RU2017144606A - Иммуноцитокины на основе il-15 и il-15rа домена sushi - Google Patents
Иммуноцитокины на основе il-15 и il-15rа домена sushi Download PDFInfo
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- RU2017144606A RU2017144606A RU2017144606A RU2017144606A RU2017144606A RU 2017144606 A RU2017144606 A RU 2017144606A RU 2017144606 A RU2017144606 A RU 2017144606A RU 2017144606 A RU2017144606 A RU 2017144606A RU 2017144606 A RU2017144606 A RU 2017144606A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Claims (16)
1. Конъюгат, содержащий аминокислотную последовательность RLI, соответствующую SEQ ID NO: 17.
2. Конъюгат по п. 1, дополнительно содержащий антитело или фрагмент антитела, способный вступать в реакцию с тем же антигеном, что и антитело, напрямую или опосредованно связанные при помощи ковалентной связи с указанным конъюгатом.
3. Конъюгат по п. 2, где антитело или его фрагмент, связанные при помощи ковалентной связи, содержат тяжелую цепь и/или легкую цепь.
4. Конъюгат по п. 3, где антитело содержит тяжелую цепь, включающую аминокислотную последовательность, соответствующую SEQ ID NO: 19.
5. Конъюгат по п. 3 или 4, где антитело содержит легкую цепь, включающую аминокислотную последовательность, соответствующую SEQ ID NO: 18.
6. Конъюгат по любому из пп. 2-5, где аминокислотная последовательность конъюгата и аминокислотная последовательность антитела или его фрагмента не разделены какой-либо линкерной аминокислотной последовательностью.
7. Конъюгат по любому из пп. 2-5, где аминокислотная последовательность конъюгата и аминокислотная последовательность антитела или его фрагмента разделены второй линкерной аминокислотной последовательностью.
8. Конъюгат по любому из пп. 2-7, где антитело или его фрагмент направлены против антигена, выбранного из группы, содержащей антигены, имеющие отношение к неоваскуляризации опухолей или к внеклеточному матриксу опухоли, и опухолевые антигены.
9. Конъюгат по любому из пп. 2-8, где аминокислотная последовательность конъюгата находится в C-концевом положении относительно аминокислотной последовательности антитела или его фрагмента.
10. Нуклеиновая кислота, кодирующая конъюгат по любому из пп. 1-9.
11. Вектор, содержащий нуклеиновую кислоту по п. 10.
12. Клетка-хозяин, генетически модифицированная нуклеиновой кислотой по п. 10 или вектором по п. 11.
13. Фармацевтическая композиция, содержащая конъюгат по любому из пп. 1-9, нуклеиновую кислоту по п. 10 или вектор по п. 11 и фармацевтически приемлемый носитель.
14. Фармацевтическая композиция по п. 13, где фармацевтически приемлемый носитель представляет собой растворитель, адъювант, эксципиент или наполнитель.
15. Способ лечения рака у субъекта, включающий введение фармацевтической композиции по п. 13 или 14 путем инъекции в дозе 2,5 мг/кг или менее, излечивающей тем самым рак у нуждающегося в этом субъекта.
16. Применение фармацевтической композиции по п. 13 или 14 для изготовления лекарственного средства для лечения рака у нуждающегося в этом субъекта, где лекарственное средство является подходящим для введения путем инъекции в дозе 2,5 мг/кг или менее.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11358005A EP2537933A1 (en) | 2011-06-24 | 2011-06-24 | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
EP11358005.4 | 2011-06-24 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2014100350A Division RU2644671C2 (ru) | 2011-06-24 | 2012-06-22 | ИММУНОЦИТОКИНЫ НА ОСНОВЕ IL-15 И IL-R[альфа] ДОМЕНА SUSHI |
Publications (3)
Publication Number | Publication Date |
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RU2017144606A true RU2017144606A (ru) | 2019-03-04 |
RU2017144606A3 RU2017144606A3 (ru) | 2021-02-10 |
RU2763298C2 RU2763298C2 (ru) | 2021-12-28 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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RU2014100350A RU2644671C2 (ru) | 2011-06-24 | 2012-06-22 | ИММУНОЦИТОКИНЫ НА ОСНОВЕ IL-15 И IL-R[альфа] ДОМЕНА SUSHI |
RU2017144606A RU2763298C2 (ru) | 2011-06-24 | 2012-06-22 | ИММУНОЦИТОКИНЫ НА ОСНОВЕ IL-15 И IL-15Rα ДОМЕНА SUSHI |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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RU2014100350A RU2644671C2 (ru) | 2011-06-24 | 2012-06-22 | ИММУНОЦИТОКИНЫ НА ОСНОВЕ IL-15 И IL-R[альфа] ДОМЕНА SUSHI |
Country Status (19)
Country | Link |
---|---|
US (5) | US20150152188A1 (ru) |
EP (3) | EP2537933A1 (ru) |
JP (4) | JP6151687B2 (ru) |
KR (3) | KR20220150407A (ru) |
CN (3) | CN104093841A (ru) |
AU (3) | AU2012272138B2 (ru) |
BR (1) | BR112013033350B1 (ru) |
CA (1) | CA2840113C (ru) |
DK (1) | DK2723869T3 (ru) |
ES (1) | ES2727806T3 (ru) |
HR (1) | HRP20190799T1 (ru) |
HU (1) | HUE043442T2 (ru) |
MX (1) | MX354923B (ru) |
PL (1) | PL2723869T3 (ru) |
PT (1) | PT2723869T (ru) |
RU (2) | RU2644671C2 (ru) |
SI (1) | SI2723869T1 (ru) |
TR (1) | TR201907397T4 (ru) |
WO (1) | WO2012175222A1 (ru) |
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- 2023-07-14 US US18/352,998 patent/US20240083963A1/en active Pending
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