ATE394492T1 - Verfahren zur oligomerisation von peptiden - Google Patents

Verfahren zur oligomerisation von peptiden

Info

Publication number
ATE394492T1
ATE394492T1 AT97948802T AT97948802T ATE394492T1 AT E394492 T1 ATE394492 T1 AT E394492T1 AT 97948802 T AT97948802 T AT 97948802T AT 97948802 T AT97948802 T AT 97948802T AT E394492 T1 ATE394492 T1 AT E394492T1
Authority
AT
Austria
Prior art keywords
oligomerization
peptides
oligomer
oligomerizing
domain
Prior art date
Application number
AT97948802T
Other languages
English (en)
Inventor
Alexey Terskikh
Reto Crameri
Jean-Pierre Mach
Doussal Jean-Marc Le
Andrey Kajava
Original Assignee
Univ Lausanne
Swiss Inst For Allergy And Ast
Inst Suisse De Rech S Experime
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lausanne, Swiss Inst For Allergy And Ast, Inst Suisse De Rech S Experime, Novartis Pharma Gmbh filed Critical Univ Lausanne
Application granted granted Critical
Publication of ATE394492T1 publication Critical patent/ATE394492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT97948802T 1996-10-28 1997-10-24 Verfahren zur oligomerisation von peptiden ATE394492T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96810719 1996-10-28

Publications (1)

Publication Number Publication Date
ATE394492T1 true ATE394492T1 (de) 2008-05-15

Family

ID=8225734

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948802T ATE394492T1 (de) 1996-10-28 1997-10-24 Verfahren zur oligomerisation von peptiden

Country Status (7)

Country Link
US (1) US20100105876A1 (de)
EP (1) EP0938571B8 (de)
AT (1) ATE394492T1 (de)
AU (1) AU6909298A (de)
DE (1) DE69738670D1 (de)
ES (1) ES2309999T3 (de)
WO (1) WO1998018943A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160088A (en) * 1998-07-29 2000-12-12 Sloan-Kettering Institute For Cancer KDEL receptor inhibitors
EP1149168A2 (de) * 1999-02-01 2001-10-31 Beth Israel Deaconess Medical Center Comp/tsp-1, comp/tsp-2 und andere chimerische proteinen
JP2003502024A (ja) * 1999-05-14 2003-01-21 メディカル リサーチ カウンシル タンパク質骨格および単量体ポリペプチドを多量体化するためのその使用
JP2002544285A (ja) * 1999-05-14 2002-12-24 メディカル リサーチ カウンシル オリゴマーシャペロンタンパク質
CA2440235A1 (en) * 2001-03-06 2002-09-12 Mustapha Abdelouahed Carrier chimeric proteins, targeted carrier chimeric proteins and preparation thereof
JP4471656B2 (ja) * 2001-11-30 2010-06-02 ナショナル リサーチ カウンシル オブ カナダ 新規自己集合分子
AU2004226162A1 (en) * 2003-04-04 2004-10-14 Universite De Lausanne Peptabody for cancer treatment
GB2408507B (en) * 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
MXPA06007252A (es) 2003-12-23 2007-01-23 Cythera Inc Endodermo definitivo.
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
CA2576872C (en) 2004-08-13 2013-11-12 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
TWI489993B (zh) 2007-10-12 2015-07-01 Novartis Ag 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法
PY09026846A (es) 2008-08-05 2015-09-01 Novartis Ag Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
SG174223A1 (en) 2009-03-10 2011-10-28 Med Discovery Sa Use of serine protease inhibitors in the treatment of neutropenia
WO2010102518A1 (zh) * 2009-03-13 2010-09-16 北京表源生物技术有限公司 一种融合蛋白多聚体
EA027071B1 (ru) 2009-04-27 2017-06-30 Новартис Аг АНТИТЕЛО К ActRIIB И СОДЕРЖАЩАЯ ЕГО КОМПОЗИЦИЯ
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
JP6472999B2 (ja) 2011-07-01 2019-02-20 ノバルティス アーゲー 代謝障害を治療するための方法
HUE053669T2 (hu) 2012-12-05 2021-07-28 Novartis Ag Készítmények és eljárások EPO-t célzó antitestekre
EP3033358A2 (de) 2013-08-14 2016-06-22 Novartis AG Verfahren zur behandlung sporadischer einschlusskörper-myositis
TW201622746A (zh) 2014-04-24 2016-07-01 諾華公司 改善或加速髖部骨折術後身體復原之方法
CN110461359B (zh) 2017-03-24 2025-01-21 诺华股份有限公司 用于预防和治疗心脏病的方法
JP2020511992A (ja) * 2017-03-29 2020-04-23 サニーブルック リサーチ インスティテュート 遺伝子組換えｔ細胞調節分子およびその使用方法
JP2021500930A (ja) * 2017-11-01 2021-01-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｏｍｐボディ−多価標的結合物質
CN115232205A (zh) * 2022-08-03 2022-10-25 南京京达生物技术有限公司 一种鼠源IgM亚型单克隆抗体纯化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026985A1 (en) * 1994-04-05 1995-10-12 Board Of Regents, The University Of Texas System Modified receptors that continuously signal
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
DE69633175T2 (de) * 1995-05-23 2005-08-11 Morphosys Ag Multimere proteine

Also Published As

Publication number Publication date
EP0938571B8 (de) 2008-07-02
DE69738670D1 (de) 2008-06-19
ES2309999T3 (es) 2008-12-16
EP0938571B1 (de) 2008-05-07
EP0938571A1 (de) 1999-09-01
US20100105876A1 (en) 2010-04-29
AU6909298A (en) 1998-05-22
WO1998018943A1 (en) 1998-05-07

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