RU2015156801A - Генетически стерильные животные - Google Patents
Генетически стерильные животные Download PDFInfo
- Publication number
- RU2015156801A RU2015156801A RU2015156801A RU2015156801A RU2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A
- Authority
- RU
- Russia
- Prior art keywords
- animal
- gene
- cell
- group
- sperm
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims 41
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 210000004027 cell Anatomy 0.000 claims 15
- 241000282414 Homo sapiens Species 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000006378 damage Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 108010069446 Fertilins Proteins 0.000 claims 6
- 102000001133 Fertilins Human genes 0.000 claims 6
- 210000000349 chromosome Anatomy 0.000 claims 6
- -1 CatSper Proteins 0.000 claims 5
- 101710163270 Nuclease Proteins 0.000 claims 5
- 241000251468 Actinopterygii Species 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 4
- 241000283707 Capra Species 0.000 claims 4
- 241000283073 Equus caballus Species 0.000 claims 4
- 241000282326 Felis catus Species 0.000 claims 4
- 241000287828 Gallus gallus Species 0.000 claims 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 4
- 241001494479 Pecora Species 0.000 claims 4
- 241000009328 Perro Species 0.000 claims 4
- 241000282898 Sus scrofa Species 0.000 claims 4
- 238000010459 TALEN Methods 0.000 claims 4
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 4
- 230000002759 chromosomal effect Effects 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 230000006543 gametophyte development Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000014639 sexual reproduction Effects 0.000 claims 4
- 230000019100 sperm motility Effects 0.000 claims 4
- 102100032578 Adenosine deaminase domain-containing protein 1 Human genes 0.000 claims 3
- 102100033672 Deleted in azoospermia-like Human genes 0.000 claims 3
- 102100031780 Endonuclease Human genes 0.000 claims 3
- 108010042407 Endonucleases Proteins 0.000 claims 3
- 101000797006 Homo sapiens Adenosine deaminase domain-containing protein 1 Proteins 0.000 claims 3
- 101000871280 Homo sapiens Deleted in azoospermia-like Proteins 0.000 claims 3
- 241000288906 Primates Species 0.000 claims 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 3
- 210000002593 Y chromosome Anatomy 0.000 claims 3
- 238000010171 animal model Methods 0.000 claims 3
- 108010072122 calmegin Proteins 0.000 claims 3
- 108010084071 complexin I Proteins 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 230000021595 spermatogenesis Effects 0.000 claims 3
- 238000012360 testing method Methods 0.000 claims 3
- 210000001550 testis Anatomy 0.000 claims 3
- 108091022885 ADAM Proteins 0.000 claims 2
- 102000029791 ADAM Human genes 0.000 claims 2
- 101150040384 ATP2B4 gene Proteins 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 2
- 102100026092 Calmegin Human genes 0.000 claims 2
- 101710200976 Cation channel sperm-associated auxiliary subunit beta Proteins 0.000 claims 2
- 102100028013 Cation channel sperm-associated auxiliary subunit beta Human genes 0.000 claims 2
- 101710119341 Cation channel sperm-associated auxiliary subunit delta Proteins 0.000 claims 2
- 102100028012 Cation channel sperm-associated auxiliary subunit delta Human genes 0.000 claims 2
- 101710132751 Cation channel sperm-associated protein 1 Proteins 0.000 claims 2
- 102100028004 Cation channel sperm-associated protein 1 Human genes 0.000 claims 2
- 101710132770 Cation channel sperm-associated protein 2 Proteins 0.000 claims 2
- 102100028062 Cation channel sperm-associated protein 2 Human genes 0.000 claims 2
- 101710132768 Cation channel sperm-associated protein 3 Proteins 0.000 claims 2
- 102100028061 Cation channel sperm-associated protein 3 Human genes 0.000 claims 2
- 102100027826 Complexin-1 Human genes 0.000 claims 2
- 102100031637 Dynein axonemal heavy chain 8 Human genes 0.000 claims 2
- 101000866323 Homo sapiens Dynein axonemal heavy chain 8 Proteins 0.000 claims 2
- 101001002508 Homo sapiens Immunoglobulin-binding protein 1 Proteins 0.000 claims 2
- 101000944004 Homo sapiens Potassium channel subfamily U member 1 Proteins 0.000 claims 2
- 102100021042 Immunoglobulin-binding protein 1 Human genes 0.000 claims 2
- 101100322565 Mus musculus Adam3 gene Proteins 0.000 claims 2
- 101100222253 Mus musculus Catsper4 gene Proteins 0.000 claims 2
- 101100160972 Mus musculus Zmynd15 gene Proteins 0.000 claims 2
- 102100033525 Potassium channel subfamily U member 1 Human genes 0.000 claims 2
- 102000018120 Recombinases Human genes 0.000 claims 2
- 108010091086 Recombinases Proteins 0.000 claims 2
- 101150002402 Smcp gene Proteins 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 210000003794 male germ cell Anatomy 0.000 claims 2
