EP3004345A4 - Genetically sterile animals - Google Patents

Genetically sterile animals Download PDF

Info

Publication number
EP3004345A4
EP3004345A4 EP14804562.8A EP14804562A EP3004345A4 EP 3004345 A4 EP3004345 A4 EP 3004345A4 EP 14804562 A EP14804562 A EP 14804562A EP 3004345 A4 EP3004345 A4 EP 3004345A4
Authority
EP
European Patent Office
Prior art keywords
sterile animals
genetically sterile
genetically
animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP14804562.8A
Other languages
German (de)
French (fr)
Other versions
EP3004345A2 (en
Inventor
Daniel F. Carlson
Scott C. Fahrenkrug
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recombinetics Inc
Original Assignee
Recombinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361829656P priority Critical
Priority to US201361870558P priority
Application filed by Recombinetics Inc filed Critical Recombinetics Inc
Priority to PCT/US2014/035847 priority patent/WO2014193583A2/en
Publication of EP3004345A2 publication Critical patent/EP3004345A2/en
Publication of EP3004345A4 publication Critical patent/EP3004345A4/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knockout animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0273Cloned animals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/101Bovine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/103Ovine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/108Swine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/80Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
EP14804562.8A 2013-05-31 2014-04-29 Genetically sterile animals Pending EP3004345A4 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201361829656P true 2013-05-31 2013-05-31
US201361870558P true 2013-08-27 2013-08-27
PCT/US2014/035847 WO2014193583A2 (en) 2013-05-31 2014-04-29 Genetically sterile animals

Publications (2)

Publication Number Publication Date
EP3004345A2 EP3004345A2 (en) 2016-04-13
EP3004345A4 true EP3004345A4 (en) 2017-02-15

Family

ID=51986779

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14804562.8A Pending EP3004345A4 (en) 2013-05-31 2014-04-29 Genetically sterile animals

Country Status (13)

Country Link
US (2) US20140359796A1 (en)
EP (1) EP3004345A4 (en)
JP (1) JP2016525890A (en)
KR (1) KR20160013219A (en)
CN (1) CN105473714A (en)
AP (1) AP201508963A0 (en)
AU (1) AU2014272106A1 (en)
BR (1) BR112015029904A2 (en)
CA (1) CA2913411A1 (en)
MX (1) MX2015016385A (en)
PH (1) PH12015502640A1 (en)
RU (1) RU2015156801A (en)
WO (1) WO2014193583A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2853829A1 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9840699B2 (en) 2013-12-12 2017-12-12 President And Fellows Of Harvard College Methods for nucleic acid editing
US9745561B2 (en) * 2014-01-08 2017-08-29 Iowa State University Research Foundation, Inc. Genetic test and genetic basis for SCID in pigs
WO2016011029A2 (en) * 2014-07-14 2016-01-21 Washington State University Nanos knock-out that ablates germline cells
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
US20170099813A1 (en) * 2015-10-07 2017-04-13 Recombinetics, Inc. Method of generating sterile terminal sires in livestock and animals produced thereby
CN108513575A (en) 2015-10-23 2018-09-07 哈佛大学的校长及成员们 Nucleobase editing machine and application thereof
CN105543257A (en) * 2016-01-18 2016-05-04 安徽农业大学 PAPN gene site-directed modified pig
JP2019536425A (en) 2016-08-03 2019-12-19 プレジデント アンド フェローズ オブ ハーバード カレッジ Adenosine nucleobase editing factors and their uses
WO2019165465A1 (en) * 2018-02-26 2019-08-29 Aggenetics, Inc. Materials and methods for preventing transmission of a particular chromosome
GB201816633D0 (en) * 2018-10-12 2018-11-28 Univ Court Of The Univ Of Edinburgh Genetically modified avians and method for the reconstitution thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001062076A1 (en) * 2000-02-24 2001-08-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of mammals which produce progeny of a single sex
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
US20050125853A1 (en) * 2002-03-22 2005-06-09 St. Jude Children's Resarch Hospital Method for generating genetically modified animals
WO2011023740A1 (en) * 2009-08-28 2011-03-03 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids
WO2012158985A2 (en) * 2011-05-17 2012-11-22 Transposagen Biopharmaceuticals, Inc. Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
US20140123330A1 (en) * 2012-10-30 2014-05-01 Recombinetics, Inc. Control of sexual maturation in animals
WO2014193584A2 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetic techniques for making animals with sortable sperm

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543814A (en) * 1999-05-13 2002-12-24 インペリアル カレッジ イノベイションズ リミテッド Genetic modification of male germ cells for transgenic species development and gene therapy
US8735156B2 (en) * 2008-12-01 2014-05-27 The Board Of Regents Of The University Of Texas System Production and use of rat spermatogonial stem cell lines
WO2011011767A1 (en) * 2009-07-24 2011-01-27 Sigma-Aldrich Co. Method for genome editing
EP3461898A1 (en) * 2011-02-25 2019-04-03 The University Court Of The University of Edinburgh Genetically modified animals and methods for making the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001062076A1 (en) * 2000-02-24 2001-08-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of mammals which produce progeny of a single sex
US20050081256A1 (en) * 2001-03-22 2005-04-14 Forsberg Erik J. Sex- specific selection of sperm from transgenic animals
US20050125853A1 (en) * 2002-03-22 2005-06-09 St. Jude Children's Resarch Hospital Method for generating genetically modified animals
WO2011023740A1 (en) * 2009-08-28 2011-03-03 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids
WO2012158985A2 (en) * 2011-05-17 2012-11-22 Transposagen Biopharmaceuticals, Inc. Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms
US20140123330A1 (en) * 2012-10-30 2014-05-01 Recombinetics, Inc. Control of sexual maturation in animals
WO2014193584A2 (en) * 2013-05-31 2014-12-04 Recombinetics, Inc. Genetic techniques for making animals with sortable sperm

Also Published As

Publication number Publication date
EP3004345A2 (en) 2016-04-13
RU2015156801A (en) 2017-07-06
US20140359796A1 (en) 2014-12-04
PH12015502640A1 (en) 2016-03-07
KR20160013219A (en) 2016-02-03
US20190335725A1 (en) 2019-11-07
BR112015029904A2 (en) 2017-09-26
MX2015016385A (en) 2016-04-11
WO2014193583A3 (en) 2015-01-22
CN105473714A (en) 2016-04-06
AU2014272106A1 (en) 2016-01-21
JP2016525890A (en) 2016-09-01
WO2014193583A2 (en) 2014-12-04
AP201508963A0 (en) 2016-01-31
CA2913411A1 (en) 2014-12-04

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