RU2014113641A - Сконструированные ткани для применения в исследованиях in vitro, их массивы и способы их изготовления - Google Patents
Сконструированные ткани для применения в исследованиях in vitro, их массивы и способы их изготовления Download PDFInfo
- Publication number
- RU2014113641A RU2014113641A RU2014113641/10A RU2014113641A RU2014113641A RU 2014113641 A RU2014113641 A RU 2014113641A RU 2014113641/10 A RU2014113641/10 A RU 2014113641/10A RU 2014113641 A RU2014113641 A RU 2014113641A RU 2014113641 A RU2014113641 A RU 2014113641A
- Authority
- RU
- Russia
- Prior art keywords
- tissue
- cells
- array
- tissue structure
- fabric
- Prior art date
Links
- 239000004744 fabric Substances 0.000 title claims abstract 21
- 238000000338 in vitro Methods 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims 13
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000853 adhesive Substances 0.000 claims abstract 13
- 230000001070 adhesive effect Effects 0.000 claims abstract 13
- 230000002792 vascular Effects 0.000 claims abstract 6
- -1 antibody Substances 0.000 claims abstract 4
- 239000003102 growth factor Substances 0.000 claims abstract 4
- 239000000017 hydrogel Substances 0.000 claims abstract 4
- 239000012528 membrane Substances 0.000 claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 3
- 230000001464 adherent effect Effects 0.000 claims abstract 2
- 210000001519 tissue Anatomy 0.000 claims 65
- 210000004027 cell Anatomy 0.000 claims 29
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 210000000481 breast Anatomy 0.000 claims 3
- 238000003255 drug test Methods 0.000 claims 3
- 230000002124 endocrine Effects 0.000 claims 3
- 238000000099 in vitro assay Methods 0.000 claims 3
- 210000004379 membrane Anatomy 0.000 claims 3
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 210000002216 heart Anatomy 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 210000003668 pericyte Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 210000004994 reproductive system Anatomy 0.000 claims 2
- 210000004116 schwann cell Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 210000003437 trachea Anatomy 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 210000003321 cartilage cell Anatomy 0.000 claims 1
- 210000001608 connective tissue cell Anatomy 0.000 claims 1
- 238000007877 drug screening Methods 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000002064 heart cell Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000005265 lung cell Anatomy 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 210000005033 mesothelial cell Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 210000002747 omentum Anatomy 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000002363 skeletal muscle cell Anatomy 0.000 claims 1
- 210000004927 skin cell Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 210000005092 tracheal tissue Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
- 238000010276 construction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/27—Lung cells, respiratory tract cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533757P | 2011-09-12 | 2011-09-12 | |
| US201161533761P | 2011-09-12 | 2011-09-12 | |
| US201161533753P | 2011-09-12 | 2011-09-12 | |
| US61/533,761 | 2011-09-12 | ||
| US61/533,757 | 2011-09-12 | ||
| US61/533,753 | 2011-09-12 | ||
| PCT/US2012/054923 WO2013040078A2 (en) | 2011-09-12 | 2012-09-12 | Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014113641A true RU2014113641A (ru) | 2015-10-20 |
Family
