RU2015106818A - Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей - Google Patents
Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей Download PDFInfo
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- RU2015106818A RU2015106818A RU2015106818A RU2015106818A RU2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A
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Links
- 241001465754 Metazoa Species 0.000 title claims abstract 32
- 241000710198 Foot-and-mouth disease virus Species 0.000 title claims abstract 15
- 101710091919 Eukaryotic translation initiation factor 4G Proteins 0.000 claims abstract 58
- 108020004707 nucleic acids Proteins 0.000 claims abstract 13
- 102000039446 nucleic acids Human genes 0.000 claims abstract 13
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 13
- 108091005804 Peptidases Proteins 0.000 claims abstract 12
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract 12
- 102000035195 Peptidases Human genes 0.000 claims abstract 9
- 102000004190 Enzymes Human genes 0.000 claims abstract 8
- 108090000790 Enzymes Proteins 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 8
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims abstract 7
- 108010029485 Protein Isoforms Proteins 0.000 claims abstract 7
- 102000001708 Protein Isoforms Human genes 0.000 claims abstract 7
- 238000003776 cleavage reaction Methods 0.000 claims abstract 7
- 235000019833 protease Nutrition 0.000 claims abstract 7
- 230000007017 scission Effects 0.000 claims abstract 7
- 238000000338 in vitro Methods 0.000 claims abstract 6
- 101710163270 Nuclease Proteins 0.000 claims abstract 4
- 239000004365 Protease Substances 0.000 claims abstract 4
- 238000010367 cloning Methods 0.000 claims abstract 4
- 241000251468 Actinopterygii Species 0.000 claims abstract 3
- 241000283690 Bos taurus Species 0.000 claims abstract 3
- 241000283707 Capra Species 0.000 claims abstract 3
- 241000287828 Gallus gallus Species 0.000 claims abstract 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims abstract 3
- 241001494479 Pecora Species 0.000 claims abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract 3
- 241000282898 Sus scrofa Species 0.000 claims abstract 3
- 238000012986 modification Methods 0.000 claims abstract 3
- 230000004048 modification Effects 0.000 claims abstract 3
- 235000019419 proteases Nutrition 0.000 claims abstract 3
- 230000017854 proteolysis Effects 0.000 claims abstract 3
- 241000700605 Viruses Species 0.000 claims abstract 2
- 235000003869 genetically modified organism Nutrition 0.000 claims abstract 2
- 238000012216 screening Methods 0.000 claims abstract 2
- 108700028369 Alleles Proteins 0.000 claims 4
- 238000010362 genome editing Methods 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 101800001491 Protease 3C Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 101150096316 5 gene Proteins 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677904P | 2012-07-31 | 2012-07-31 | |
| US61/677,904 | 2012-07-31 | ||
| US13/836,860 | 2013-03-15 | ||
| US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
| PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015106818A true RU2015106818A (ru) | 2016-09-27 |
Family
ID=50026918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015106818A RU2015106818A (ru) | 2012-07-31 | 2013-07-19 | Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10058078B2 (enExample) |
| EP (2) | EP3540050A1 (enExample) |
| JP (1) | JP6446360B2 (enExample) |
| KR (1) | KR20150036792A (enExample) |
| CN (1) | CN104837989A (enExample) |
| AR (1) | AR091948A1 (enExample) |
| AU (1) | AU2013296901B2 (enExample) |
| BR (1) | BR112015002280A2 (enExample) |
| CA (1) | CA2880616A1 (enExample) |
| CL (1) | CL2015000248A1 (enExample) |
| MX (1) | MX366723B (enExample) |
| NZ (1) | NZ629582A (enExample) |
| PH (1) | PH12015500213A1 (enExample) |
| RU (1) | RU2015106818A (enExample) |
| WO (1) | WO2014022120A1 (enExample) |
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| US20110197290A1 (en) * | 2010-02-11 | 2011-08-11 | Fahrenkrug Scott C | Methods and materials for producing transgenic artiodactyls |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| EP2997146A4 (en) * | 2013-05-15 | 2017-04-26 | Sangamo BioSciences, Inc. | Methods and compositions for treatment of a genetic condition |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| ES2962492T3 (es) | 2013-10-25 | 2024-03-19 | Livestock Improvement Corporation Ltd | Marcadores genéticos y usos de los mismos |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
| AU2015236033B2 (en) * | 2014-03-26 | 2018-06-07 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
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| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
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| WO2019216338A1 (ja) * | 2018-05-08 | 2019-11-14 | 国立大学法人大阪大学 | ホモ接合型細胞の作製方法 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
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2013
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- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en not_active Ceased
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Ceased
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
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2015
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- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
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2018
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| WO2014022120A1 (en) | 2014-02-06 |
| US10058078B2 (en) | 2018-08-28 |
| EP3540050A1 (en) | 2019-09-18 |
| US20180310536A1 (en) | 2018-11-01 |
| MX366723B (es) | 2019-07-22 |
| BR112015002280A2 (pt) | 2019-01-15 |
| JP6446360B2 (ja) | 2018-12-26 |
| EP2880153A1 (en) | 2015-06-10 |
| PH12015500213A1 (en) | 2015-03-30 |
| KR20150036792A (ko) | 2015-04-07 |
| MX2015001299A (es) | 2015-06-05 |
| EP2880153A4 (en) | 2016-03-30 |
| JP2015523098A (ja) | 2015-08-13 |
| US20140041066A1 (en) | 2014-02-06 |
| CN104837989A (zh) | 2015-08-12 |
| AR091948A1 (es) | 2015-03-11 |
| CL2015000248A1 (es) | 2015-10-02 |
| AU2013296901A1 (en) | 2015-02-12 |
| AU2013296901B2 (en) | 2019-05-09 |
| NZ629582A (en) | 2017-07-28 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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