JP2015523098A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523098A5 JP2015523098A5 JP2015525450A JP2015525450A JP2015523098A5 JP 2015523098 A5 JP2015523098 A5 JP 2015523098A5 JP 2015525450 A JP2015525450 A JP 2015525450A JP 2015525450 A JP2015525450 A JP 2015525450A JP 2015523098 A5 JP2015523098 A5 JP 2015523098A5
- Authority
- JP
- Japan
- Prior art keywords
- eif4g
- animal
- modified
- protein
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710091919 Eukaryotic translation initiation factor 4G Proteins 0.000 claims 58
- 241001465754 Metazoa Species 0.000 claims 32
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 108091005804 Peptidases Proteins 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 102000004190 Enzymes Human genes 0.000 claims 10
- 108090000790 Enzymes Proteins 0.000 claims 10
- 238000003776 cleavage reaction Methods 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 230000007017 scission Effects 0.000 claims 10
- 102000035195 Peptidases Human genes 0.000 claims 8
- 235000019833 protease Nutrition 0.000 claims 8
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims 7
- 108700028369 Alleles Proteins 0.000 claims 6
- 210000001161 mammalian embryo Anatomy 0.000 claims 5
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 235000019419 proteases Nutrition 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- 241000251468 Actinopterygii Species 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000287828 Gallus gallus Species 0.000 claims 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 3
- 241001494479 Pecora Species 0.000 claims 3
- 108010029485 Protein Isoforms Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 3
- 235000013330 chicken meat Nutrition 0.000 claims 3
- 238000010362 genome editing Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 101710163270 Nuclease Proteins 0.000 claims 2
- 238000010459 TALEN Methods 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000037442 genomic alteration Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 235000003869 genetically modified organism Nutrition 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 nucleic acid compound Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677904P | 2012-07-31 | 2012-07-31 | |
| US61/677,904 | 2012-07-31 | ||
| US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
| US13/836,860 | 2013-03-15 | ||
| PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523098A JP2015523098A (ja) | 2015-08-13 |
| JP2015523098A5 true JP2015523098A5 (enExample) | 2016-09-08 |
| JP6446360B2 JP6446360B2 (ja) | 2018-12-26 |
Family
ID=50026918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525450A Expired - Fee Related JP6446360B2 (ja) | 2012-07-31 | 2013-07-19 | 対立遺伝子置換によるｆｍｄｖ抵抗性家畜の産生 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10058078B2 (enExample) |
| EP (2) | EP3540050A1 (enExample) |
| JP (1) | JP6446360B2 (enExample) |
| KR (1) | KR20150036792A (enExample) |
| CN (1) | CN104837989A (enExample) |
| AR (1) | AR091948A1 (enExample) |
| AU (1) | AU2013296901B2 (enExample) |
| BR (1) | BR112015002280A2 (enExample) |
| CA (1) | CA2880616A1 (enExample) |
| CL (1) | CL2015000248A1 (enExample) |
| MX (1) | MX366723B (enExample) |
| NZ (1) | NZ629582A (enExample) |
| PH (1) | PH12015500213A1 (enExample) |
| RU (1) | RU2015106818A (enExample) |
| WO (1) | WO2014022120A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2533629B1 (en) * | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| JP2016521975A (ja) * | 2013-05-15 | 2016-07-28 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 遺伝的状態の処置のための方法および組成物 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| WO2015060732A1 (en) | 2013-10-25 | 2015-04-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| EP3066201B1 (en) | 2013-11-07 | 2018-03-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
| CA2943794C (en) * | 2014-03-26 | 2023-01-24 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
| AP2016009588A0 (en) | 2014-04-28 | 2016-11-30 | Recombinetics Inc | Multiplex gene editing in swine |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| AU2017306676B2 (en) | 2016-08-03 | 2024-02-22 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| EP3497214B1 (en) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US20210230637A1 (en) * | 2018-05-08 | 2021-07-29 | Osaka University | Method for producing homozygous cells |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| WO2020014261A1 (en) | 2018-07-09 | 2020-01-16 | The Broad Institute, Inc. | Rna programmable epigenetic rna modifiers and uses thereof |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| BR112021018607A2 (pt) | 2019-03-19 | 2021-11-23 | Massachusetts Inst Technology | Métodos e composições para editar sequências de nucleotídeos |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN111534519B (zh) * | 2020-05-26 | 2021-12-14 | 中国农业科学院北京畜牧兽医研究所 | 识别猪eIF4G1基因的sgRNA及其编码DNA和应用 |
