RU2015106818A - Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей - Google Patents
Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей Download PDFInfo
- Publication number
- RU2015106818A RU2015106818A RU2015106818A RU2015106818A RU2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A RU 2015106818 A RU2015106818 A RU 2015106818A
- Authority
- RU
- Russia
- Prior art keywords
- eif4g
- animal
- gene
- protein
- cell
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims abstract 32
- 241000710198 Foot-and-mouth disease virus Species 0.000 title claims abstract 15
- 101710091919 Eukaryotic translation initiation factor 4G Proteins 0.000 claims abstract 58
- 108020004707 nucleic acids Proteins 0.000 claims abstract 13
- 102000039446 nucleic acids Human genes 0.000 claims abstract 13
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 13
- 108091005804 Peptidases Proteins 0.000 claims abstract 12
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract 12
- 102000035195 Peptidases Human genes 0.000 claims abstract 9
- 102000004190 Enzymes Human genes 0.000 claims abstract 8
- 108090000790 Enzymes Proteins 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 8
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims abstract 7
- 108010029485 Protein Isoforms Proteins 0.000 claims abstract 7
- 102000001708 Protein Isoforms Human genes 0.000 claims abstract 7
- 238000003776 cleavage reaction Methods 0.000 claims abstract 7
- 235000019833 protease Nutrition 0.000 claims abstract 7
- 230000007017 scission Effects 0.000 claims abstract 7
- 238000000338 in vitro Methods 0.000 claims abstract 6
- 101710163270 Nuclease Proteins 0.000 claims abstract 4
- 239000004365 Protease Substances 0.000 claims abstract 4
- 238000010367 cloning Methods 0.000 claims abstract 4
- 241000251468 Actinopterygii Species 0.000 claims abstract 3
- 241000283690 Bos taurus Species 0.000 claims abstract 3
- 241000283707 Capra Species 0.000 claims abstract 3
- 241000287828 Gallus gallus Species 0.000 claims abstract 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims abstract 3
- 241001494479 Pecora Species 0.000 claims abstract 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract 3
- 241000282898 Sus scrofa Species 0.000 claims abstract 3
- 238000012986 modification Methods 0.000 claims abstract 3
- 230000004048 modification Effects 0.000 claims abstract 3
- 235000019419 proteases Nutrition 0.000 claims abstract 3
- 230000017854 proteolysis Effects 0.000 claims abstract 3
- 241000700605 Viruses Species 0.000 claims abstract 2
- 235000003869 genetically modified organism Nutrition 0.000 claims abstract 2
- 238000012216 screening Methods 0.000 claims abstract 2
- 108700028369 Alleles Proteins 0.000 claims 4
- 238000010362 genome editing Methods 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 101800001491 Protease 3C Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 101150096316 5 gene Proteins 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261677904P | 2012-07-31 | 2012-07-31 | |
| US61/677,904 | 2012-07-31 | ||
| US13/836,860 | 2013-03-15 | ||
| US13/836,860 US10058078B2 (en) | 2012-07-31 | 2013-03-15 | Production of FMDV-resistant livestock by allele substitution |
| PCT/US2013/051222 WO2014022120A1 (en) | 2012-07-31 | 2013-07-19 | Production of fmdv-resistant livestock by allele substitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015106818A true RU2015106818A (ru) | 2016-09-27 |
Family
ID=50026918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015106818A RU2015106818A (ru) | 2012-07-31 | 2013-07-19 | Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10058078B2 (enExample) |
| EP (2) | EP2880153A4 (enExample) |
| JP (1) | JP6446360B2 (enExample) |
| KR (1) | KR20150036792A (enExample) |
| CN (1) | CN104837989A (enExample) |
| AR (1) | AR091948A1 (enExample) |
| AU (1) | AU2013296901B2 (enExample) |
| BR (1) | BR112015002280A2 (enExample) |
| CA (1) | CA2880616A1 (enExample) |
| CL (1) | CL2015000248A1 (enExample) |
| MX (1) | MX366723B (enExample) |
| NZ (1) | NZ629582A (enExample) |
| PH (1) | PH12015500213A1 (enExample) |
| RU (1) | RU2015106818A (enExample) |
| WO (1) | WO2014022120A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2533629B1 (en) * | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