ID=47883950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014113641/10A RU2014113641A (ru) | 2011-09-12 | 2012-09-12 | Сконструированные ткани для применения в исследованиях in vitro, их массивы и способы их изготовления |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20130190210A1 (enExample) |
| EP (1) | EP2756073B1 (enExample) |
| JP (2) | JP2014531204A (enExample) |
| KR (1) | KR20140072883A (enExample) |
| CN (2) | CN103946374A (enExample) |
| AU (2) | AU2012308715A1 (enExample) |
| BR (1) | BR112014005746A2 (enExample) |
| CA (2) | CA2848043C (enExample) |
| DK (1) | DK2756073T3 (enExample) |
| HK (1) | HK1200483A1 (enExample) |
| IL (1) | IL231449A0 (enExample) |
| RU (1) | RU2014113641A (enExample) |
| WO (1) | WO2013040078A2 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005081970A2 (en) | 2004-02-24 | 2005-09-09 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| WO2008055316A1 (en) * | 2006-11-10 | 2008-05-15 | Marshall Barry J | Methods and devices for the delivery of peptides into the gastric mucosa |
| JP5624981B2 (ja) | 2008-06-24 | 2014-11-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリThe Curators Ofthe University Of Missouri | 自己集合性多細胞体、および前記多細胞体を用いて3次元の生物構造体を作製する方法 |
| KR20160125530A (ko) | 2010-10-21 | 2016-10-31 | 오가노보, 인크. | 조직의 제작을 위한 디바이스, 시스템 및 방법 |
| BR112014005746A2 (pt) * | 2011-09-12 | 2017-03-28 | Organovo Inc | tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos |
| EP2782866A4 (en) | 2011-11-23 | 2015-08-05 | Univ Toronto | DEVICES AND METHOD FOR PRODUCING PLANAR POLYMER MATERIALS USING MICROFLUIDICS |
| US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| US10544036B2 (en) | 2013-04-30 | 2020-01-28 | The Governing Council Of The University Of Toronto | Microfluidic devices and methods for the extrusion of tubular structures |
| WO2014194180A1 (en) * | 2013-05-30 | 2014-12-04 | The University Of Akron | Automated cell and tissue bioprinter |
| ES2938044T3 (es) * | 2013-06-24 | 2023-04-04 | Univ Ramot | Estructura a base de epiplón y sistema de suministro |
| US20150037445A1 (en) | 2013-07-31 | 2015-02-05 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
| WO2015054577A1 (en) | 2013-10-11 | 2015-04-16 | Advanced Solutions Life Sciences, Llc | System and workstation for the design, fabrication and assembly of bio-material constructs |
| WO2015069619A1 (en) | 2013-11-05 | 2015-05-14 | President And Fellows Of Harvard College | Method of printing a tissue construct with embedded vasculature |
| WO2015080671A1 (en) | 2013-11-30 | 2015-06-04 | Agency For Science, Technology And Research | Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing |
| WO2015129881A1 (ja) * | 2014-02-28 | 2015-09-03 | 国立大学法人大阪大学 | 細胞の立体構造体の製造方法 |
| EP3808838B1 (en) * | 2014-04-04 | 2024-04-10 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
| GB201406716D0 (en) * | 2014-04-15 | 2014-05-28 | Insphero Ag | Method of preparing cells for 3D tissue culture |
| WO2016022830A1 (en) * | 2014-08-06 | 2016-02-11 | Oregon Health & Science University | Three-dimensional bioprinted pancreatic tumor model |
| EA028039B1 (ru) * | 2014-09-05 | 2017-09-29 | Частное Учреждение Лаборатория Биотехнологических Исследований "3Д Биопринтинг Солюшенс" | Устройство и способы печати биологических тканей и органов |
| WO2016049345A1 (en) * | 2014-09-24 | 2016-03-31 | The Regents Of The University Of California | Three-dimensional bioprinted artificial cornea |
| MA40495A (fr) * | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
| US11529436B2 (en) | 2014-11-05 | 2022-12-20 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
