RU2017119009A - Анализы для обнаружения субпопуляций иммунных т-клеток и способы их применения - Google Patents
Анализы для обнаружения субпопуляций иммунных т-клеток и способы их применения Download PDFInfo
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- RU2017119009A RU2017119009A RU2017119009A RU2017119009A RU2017119009A RU 2017119009 A RU2017119009 A RU 2017119009A RU 2017119009 A RU2017119009 A RU 2017119009A RU 2017119009 A RU2017119009 A RU 2017119009A RU 2017119009 A RU2017119009 A RU 2017119009A
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- Prior art keywords
- lymphocytes
- foxp3
- hvr
- seq
- amino acid
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 85
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 85
- 238000000034 method Methods 0.000 claims 62
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 55
- 125000003275 alpha amino acid group Chemical group 0.000 claims 54
- 210000004698 lymphocyte Anatomy 0.000 claims 48
- 206010028980 Neoplasm Diseases 0.000 claims 36
- 201000011510 cancer Diseases 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 17
- 239000000556 agonist Substances 0.000 claims 16
- 238000004393 prognosis Methods 0.000 claims 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
- 230000002349 favourable effect Effects 0.000 claims 6
- 238000002372 labelling Methods 0.000 claims 6
- 208000037819 metastatic cancer Diseases 0.000 claims 5
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 201000008275 breast carcinoma Diseases 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 102000004473 OX40 Ligand Human genes 0.000 claims 2
- 108010042215 OX40 Ligand Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 102000050320 human TNFRSF4 Human genes 0.000 claims 2
- 238000003125 immunofluorescent labeling Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940126625 tavolimab Drugs 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462074594P | 2014-11-03 | 2014-11-03 | |
| US62/074,594 | 2014-11-03 | ||
| PCT/US2015/058674 WO2016073378A1 (en) | 2014-11-03 | 2015-11-02 | Assays for detecting t cell immune subsets and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017119009A true RU2017119009A (ru) | 2018-12-05 |
| RU2017119009A3 RU2017119009A3 (enExample) | 2019-06-14 |
Family
ID=54602017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017119009A RU2017119009A (ru) | 2014-11-03 | 2015-11-02 | Анализы для обнаружения субпопуляций иммунных т-клеток и способы их применения |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20160161485A1 (enExample) |
| EP (1) | EP3215850B1 (enExample) |
| JP (1) | JP6702991B2 (enExample) |
| KR (1) | KR20170086540A (enExample) |
| CN (1) | CN106796235B (enExample) |
| AR (1) | AR102517A1 (enExample) |
| AU (1) | AU2015343337A1 (enExample) |
| BR (1) | BR112017009151A2 (enExample) |
| CA (1) | CA2966523A1 (enExample) |
| IL (1) | IL251977A0 (enExample) |
| MX (1) | MX2017005750A (enExample) |
| RU (1) | RU2017119009A (enExample) |
| SG (1) | SG11201703448QA (enExample) |
| WO (1) | WO2016073378A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160006168A (ko) | 2013-03-18 | 2016-01-18 | 바이오서오엑스 프로덕스 비.브이. | 인간화 항-cd134(ox40) 항체 및 이의 용도 |
| RU2016142476A (ru) | 2014-03-31 | 2018-05-07 | Дженентек, Инк. | Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40 |
| CA2966507A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment |
