RU2016145921A - Способы улучшения или ускорения физического восстановления после операции по поводу перелома шейки бедра - Google Patents
Способы улучшения или ускорения физического восстановления после операции по поводу перелома шейки бедра Download PDFInfo
- Publication number
- RU2016145921A RU2016145921A RU2016145921A RU2016145921A RU2016145921A RU 2016145921 A RU2016145921 A RU 2016145921A RU 2016145921 A RU2016145921 A RU 2016145921A RU 2016145921 A RU2016145921 A RU 2016145921A RU 2016145921 A RU2016145921 A RU 2016145921A
- Authority
- RU
- Russia
- Prior art keywords
- myostatin antagonist
- myostatin
- antagonist
- patient
- bimagrumab
- Prior art date
Links
- 238000011084 recovery Methods 0.000 title claims 10
- 208000020089 femoral neck fracture Diseases 0.000 title claims 7
- 102000004472 Myostatin Human genes 0.000 claims 46
- 108010056852 Myostatin Proteins 0.000 claims 46
- 239000005557 antagonist Substances 0.000 claims 44
- 238000000034 method Methods 0.000 claims 17
- 229950006326 bimagrumab Drugs 0.000 claims 13
- 238000001356 surgical procedure Methods 0.000 claims 11
- 206010003694 Atrophy Diseases 0.000 claims 9
- 230000037444 atrophy Effects 0.000 claims 9
- 102000005962 receptors Human genes 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 210000002436 femur neck Anatomy 0.000 claims 5
- 208000010392 Bone Fractures Diseases 0.000 claims 4
- 206010017076 Fracture Diseases 0.000 claims 4
- 210000003205 muscle Anatomy 0.000 claims 2
- 230000037257 muscle growth Effects 0.000 claims 2
- 230000037081 physical activity Effects 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 230000000472 traumatic effect Effects 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 230000001133 acceleration Effects 0.000 claims 1
- 238000012790 confirmation Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983565P | 2014-04-24 | 2014-04-24 | |
| US61/983,565 | 2014-04-24 | ||
| PCT/IB2015/052990 WO2015162590A1 (en) | 2014-04-24 | 2015-04-24 | Methods of improving or accelerating physical recovery after surgery for hip fracture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016145921A true RU2016145921A (ru) | 2018-05-25 |
| RU2016145921A3 RU2016145921A3 (enExample) | 2018-12-18 |
Family
ID=53175568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016145921A RU2016145921A (ru) | 2014-04-24 | 2015-04-24 | Способы улучшения или ускорения физического восстановления после операции по поводу перелома шейки бедра |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9969806B2 (enExample) |
| EP (2) | EP3461495A1 (enExample) |
| JP (1) | JP2017513882A (enExample) |
| KR (1) | KR20160147863A (enExample) |
| CN (1) | CN106456754A (enExample) |
| AU (2) | AU2015249396A1 (enExample) |
| BR (1) | BR112016023979A2 (enExample) |
| CA (1) | CA2944842A1 (enExample) |
| CL (1) | CL2016002679A1 (enExample) |
| IL (1) | IL248215A0 (enExample) |
| MX (1) | MX2016013916A (enExample) |
| PH (1) | PH12016501927A1 (enExample) |
| RU (1) | RU2016145921A (enExample) |
| SG (1) | SG11201608042RA (enExample) |
| TW (1) | TW201622746A (enExample) |
| WO (1) | WO2015162590A1 (enExample) |
| ZA (1) | ZA201606741B (enExample) |
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| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| MX354099B (es) | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TWI432449B (zh) | 2007-02-02 | 2014-04-01 | Acceleron Pharma Inc | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR20160129095A (ko) | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| NZ717429A (en) | 2008-04-11 | 2018-07-27 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| PT2340031T (pt) | 2008-08-14 | 2019-07-25 | Acceleron Pharma Inc | Armadilhas de gdf para uso no tratamento de anemia |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| WO2011063018A1 (en) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| US20120121576A1 (en) | 2010-11-08 | 2012-05-17 | Jasbir Seehra | Actriia binding agents and uses thereof |