| AU2014277667B2 (en) | 2014-12-15 | 2022-07-14 | The University Of Queensland | Differentiation of pluripotent stem cells to form renal organoids |
| KR102311639B1 (ko) * | 2015-03-26 | 2021-10-12 | 주식회사 티앤알바이오팹 | 심근조직 재생용 3차원 구조체의 제조방법 |
| TWI741980B (zh) * | 2015-04-07 | 2021-10-11 | 大陸商四川藍光英諾生物科技股份有限公司 | 一種生物磚及其用途 |
| EP3280463B1 (en) | 2015-04-07 | 2021-06-09 | Revotek Co., Ltd | Compositions for cell-based three dimensional printing |
| US11746333B2 (en) * | 2015-06-16 | 2023-09-05 | Aspect Biosystems Ltd. | Continuously bioprinted multilayer tissue structure |
| CN105056302B (zh) * | 2015-08-26 | 2017-12-26 | 上海市肺科医院 | 一种生物性复合人工气管的制备方法及其应用 |
| EP3362554B1 (en) * | 2015-10-16 | 2025-09-03 | Wake Forest University Health Sciences | Multi-layer airway organoids and methods of making and using the same |
| JP6817619B2 (ja) * | 2015-10-27 | 2021-01-20 | 学校法人慶應義塾 | マイクロビーズの製造方法及び足場の製造方法 |
| AU2016352873B2 (en) | 2015-11-09 | 2023-01-05 | Organovo, Inc. | Improved methods for tissue fabrication |
| ES2984278T3 (es) | 2015-12-16 | 2024-10-29 | Univ Ramot | Partículas que comprenden epiplón descelularizado |
| US10934538B2 (en) | 2016-01-12 | 2021-03-02 | Cleveland State University | 3D-printed miniature biological constructs |
| US11479753B2 (en) | 2016-05-11 | 2022-10-25 | The Regents Of The University Of Michigan | Hierarchically structured protein materials for three dimensional (3D) cellular support systems |
| US10738297B2 (en) | 2016-05-13 | 2020-08-11 | University Of Washington | 3D printable hydrogel materials |
| DE102016109067B4 (de) * | 2016-05-17 | 2018-07-19 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Verfahren zur Bildung von Nierentubuli |
| US11254901B2 (en) | 2016-07-12 | 2022-02-22 | Deka Products Limited Partnership | System and method for printing tissue |
| US10345208B2 (en) | 2016-07-12 | 2019-07-09 | Deka Products Limited Partnership | System and method for applying force to a device |
| WO2018026172A1 (ko) * | 2016-08-01 | 2018-02-08 | 포항공과대학교 산학협력단 | 통합형 3차원 세포 프린팅 기술을 이용한 세포 배양체 및 이의 제조방법 |
| JP2019530435A (ja) * | 2016-08-15 | 2019-10-24 | オルガノボ インコーポレイテッド | 薬物試験のための三次元バイオプリント腫瘍モデル |
| US11439731B2 (en) | 2016-09-14 | 2022-09-13 | Revotek Co., Ltd. | Artificial tissue progenitor and method for preparing the same |
| JP2019537729A (ja) | 2016-09-28 | 2019-12-26 | オルガノボ インコーポレイテッド | アッセイにおける人工腎臓組織の使用 |
| US11299705B2 (en) | 2016-11-07 | 2022-04-12 | Deka Products Limited Partnership | System and method for creating tissue |
| US11655456B2 (en) | 2016-11-10 | 2023-05-23 | Organovo, Inc. | Engineered intestinal tissue and uses thereof |
| EP3538169A4 (en) | 2016-11-10 | 2020-09-30 | Organovo, Inc. | BIO-PRINTED PILEUX FOLLICLES AND THEIR USES |
| EP3541518A4 (en) | 2016-11-17 | 2020-09-30 | Cleveland State University | CHIP PLATFORMS FOR MICRO-NETWORK 3D BIO-PRINTING |
| IL249977A0 (en) | 2017-01-08 | 2017-04-30 | Ramot At Tel-Aviv Univ Ltd | 3D models of crops, methods for their preparation and their uses |
| US12252712B2 (en) | 2017-04-03 | 2025-03-18 | Organovo, Inc. | Use of engineered liver tissue constructs for modeling liver disorders |
| US10570362B2 (en) | 2017-07-12 | 2020-02-25 | Deka Products Limited Partnership | System and method for transferring tissue |
| US12297416B2 (en) | 2017-07-12 | 2025-05-13 | Deka Products Limited Partneship | System and method for transferring tissue |
| US11262349B2 (en) | 2017-10-11 | 2022-03-01 | Cleveland State University | Multiplexed immune cell assays on a micropillar/microwell chip platform |
| CN108355174A (zh) * | 2018-05-06 | 2018-08-03 | 西北工业大学 | 一种多功能分层关节软骨支架的制备方法 |