| CN111944770B (zh) * | 2020-08-27 | 2022-04-15 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫病毒致弱突变株及其制备方法和应用 |
| GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
| CA3255225A1 (en) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | COMPOSITIONS AND METHODS OF GENETIC COMPLEMENTATION |
| KR102871704B1 (ko) * | 2022-06-16 | 2025-10-17 | 대한민국 | 구제역 바이러스에 저항성을 갖는 lc3 단백질을 암호화하는 유전자 편집 세포 및 이의 용도 |
| GB2621813A (en) | 2022-06-30 | 2024-02-28 | Univ Newcastle | Preventing disease recurrence in Mitochondrial replacement therapy |
| GB202314578D0 (en) | 2023-09-22 | 2023-11-08 | Univ Manchester | Methods of producing homoplasmic modified plants or parts thereof |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4888274A (en) | 1985-09-18 | 1989-12-19 | Yale University | RecA nucleoprotein filament and methods |
| US5731178A (en) | 1990-03-21 | 1998-03-24 | Behringwerke Aktiengesellschaft | Attachment-elements for stimulation of eukaryotic expression systems |
| US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| AU3078295A (en) | 1994-07-22 | 1996-02-22 | Boehringer Ingelheim Vetmedica Gmbh | Picornavirus l proteinase and methods of making and using thereof |
| EP0821070A1 (en) | 1996-07-22 | 1998-01-28 | Carelli, Claude Marcel Henri | Pit-1 gene polymorphism and trait selection in animals |
| US6037525A (en) | 1996-08-01 | 2000-03-14 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
| US6541684B1 (en) | 1998-02-13 | 2003-04-01 | Trustees Of Columbia University In The City Of New York | Nucleotide sequences encoding maize RAD51 |
| AU5898599A (en) | 1998-08-19 | 2000-03-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| GB2365445A (en) | 1998-10-12 | 2002-02-20 | Geron Bio Med Ltd | Porcine occcytes with improved developmental competence |
| AU1128400A (en) | 1998-10-22 | 2000-05-08 | Medical College Of Georgia Institute, Inc. | Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors |
| US6610508B1 (en) | 1999-03-08 | 2003-08-26 | Anadys Pharmaceuticals, Inc. | Translation driver system and methods for use thereof |
| US6720478B1 (en) | 1999-05-05 | 2004-04-13 | Pioneer Hi-Bred International, Inc. | RAD51-like polynucleotide and uses thereof |
| AU1100201A (en) | 1999-10-28 | 2001-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
| WO2003022220A2 (en) | 2001-09-07 | 2003-03-20 | The Regents Of The University Of California | Method of generating a transgenic livestock animal |
| CN100575485C (zh) | 2002-01-23 | 2009-12-30 | 犹他大学研究基金会 | 使用锌指核酸酶的定向染色体诱变 |
| WO2003080809A2 (en) | 2002-03-21 | 2003-10-02 | Sangamo Biosciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| US7511127B2 (en) | 2002-12-31 | 2009-03-31 | Cargill, Incorporated | Compositions, methods and systems for inferring bovine breed |
| WO2004065581A2 (en) | 2003-01-15 | 2004-08-05 | Discovery Genomics, Inc. | Transposon-insulator element delivery systems |
| US7985739B2 (en) | 2003-06-04 | 2011-07-26 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced sleeping beauty transposon system and methods for using the same |
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| WO2005040400A2 (en) | 2003-10-24 | 2005-05-06 | Mmi Genomics, Inc. | Methods and systems for inferring traits to manage non-beef livestock |
| WO2007002372A2 (en) | 2005-06-24 | 2007-01-04 | Regents Of The University Of Minnesota | Using cytosine deaminases to diminish retroelement transfer from pigs to humans |
| EP2134847B1 (en) | 2007-03-07 | 2015-06-24 | Aarhus Universitet | Pig model for atherosclerosis |
| CN101225395A (zh) * | 2007-10-18 | 2008-07-23 | 云南省畜牧兽医科学研究所 | 亚洲一型口蹄疫病毒感染性cDNA及其构建方法 |
| US8309791B2 (en) | 2008-07-16 | 2012-11-13 | Recombinectics, Inc. | Method for producing a transgenic pig using a hyper-methylated transposon |
| US20100105140A1 (en) | 2008-07-16 | 2010-04-29 | Fahrenkrug Scott C | Plaice dna transposon system |
| US20110023140A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Rabbit genome editing with zinc finger nucleases |
| US20110023159A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Ovine genome editing with zinc finger nucleases |
| KR20100080068A (ko) | 2008-12-31 | 2010-07-08 | 주식회사 툴젠 | 신규한 징크 핑거 뉴클레아제 및 이의 용도 |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20120149115A1 (en) | 2009-06-11 | 2012-06-14 | Snu R&Db Foundation | Targeted genomic rearrangements using site-specific nucleases |
| US20120192298A1 (en) | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
| DK2462230T3 (en) | 2009-08-03 | 2015-10-19 | Recombinetics Inc | METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION |
