282VA
Inventor
Lorena Lerner
Edward M Kennedy
Mitchell H Finer
Christophe Quéva
Original Assignee
Oncorus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncorus Inc filed Critical Oncorus Inc
Publication of SG11202107282VA publication Critical patent/SG11202107282VA/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
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    • A61K9/10—Dispersions; Emulsions
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/5115—Inorganic compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N15/86—Viral vectors
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
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    • C12N2770/32311—Enterovirus
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    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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SG11202107282VA 2019-01-04 2020-01-03 Encapsulated rna polynucleotides and methods of use SG11202107282VA (en)

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EP (1) EP3906039A4 (en)
JP (1) JP2022516318A (en)
KR (1) KR20210113260A (en)
CN (1) CN113453699A (en)
AU (1) AU2020204989A1 (en)
BR (1) BR112021013155A2 (en)
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IL (1) IL284433A (en)
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PT3864163T (en) 2018-10-09 2024-04-30 Univ British Columbia Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
CA3150053A1 (en) * 2019-08-05 2021-02-11 Virogin Biotech Canada Ltd Genetically modified enterovirus vectors
JP2024503703A (en) * 2021-01-19 2024-01-26 セネカ セラピューティクス、インク． Armed Seneca Valley virus oncolytic therapy compositions and methods thereof
AU2022227607A1 (en) * 2021-02-23 2023-08-24 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
WO2023019310A1 (en) * 2021-08-17 2023-02-23 Monash University Lipid nanoparticle formulations
CN113980915B (en) * 2021-11-04 2023-07-07 江苏省人民医院（南京医科大学第一附属医院） Novel CXCL 10-expressing replicative oncolytic adenovirus and application thereof
FR3129833B1 (en) 2021-12-03 2024-09-06 Univ Claude Bernard Lyon NANOPARTICLES FOR THE RELEASE OF NUCLEIC ACIDS
WO2023165583A1 (en) * 2022-03-04 2023-09-07 益杰立科(上海)生物科技有限公司 Delivery system and method targeting ocular cell
WO2024009316A1 (en) * 2022-07-04 2024-01-11 Bharat Biotech International Limited Cationic lipid based composition, formulation and use for nucleic acid vaccine delivery and preparation thereof
CN115227674B (en) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 Encapsulated oncolytic viral genetic material and uses thereof
WO2024086810A1 (en) * 2022-10-21 2024-04-25 Georgia Tech Research Corporation Lymphatic endothelial cell-specific lipid nanoparticle and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638318B2 (en) * 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
CN101132798B (en) * 2005-01-17 2011-04-27 溶瘤病毒有限公司 Application of nucleic acid molecule in preparing medicine for treatment of neoplasms and composition
SG162726A1 (en) * 2005-05-27 2010-07-29 San Raffaele Centro Fond Gene vector comprising mi-rna
EP2125032A4 (en) * 2007-02-20 2011-02-23 Mayo Foundation Treating cancer with viral nucleic acid
WO2010057155A1 (en) * 2008-11-17 2010-05-20 Enzon Pharmaceuticals, Inc. Releasable cationic lipids for nucleic acids delivery systems
WO2013073480A1 (en) * 2011-11-18 2013-05-23 日油株式会社 Cationic lipid having improved intracellular kinetics
JP6228191B2 (en) * 2012-05-23 2017-11-08 ジ・オハイオ・ステート・ユニバーシティ Lipid-coated albumin nanoparticle composition, method of making the same, and method of using the same
JP6396891B2 (en) * 2013-04-17 2018-09-26 新日本製薬株式会社 Genetically modified Coxsackie virus
EP3247363A4 (en) * 2015-01-21 2018-10-03 Moderna Therapeutics, Inc. Lipid nanoparticle compositions
DK3408382T3 (en) * 2016-01-27 2022-06-20 Oncorus Inc ONCOLYTIC VIRAL VECTORS AND USES THEREOF
AU2017290828A1 (en) * 2016-06-30 2019-01-24 Virogin Biotech Canada Ltd Pseudotyped oncolytic viral delivery of therapeutic polypeptides
EP3597197A4 (en) * 2017-03-17 2021-01-06 National University Corporation Chiba University Novel technique for treating cancer using structurally-reinforced s-tud
JP6832422B2 (en) * 2017-04-19 2021-02-24 国立大学法人 東京大学 Genetically modified coxsackievirus and pharmaceutical composition
JP7187486B2 (en) * 2017-05-25 2022-12-12 レイドス， インコーポレイテッド PD-1 and CTLA-4 Dual Inhibitor Peptides
AU2018301701A1 (en) * 2017-07-14 2020-02-27 Elevatebio Technologies, Inc. Encapsulated polynucleotides and methods of use

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