| WO2020256580A1 (ru) * | 2019-06-19 | 2020-12-24 | Общество с ограниченной ответственностью "Национальный БиоСервис" | Матричный блок для изготовления тканевых микрочипов |
| AU2020349580B2 (en) * | 2019-09-22 | 2022-06-02 | Meatech 3D, Ltd. | Physical manipulation of cultured muscle tissue |
| KR102284592B1 (ko) * | 2020-01-31 | 2021-08-02 | 성균관대학교산학협력단 | 생체 적합성 고분자를 이용한 배열된 구조체의 제조방법 및 이를 이용하여 제조된 배열된 구조체 |
| DK4126088T3 (da) * | 2020-03-22 | 2025-10-20 | Collplant Ltd | Collagenbaserede formuleringer, der kan anvendes som bløde vævsfyldstoffer og/eller implantater |
| WO2022125585A1 (en) * | 2020-12-07 | 2022-06-16 | The Regents Of The University Of California | Tissue organoid bioprinting and high-throughput screening methodology |
| CA3206143A1 (en) | 2021-02-26 | 2022-09-01 | Wei Hsu | Skeletal stem cell isolation and uses thereof |
| WO2022195242A1 (en) * | 2021-03-14 | 2022-09-22 | Copner Biotech Ltd | Cell culture scaffold formed via 3d printing |
| EP4479422A1 (en) | 2022-02-18 | 2024-12-25 | Ada Forsyth Institute, Inc. | Markers for skeletal stem cell and uses thereof |
| US12435312B2 (en) | 2022-02-28 | 2025-10-07 | Brown University | Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model |
| CN118871567A (zh) | 2022-03-24 | 2024-10-29 | 凸版控股株式会社 | 生物油墨及结构体的制造方法 |
| US20230357710A1 (en) * | 2022-05-06 | 2023-11-09 | The Regents Of The University Of Michigan | Engineered fibrillar extracellular matrix networks for three-dimensional (3d) cellular support systems |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| WO2024220607A2 (en) * | 2023-04-19 | 2024-10-24 | President And Fellows Of Harvard College | Protective mesh for tissue constructs |
| CN116714276B (zh) * | 2023-06-13 | 2025-06-24 | 青岛理工大学 | 一种无线无源电刺激导电可降解生物支架及其制备方法 |
| WO2025019869A2 (en) * | 2023-07-20 | 2025-01-23 | The Johns Hopkins University | Cell culture medium and compositions thereof |
| WO2025027510A2 (en) * | 2023-07-28 | 2025-02-06 | Hanjaya Putra Donny | Multi-parameter tunable synthetic matrix for engineering lymphatic vessels |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4759764A (en) | 1985-05-24 | 1988-07-26 | Clayton Foundation For Research | Peripheral nerve regeneration |
| US4808435A (en) | 1987-04-06 | 1989-02-28 | International Business Machines Corporation | Screen printing method for producing lines of uniform width and height |
| US5099090A (en) | 1988-05-11 | 1992-03-24 | Ariel Electronics, Inc. | Circuit writer |
| CA2306346C (en) | 1997-07-03 | 2010-09-14 | Massachusetts Institute Of Technology | Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells |
| US6401795B1 (en) | 1997-10-28 | 2002-06-11 | Sandia Corporation | Method for freeforming objects with low-binder slurry |
| JP4564655B2 (ja) | 1998-04-21 | 2010-10-20 | ユニバーシティ オブ コネチカット | 多光子励起を用いたフリーフォームナノ製作 |
| US6697694B2 (en) | 1998-08-26 | 2004-02-24 | Electronic Materials, L.L.C. | Apparatus and method for creating flexible circuits |
| US7338798B2 (en) | 1998-09-15 | 2008-03-04 | The Regents Of The University Of Michigan | System and method for forming a cardiac muscle construct |
| ATE305967T1 (de) * | 1998-11-19 | 2005-10-15 | Organogenesis Inc | Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung |
| DE69907397T2 (de) | 1999-02-17 | 2004-01-22 | Hewlett-Packard Co. (N.D.Ges.D.Staates Delaware), Palo Alto | Druckvorrichtung |
| US6979670B1 (en) | 1999-03-10 | 2005-12-27 | Biora Bioex Ab | Matrix protein compositions for grafting |
| US6642243B1 (en) | 1999-07-22 | 2003-11-04 | Ashkan Imanzahrai | Migraine medicine and method for treating same |