- 210000000287 oocyte Anatomy 0.000 claims 2
- 101150079865 Atp1a4 gene Proteins 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 101000728117 Homo sapiens Plasma membrane calcium-transporting ATPase 4 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102100029743 Plasma membrane calcium-transporting ATPase 4 Human genes 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000001448 gametogenic effect Effects 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000034004 oogenesis Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829656P | 2013-05-31 | 2013-05-31 | |
| US61/829,656 | 2013-05-31 | ||
| US201361870558P | 2013-08-27 | 2013-08-27 | |
| US61/870,558 | 2013-08-27 | ||
| PCT/US2014/035847 WO2014193583A2 (en) | 2013-05-31 | 2014-04-29 | Genetically sterile animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015156801A true RU2015156801A (ru) | 2017-07-06 |
Family
ID=51986779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015156801A RU2015156801A (ru) | 2013-05-31 | 2014-04-29 | Генетически стерильные животные |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20140359796A1 (enExample) |
| EP (1) | EP3004345A4 (enExample) |
| JP (1) | JP2016525890A (enExample) |
| KR (1) | KR20160013219A (enExample) |
| CN (1) | CN105473714A (enExample) |
| AP (1) | AP2015008963A0 (enExample) |
| AU (1) | AU2014272106A1 (enExample) |
| BR (1) | BR112015029904A2 (enExample) |
| CA (1) | CA2913411A1 (enExample) |
| MX (1) | MX2015016385A (enExample) |
| PH (1) | PH12015502640A1 (enExample) |
| RU (1) | RU2015156801A (enExample) |
| WO (1) | WO2014193583A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| MX388563B (es) | 2013-10-25 | 2025-03-20 | Livestock Improvement Corporation Ltd | Marcadores geneticos y usos de los mismos. |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| US9745561B2 (en) * | 2014-01-08 | 2017-08-29 | Iowa State University Research Foundation, Inc. | Genetic test and genetic basis for SCID in pigs |
| MX2016014066A (es) | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| WO2016011029A2 (en) * | 2014-07-14 | 2016-01-21 | Washington State University | Nanos knock-out that ablates germline cells |
| EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016163386A1 (ja) | 2015-04-08 | 2016-10-13 | 全国農業協同組合連合会 | 異個体由来の配偶子を生産する非ヒト大型哺乳動物又は魚類の作出方法 |
| EP3303585A4 (en) | 2015-06-03 | 2018-10-31 | Board of Regents of the University of Nebraska | Dna editing using single-stranded dna |
| US20170099813A1 (en) * | 2015-10-07 | 2017-04-13 | Recombinetics, Inc. | Method of generating sterile terminal sires in livestock and animals produced thereby |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3498096A1 (en) * | 2017-12-18 | 2019-06-19 | IMV Technologies | Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel |
| CN110184296B (zh) * | 2018-02-07 | 2023-06-09 | 上海大学 | 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物 |
| MX2020008847A (es) * | 2018-02-26 | 2020-10-01 | Aggenetics Inc | Materiales y metodos para prevenir la transmision de un cromosoma en particular. |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020047514A2 (en) * | 2018-08-31 | 2020-03-05 | Recombinetics, Inc. | Production method for animal models with disease associated phenotypes |
| GB201816633D0 (en) | 2018-10-12 | 2018-11-28 | Univ Edinburgh | Genetically modified avians and method for the reconstitution thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109837347B (zh) * | 2019-01-02 | 2021-01-29 | 华中农业大学 | Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| BR112021020349A2 (pt) * | 2019-04-09 | 2021-12-14 | Mayo Found Medical Education & Res | Peixe estéril |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| CN111378663B (zh) * | 2020-03-18 | 2021-07-13 | 吉林省农业科学院 | lncRNA SFR1及其应用、调控卵泡发育的产品和方法 |
| GB2614813B (en) | 2020-05-08 | 2025-05-07 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN111549032A (zh) * | 2020-05-26 | 2020-08-18 | 肇庆学院 | 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
| KR102285906B1 (ko) | 2021-02-18 | 2021-08-04 | 주식회사 엔에이피 | 수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물 |
| IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| WO2024042515A1 (en) * | 2022-08-22 | 2024-02-29 | Ramot At Tel-Aviv University Ltd. | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations |
| CN116064541B (zh) * | 2022-10-21 | 2025-03-18 | 华南农业大学 | 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法 |
| KR20250033452A (ko) | 2023-08-30 | 2025-03-10 | 서울대학교산학협력단 | Cyp17a1 형질전환 비만 및 불임치료제 개발 모델 제조방법 및 용도 |
| CN116884488B (zh) * | 2023-09-07 | 2023-11-24 | 中国医学科学院基础医学研究所 | 一种男性不育标志物的筛查方法、系统及设备 |
