RU2014151567A - Конъюгат менингококка серогруппы х - Google Patents
Конъюгат менингококка серогруппы х Download PDFInfo
- Publication number
- RU2014151567A RU2014151567A RU2014151567A RU2014151567A RU2014151567A RU 2014151567 A RU2014151567 A RU 2014151567A RU 2014151567 A RU2014151567 A RU 2014151567A RU 2014151567 A RU2014151567 A RU 2014151567A RU 2014151567 A RU2014151567 A RU 2014151567A
- Authority
- RU
- Russia
- Prior art keywords
- conjugate
- polysaccharide
- capsular polysaccharide
- serogroup
- carrier molecule
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 claims abstract 40
- 229920001282 polysaccharide Polymers 0.000 claims abstract 40
- 239000005017 polysaccharide Substances 0.000 claims abstract 40
- 238000000034 method Methods 0.000 claims abstract 14
- 125000003172 aldehyde group Chemical group 0.000 claims abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 7
- 230000003647 oxidation Effects 0.000 claims abstract 4
- 238000007254 oxidation reaction Methods 0.000 claims abstract 4
- 241000588650 Neisseria meningitidis Species 0.000 claims abstract 2
- 230000001590 oxidative effect Effects 0.000 claims abstract 2
- 238000006268 reductive amination reaction Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 11
- 230000002163 immunogen Effects 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 206010013023 diphtheria Diseases 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- QWDBGVNDGYUIAC-QZABAPFNSA-N glucosamine 4-phosphate Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](OP(O)(O)=O)[C@@H]1O QWDBGVNDGYUIAC-QZABAPFNSA-N 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650025P | 2012-05-22 | 2012-05-22 | |
| US61/650,025 | 2012-05-22 | ||
| US201261698677P | 2012-09-09 | 2012-09-09 | |
| US61/698,677 | 2012-09-09 | ||
| US201361799528P | 2013-03-15 | 2013-03-15 | |
| US61/799,528 | 2013-03-15 | ||
| PCT/EP2013/060447 WO2013174832A1 (en) | 2012-05-22 | 2013-05-22 | Meningococcus serogroup x conjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014151567A true RU2014151567A (ru) | 2016-07-10 |
Family
ID=48470983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014151567A RU2014151567A (ru) | 2012-05-22 | 2013-05-22 | Конъюгат менингококка серогруппы х |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10124051B2 (enExample) |
| EP (1) | EP2852414B9 (enExample) |
| JP (2) | JP2015518845A (enExample) |
| KR (1) | KR20150021933A (enExample) |
| CN (1) | CN104736180A (enExample) |
| AU (1) | AU2013265336A1 (enExample) |
| BR (1) | BR112014029313A2 (enExample) |
| CA (1) | CA2874210A1 (enExample) |
| ES (1) | ES2820898T3 (enExample) |
| IL (1) | IL235543A0 (enExample) |
| MX (1) | MX2014014067A (enExample) |
| RU (1) | RU2014151567A (enExample) |
| SG (2) | SG10201608675YA (enExample) |
| WO (1) | WO2013174832A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201961B1 (en) | 2005-06-27 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| JP6042455B2 (ja) * | 2012-01-30 | 2016-12-14 | セラム インスティチュート オブ インディア プライベイト リミテッド | 免疫原性組成物の調製方法 |
| US10124051B2 (en) * | 2012-05-22 | 2018-11-13 | Glaxosmithkline Biologicals Sa | Meningococcus serogroup X conjugate |
| CA2892035C (en) * | 2012-11-21 | 2019-11-05 | Serum Institute Of India Ltd. | Production of neisseria meningitidis x capsular polysaccharide |
| EP3131576B1 (en) * | 2014-04-17 | 2021-06-30 | Medizinische Hochschule Hannover | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity |
