RU2016138172A - Моделирование распространения фармацевтического препарата и генерирование параметров для инъекционных протоколов - Google Patents
Моделирование распространения фармацевтического препарата и генерирование параметров для инъекционных протоколов Download PDFInfo
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- RU2016138172A RU2016138172A RU2016138172A RU2016138172A RU2016138172A RU 2016138172 A RU2016138172 A RU 2016138172A RU 2016138172 A RU2016138172 A RU 2016138172A RU 2016138172 A RU2016138172 A RU 2016138172A RU 2016138172 A RU2016138172 A RU 2016138172A
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- pharmacokinetic model
- parameter
- physiologically
- based pharmacokinetic
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- 238000002347 injection Methods 0.000 title claims 14
- 239000007924 injection Substances 0.000 title claims 14
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 claims 27
- 239000002872 contrast media Substances 0.000 claims 13
- 230000017531 blood circulation Effects 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 4
- 238000005457 optimization Methods 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 230000006978 adaptation Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/17—General characteristics of the apparatus with redundant control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Primary Health Care (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Claims (29)
1. Способ моделирования распространения контрастного вещества, введенного пациенту с использованием физиологически обоснованной фармакокинетической модели, содержащий: моделирование объемной скорости потока крови и ее эффекта на распространение контрастного вещества, содержащего средство усиления контрастности, после того, как инъекция контрастного вещества прекращена.
2. Способ по п. 1, где физиологически обоснованная фармакокинетическая модель моделирует эффект распространения контрастного вещества после инъекции флюида, не содержащего средство усиления контрастности, после инъекции контрастного вещества.
3. Способ по п. 2, где флюид, не содержащий средство усиления контрастности, содержит физиологический раствор.
4. Способ по п. 2, где физиологически обоснованная фармакокинетическая модель является дискретизируемой.
5. Способ по п. 2, где физиологически обоснованная фармакокинетическая модель адаптирована для оценки кривой времени усиления для зоны интереса пациента.
6. Способ по п. 2, где физиологически обоснованная фармакокинетическая модель содержит, по меньшей мере, один нелинейный период насыщения в периферическом венозном компартменте, или, по меньшей мере, один конфигурируемый период транспортной задержки через, по меньшей мере, один компартмент.
7. Способ по п. 2, где физиологически обоснованная фармакокинетическая модель содержит, по меньшей мере, один нелинейный период насыщения в периферическом венозном компартменте.
8. Способ по п. 2, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично на основе данных от множества индивидуумов.
9. Способ по п. 2, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично на основе одной переменной для конкретного пациента.
10. Способ по п. 5, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично на основе по меньшей мере одной кривой времени усиления для зоны интереса пациента, полученной при инъекции контрастного вещества.
11. Способ по п. 2, дополнительно содержащий понижение порядка физиологически обоснованной фармакокинетической модели.
12. Способ по п. 11, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично на основе по меньшей мере одной кривой времени усиления для зоны интереса пациента.
13. Способ по п. 2, где физиологически обоснованная фармакокинетическая модель включена в систему, содержащую инъекторную систему и систему визуализации, и использована в генерировании по меньшей мере одного параметра для инъекционной процедуры.
14. Способ по п. 6, где физиологически обоснованная фармакокинетическая модель включена в систему, содержащую инъекторную систему и систему визуализации, и использована в генерировании по меньшей мере одного параметра для инъекционной процедуры.
15. Способ по п. 5, дополнительно содержащий использование физиологически обоснованной фармакокинетической модели для оценки кривой времени усиления для пациента и для определения по меньшей мере одного параметра инъекционной процедуры по меньшей мере частично по расчетной кривой времени усиления.
16. Способ по п. 15, дополнительно содержащий использование измеренной кривой времени усиления во время диагностической инъекции контрастного вещества для корректировки модели и для изменения по меньшей мере одного параметра инъекционной процедуры.
17. Способ по п. 1, где объемную скорость потока крови и массовую скорость потока контрастного вещества обрабатывают назависимо и эффект объемной скорости потока крови экзогенного флюида на объемную скорость потока крови рассматривают в физиологически обоснованной фармакокинетической модели.
18. Система, содержащая систему генерирования параметров для определения по меньшей мере одного параметра для инъекционной процедуры, систему генерирования параметров, содержащую физиологически обоснованную фармакокинетическую модель для моделирования распространения контрастного вещества, введенного пациенту, содержащую адаптацию к моделированию объемной скорости потока крови и ее эффекта на распространение контрастного вещества после того, как инъекция контрастного вещества прекращена.