| WO2014186585A2 (en) * | 2013-05-15 | 2014-11-20 | Sangamo Biosciences, Inc. | Methods and compositions for treatment of a genetic condition |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| MX388563B (es) | 2013-10-25 | 2025-03-20 | Livestock Improvement Corporation Ltd | Marcadores geneticos y usos de los mismos. |
| EP4372090A3 (en) | 2013-11-07 | 2024-08-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| US20180142307A1 (en) * | 2014-02-11 | 2018-05-24 | California Institute Of Technology | Recording and mapping lineage information and molecular events in individual cells |
| US10349639B2 (en) * | 2014-03-26 | 2019-07-16 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
| MX2016014066A (es) | 2014-04-28 | 2017-05-03 | Recombinetics Inc | Edicion de genes multiples en cerdos. |
| EP4079847A1 (en) | 2014-07-30 | 2022-10-26 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US20210230637A1 (en) * | 2018-05-08 | 2021-07-29 | Osaka University | Method for producing homozygous cells |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| GB2614813B (en) | 2020-05-08 | 2025-05-07 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN111534519B (zh) * | 2020-05-26 | 2021-12-14 | 中国农业科学院北京畜牧兽医研究所 | 识别猪eIF4G1基因的sgRNA及其编码DNA和应用 |
| CN111944770B (zh) * | 2020-08-27 | 2022-04-15 | 中国农业科学院兰州兽医研究所 | 一种口蹄疫病毒致弱突变株及其制备方法和应用 |
| GB202118058D0 (en) | 2021-12-14 | 2022-01-26 | Univ Warwick | Methods to increase yields in crops |
| CA3255225A1 (en) | 2022-04-04 | 2023-10-12 | Univ California | COMPOSITIONS AND METHODS OF GENETIC COMPLEMENTATION |
| KR102871704B1 (ko) * | 2022-06-16 | 2025-10-17 | 대한민국 | 구제역 바이러스에 저항성을 갖는 lc3 단백질을 암호화하는 유전자 편집 세포 및 이의 용도 |
| GB2621813A (en) | 2022-06-30 | 2024-02-28 | Univ Newcastle | Preventing disease recurrence in Mitochondrial replacement therapy |
| GB202314578D0 (en) | 2023-09-22 | 2023-11-08 | Univ Manchester | Methods of producing homoplasmic modified plants or parts thereof |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4888274A (en) | 1985-09-18 | 1989-12-19 | Yale University | RecA nucleoprotein filament and methods |
| US5731178A (en) | 1990-03-21 | 1998-03-24 | Behringwerke Aktiengesellschaft | Attachment-elements for stimulation of eukaryotic expression systems |
| US5763240A (en) | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| AU3078295A (en) | 1994-07-22 | 1996-02-22 | Boehringer Ingelheim Vetmedica Gmbh | Picornavirus l proteinase and methods of making and using thereof |
| EP0821070A1 (en) | 1996-07-22 | 1998-01-28 | Carelli, Claude Marcel Henri | Pit-1 gene polymorphism and trait selection in animals |
| US6037525A (en) | 1996-08-01 | 2000-03-14 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
| US6541684B1 (en) | 1998-02-13 | 2003-04-01 | Trustees Of Columbia University In The City Of New York | Nucleotide sequences encoding maize RAD51 |
| AU5898599A (en) | 1998-08-19 | 2000-03-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| AU6218899A (en) | 1998-10-12 | 2000-05-01 | Geron Bio-Med Limited | Porcine oocytes with improved developmental competence |
| WO2000023606A1 (en) | 1998-10-22 | 2000-04-27 | Medical College Of Georgia Institute, Inc. | Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors |
| US6610508B1 (en) | 1999-03-08 | 2003-08-26 | Anadys Pharmaceuticals, Inc. | Translation driver system and methods for use thereof |
| US6720478B1 (en) | 1999-05-05 | 2004-04-13 | Pioneer Hi-Bred International, Inc. | RAD51-like polynucleotide and uses thereof |
| AU1100201A (en) | 1999-10-28 | 2001-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
| AU2002324941A1 (en) | 2001-09-07 | 2003-03-24 | The Regents Of The University Of California | Method of generating a transgenic livestock animal |
| JP4968498B2 (ja) | 2002-01-23 | 2012-07-04 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | ジンクフィンガーヌクレアーゼを用いる、標的化された染色体変異誘発 |
| AU2003218382B2 (en) | 2002-03-21 | 2007-12-13 | Sangamo Therapeutics, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| CA2512134A1 (en) | 2002-12-31 | 2004-07-22 | Mmi Genomics, Inc. | Compositions, methods and systems for inferring bovine traits |
| WO2004065581A2 (en) | 2003-01-15 | 2004-08-05 | Discovery Genomics, Inc. | Transposon-insulator element delivery systems |
