JP2016525890A5 - - Google Patents
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- JP2016525890A5 JP2016525890A5 JP2016516661A JP2016516661A JP2016525890A5 JP 2016525890 A5 JP2016525890 A5 JP 2016525890A5 JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016525890 A5 JP2016525890 A5 JP 2016525890A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- animal
- catsper
- chromosome
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 241001465754 Metazoa Species 0.000 claims 18
- -1 meganuclease Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 230000014509 gene expression Effects 0.000 claims 7
- 102100028014 Cation channel sperm-associated protein 4 Human genes 0.000 claims 6
- 101710132763 Cation channel sperm-associated protein 4 Proteins 0.000 claims 6
- 102100031780 Endonuclease Human genes 0.000 claims 5
- 108010042407 Endonucleases Proteins 0.000 claims 5
- 102000001133 Fertilins Human genes 0.000 claims 4
- 108010069446 Fertilins Proteins 0.000 claims 4
- 101710163270 Nuclease Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000000349 chromosome Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000014639 sexual reproduction Effects 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 102000018120 Recombinases Human genes 0.000 claims 3
- 108010091086 Recombinases Proteins 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 102000029791 ADAM Human genes 0.000 claims 2
- 108091022885 ADAM Proteins 0.000 claims 2
- 101150040384 ATP2B4 gene Proteins 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 2
- 102100032578 Adenosine deaminase domain-containing protein 1 Human genes 0.000 claims 2
- 241000271566 Aves Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 102100028012 Cation channel sperm-associated auxiliary subunit delta Human genes 0.000 claims 2
- 101710119341 Cation channel sperm-associated auxiliary subunit delta Proteins 0.000 claims 2
- 102100028004 Cation channel sperm-associated protein 1 Human genes 0.000 claims 2
- 101710132751 Cation channel sperm-associated protein 1 Proteins 0.000 claims 2
- 102100028062 Cation channel sperm-associated protein 2 Human genes 0.000 claims 2
- 101710132770 Cation channel sperm-associated protein 2 Proteins 0.000 claims 2
- 102100028061 Cation channel sperm-associated protein 3 Human genes 0.000 claims 2
- 101710132768 Cation channel sperm-associated protein 3 Proteins 0.000 claims 2
- 102100027826 Complexin-1 Human genes 0.000 claims 2
- 102100033672 Deleted in azoospermia-like Human genes 0.000 claims 2
- 102100031637 Dynein axonemal heavy chain 8 Human genes 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 2
- 101000797006 Homo sapiens Adenosine deaminase domain-containing protein 1 Proteins 0.000 claims 2
- 101000871280 Homo sapiens Deleted in azoospermia-like Proteins 0.000 claims 2
- 101000866323 Homo sapiens Dynein axonemal heavy chain 8 Proteins 0.000 claims 2
- 101000944004 Homo sapiens Potassium channel subfamily U member 1 Proteins 0.000 claims 2
- 108700011259 MicroRNAs Proteins 0.000 claims 2
- 101100160972 Mus musculus Zmynd15 gene Proteins 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 102100033525 Potassium channel subfamily U member 1 Human genes 0.000 claims 2
- 101150002402 Smcp gene Proteins 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 210000001766 X chromosome Anatomy 0.000 claims 2
- 210000002593 Y chromosome Anatomy 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 235000013330 chicken meat Nutrition 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 2
- 108010084071 complexin I Proteins 0.000 claims 2
- 230000006543 gametophyte development Effects 0.000 claims 2
- 244000144972 livestock Species 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 230000034004 oogenesis Effects 0.000 claims 2
- 210000000717 sertoli cell Anatomy 0.000 claims 2
- 230000021595 spermatogenesis Effects 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000004581 coalescence Methods 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000019100 sperm motility Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829656P | 2013-05-31 | 2013-05-31 | |
| US61/829,656 | 2013-05-31 | ||
| US201361870558P | 2013-08-27 | 2013-08-27 | |
| US61/870,558 | 2013-08-27 | ||
| PCT/US2014/035847 WO2014193583A2 (en) | 2013-05-31 | 2014-04-29 | Genetically sterile animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016525890A JP2016525890A (ja) | 2016-09-01 |
| JP2016525890A5 true JP2016525890A5 (enExample) | 2017-06-15 |
Family
ID=51986779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516661A Pending JP2016525890A (ja) | 2013-05-31 | 2014-04-29 | 遺伝的不妊性動物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20140359796A1 (enExample) |
| EP (1) | EP3004345A4 (enExample) |
| JP (1) | JP2016525890A (enExample) |
| KR (1) | KR20160013219A (enExample) |
| CN (1) | CN105473714A (enExample) |
| AP (1) | AP2015008963A0 (enExample) |
| AU (1) | AU2014272106A1 (enExample) |
| BR (1) | BR112015029904A2 (enExample) |
| CA (1) | CA2913411A1 (enExample) |
| MX (1) | MX2015016385A (enExample) |
| PH (1) | PH12015502640A1 (enExample) |
| RU (1) | RU2015156801A (enExample) |
| WO (1) | WO2014193583A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| US9745561B2 (en) * | 2014-01-08 | 2017-08-29 | Iowa State University Research Foundation, Inc. | Genetic test and genetic basis for SCID in pigs |
