RU2014130080A - Липосомальные композиции хлоритов или хлоратов - Google Patents
Липосомальные композиции хлоритов или хлоратов Download PDFInfo
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- RU2014130080A RU2014130080A RU2014130080A RU2014130080A RU2014130080A RU 2014130080 A RU2014130080 A RU 2014130080A RU 2014130080 A RU2014130080 A RU 2014130080A RU 2014130080 A RU2014130080 A RU 2014130080A RU 2014130080 A RU2014130080 A RU 2014130080A
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- 239000000203 mixture Substances 0.000 title claims abstract 96
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 title claims abstract 41
- 239000002502 liposome Substances 0.000 claims abstract 38
- 229910001919 chlorite Inorganic materials 0.000 claims abstract 36
- 229910052619 chlorite group Inorganic materials 0.000 claims abstract 36
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims abstract 36
- 150000002632 lipids Chemical class 0.000 claims abstract 26
- 239000000232 Lipid Bilayer Substances 0.000 claims abstract 15
- 150000002500 ions Chemical class 0.000 claims abstract 7
- 238000000034 method Methods 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000030507 AIDS Diseases 0.000 claims 3
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 3
- BPHQZTVXXXJVHI-IADGFXSZSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-tetradecanoyloxypropyl] tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-IADGFXSZSA-N 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- BPHQZTVXXXJVHI-UHFFFAOYSA-N dimyristoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-UHFFFAOYSA-N 0.000 claims 3
- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 claims 3
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- LVNGJLRDBYCPGB-LDLOPFEMSA-N (R)-1,2-distearoylphosphatidylethanolamine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[NH3+])OC(=O)CCCCCCCCCCCCCCCCC LVNGJLRDBYCPGB-LDLOPFEMSA-N 0.000 claims 2
- DSNRWDQKZIEDDB-SQYFZQSCSA-N 1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-SQYFZQSCSA-N 0.000 claims 2
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims 2
- TYAQXZHDAGZOEO-KXQOOQHDSA-N 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCC TYAQXZHDAGZOEO-KXQOOQHDSA-N 0.000 claims 2
- ATHVAWFAEPLPPQ-VRDBWYNSSA-N 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC ATHVAWFAEPLPPQ-VRDBWYNSSA-N 0.000 claims 2
- YKIOPDIXYAUOFN-UHFFFAOYSA-N 2,3-di(icosanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCCC YKIOPDIXYAUOFN-UHFFFAOYSA-N 0.000 claims 2
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- FVJZSBGHRPJMMA-DHPKCYQYSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-DHPKCYQYSA-N 0.000 claims 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 claims 2
- 239000008344 egg yolk phospholipid Substances 0.000 claims 2
- 229940068998 egg yolk phospholipid Drugs 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
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- 210000002540 macrophage Anatomy 0.000 claims 2
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- 150000003904 phospholipids Chemical class 0.000 claims 2
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- 150000003408 sphingolipids Chemical class 0.000 claims 2
- XUOBSVNBXQMJJN-UHFFFAOYSA-N (3-hydroxy-2-tetradecanoyloxypropyl) octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCC XUOBSVNBXQMJJN-UHFFFAOYSA-N 0.000 claims 1
- BIABMEZBCHDPBV-BEBVUIBBSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-BEBVUIBBSA-N 0.000 claims 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- UIXXHROAQSBBOV-PSXMRANNSA-N 1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC UIXXHROAQSBBOV-PSXMRANNSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
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- 206010055128 Autoimmune neutropenia Diseases 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 claims 1
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- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
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- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
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Classifications
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201161579326P | 2011-12-22 | 2011-12-22 | |
| US61/579,326 | 2011-12-22 | ||