| JP2001145956A (ja) | 1999-11-19 | 2001-05-29 | Meiko:Kk | 光硬化性樹脂三次元造形物の積層造形装置及びその積層造形方法 |
| US6503273B1 (en) | 1999-11-22 | 2003-01-07 | Cyograft Tissue Engineering, Inc. | Tissue engineered blood vessels and methods and apparatus for their manufacture |
| US6454972B1 (en) | 1999-11-24 | 2002-09-24 | Sandia Corporation | Solid freeform fabrication using chemically reactive suspensions |
| US6520997B1 (en) * | 1999-12-08 | 2003-02-18 | Baxter International Inc. | Porous three dimensional structure |
| US6315469B1 (en) | 2000-01-19 | 2001-11-13 | Hewlett-Packard Company | Tool and method for adjustment of printhead to platen spacing in a printer |
| DE10013223C2 (de) | 2000-03-13 | 2002-07-18 | Co Don Ag | Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial |
| US20050091576A1 (en) | 2003-10-24 | 2005-04-28 | Microsoft Corporation | Programming interface for a computer platform |
| DE10018987A1 (de) | 2000-04-17 | 2001-10-31 | Envision Technologies Gmbh | Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten |
| AU2001283492A1 (en) | 2000-07-11 | 2002-01-21 | The Johns Hopkins University School Of Medicine | Methods of patterning protein and cell adhesivity |
| US7998735B2 (en) | 2000-08-21 | 2011-08-16 | Victorian Tissue Engineering Centre Pty. Ltd. | Vascularized tissue graft |
| US6561607B1 (en) | 2000-10-05 | 2003-05-13 | Eastman Kodak Company | Apparatus and method for maintaining a substantially constant closely spaced working distance between an inkjet printhead and a printing receiver |
| US6939489B2 (en) | 2001-03-23 | 2005-09-06 | Ivoclar Vivadent Ag | Desktop process for producing dental products by means of 3-dimensional plotting |
| US6849223B2 (en) | 2001-04-19 | 2005-02-01 | Case Western Reserve University | Fabrication of a polymeric prosthetic implant |
| DE10127225A1 (de) | 2001-05-22 | 2002-11-28 | Zeiss Carl | Ultraviolettlicht-Abschwächungsfilter |
| US20030049839A1 (en) | 2001-08-01 | 2003-03-13 | The University Of Texas System | Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient |
| AU2002324775A1 (en) | 2001-08-23 | 2003-03-10 | Sciperio, Inc. | Architecture tool and methods of use |
| US6934600B2 (en) | 2002-03-14 | 2005-08-23 | Auburn University | Nanotube fiber reinforced composite materials and method of producing fiber reinforced composites |
| WO2003079985A2 (en) | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| US20100254900A1 (en) | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
| US6907307B2 (en) | 2002-07-02 | 2005-06-14 | 3D Systems, Inc. | Support volume calculation for a CAD model |
| WO2004006840A2 (en) | 2002-07-12 | 2004-01-22 | The Regents Of The University Of California | Three dimensional cell patterned bioploymer scaffolds and method of making the same |
| US7641898B2 (en) | 2003-03-21 | 2010-01-05 | Materials Evolution And Development Usa, Inc. | Keratinocyte-fibrocyte concomitant grafting for wound healing |
| US20040197375A1 (en) | 2003-04-02 | 2004-10-07 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| US7051654B2 (en) * | 2003-05-30 | 2006-05-30 | Clemson University | Ink-jet printing of viable cells |
| WO2005003300A2 (en) | 2003-06-04 | 2005-01-13 | University Of South Carolina | Tissue scaffold having aligned fibrils, apparatus and method for producing same, and methods of using same |
| JP4474858B2 (ja) | 2003-07-07 | 2010-06-09 | セイコーエプソン株式会社 | ギャップ調整装置、これに使用されるキャリブレーション用治具、およびギャップ調整装置を備えた液滴吐出装置、並びに電気光学装置の製造方法 |