| EP3156504B1 (en) * | 2009-08-11 | 2018-10-31 | Sangamo Therapeutics, Inc. | Organisms homozygous for targeted modification |
| CN106987595B (zh) | 2009-11-02 | 2021-07-06 | 宾夕法尼亚大学托管会 | 口蹄疫病毒病毒(fmdv)共有蛋白质、其编码序列及由其制备的疫苗 |
| DK2510096T4 (en) | 2009-12-10 | 2018-05-14 | Univ Iowa State Res Found Inc | NUMBER EFFECTOR-MEDIATED DNA MODIFICATION |
| EP2534173B1 (en) | 2010-02-08 | 2019-09-11 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
| AU2011215557B2 (en) | 2010-02-09 | 2016-03-10 | Sangamo Therapeutics, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
| EP2533629B1 (en) | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| KR101953237B1 (ko) | 2010-05-17 | 2019-02-28 | 상가모 테라퓨틱스, 인코포레이티드 | 신규 dna 결합 단백질 및 이의 용도 |
| EP2392208B1 (en) | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| AU2011265733B2 (en) | 2010-06-14 | 2014-04-17 | Iowa State University Research Foundation, Inc. | Nuclease activity of TAL effector and Foki fusion protein |
| JP2013537410A (ja) | 2010-07-23 | 2013-10-03 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | 標的化エンドヌクレアーゼおよび一本鎖核酸を用いたゲノム編集 |
| EP2622090B1 (en) * | 2010-09-27 | 2019-06-19 | Sangamo Therapeutics, Inc. | Compositions for inhibiting viral entry into cells |
| CN101979607A (zh) | 2010-11-08 | 2011-02-23 | 山东省农业科学院奶牛研究中心 | 抗口蹄疫病毒RNAi转基因家畜的制备方法 |
| WO2012093833A2 (en) | 2011-01-03 | 2012-07-12 | Toolgen Incorporation | Genome engineering via designed tal effector nucleases |
| CN103930550B (zh) | 2011-02-25 | 2017-02-15 | 重组股份有限公司 | 经遗传修饰的动物及其生成方法 |
| WO2012152912A1 (en) | 2011-05-12 | 2012-11-15 | Newvectys | Genetically modified pig as a cancer prone model |
| WO2012168307A2 (en) | 2011-06-07 | 2012-12-13 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Improved recombination efficiency by inhibition of nhej dna repair |
| PT2718440T (pt) | 2011-06-07 | 2019-02-06 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Proteína que tem atividade de nuclease, proteínas de fusão e utilizações das mesmas |
| JP2015500648A (ja) | 2011-12-16 | 2015-01-08 | ターゲットジーン バイオテクノロジーズ リミテッド | 所定の標的核酸配列を修飾するための組成物及び方法 |
| US20130212722A1 (en) | 2012-02-15 | 2013-08-15 | Mice With Horns, Llc | Transgenic animals with customizable traits |
| CA2871524C (en) | 2012-05-07 | 2021-07-27 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
| WO2013191769A1 (en) | 2012-06-22 | 2013-12-27 | Mayo Foundation For Medical Education And Research | Genome editing |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
-
2013
- 2013-03-15 US US13/836,860 patent/US10058078B2/en active Active
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en not_active Ceased
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Ceased
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
-
2015
- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
- 2015-01-30 PH PH12015500213A patent/PH12015500213A1/en unknown
-
2018
- 2018-07-13 US US16/035,411 patent/US20180310536A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015523098A5 (enExample) | ||
| Ruan et al. | Genome editing in livestock: Are we ready for a revolution in animal breeding industry? | |
| AU2020286315B2 (en) | Efficient non-meiotic allele introgression | |
| Van Eenennaam | Genetic modification of food animals | |
| JP6878482B2 (ja) | 大型家畜の接合体における標的化ゲノム編集 | |
| US11140883B2 (en) | Gene editing of reproductive hormones to sterilize aquatic animals | |
| AU2013296901B2 (en) | Production of FMDV-resistant livestock by allele substitution | |
| Chen et al. | Advances in genome editing technology and its promising application in evolutionary and ecological studies | |
| JP2015533284A5 (enExample) | ||
| Suzuki et al. | Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration | |
| JP2019047794A (ja) | 動物における性成熟の制御 | |
| Li et al. | One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish | |
| CN104195177B (zh) | 一种显著提高鱼类基因组编辑效率的方法 | |
| JP2018525000A5 (enExample) | ||
| West et al. | Genome editing in large animals | |
| US20190223416A1 (en) | Canine genome editing | |
| Doran et al. | Genome editing in poultry-opportunities and impacts | |
| US10920242B2 (en) | Non-meiotic allele introgression | |
| National Academies of Sciences, Engineering, and Medicine | Heritable Genetic Modification in Food Animals | |
| Proudfoot et al. | Genome editing for disease resistance in livestock | |
| Clark | Breeding in an era of genome editing | |
| Salisu et al. | Harnessing the Potential of Genome Editing in Large Animals for Food Security: Prospects and Challenges | |
| US20240397918A1 (en) | Non-meiotic allele introgression | |
| Yen et al. | The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae | |
| JPWO2018124155A1 (ja) | 条件付きノックアウト動物の製造方法 |