| US7985739B2 (en) | 2003-06-04 | 2011-07-26 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced sleeping beauty transposon system and methods for using the same |
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| US20050153317A1 (en) | 2003-10-24 | 2005-07-14 | Metamorphix, Inc. | Methods and systems for inferring traits to breed and manage non-beef livestock |
| AU2006262020B8 (en) | 2005-06-24 | 2011-02-17 | Recombinetics, Inc. | Using cytosine deaminases to diminish retroelement transfer from pigs to humans |
| ES2547015T3 (es) | 2007-03-07 | 2015-09-30 | Aarhus Universitet | Modelo de aterosclerosis en cerdos |
| CN101225395A (zh) * | 2007-10-18 | 2008-07-23 | 云南省畜牧兽医科学研究所 | 亚洲一型口蹄疫病毒感染性cDNA及其构建方法 |
| US20100105140A1 (en) | 2008-07-16 | 2010-04-29 | Fahrenkrug Scott C | Plaice dna transposon system |
| WO2010008562A2 (en) | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| US20110023159A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Ovine genome editing with zinc finger nucleases |
| US20110023140A1 (en) | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Rabbit genome editing with zinc finger nucleases |
| KR20100080068A (ko) | 2008-12-31 | 2010-07-08 | 주식회사 툴젠 | 신규한 징크 핑거 뉴클레아제 및 이의 용도 |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| WO2010143917A2 (en) | 2009-06-11 | 2010-12-16 | Toolgen Incorporation | Targeted genomic rearrangements using site-specific nucleases |
| US20120192298A1 (en) | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
| DK2462230T3 (en) | 2009-08-03 | 2015-10-19 | Recombinetics Inc | METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION |
| EP3156504B1 (en) | 2009-08-11 | 2018-10-31 | Sangamo Therapeutics, Inc. | Organisms homozygous for targeted modification |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| WO2011054011A2 (en) | 2009-11-02 | 2011-05-05 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (fmdv) consensus proteins, coding sequences therefor and vaccines made therefrom |
| US8586363B2 (en) | 2009-12-10 | 2013-11-19 | Regents Of The University Of Minnesota | TAL effector-mediated DNA modification |
| CA2788560A1 (en) | 2010-02-08 | 2011-08-11 | Sangamo Biosciences, Inc. | Engineered cleavage half-domains |
| CA2788850C (en) | 2010-02-09 | 2019-06-25 | Sangamo Biosciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
| EP2533629B1 (en) | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| EP2392208B1 (en) | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| EP2580331A4 (en) | 2010-06-14 | 2013-11-27 | Univ Iowa State Res Found Inc | NUCLEASE ACTIVITY OF THE TAL EFFECTOR AND FUSION PROTEIN FOKI |
| KR20180121665A (ko) | 2010-07-23 | 2018-11-07 | 시그마-알드리치 컴퍼니., 엘엘씨 | 표적화 엔도뉴클레아제 및 단일-가닥 핵산을 사용하는 게놈 편집 |
| AU2011312562B2 (en) * | 2010-09-27 | 2014-10-09 | Sangamo Therapeutics, Inc. | Methods and compositions for inhibiting viral entry into cells |
| CN101979607A (zh) | 2010-11-08 | 2011-02-23 | 山东省农业科学院奶牛研究中心 | 抗口蹄疫病毒RNAi转基因家畜的制备方法 |
| KR101556359B1 (ko) | 2011-01-03 | 2015-10-01 | 주식회사 툴젠 | 디자인된 tal 이펙터 뉴클레아제를 통한 게놈 엔지니어링 |
| EP3461898A1 (en) | 2011-02-25 | 2019-04-03 | The University Court Of The University of Edinburgh | Genetically modified animals and methods for making the same |
| WO2012152912A1 (en) | 2011-05-12 | 2012-11-15 | Newvectys | Genetically modified pig as a cancer prone model |
| US20140304847A1 (en) | 2011-06-07 | 2014-10-09 | Ralf Kühn | Recombination efficiency by inhibition of nhej dna repair |
| EP3434775B1 (en) | 2011-06-07 | 2020-03-18 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Protein having nuclease activity, fusion proteins and uses thereof |
| CA2858801C (en) | 2011-12-16 | 2024-02-27 | Targetgene Biotechnologies Ltd | Compositions and methods for modifying a predetermined target nucleic acid sequence |
| US20130212722A1 (en) | 2012-02-15 | 2013-08-15 | Mice With Horns, Llc | Transgenic animals with customizable traits |
| CA2871524C (en) | 2012-05-07 | 2021-07-27 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
| WO2013191769A1 (en) | 2012-06-22 | 2013-12-27 | Mayo Foundation For Medical Education And Research | Genome editing |
