CA2913411A1 - Genetically sterile animals - Google Patents
Genetically sterile animalsInfo
- Publication number
- CA2913411A1 CA2913411A1 CA2913411A CA2913411A CA2913411A1 CA 2913411 A1 CA2913411 A1 CA 2913411A1 CA 2913411 A CA2913411 A CA 2913411A CA 2913411 A CA2913411 A CA 2913411A CA 2913411 A1 CA2913411 A1 CA 2913411A1
- Authority
- CA
- Canada
- Prior art keywords
- animal
- gene
- cell
- sperm
- chosen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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| WO2016163386A1 (ja) | 2015-04-08 | 2016-10-13 | 全国農業協同組合連合会 | 異個体由来の配偶子を生産する非ヒト大型哺乳動物又は魚類の作出方法 |
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| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
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| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
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| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3498096A1 (en) * | 2017-12-18 | 2019-06-19 | IMV Technologies | Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel |
| CN110184296B (zh) * | 2018-02-07 | 2023-06-09 | 上海大学 | 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物 |
| MX2020008847A (es) * | 2018-02-26 | 2020-10-01 | Aggenetics Inc | Materiales y metodos para prevenir la transmision de un cromosoma en particular. |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020047514A2 (en) * | 2018-08-31 | 2020-03-05 | Recombinetics, Inc. | Production method for animal models with disease associated phenotypes |
| GB201816633D0 (en) | 2018-10-12 | 2018-11-28 | Univ Edinburgh | Genetically modified avians and method for the reconstitution thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109837347B (zh) * | 2019-01-02 | 2021-01-29 | 华中农业大学 | Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| BR112021020349A2 (pt) * | 2019-04-09 | 2021-12-14 | Mayo Found Medical Education & Res | Peixe estéril |
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| CN111549032A (zh) * | 2020-05-26 | 2020-08-18 | 肇庆学院 | 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
| KR102285906B1 (ko) | 2021-02-18 | 2021-08-04 | 주식회사 엔에이피 | 수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물 |
| IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| WO2024042515A1 (en) * | 2022-08-22 | 2024-02-29 | Ramot At Tel-Aviv University Ltd. | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations |
| CN116064541B (zh) * | 2022-10-21 | 2025-03-18 | 华南农业大学 | 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法 |
| KR20250033452A (ko) | 2023-08-30 | 2025-03-10 | 서울대학교산학협력단 | Cyp17a1 형질전환 비만 및 불임치료제 개발 모델 제조방법 및 용도 |
| CN116884488B (zh) * | 2023-09-07 | 2023-11-24 | 中国医学科学院基础医学研究所 | 一种男性不育标志物的筛查方法、系统及设备 |
| CN118910165A (zh) * | 2024-10-11 | 2024-11-08 | 上海南方模式生物科技股份有限公司 | 一种cxcl16基因人源化动物模型的构建方法及应用 |
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| JP2002543814A (ja) * | 1999-05-13 | 2002-12-24 | セダーシナイ メディカル センター | トランスジェニック種の発生と遺伝子療法用の雄性生殖細胞の遺伝的修飾法 |
| CN101024829A (zh) * | 2000-02-24 | 2007-08-29 | 马萨诸塞大学 | 只生育单一性别后代的哺乳动物的生产 |
| WO2002077637A1 (en) * | 2001-03-22 | 2002-10-03 | Infigen, Inc. | Sex-specific selection of sperm from transgenic animals |
| AU2003213813A1 (en) * | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| WO2010065550A2 (en) * | 2008-12-01 | 2010-06-10 | Board Of Regents University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| EP2470557A1 (en) * | 2009-08-28 | 2012-07-04 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| EP3461898A1 (en) * | 2011-02-25 | 2019-04-03 | The University Court Of The University of Edinburgh | Genetically modified animals and methods for making the same |
| WO2012158985A2 (en) * | 2011-05-17 | 2012-11-22 | Transposagen Biopharmaceuticals, Inc. | Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms |
| AU2013337951B2 (en) * | 2012-10-30 | 2019-10-03 | Recombinetics, Inc. | Control of sexual maturation in animals |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
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- 2014-04-29 RU RU2015156801A patent/RU2015156801A/ru not_active Application Discontinuation
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- 2014-04-29 AP AP2015008963A patent/AP2015008963A0/en unknown
- 2014-04-29 CN CN201480042269.4A patent/CN105473714A/zh active Pending
- 2014-04-29 EP EP14804562.8A patent/EP3004345A4/en not_active Withdrawn
- 2014-04-29 KR KR1020157037273A patent/KR20160013219A/ko not_active Ceased
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| MX2015016385A (es) | 2016-04-11 |
| CN105473714A (zh) | 2016-04-06 |
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| NZ715540A (en) | 2021-04-30 |
| US20140359796A1 (en) | 2014-12-04 |
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| AP2015008963A0 (en) | 2016-01-31 |
| EP3004345A4 (en) | 2017-02-15 |
| WO2014193583A2 (en) | 2014-12-04 |
| JP2016525890A (ja) | 2016-09-01 |
| EP3004345A2 (en) | 2016-04-13 |
| US20190335725A1 (en) | 2019-11-07 |
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