| MX2017005750A (es) | 2014-11-03 | 2017-12-15 | Genentech Inc | Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso. |
| KR20180053674A (ko) | 2015-10-02 | 2018-05-23 | 에프. 호프만-라 로슈 아게 | 공자극 tnf 수용체에 특이적인 이중특이성 항체 |
| WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
| SMT202200157T1 (it) * | 2016-08-08 | 2022-05-12 | Aerase Inc | Composizioni e procedimenti per trattare il cancro con deplezione di arginina e agenti immuno-oncologici |
| CN109232738B (zh) * | 2017-07-11 | 2021-11-09 | 南京金斯瑞生物科技有限公司 | 一种抗人ox40单克隆抗体及其应用 |
| CA3070297A1 (en) * | 2017-08-11 | 2019-02-14 | Genentech, Inc. | Anti-cd8 antibodies and uses thereof |
| EP3866837A1 (en) | 2018-10-19 | 2021-08-25 | AERase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| MX2021005047A (es) | 2018-10-31 | 2021-09-08 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1. |
| CN117105933A (zh) | 2018-10-31 | 2023-11-24 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
| TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
| JP2022545738A (ja) | 2019-08-30 | 2022-10-28 | アエグリア バイオセラピューティクス， インク． | ヒト組換えアルギナーゼ１の製造方法およびその使用 |
| CN111704671B (zh) * | 2020-08-19 | 2020-11-24 | 广东赛尔生物科技有限公司 | Ox40抗体及其在治疗癌症中的应用 |
| US20240044901A1 (en) * | 2021-02-09 | 2024-02-08 | Institut National de la Santé et de la Recherche Médicale | New method to pronostic lung cancer |
| CN116559436A (zh) * | 2023-02-03 | 2023-08-08 | 深圳沃德生命科技有限公司 | 一种利用外周血定量检测COVID-19 IFN-γ的试剂盒及其应用 |
| WO2025047660A1 (ja) * | 2023-08-31 | 2025-03-06 | 国立大学法人筑波大学 | 腫瘍性濾胞制御性ｔ細胞及び腫瘍性濾胞殺細胞性ｔ細胞を定量する方法、腫瘍性濾胞制御性ｔ細胞及び腫瘍性濾胞殺細胞性ｔ細胞をスクリーニングする方法、治療用組成物、及びキット |
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- 2015-11-02 AU AU2015343337A patent/AU2015343337A1/en not_active Abandoned
- 2015-11-02 CN CN201580054047.9A patent/CN106796235B/zh active Active
- 2015-11-02 EP EP15797510.3A patent/EP3215850B1/en active Active
- 2015-11-02 KR KR1020177014868A patent/KR20170086540A/ko not_active Withdrawn
- 2015-11-02 JP JP2017542821A patent/JP6702991B2/ja active Active
- 2015-11-02 WO PCT/US2015/058674 patent/WO2016073378A1/en not_active Ceased
- 2015-11-02 US US14/930,603 patent/US20160161485A1/en not_active Abandoned
- 2015-11-02 CA CA2966523A patent/CA2966523A1/en not_active Abandoned
- 2015-11-02 SG SG11201703448QA patent/SG11201703448QA/en unknown
- 2015-11-02 RU RU2017119009A patent/RU2017119009A/ru not_active Application Discontinuation
- 2015-11-02 BR BR112017009151-8A patent/BR112017009151A2/pt not_active Application Discontinuation
- 2015-11-03 AR ARP150103558A patent/AR102517A1/es unknown
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- 2017-12-21 US US15/849,805 patent/US10845364B2/en active Active
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| US20210109099A1 (en) | 2021-04-15 |
| CA2966523A1 (en) | 2016-05-12 |
| IL251977A0 (en) | 2017-06-29 |
| US20160161485A1 (en) | 2016-06-09 |
| RU2017119009A3 (enExample) | 2019-06-14 |
| US20180238878A1 (en) | 2018-08-23 |
| US10845364B2 (en) | 2020-11-24 |
| AU2015343337A1 (en) | 2017-06-15 |
| MX2017005750A (es) | 2017-12-15 |
| CN106796235A (zh) | 2017-05-31 |
| AR102517A1 (es) | 2017-03-08 |
| EP3215850A1 (en) | 2017-09-13 |
| JP2018504610A (ja) | 2018-02-15 |
| CN106796235B (zh) | 2021-01-29 |
| BR112017009151A2 (pt) | 2018-03-06 |
| WO2016073378A1 (en) | 2016-05-12 |
| KR20170086540A (ko) | 2017-07-26 |
| SG11201703448QA (en) | 2017-05-30 |
| JP6702991B2 (ja) | 2020-06-03 |
| EP3215850B1 (en) | 2019-07-03 |
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