| US20050074877A1 (en) | 2003-07-28 | 2005-04-07 | Mao Jeremy Jian | Biological engineering of articular structures containing both cartilage and bone |
| US8043614B2 (en) | 2004-03-09 | 2011-10-25 | Ahlfors Jan-Eric W | Autogenic living scaffolds and living tissue matrices: methods and uses thereof |
| FR2859128B1 (fr) | 2003-08-29 | 2006-03-10 | Centre Nat Rech Scient | Procede et dispositif de fabrication d'un composant multimateriaux tridimensionnel par impression du type jet d'encre |
| US20050276791A1 (en) | 2004-02-20 | 2005-12-15 | The Ohio State University | Multi-layer polymer scaffolds |
| WO2005081970A2 (en) | 2004-02-24 | 2005-09-09 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
| WO2007115337A2 (en) | 2006-04-05 | 2007-10-11 | William Marsh Rice University | Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering |
| US20090142307A1 (en) | 2004-07-09 | 2009-06-04 | Athanasiou Kyriacos A | Shape-Based Approach for Scaffoldless Tissue Engineering |
| US7625198B2 (en) | 2004-08-11 | 2009-12-01 | Cornell Research Foundation, Inc. | Modular fabrication systems and methods |
| US7651665B2 (en) | 2004-09-07 | 2010-01-26 | Hewlett-Packard Development Company, L.P. | Microtray for handling biosubstances |
| KR100606457B1 (ko) | 2004-11-11 | 2006-11-23 | 한국기계연구원 | 3차원 프린팅 조형시스템 |
| JP4539316B2 (ja) | 2004-12-08 | 2010-09-08 | セイコーエプソン株式会社 | ヘッド位置補正方法およびヘッド位置補正装置、並びに液滴吐出装置、電気光学装置の製造方法 |
| WO2006093153A1 (ja) | 2005-02-28 | 2006-09-08 | Cellseed Inc. | 培養細胞シート、製造方法及びその利用した組織修復方法 |
| US7568904B2 (en) | 2005-03-03 | 2009-08-04 | Laser Solutions Co., Ltd. | Stereolithography apparatus |
| JP4729948B2 (ja) | 2005-03-09 | 2011-07-20 | ブラザー工業株式会社 | 液体供給装置、この液体供給装置を備えたインクジェット記録装置 |
| US7780897B2 (en) | 2005-04-22 | 2010-08-24 | Board Of Regents, The University Of Texas System | Hydrogel constructs using stereolithography |
| JP2008545410A (ja) | 2005-05-24 | 2008-12-18 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 微小規模のマイクロパターン化インビトロ操作・作製組織 |
| JP5475283B2 (ja) | 2005-07-28 | 2014-04-16 | カーネギー メロン ユニバーシティ | 生体適合性ポリマーおよび使用方法 |
| US20070116678A1 (en) | 2005-11-23 | 2007-05-24 | Hsing-Wen Sung | Medical device with living cell sheet |
| US8690957B2 (en) | 2005-12-21 | 2014-04-08 | Warsaw Orthopedic, Inc. | Bone graft composition, method and implant |
| US20070200276A1 (en) | 2006-02-24 | 2007-08-30 | Micron Technology, Inc. | Method for rapid printing of near-field and imprint lithographic features |
| US7680555B2 (en) | 2006-04-03 | 2010-03-16 | Stratasys, Inc. | Auto tip calibration in an extrusion apparatus |
| US20070231787A1 (en) | 2006-04-04 | 2007-10-04 | Voelker Mark A | Methods and devices for imaging and manipulating biological samples |
| US20090208466A1 (en) | 2006-04-21 | 2009-08-20 | James Yoo | Ink-jet printing of tissues |
| JP4051077B2 (ja) | 2006-04-28 | 2008-02-20 | シャープ株式会社 | 液滴塗布装置、液滴吐出部のギャップ測定方法、および、液滴吐出部のギャップ調整方法 |
| FR2901143B1 (fr) | 2006-05-16 | 2008-10-03 | Centre Nat Rech Scient | "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications" |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| DE102006053121B3 (de) | 2006-11-10 | 2007-12-27 | Eos Gmbh Electro Optical Systems | Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes mittels eines Beschichters für pulverförmiges Aufbaumaterial |
| US8764828B2 (en) | 2007-02-02 | 2014-07-01 | The Regents Of The University Of Michigan | System and method for forming bone, ligament, and bone-ligament constructs |
| US8343740B2 (en) | 2007-03-29 | 2013-01-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Micro-organ device |