| US20160029604A1 (en) | 2014-04-28 | 2016-02-04 | Recombinetics, Inc. | Multiplex gene editing |
| FI3169778T3 (fi) | 2014-07-14 | 2023-12-13 | Univ Washington State | Ituradan soluja ablatoiva nanos-geeninpoisto |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| DE112016001619B4 (de) | 2015-04-08 | 2024-07-18 | National Federation Of Agricultural Cooperative Associations | Verfahren zum herstellen eines nicht-humanen säugetiers oder fisches, das/der jeweils in der lage ist, gameten herzustellen, die ihren ursprung in einem anderen individuum haben |
| EP3303585A4 (en) | 2015-06-03 | 2018-10-31 | Board of Regents of the University of Nebraska | Dna editing using single-stranded dna |
| US20170099813A1 (en) * | 2015-10-07 | 2017-04-13 | Recombinetics, Inc. | Method of generating sterile terminal sires in livestock and animals produced thereby |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3498096A1 (en) * | 2017-12-18 | 2019-06-19 | IMV Technologies | Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel |
| CN110184296B (zh) * | 2018-02-07 | 2023-06-09 | 上海大学 | 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物 |
| WO2019165465A1 (en) * | 2018-02-26 | 2019-08-29 | Aggenetics, Inc. | Materials and methods for preventing transmission of a particular chromosome |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020047514A2 (en) * | 2018-08-31 | 2020-03-05 | Recombinetics, Inc. | Production method for animal models with disease associated phenotypes |
| GB201816633D0 (en) * | 2018-10-12 | 2018-11-28 | Univ Edinburgh | Genetically modified avians and method for the reconstitution thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109837347B (zh) * | 2019-01-02 | 2021-01-29 | 华中农业大学 | Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| NO20211349A1 (en) * | 2019-04-09 | 2021-11-09 | Mayo Found Medical Education & Res | Sterile fish |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN111378663B (zh) * | 2020-03-18 | 2021-07-13 | 吉林省农业科学院 | lncRNA SFR1及其应用、调控卵泡发育的产品和方法 |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| CN111549032A (zh) * | 2020-05-26 | 2020-08-18 | 肇庆学院 | 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
| KR102285906B1 (ko) | 2021-02-18 | 2021-08-04 | 주식회사 엔에이피 | 수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물 |
| IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| EP4577041A1 (en) * | 2022-08-22 | 2025-07-02 | Ramot at Tel-Aviv University Ltd. | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations |
| CN116064541B (zh) * | 2022-10-21 | 2025-03-18 | 华南农业大学 | 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法 |
| KR20250033452A (ko) | 2023-08-30 | 2025-03-10 | 서울대학교산학협력단 | Cyp17a1 형질전환 비만 및 불임치료제 개발 모델 제조방법 및 용도 |
| CN116884488B (zh) * | 2023-09-07 | 2023-11-24 | 中国医学科学院基础医学研究所 | 一种男性不育标志物的筛查方法、系统及设备 |
| CN118910165A (zh) * | 2024-10-11 | 2024-11-08 | 上海南方模式生物科技股份有限公司 | 一种cxcl16基因人源化动物模型的构建方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002543814A (ja) * | 1999-05-13 | 2002-12-24 | セダーシナイ メディカル センター | トランスジェニック種の発生と遺伝子療法用の雄性生殖細胞の遺伝的修飾法 |
| CA2400292A1 (en) * | 2000-02-24 | 2001-08-30 | James M. Robl | Production of mammals which produce progeny of a single sex |
| US20050081256A1 (en) * | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
| WO2003081990A2 (en) * | 2002-03-22 | 2003-10-09 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| WO2010065550A2 (en) * | 2008-12-01 | 2010-06-10 | Board Of Regents University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| CA2767377A1 (en) * | 2009-07-24 | 2011-01-27 | Sigma-Aldrich Co. Llc | Method for genome editing |
| US8633348B2 (en) * | 2009-08-28 | 2014-01-21 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids |
| BR112013021785A8 (pt) * | 2011-02-25 | 2018-07-03 | Recombinetics Inc | animais geneticamente modificados e métodos para fazer os mesmos |
| WO2012158985A2 (en) * | 2011-05-17 | 2012-11-22 | Transposagen Biopharmaceuticals, Inc. | Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms |
| AP2015008495A0 (en) * | 2012-10-30 | 2015-05-31 | Ct For Aquaculture Technologies Inc | Control of sexual maturation in animals |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
-
2014
- 2014-04-28 US US14/263,408 patent/US20140359796A1/en not_active Abandoned
- 2014-04-29 AU AU2014272106A patent/AU2014272106A1/en not_active Abandoned
- 2014-04-29 EP EP14804562.8A patent/EP3004345A4/en not_active Withdrawn
- 2014-04-29 RU RU2015156801A patent/RU2015156801A/ru not_active Application Discontinuation
- 2014-04-29 CA CA2913411A patent/CA2913411A1/en not_active Abandoned
- 2014-04-29 CN CN201480042269.4A patent/CN105473714A/zh active Pending
- 2014-04-29 WO PCT/US2014/035847 patent/WO2014193583A2/en not_active Ceased
- 2014-04-29 AP AP2015008963A patent/AP2015008963A0/en unknown
- 2014-04-29 MX MX2015016385A patent/MX2015016385A/es unknown
- 2014-04-29 BR BR112015029904A patent/BR112015029904A2/pt not_active Application Discontinuation
- 2014-04-29 JP JP2016516661A patent/JP2016525890A/ja active Pending
- 2014-04-29 KR KR1020157037273A patent/KR20160013219A/ko not_active Ceased
-
2015
- 2015-11-26 PH PH12015502640A patent/PH12015502640A1/en unknown
-
2019
- 2019-06-03 US US16/430,251 patent/US20190335725A1/en not_active Abandoned
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