| CN118910165A (zh) * | 2024-10-11 | 2024-11-08 | 上海南方模式生物科技股份有限公司 | 一种cxcl16基因人源化动物模型的构建方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002543814A (ja) * | 1999-05-13 | 2002-12-24 | セダーシナイ メディカル センター | トランスジェニック種の発生と遺伝子療法用の雄性生殖細胞の遺伝的修飾法 |
| CN101024829A (zh) * | 2000-02-24 | 2007-08-29 | 马萨诸塞大学 | 只生育单一性别后代的哺乳动物的生产 |
| WO2002077637A1 (en) * | 2001-03-22 | 2002-10-03 | Infigen, Inc. | Sex-specific selection of sperm from transgenic animals |
| AU2003213813A1 (en) * | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| WO2010065550A2 (en) * | 2008-12-01 | 2010-06-10 | Board Of Regents University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| EP2470557A1 (en) * | 2009-08-28 | 2012-07-04 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| EP3461898A1 (en) * | 2011-02-25 | 2019-04-03 | The University Court Of The University of Edinburgh | Genetically modified animals and methods for making the same |
| WO2012158985A2 (en) * | 2011-05-17 | 2012-11-22 | Transposagen Biopharmaceuticals, Inc. | Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms |
| AU2013337951B2 (en) * | 2012-10-30 | 2019-10-03 | Recombinetics, Inc. | Control of sexual maturation in animals |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
-
2014
- 2014-04-28 US US14/263,408 patent/US20140359796A1/en not_active Abandoned
- 2014-04-29 CA CA2913411A patent/CA2913411A1/en not_active Abandoned
- 2014-04-29 RU RU2015156801A patent/RU2015156801A/ru not_active Application Discontinuation
- 2014-04-29 BR BR112015029904A patent/BR112015029904A2/pt not_active Application Discontinuation
- 2014-04-29 MX MX2015016385A patent/MX2015016385A/es unknown
- 2014-04-29 JP JP2016516661A patent/JP2016525890A/ja active Pending
- 2014-04-29 WO PCT/US2014/035847 patent/WO2014193583A2/en not_active Ceased
- 2014-04-29 AU AU2014272106A patent/AU2014272106A1/en not_active Abandoned
- 2014-04-29 AP AP2015008963A patent/AP2015008963A0/en unknown
- 2014-04-29 CN CN201480042269.4A patent/CN105473714A/zh active Pending
- 2014-04-29 EP EP14804562.8A patent/EP3004345A4/en not_active Withdrawn
- 2014-04-29 KR KR1020157037273A patent/KR20160013219A/ko not_active Ceased
-
2015
- 2015-11-26 PH PH12015502640A patent/PH12015502640A1/en unknown
-
2019
- 2019-06-03 US US16/430,251 patent/US20190335725A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015029904A2 (pt) | 2017-09-26 |
| MX2015016385A (es) | 2016-04-11 |
| CA2913411A1 (en) | 2014-12-04 |
| CN105473714A (zh) | 2016-04-06 |
| KR20160013219A (ko) | 2016-02-03 |
| NZ715540A (en) | 2021-04-30 |
| US20140359796A1 (en) | 2014-12-04 |
| WO2014193583A3 (en) | 2015-01-22 |
| PH12015502640A1 (en) | 2016-03-07 |
| AU2014272106A1 (en) | 2016-01-21 |
| AP2015008963A0 (en) | 2016-01-31 |
| EP3004345A4 (en) | 2017-02-15 |
| WO2014193583A2 (en) | 2014-12-04 |
| JP2016525890A (ja) | 2016-09-01 |
| EP3004345A2 (en) | 2016-04-13 |
| US20190335725A1 (en) | 2019-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015156801A (ru) | Генетически стерильные животные | |
| US12070022B2 (en) | Methods for making genetic edits | |
| JP2016525890A5 (enExample) | ||
| JP2015533284A5 (enExample) | ||
| JP2019047794A (ja) | 動物における性成熟の制御 | |
| WO2016097751A1 (en) | Method of cas9 mediated genome engineering | |
| US20140359795A1 (en) | Genetic techniques for making animals with sortable sperm | |
| EP3367788A1 (en) | Engineering of humanized car t-cells and platelets by genetic complementation | |
| CN107426986A (zh) | 一种培育雄性不育库蚊的方法 | |
| US20170079251A1 (en) | Genetically modified animals having increased heat tolerance | |
| US20210251200A1 (en) | Production method for animal models with disease associated phenotypes | |
| US10920242B2 (en) | Non-meiotic allele introgression | |
| CA2967027A1 (en) | Heterozygous modifications of tumor suppressor genes | |
| WO2024042515A1 (en) | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations | |
| WO2009088189A3 (ko) | 형질전환된 복제개의 생산방법 | |
| HASAN et al. | Possibilities of using CRISPR-based genome editing Technologies in Livestock | |
| Wadhwa et al. | Generating transgenic animal models: recent technological advancements | |
| US20240397918A1 (en) | Non-meiotic allele introgression | |
| KOVTUN et al. | The use of biotechnological methods for conservation of animal genetic resources | |
| Andrabi et al. | A first study on sperm sexing in water buffalo through magnetic nanoparticles. | |
| FAYYAZ et al. | Future Frontiers: Emerging Trends and Applications in Animal Biotechnology | |
| Akbulut | Transgenic animal technology with genetic engineering and its use with advantages and disadvantages. | |
| Yum et al. | Application of GFP locus for gene Editing in Transgenic Cattle using CRISPR/Cas9 System | |
| Blomberg | Potential for selection of beneficial traits in swine with site-specific nucleases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180604 |