19. Система по п. 18, где физиологически обоснованная фармакокинетическая модель является дискретизируемой.
20. Система по п. 18, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично из по меньшей мере одной кривой времени усиления пациента.
21. Система по п. 18, дополнительно, где порядок физиологически обоснованной фармакокинетической модели понижен.
22. Система по п. 21, где по меньшей мере один параметр для физиологически обоснованной фармакокинетической модели определен по меньшей мере частично из по меньшей мере одной кривой времени усиления пациента.
23. Система по п. 18, дополнительно содержащая непараметрическую модель для моделирования распространения контрастного вещества, введенного пациенту.
24. Система по п. 23, где непараметрическая модель основана по меньшей мере частично на усеченном деконволюционном методе разложения по сингулярным числам матрицы (tSVD).
25. Система по п. 18, где по меньшей мере один параметр определен с использованием способа оптимизации на основе физиологически обоснованной фармакокинетической модели.
26. Система по п. 25, где способ оптимизации является ограниченным способом оптимизации.
27. Система по п. 23, где по меньшей мере один параметр определен с использованием способа оптимизации на основе по меньшей мере одной физиологически обоснованной фармакокинетической модели или непараметрической модели.
28. Система по п. 23, где непараметрическая модель основана по меньшей мере частично на по меньшей мере одной кривой времени усиления для зоны интереса пациента.
29. Система по п. 18, где объемная скорость потока крови и массовая скорость потока контрастного вещества обрабатываются назависимо и эффект объемной скорости потока крови экзогенного флюида на объемную скорость потока крови рассматривается в физиологически обоснованной фармакокинетической модели.
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US35840010P | 2010-06-24 | 2010-06-24 | |
US61/358,400 | 2010-06-24 |
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RU2013102902/15A Division RU2600892C2 (ru) | 2010-06-24 | 2011-06-24 | Моделирование распространения фармацевтического препарата и генерирование параметров для инъекционных протоколов |
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RU2016138172A RU2016138172A (ru) | 2010-06-24 | 2011-06-24 | Моделирование распространения фармацевтического препарата и генерирование параметров для инъекционных протоколов |
RU2013102902/15A RU2600892C2 (ru) | 2010-06-24 | 2011-06-24 | Моделирование распространения фармацевтического препарата и генерирование параметров для инъекционных протоколов |
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Country Status (10)
Country | Link |
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US (1) | US9959389B2 (ru) |
EP (1) | EP2585116A4 (ru) |
JP (2) | JP6025718B2 (ru) |
KR (2) | KR20180015279A (ru) |
CN (2) | CN106075634A (ru) |
AU (2) | AU2011270772C1 (ru) |
BR (1) | BR112012033116A2 (ru) |
CA (1) | CA2803169C (ru) |
RU (2) | RU2016138172A (ru) |
WO (1) | WO2011163578A2 (ru) |
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WO2011163578A2 (en) | 2011-12-29 |
RU2013102902A (ru) | 2014-07-27 |
AU2011270772B2 (en) | 2016-08-11 |
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JP2013533028A (ja) | 2013-08-22 |
WO2011163578A3 (en) | 2012-04-05 |
CN103221071A (zh) | 2013-07-24 |
RU2600892C2 (ru) | 2016-10-27 |
KR20180015279A (ko) | 2018-02-12 |
CA2803169A1 (en) | 2011-12-29 |
JP6025718B2 (ja) | 2016-11-16 |
EP2585116A4 (en) | 2017-03-29 |
AU2016253559B2 (en) | 2018-03-29 |
CN103221071B (zh) | 2016-09-21 |
CA2803169C (en) | 2020-09-22 |
JP2016152940A (ja) | 2016-08-25 |
KR20130088760A (ko) | 2013-08-08 |
US9959389B2 (en) | 2018-05-01 |
US20130211247A1 (en) | 2013-08-15 |
AU2016253559A1 (en) | 2017-01-05 |
BR112012033116A2 (pt) | 2016-10-25 |
CN106075634A (zh) | 2016-11-09 |
JP6410753B2 (ja) | 2018-10-24 |
EP2585116A2 (en) | 2013-05-01 |
AU2011270772C1 (en) | 2017-04-20 |
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