| US10058078B2 (en) | 2012-07-31 | 2018-08-28 | Recombinetics, Inc. | Production of FMDV-resistant livestock by allele substitution |
-
2013
- 2013-03-15 US US13/836,860 patent/US10058078B2/en active Active
- 2013-07-19 MX MX2015001299A patent/MX366723B/es active IP Right Grant
- 2013-07-19 RU RU2015106818A patent/RU2015106818A/ru not_active Application Discontinuation
- 2013-07-19 EP EP13825988.2A patent/EP2880153A4/en not_active Ceased
- 2013-07-19 CN CN201380048009.3A patent/CN104837989A/zh active Pending
- 2013-07-19 NZ NZ629582A patent/NZ629582A/en not_active IP Right Cessation
- 2013-07-19 KR KR1020157005357A patent/KR20150036792A/ko not_active Ceased
- 2013-07-19 JP JP2015525450A patent/JP6446360B2/ja not_active Expired - Fee Related
- 2013-07-19 CA CA2880616A patent/CA2880616A1/en not_active Abandoned
- 2013-07-19 BR BR112015002280A patent/BR112015002280A2/pt not_active Application Discontinuation
- 2013-07-19 WO PCT/US2013/051222 patent/WO2014022120A1/en not_active Ceased
- 2013-07-19 EP EP19159141.1A patent/EP3540050A1/en not_active Withdrawn
- 2013-07-19 AU AU2013296901A patent/AU2013296901B2/en not_active Ceased
- 2013-07-31 AR ARP130102723A patent/AR091948A1/es unknown
-
2015
- 2015-01-30 CL CL2015000248A patent/CL2015000248A1/es unknown
- 2015-01-30 PH PH12015500213A patent/PH12015500213A1/en unknown
-
2018
- 2018-07-13 US US16/035,411 patent/US20180310536A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013296901A1 (en) | 2015-02-12 |
| JP2015523098A (ja) | 2015-08-13 |
| JP6446360B2 (ja) | 2018-12-26 |
| NZ629582A (en) | 2017-07-28 |
| WO2014022120A1 (en) | 2014-02-06 |
| US20180310536A1 (en) | 2018-11-01 |
| CL2015000248A1 (es) | 2015-10-02 |
| EP2880153A4 (en) | 2016-03-30 |
| BR112015002280A2 (pt) | 2019-01-15 |
| AR091948A1 (es) | 2015-03-11 |
| CN104837989A (zh) | 2015-08-12 |
| AU2013296901B2 (en) | 2019-05-09 |
| PH12015500213A1 (en) | 2015-03-30 |
| EP2880153A1 (en) | 2015-06-10 |
| EP3540050A1 (en) | 2019-09-18 |
| MX366723B (es) | 2019-07-22 |
| KR20150036792A (ko) | 2015-04-07 |
| US20140041066A1 (en) | 2014-02-06 |
| CA2880616A1 (en) | 2014-02-06 |
| US10058078B2 (en) | 2018-08-28 |
| MX2015001299A (es) | 2015-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015106818A (ru) | Получение сельскохозяйственных животных, устойчивых к fmdv, путем замещения аллелей | |
| Xiang et al. | Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs | |
| US20220015342A1 (en) | Gene editing of reproductive hormones to reduce fertility in ictalurus punctatus | |
| JP2015523098A5 (enExample) | ||
| Chakrapani et al. | Establishing targeted carp TLR22 gene disruption via homologous recombination using CRISPR/Cas9 | |
| CN106191114B (zh) | 利用CRISPR-Cas9系统敲除鱼类MC4R基因的育种方法 | |
| US20190216063A1 (en) | Genetically Edited Animal | |
| Dong et al. | Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases | |
| Xu et al. | Production of a mutant of large-scale loach Paramisgurnus dabryanus with skin pigmentation loss by genome editing with CRISPR/Cas9 system | |
| RU2015120467A (ru) | Контроль полового созревания у животных | |
| JP2015533284A5 (enExample) | ||
| CN101421408A (zh) | 昆虫中利用可变剪接的基因表达系统 | |
| US20190037817A1 (en) | Ldl receptor gene knockout, genetically-engineered hamster | |
| Tu et al. | The application of new breeding technology based on gene editing in pig industry—A review | |
| CN117580955A (zh) | 用于产生雌性刚孵化的雏鸟的鸟类及其产生方法 | |
| JP5997772B2 (ja) | カイコフィブロイン重鎖遺伝子の突然変異配列、及び突然変異を誘発する方法と応用 | |
| Hua et al. | Dual single guide RNAs-mediating deletion of mature myostatin peptide results in concomitant muscle fibre hyperplasia and adipocyte hypotrophy in pigs | |
| Schetelig et al. | Development of an embryonic lethality system in Mediterranean fruit fly Ceratitis capitata | |
| CN110257434A (zh) | 利用Crispr/Cas9技术制备MyoG基因敲入和MSTN基因敲除的细胞克隆 | |
| Reardon | Hybrid zoo: introducing pig–human embryos and a rat–mouse | |
| Barman et al. | Status and prospects of gene editing and transgenic in fishes | |
| AU2016353057A1 (en) | Biocontainment/biocontrol system and methods | |
| Mushtaq et al. | Genomics and Biotechnological Advancements in Fisheries, Poultry | |
| Agina | Application of advanced biotechnology tools in veterinary medicine | |
| Clark | Playing catch-up |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180201 |