JP2016529904A5 - - Google Patents
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- JP2016529904A5 JP2016529904A5 JP2016538910A JP2016538910A JP2016529904A5 JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5 JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- target
- hdr
- sequence
- chromosomal dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 18
- 108700028369 Alleles Proteins 0.000 claims 11
- 101710163270 Nuclease Proteins 0.000 claims 11
- 108010042407 Endonucleases Proteins 0.000 claims 10
- 102000004533 Endonucleases Human genes 0.000 claims 10
- 239000013611 chromosomal DNA Substances 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 6
- 108020005004 Guide RNA Proteins 0.000 claims 5
- 108091033409 CRISPR Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 210000002459 blastocyst Anatomy 0.000 claims 2
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 235000013372 meat Nutrition 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 208000035240 Disease Resistance Diseases 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 108091081548 Palindromic sequence Proteins 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361870401P | 2013-08-27 | 2013-08-27 | |
| US61/870,401 | 2013-08-27 | ||
| PCT/US2014/035854 WO2015030881A1 (en) | 2013-08-27 | 2014-04-29 | Efficient non-meiotic allele introgression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Division JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016529904A JP2016529904A (ja) | 2016-09-29 |
| JP2016529904A5 true JP2016529904A5 (enExample) | 2017-06-15 |
Family
ID=52585270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538910A Pending JP2016529904A (ja) | 2013-08-27 | 2014-04-29 | 効率的な非減数分裂対立遺伝子移入 |
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9528124B2 (enExample) |
| EP (1) | EP3039145B1 (enExample) |
| JP (2) | JP2016529904A (enExample) |
| KR (1) | KR20160048179A (enExample) |
| CN (2) | CN111471719B (enExample) |
| AP (1) | AP2016009113A0 (enExample) |
| AR (1) | AR096143A1 (enExample) |
| AU (2) | AU2014311855A1 (enExample) |
| BR (1) | BR112016004020B1 (enExample) |
| CA (1) | CA2922084C (enExample) |
| MX (1) | MX2016002564A (enExample) |
| PH (1) | PH12016500378A1 (enExample) |
| RU (1) | RU2016110827A (enExample) |
| WO (1) | WO2015030881A1 (enExample) |
Families Citing this family (70)
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| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| WO2015060732A1 (en) | 2013-10-25 | 2015-04-30 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| EP3066201B1 (en) | 2013-11-07 | 2018-03-07 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| CN110951779B (zh) | 2013-12-11 | 2024-04-16 | 瑞泽恩制药公司 | 用于靶向修饰基因组的方法和组合物 |
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| CA2943794C (en) * | 2014-03-26 | 2023-01-24 | University Of Maryland, College Park | Targeted genome editing in zygotes of domestic large animals |
| AP2016009588A0 (en) | 2014-04-28 | 2016-11-30 | Recombinetics Inc | Multiplex gene editing in swine |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US10716298B2 (en) | 2014-09-23 | 2020-07-21 | Acceligen, Inc. | Materials and methods for producing animals with short hair |
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| AU2015342749B2 (en) | 2014-11-07 | 2022-01-27 | Editas Medicine, Inc. | Methods for improving CRISPR/Cas-mediated genome-editing |
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| WO2016196887A1 (en) | 2015-06-03 | 2016-12-08 | Board Of Regents Of The University Of Nebraska | Dna editing using single-stranded dna |
| CA2993431A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Nuclease based knockouts of immunological checkpoint genes in immune cells |
| CN108474007A (zh) * | 2015-08-07 | 2018-08-31 | 联邦科学技术研究组织 | 产生包含种系遗传修饰的动物的方法 |
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| US11085057B2 (en) | 2015-12-02 | 2021-08-10 | The Regents Of The University Of California | Compositions and methods for modifying a target nucleic acid |
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| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
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| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| WO2020014261A1 (en) | 2018-07-09 | 2020-01-16 | The Broad Institute, Inc. | Rna programmable epigenetic rna modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
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| CN110211635B (zh) * | 2019-06-12 | 2020-07-21 | 北京康普森农业科技有限公司 | 用于畜禽基因组选择分析的方法及畜禽育种方法 |
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2014
- 2014-04-28 US US14/263,446 patent/US9528124B2/en active Active
- 2014-04-29 AU AU2014311855A patent/AU2014311855A1/en not_active Abandoned
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- 2014-04-29 AP AP2016009113A patent/AP2016009113A0/xx unknown
- 2014-04-29 EP EP14840061.7A patent/EP3039145B1/en active Active
- 2014-04-29 CN CN202010106589.9A patent/CN111471719B/zh active Active
- 2014-04-29 WO PCT/US2014/035854 patent/WO2015030881A1/en not_active Ceased
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- 2014-04-29 BR BR112016004020-1A patent/BR112016004020B1/pt active IP Right Grant
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- 2014-04-29 KR KR1020167008152A patent/KR20160048179A/ko not_active Ceased
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- 2015-02-19 US US14/625,797 patent/US20150156996A1/en not_active Abandoned
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