JP2016529904A5 - - Google Patents
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- JP2016529904A5 JP2016529904A5 JP2016538910A JP2016538910A JP2016529904A5 JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5 JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- target
- hdr
- sequence
- chromosomal dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 18
- 108700028369 Alleles Proteins 0.000 claims 11
- 101710163270 Nuclease Proteins 0.000 claims 11
- 108010042407 Endonucleases Proteins 0.000 claims 10
- 102000004533 Endonucleases Human genes 0.000 claims 10
- 239000013611 chromosomal DNA Substances 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 6
- 108020005004 Guide RNA Proteins 0.000 claims 5
- 108091033409 CRISPR Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 210000002459 blastocyst Anatomy 0.000 claims 2
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 235000013372 meat Nutrition 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 208000035240 Disease Resistance Diseases 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 108091081548 Palindromic sequence Proteins 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361870401P | 2013-08-27 | 2013-08-27 | |
| US61/870,401 | 2013-08-27 | ||
| PCT/US2014/035854 WO2015030881A1 (en) | 2013-08-27 | 2014-04-29 | Efficient non-meiotic allele introgression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Division JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016529904A JP2016529904A (ja) | 2016-09-29 |
| JP2016529904A5 true JP2016529904A5 (enExample) | 2017-06-15 |
Family
ID=52585270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538910A Pending JP2016529904A (ja) | 2013-08-27 | 2014-04-29 | 効率的な非減数分裂対立遺伝子移入 |
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9528124B2 (enExample) |
| EP (1) | EP3039145B1 (enExample) |
| JP (2) | JP2016529904A (enExample) |
| KR (1) | KR20160048179A (enExample) |
| CN (2) | CN105960461B (enExample) |
| AP (1) | AP2016009113A0 (enExample) |
| AR (1) | AR096143A1 (enExample) |
| AU (2) | AU2014311855A1 (enExample) |
| BR (1) | BR112016004020B1 (enExample) |
| CA (1) | CA2922084C (enExample) |
| MX (1) | MX2016002564A (enExample) |
| PH (1) | PH12016500378A1 (enExample) |
| RU (1) | RU2016110827A (enExample) |
| WO (1) | WO2015030881A1 (enExample) |
Families Citing this family (69)
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| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| MX388563B (es) | 2013-10-25 | 2025-03-20 | Livestock Improvement Corporation Ltd | Marcadores geneticos y usos de los mismos. |
| EP4372090A3 (en) | 2013-11-07 | 2024-08-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| CN110951779B (zh) | 2013-12-11 | 2024-04-16 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
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| US10349639B2 (en) | 2014-03-26 | 2019-07-16 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
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| KR102763527B1 (ko) | 2014-12-03 | 2025-02-05 | 애질런트 테크놀로지스, 인크. | 화학적 변형을 갖는 가이드 rna |
| KR102648489B1 (ko) | 2015-04-06 | 2024-03-15 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
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| EP4338799A3 (en) | 2016-10-18 | 2024-06-05 | Regents of the University of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
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| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
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| CN110211635B (zh) * | 2019-06-12 | 2020-07-21 | 北京康普森农业科技有限公司 | 用于畜禽基因组选择分析的方法及畜禽育种方法 |
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| CN112941108B (zh) * | 2021-05-13 | 2021-10-15 | 中国农业科学院北京畜牧兽医研究所 | 一种具有无角Pc位点纯合基因型的荷斯坦牛的制备方法 |
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2014
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- 2014-04-29 CN CN201480057624.5A patent/CN105960461B/zh active Active
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- 2014-04-29 AU AU2014311855A patent/AU2014311855A1/en not_active Abandoned
- 2014-04-29 KR KR1020167008152A patent/KR20160048179A/ko not_active Ceased
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