BR112015002280A2 - produção de gado resistente a vfa por substituição de alelo - Google Patents
produção de gado resistente a vfa por substituição de aleloInfo
- Publication number
- BR112015002280A2 BR112015002280A2 BR112015002280A BR112015002280A BR112015002280A2 BR 112015002280 A2 BR112015002280 A2 BR 112015002280A2 BR 112015002280 A BR112015002280 A BR 112015002280A BR 112015002280 A BR112015002280 A BR 112015002280A BR 112015002280 A2 BR112015002280 A2 BR 112015002280A2
- Authority
- BR
- Brazil
- Prior art keywords
- vfa
- production
- allele substitution
- resistant
- resistant cattle
- Prior art date
Links
- 108700028369 Alleles Proteins 0.000 title abstract 2
- 241000283690 Bos taurus Species 0.000 title abstract 2
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 238000010362 genome editing Methods 0.000 abstract 1
- 244000144980 herd Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677904P | 2012-07-31 | 2012-07-31 | |
| US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
| PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015002280A2 true BR112015002280A2 (pt) | 2019-01-15 |
Family
ID=50026918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015002280A BR112015002280A2 (pt) | 2012-07-31 | 2013-07-19 | produção de gado resistente a vfa por substituição de alelo |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10058078B2 (enExample) |
| EP (2) | EP3540050A1 (enExample) |
| JP (1) | JP6446360B2 (enExample) |
| KR (1) | KR20150036792A (enExample) |
| CN (1) | CN104837989A (enExample) |
| AR (1) | AR091948A1 (enExample) |
| AU (1) | AU2013296901B2 (enExample) |
| BR (1) | BR112015002280A2 (enExample) |
| CA (1) | CA2880616A1 (enExample) |
| CL (1) | CL2015000248A1 (enExample) |
| MX (1) | MX366723B (enExample) |
| NZ (1) | NZ629582A (enExample) |
| PH (1) | PH12015500213A1 (enExample) |
| RU (1) | RU2015106818A (enExample) |
| WO (1) | WO2014022120A1 (enExample) |
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| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
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| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| HK1223401A1 (zh) * | 2013-05-15 | 2017-07-28 | 桑格摩生物科学股份有限公司 | 用於治疗遗传病状的方法和组合物 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| EP3060682B1 (en) | 2013-10-25 | 2023-08-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
| WO2015148761A1 (en) * | 2014-03-26 | 2015-10-01 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
| CN111647627A (zh) | 2014-04-28 | 2020-09-11 | 重组股份有限公司 | 多重基因编辑 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
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| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
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| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物 |
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| JP2015500648A (ja) | 2011-12-16 | 2015-01-08 | ターゲットジーン バイオテクノロジーズ リミテッド | 所定の標的核酸配列を修飾するための組成物及び方法 |
| CA2864444A1 (en) | 2012-02-15 | 2013-08-22 | Mice With Horns, Llc | Transgenic animals with customizable traits |
| WO2013169802A1 (en) | 2012-05-07 | 2013-11-14 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
| US20150291951A1 (en) | 2012-06-22 | 2015-10-15 | Mayo Foundation For Medical Education And Research | Genome editing |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
-
2013
- 2013-03-15 US US13/836,860 patent/US10058078B2/en active Active
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Ceased
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en not_active Ceased
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
-
2015
- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
- 2015-01-30 PH PH12015500213A patent/PH12015500213A1/en unknown
-
2018
- 2018-07-13 US US16/035,411 patent/US20180310536A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2880153A1 (en) | 2015-06-10 |
| MX366723B (es) | 2019-07-22 |
| NZ629582A (en) | 2017-07-28 |
| AU2013296901B2 (en) | 2019-05-09 |
| US20180310536A1 (en) | 2018-11-01 |
| JP6446360B2 (ja) | 2018-12-26 |
| PH12015500213A1 (en) | 2015-03-30 |
| AR091948A1 (es) | 2015-03-11 |
| EP2880153A4 (en) | 2016-03-30 |
| CL2015000248A1 (es) | 2015-10-02 |
| US10058078B2 (en) | 2018-08-28 |
| WO2014022120A1 (en) | 2014-02-06 |
| CA2880616A1 (en) | 2014-02-06 |
| CN104837989A (zh) | 2015-08-12 |
| US20140041066A1 (en) | 2014-02-06 |
| AU2013296901A1 (en) | 2015-02-12 |
| RU2015106818A (ru) | 2016-09-27 |
| JP2015523098A (ja) | 2015-08-13 |
| KR20150036792A (ko) | 2015-04-07 |
| EP3540050A1 (en) | 2019-09-18 |
| MX2015001299A (es) | 2015-06-05 |
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