| AU2008262331B2 (en) | 2007-06-07 | 2013-10-17 | Wake Forest University Health Sciences | Inkjet gene printing |
| EP2664443B1 (en) | 2007-07-25 | 2021-08-25 | Stratasys Ltd. | Solid freeform fabrication using a plurality of modeling materials |
| EP2195131B1 (en) | 2007-08-29 | 2011-10-26 | Vito NV | Method for producing a three-dimensional macroporous filament construct based on phase inversion and construct thereby obtained |
| US20090076531A1 (en) | 2007-09-18 | 2009-03-19 | Richardson Charles L | Method and apparatus for bypass graft |
| CA2701884A1 (en) | 2007-10-15 | 2009-04-23 | Wake Forest University Health Sciences | Methods and compositions for printing biologically compatible nanotube composites of autologous tissue |
| US7923846B2 (en) | 2007-11-16 | 2011-04-12 | Stats Chippac Ltd. | Integrated circuit package-in-package system with wire-in-film encapsulant |
| EP2090584A1 (en) | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
| WO2009102484A2 (en) | 2008-02-14 | 2009-08-20 | Wake Forest University Health Sciences | Inkjet printing of tissues and cells |
| US20090248145A1 (en) | 2008-03-28 | 2009-10-01 | Nanyang Technological University | Method of forming a three-dimensional structure of unidirectionally aligned cells |
| US8876513B2 (en) | 2008-04-25 | 2014-11-04 | 3D Systems, Inc. | Selective deposition modeling using CW UV LED curing |
| US9303245B2 (en) * | 2008-06-20 | 2016-04-05 | Universiteit Maastricht | Self-assembling tissue modules |
| JP5624981B2 (ja) * | 2008-06-24 | 2014-11-12 | ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリThe Curators Ofthe University Of Missouri | 自己集合性多細胞体、および前記多細胞体を用いて3次元の生物構造体を作製する方法 |
| US9097702B2 (en) | 2008-07-29 | 2015-08-04 | Cornell University | Pathologically relevant tumor microenvironments for high-throughput drug screening |
| JP2010057439A (ja) * | 2008-09-05 | 2010-03-18 | Konica Minolta Holdings Inc | 細胞培養支持体とその製造方法並びに細胞培養方法 |
| WO2010030964A2 (en) | 2008-09-12 | 2010-03-18 | The Brigham And Women's Hospital, Inc. | 3-dimensional multi-layered hydrogels and methods of making the same |
| US20110250688A1 (en) | 2008-11-24 | 2011-10-13 | Immunotrex Corporation | Three Dimensional Tissue Generation |
| JP5407344B2 (ja) | 2009-01-13 | 2014-02-05 | 大日本印刷株式会社 | 生体組織の作製方法 |
| EP2450707B1 (en) | 2010-11-04 | 2016-04-27 | University of Pécs | Lung tissue model |
| US8691974B2 (en) * | 2009-09-28 | 2014-04-08 | Virginia Tech Intellectual Properties, Inc. | Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering |
| US8409603B2 (en) | 2009-10-01 | 2013-04-02 | University Of South Carolina | Compositions and methods for tissue engineering, tissue regeneration and wound healing |
| EP2521587B1 (en) | 2010-01-08 | 2020-04-08 | Wake Forest University Health Sciences | Delivery system |
| EP2523656A4 (en) | 2010-01-15 | 2013-12-11 | Univ Utah Res Found | RETICULATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME |
| JP2013518591A (ja) * | 2010-02-02 | 2013-05-23 | ザ キュレーターズ オブ ザ ユニバーシティ オブ ミズーリ | 改変された生物学的神経移植片の製造およびその用途 |
| ES2671594T3 (es) | 2010-03-04 | 2018-06-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Puesto de bioimpresión, ensamblaje que comprende dicho puesto de bioimpresión y método de bioimpresión |
| GB2478801B (en) | 2010-03-16 | 2012-05-30 | Organovo Inc | Multilayered vascular tubes |
| US9012415B2 (en) | 2010-03-26 | 2015-04-21 | Stemmatters, Biotecnologia E Medicina Regenerativa S.A. | Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof |
| CN101892285A (zh) * | 2010-06-23 | 2010-11-24 | 西安交通大学 | 一种三维细胞芯片的制备方法 |
