CN105473714A - 遗传不育动物 - Google Patents

遗传不育动物 Download PDF

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Publication number
CN105473714A
CN105473714A CN201480042269.4A CN201480042269A CN105473714A CN 105473714 A CN105473714 A CN 105473714A CN 201480042269 A CN201480042269 A CN 201480042269A CN 105473714 A CN105473714 A CN 105473714A
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CN
China
Prior art keywords
gene
animal
cells
cell
sperm
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Pending
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CN201480042269.4A
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English (en)
Chinese (zh)
Inventor
D.F.卡尔森
S.C.法伦克鲁格
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Recombinetics Inc
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Recombinetics Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
CN201480042269.4A 2013-05-31 2014-04-29 遗传不育动物 Pending CN105473714A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829656P 2013-05-31 2013-05-31
US61/829,656 2013-05-31
US201361870558P 2013-08-27 2013-08-27
US61/870,558 2013-08-27
PCT/US2014/035847 WO2014193583A2 (en) 2013-05-31 2014-04-29 Genetically sterile animals

Publications (1)

Publication Number Publication Date
CN105473714A true CN105473714A (zh) 2016-04-06

Family

ID=51986779

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480042269.4A Pending CN105473714A (zh) 2013-05-31 2014-04-29 遗传不育动物

Country Status (13)

Country Link
US (2) US20140359796A1 (enExample)
EP (1) EP3004345A4 (enExample)
JP (1) JP2016525890A (enExample)
KR (1) KR20160013219A (enExample)
CN (1) CN105473714A (enExample)
AP (1) AP2015008963A0 (enExample)
AU (1) AU2014272106A1 (enExample)
BR (1) BR112015029904A2 (enExample)
CA (1) CA2913411A1 (enExample)
MX (1) MX2015016385A (enExample)
PH (1) PH12015502640A1 (enExample)
RU (1) RU2015156801A (enExample)
WO (1) WO2014193583A2 (enExample)

Cited By (9)

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CN109837347A (zh) * 2019-01-02 2019-06-04 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN110184296A (zh) * 2018-02-07 2019-08-30 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN111549032A (zh) * 2020-05-26 2020-08-18 肇庆学院 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法
CN111787791A (zh) * 2018-02-26 2020-10-16 Ag遗传学股份有限公司 用于防止特定染色体的传播的材料和方法
CN111867373A (zh) * 2017-12-18 2020-10-30 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN116064541A (zh) * 2022-10-21 2023-05-05 华南农业大学 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法
CN116884488A (zh) * 2023-09-07 2023-10-13 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN117545350A (zh) * 2020-12-31 2024-02-09 以色列农业和农村发展部农业研究组织(沃尔卡尼研究所) 不育禽类胚胎、其产生及用途
CN118910165A (zh) * 2024-10-11 2024-11-08 上海南方模式生物科技股份有限公司 一种cxcl16基因人源化动物模型的构建方法及应用

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US20170099813A1 (en) * 2015-10-07 2017-04-13 Recombinetics, Inc. Method of generating sterile terminal sires in livestock and animals produced thereby
US12043852B2 (en) 2015-10-23 2024-07-23 President And Fellows Of Harvard College Evolved Cas9 proteins for gene editing
CN105543257A (zh) * 2016-01-18 2016-05-04 安徽农业大学 一种pAPN基因定点修饰猪
GB2568182A (en) 2016-08-03 2019-05-08 Harvard College Adenosine nucleobase editors and uses thereof
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CN110914310A (zh) 2017-03-10 2020-03-24 哈佛大学的校长及成员们 胞嘧啶至鸟嘌呤碱基编辑器
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JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111867373A (zh) * 2017-12-18 2020-10-30 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN111867373B (zh) * 2017-12-18 2023-05-02 Imv技术股份有限公司 使用slo3钾通道抑制剂提高动物精子寿命和运动力的方法
CN110184296A (zh) * 2018-02-07 2019-08-30 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN110184296B (zh) * 2018-02-07 2023-06-09 上海大学 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物
CN111787791A (zh) * 2018-02-26 2020-10-16 Ag遗传学股份有限公司 用于防止特定染色体的传播的材料和方法
CN109837347B (zh) * 2019-01-02 2021-01-29 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN109837347A (zh) * 2019-01-02 2019-06-04 华中农业大学 Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记
CN111549032A (zh) * 2020-05-26 2020-08-18 肇庆学院 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法
CN117545350A (zh) * 2020-12-31 2024-02-09 以色列农业和农村发展部农业研究组织(沃尔卡尼研究所) 不育禽类胚胎、其产生及用途
CN116064541A (zh) * 2022-10-21 2023-05-05 华南农业大学 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法
CN116884488A (zh) * 2023-09-07 2023-10-13 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN116884488B (zh) * 2023-09-07 2023-11-24 中国医学科学院基础医学研究所 一种男性不育标志物的筛查方法、系统及设备
CN118910165A (zh) * 2024-10-11 2024-11-08 上海南方模式生物科技股份有限公司 一种cxcl16基因人源化动物模型的构建方法及应用

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AP2015008963A0 (en) 2016-01-31
US20140359796A1 (en) 2014-12-04
RU2015156801A (ru) 2017-07-06
AU2014272106A1 (en) 2016-01-21
KR20160013219A (ko) 2016-02-03
NZ715540A (en) 2021-04-30
EP3004345A4 (en) 2017-02-15
WO2014193583A2 (en) 2014-12-04
BR112015029904A2 (pt) 2017-09-26
MX2015016385A (es) 2016-04-11
CA2913411A1 (en) 2014-12-04
WO2014193583A3 (en) 2015-01-22
JP2016525890A (ja) 2016-09-01
PH12015502640A1 (en) 2016-03-07
US20190335725A1 (en) 2019-11-07
EP3004345A2 (en) 2016-04-13

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