| CN108715614A (zh) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| WO2013100132A1 (ja) | 2011-12-28 | 2013-07-04 | 中外製薬株式会社 | ペプチド化合物の環化方法 |
| EP3721900A1 (en) | 2012-08-24 | 2020-10-14 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc region variant |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
| BR112016029226A2 (pt) | 2014-06-13 | 2017-10-17 | Acceleron Pharma Inc | métodos e composições para o tratamento de úlceras |
| BR112017011411A2 (pt) * | 2014-12-08 | 2018-02-14 | Novartis Ag | antagonistas da miostatina ou da activina para o tratamento da sarcopenia |
| KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| JP2018537447A (ja) * | 2015-11-11 | 2018-12-20 | ノバルティス アーゲー | ミオスタチンアンタゴニストの使用、それを含有する組合せ物およびその使用 |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| EP3426680B1 (en) | 2016-03-10 | 2024-08-14 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
| TW202300168A (zh) | 2016-08-05 | 2023-01-01 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| US12246042B2 (en) * | 2018-08-29 | 2025-03-11 | Myos Corp. | Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals |
| US20210158965A1 (en) * | 2019-11-22 | 2021-05-27 | Hill-Rom Services, Inc. | Automated mobility assessment |
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| WO2023145735A1 (ja) | 2022-01-25 | 2023-08-03 | 元詞 早野 | サルコペニアを含む老化関連異常の抑制の新規治療と予防 |
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-
2015
- 2015-04-23 TW TW104113088A patent/TW201622746A/zh unknown
- 2015-04-24 SG SG11201608042RA patent/SG11201608042RA/en unknown
- 2015-04-24 KR KR1020167032362A patent/KR20160147863A/ko not_active Withdrawn
- 2015-04-24 AU AU2015249396A patent/AU2015249396A1/en not_active Abandoned
- 2015-04-24 MX MX2016013916A patent/MX2016013916A/es unknown
- 2015-04-24 BR BR112016023979A patent/BR112016023979A2/pt not_active IP Right Cessation
- 2015-04-24 US US15/304,010 patent/US9969806B2/en not_active Expired - Fee Related
- 2015-04-24 EP EP18201533.9A patent/EP3461495A1/en not_active Withdrawn
- 2015-04-24 EP EP15722260.5A patent/EP3134112A1/en not_active Ceased
- 2015-04-24 CA CA2944842A patent/CA2944842A1/en not_active Abandoned
- 2015-04-24 WO PCT/IB2015/052990 patent/WO2015162590A1/en not_active Ceased
- 2015-04-24 CN CN201580021368.9A patent/CN106456754A/zh not_active Withdrawn
- 2015-04-24 JP JP2016564003A patent/JP2017513882A/ja active Pending
- 2015-04-24 RU RU2016145921A patent/RU2016145921A/ru not_active Application Discontinuation
-
2016
- 2016-09-29 PH PH12016501927A patent/PH12016501927A1/en unknown
- 2016-09-29 ZA ZA2016/06741A patent/ZA201606741B/en unknown
- 2016-10-06 IL IL248215A patent/IL248215A0/en unknown
- 2016-10-21 CL CL2016002679A patent/CL2016002679A1/es unknown
-
2018
- 2018-01-23 AU AU2018200537A patent/AU2018200537A1/en not_active Abandoned
- 2018-04-10 US US15/949,156 patent/US20180230221A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2016013916A (es) | 2017-04-06 |
| AU2015249396A1 (en) | 2016-10-20 |
| AU2018200537A1 (en) | 2018-02-15 |
| US9969806B2 (en) | 2018-05-15 |
| TW201622746A (zh) | 2016-07-01 |
| ZA201606741B (en) | 2017-09-27 |
| CL2016002679A1 (es) | 2017-07-07 |
| SG11201608042RA (en) | 2016-11-29 |
| WO2015162590A1 (en) | 2015-10-29 |
| US20170029513A1 (en) | 2017-02-02 |
| BR112016023979A2 (pt) | 2017-10-17 |
| EP3461495A1 (en) | 2019-04-03 |
| CN106456754A (zh) | 2017-02-22 |
| US20180230221A1 (en) | 2018-08-16 |
| IL248215A0 (en) | 2016-11-30 |
| CA2944842A1 (en) | 2015-10-29 |
| PH12016501927A1 (en) | 2016-12-19 |
| EP3134112A1 (en) | 2017-03-01 |
| KR20160147863A (ko) | 2016-12-23 |
| JP2017513882A (ja) | 2017-06-01 |
| RU2016145921A3 (enExample) | 2018-12-18 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190408 |