| EP2952586B1 (en) | 2014-06-02 | 2021-10-27 | Serum Institute Of India Private Limited | Bacterial capsular polysaccharide yield enhancement by addition of defoaming agents |
| US10365272B2 (en) * | 2014-07-25 | 2019-07-30 | Serum Institute Of India Private Limited | Highly sensitive immunoassay for rapid quantification of meningococcal capsular polysaccharide antigens |
| PH12019500399B1 (en) | 2016-09-02 | 2024-05-15 | Sanofi Pasteur Inc | Neisseria meningitidis vaccine |
| BR112019010227A2 (pt) * | 2016-11-25 | 2019-10-08 | Glaxosmithkline Biologicals Sa | conjugado imunogênico, processo para preparação de conjugado imunogênico, composição imunogênica, vacina, e, uso de nomv |
| EP3799883A1 (en) * | 2016-11-25 | 2021-04-07 | GlaxoSmithKline Biologicals S.A. | Nomv-antigen conjugated compounds and use thereof |
| TWI757499B (zh) | 2017-06-02 | 2022-03-11 | 美商輝瑞大藥廠 | 對flt3具特異性之抗體及其用途 |
| BR112019027182A2 (pt) * | 2017-06-27 | 2020-06-30 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | nova composição de vacina conjugada de proteína - polissacarídeo multivalente e formulação da mesma |
| WO2021099982A1 (en) | 2019-11-22 | 2021-05-27 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
| CN118078981A (zh) * | 2024-04-26 | 2024-05-28 | 成都康华生物制品股份有限公司 | 一种基于双蛋白载体的五价脑膜炎球菌多糖结合疫苗的制备方法及其产品 |
| CN119269700A (zh) * | 2024-12-09 | 2025-01-07 | 复星安特金(成都)生物制药有限公司 | 细菌荚膜多糖或其结合物中各单糖组分含量的检测方法 |
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2013
- 2013-05-22 US US14/401,024 patent/US10124051B2/en active Active
- 2013-05-22 SG SG10201608675YA patent/SG10201608675YA/en unknown
- 2013-05-22 CA CA 2874210 patent/CA2874210A1/en not_active Abandoned
- 2013-05-22 MX MX2014014067A patent/MX2014014067A/es unknown
- 2013-05-22 JP JP2015513141A patent/JP2015518845A/ja active Pending
- 2013-05-22 AU AU2013265336A patent/AU2013265336A1/en not_active Abandoned
- 2013-05-22 EP EP13724265.7A patent/EP2852414B9/en active Active
- 2013-05-22 CN CN201380038432.5A patent/CN104736180A/zh active Pending
- 2013-05-22 RU RU2014151567A patent/RU2014151567A/ru not_active Application Discontinuation
- 2013-05-22 BR BR112014029313A patent/BR112014029313A2/pt not_active IP Right Cessation
- 2013-05-22 WO PCT/EP2013/060447 patent/WO2013174832A1/en not_active Ceased
- 2013-05-22 KR KR20147034885A patent/KR20150021933A/ko not_active Withdrawn
- 2013-05-22 SG SG11201407440WA patent/SG11201407440WA/en unknown
- 2013-05-22 ES ES13724265T patent/ES2820898T3/es active Active
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2014
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2017
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2018
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|---|---|
| SG11201407440WA (en) | 2014-12-30 |
| US10668143B2 (en) | 2020-06-02 |
| KR20150021933A (ko) | 2015-03-03 |
| US20150104479A1 (en) | 2015-04-16 |
| IL235543A0 (en) | 2015-01-29 |
| CN104736180A (zh) | 2015-06-24 |
| MX2014014067A (es) | 2015-02-04 |
| EP2852414B9 (en) | 2020-12-09 |
| CA2874210A1 (en) | 2013-11-28 |
| AU2013265336A1 (en) | 2014-12-04 |
| BR112014029313A2 (pt) | 2017-06-27 |
| EP2852414A1 (en) | 2015-04-01 |
| US10124051B2 (en) | 2018-11-13 |
| SG10201608675YA (en) | 2016-12-29 |
| US20190060437A1 (en) | 2019-02-28 |
| ES2820898T3 (es) | 2021-04-22 |
| JP2017088622A (ja) | 2017-05-25 |
| JP2015518845A (ja) | 2015-07-06 |
| WO2013174832A1 (en) | 2013-11-28 |
| EP2852414B1 (en) | 2020-07-08 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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