| PCT/IB2012/057645 WO2013093891A1 (en) | 2011-12-22 | 2012-12-21 | Liposomal chlorite or chlorate compositions |
Publications (1)
| Publication Number | Publication Date |
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| RU2014130080A true RU2014130080A (ru) | 2016-02-10 |
Family
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|---|---|---|---|
| RU2014130080A RU2014130080A (ru) | 2011-12-22 | 2012-12-21 | Липосомальные композиции хлоритов или хлоратов |
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| US (1) | US20130177629A1 (enExample) |
| EP (1) | EP2793860A1 (enExample) |
| JP (1) | JP2015502400A (enExample) |
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| BR (1) | BR112014015333A2 (enExample) |
| CA (1) | CA2857604A1 (enExample) |
| IN (1) | IN2014DN05866A (enExample) |
| MX (1) | MX2014007664A (enExample) |
| RU (1) | RU2014130080A (enExample) |
| WO (1) | WO2013093891A1 (enExample) |
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| AU2006322076C1 (en) | 2005-12-08 | 2013-11-14 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| WO2014037927A1 (en) * | 2012-09-10 | 2014-03-13 | Nuvo Research Gmbh | Chlorate compositions and use of chlorate for treating radiation exposure |
| ES2743039T3 (es) | 2012-11-29 | 2020-02-18 | Insmed Inc | Formulaciones de vancomicina estabilizada |
| US9603799B2 (en) | 2013-03-15 | 2017-03-28 | Htd Biosystems Inc. | Liposomal vaccine adjuvants and methods of making and using same |
| US20140271815A1 (en) * | 2013-03-15 | 2014-09-18 | Aryo Sorayya | Heat-and freeze-stable vaccines and methods of making and using same |
| EP3466432B1 (en) | 2014-05-15 | 2020-07-08 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| JP6900596B2 (ja) * | 2015-08-20 | 2021-07-07 | フリードリッヒ − ヴィルヘルム キューネ | 赤血球疾患およびそれによって媒介される症状を治療するための亜塩素酸塩の使用 |
| TWI719105B (zh) | 2016-01-04 | 2021-02-21 | 中央硏究院 | 基於酯化/皂化用於微脂體負載之方法 |
| US20190142864A1 (en) * | 2017-10-11 | 2019-05-16 | California Institute Of Technology | Methods and systems, for interfering with viability of bacteria and related antimicrobials and compositions |
| EP3752833B1 (en) * | 2018-02-15 | 2025-08-13 | Yeditepe Universitesi | Exosome isolation method by two phase fluid system |
| WO2019191627A1 (en) | 2018-03-30 | 2019-10-03 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| CN110563829B (zh) * | 2019-09-17 | 2021-03-26 | 中国人民解放军国防科技大学 | 用于调控脂质体囊泡行为、功能的反光蛋白体系及其应用 |
| CN112716973A (zh) * | 2019-10-28 | 2021-04-30 | 卢序 | 一种降低细胞还原应激的氧化剂的用途 |
| TR202012260A2 (tr) * | 2020-08-05 | 2020-10-21 | Emin Zuemruetdal | Oral kullanim i̇çi̇n potasyum hi̇droksi̇t/sodyum hi̇droksi̇t solüsyonu |
| CA3253808A1 (en) * | 2022-05-19 | 2023-11-23 | Neuvivo Inc | BIOMARKERS OF NEURODEGENERATIVE DISEASES |
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-
2012
- 2012-12-21 CA CA2857604A patent/CA2857604A1/en not_active Abandoned
- 2012-12-21 CN CN201280070434.8A patent/CN104125826A/zh active Pending
- 2012-12-21 MX MX2014007664A patent/MX2014007664A/es unknown
- 2012-12-21 WO PCT/IB2012/057645 patent/WO2013093891A1/en not_active Ceased
- 2012-12-21 EP EP12820937.6A patent/EP2793860A1/en not_active Withdrawn
- 2012-12-21 US US13/724,963 patent/US20130177629A1/en not_active Abandoned
- 2012-12-21 IN IN5866DEN2014 patent/IN2014DN05866A/en unknown
- 2012-12-21 BR BR112014015333A patent/BR112014015333A2/pt not_active IP Right Cessation
- 2012-12-21 JP JP2014548324A patent/JP2015502400A/ja active Pending
- 2012-12-21 AU AU2012297589A patent/AU2012297589C1/en not_active Ceased
- 2012-12-21 RU RU2014130080A patent/RU2014130080A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
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| EP2793860A1 (en) | 2014-10-29 |
| US20130177629A1 (en) | 2013-07-11 |
| CN104125826A (zh) | 2014-10-29 |
| CA2857604A1 (en) | 2013-06-27 |
| AU2012297589A1 (en) | 2013-07-11 |
| BR112014015333A8 (pt) | 2017-06-13 |
| AU2012297589C1 (en) | 2015-04-16 |
| JP2015502400A (ja) | 2015-01-22 |
| IN2014DN05866A (enExample) | 2015-05-22 |
| WO2013093891A1 (en) | 2013-06-27 |
| BR112014015333A2 (pt) | 2017-06-13 |
| MX2014007664A (es) | 2015-05-11 |
| AU2012297589B2 (en) | 2014-10-30 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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