| WO2012003465A2 (en) | 2010-07-01 | 2012-01-05 | The Regents Of The University Of Michigan | Scaffold-free three dimensional nerve fibroblast constructs |
| US20120089238A1 (en) | 2010-10-06 | 2012-04-12 | Hyun-Wook Kang | Integrated organ and tissue printing methods, system and apparatus |
| KR20160125530A (ko) | 2010-10-21 | 2016-10-31 | 오가노보, 인크. | 조직의 제작을 위한 디바이스, 시스템 및 방법 |
| DE202011003443U1 (de) | 2011-03-02 | 2011-12-23 | Bego Medical Gmbh | Vorrichtung zur generativen Herstellung dreidimensionaler Bauteile |
| EP2683328B1 (en) | 2011-03-07 | 2017-11-08 | Wake Forest University Health Sciences | Delivery system |
| GB201105226D0 (en) | 2011-03-29 | 2011-05-11 | Univ Leiden | Methods |
| JP5599356B2 (ja) | 2011-03-31 | 2014-10-01 | 富士フイルム株式会社 | シミュレーション方法、プログラムおよびそれを記録した記録媒体、並びに、それらを利用した液滴配置パターンの作成方法、ナノインプリント方法、パターン化基板の製造方法およびインクジェット装置。 |
| BR112014005746A2 (pt) * | 2011-09-12 | 2017-03-28 | Organovo Inc | tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos |
| HK1199812A1 (en) | 2011-09-12 | 2015-07-24 | 奥加诺沃公司 | Platform for engineered implantable tissues and organs and methods of making the same |
| WO2013116443A1 (en) | 2012-02-01 | 2013-08-08 | Nscrypt, Inc. | Micro-dispensing multi-layered 3d objects with curing steps |
| US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
| US20140099709A1 (en) | 2012-06-19 | 2014-04-10 | Organovo, Inc. | Engineered three-dimensional connective tissue constructs and methods of making the same |
| US20140042657A1 (en) | 2012-08-08 | 2014-02-13 | Makerbot Industries, Llc | Printed circuit board with integrated temperature sensing |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| WO2014144255A2 (en) | 2013-03-15 | 2014-09-18 | Matterfab Corp. | Laser sintering apparatus and methods |
| US9802360B2 (en) | 2013-06-04 | 2017-10-31 | Stratsys, Inc. | Platen planarizing process for additive manufacturing system |
| US20150037445A1 (en) | 2013-07-31 | 2015-02-05 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
| MA40495A (fr) * | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
| US11529436B2 (en) | 2014-11-05 | 2022-12-20 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
| US20170130192A1 (en) | 2015-11-09 | 2017-05-11 | Organovo, Inc. | Methods for tissue fabrication |
-
2012
- 2012-09-12 BR BR112014005746A patent/BR112014005746A2/pt not_active IP Right Cessation
- 2012-09-12 CA CA2848043A patent/CA2848043C/en active Active
- 2012-09-12 RU RU2014113641/10A patent/RU2014113641A/ru not_active Application Discontinuation
- 2012-09-12 CN CN201280055564.4A patent/CN103946374A/zh active Pending
- 2012-09-12 EP EP12832125.4A patent/EP2756073B1/en active Active
- 2012-09-12 KR KR1020147008829A patent/KR20140072883A/ko not_active Withdrawn
- 2012-09-12 HK HK15100694.2A patent/HK1200483A1/xx unknown
- 2012-09-12 DK DK12832125.4T patent/DK2756073T3/da active
- 2012-09-12 CA CA3157246A patent/CA3157246A1/en active Pending
- 2012-09-12 WO PCT/US2012/054923 patent/WO2013040078A2/en not_active Ceased
- 2012-09-12 US US13/612,768 patent/US20130190210A1/en not_active Abandoned
- 2012-09-12 AU AU2012308715A patent/AU2012308715A1/en not_active Abandoned
- 2012-09-12 CN CN201810506160.1A patent/CN108619572A/zh active Pending
- 2012-09-12 JP JP2014529992A patent/JP2014531204A/ja active Pending
-
2014
- 2014-03-11 IL IL231449A patent/IL231449A0/en unknown
-
2016
- 2016-06-10 AU AU2016203930A patent/AU2016203930A1/en not_active Abandoned
-
2018
- 2018-06-26 JP JP2018121302A patent/JP2018171065A/ja active Pending
- 2018-07-09 US US16/029,919 patent/US20180313822A1/en not_active Abandoned
-
2020
- 2020-09-04 US US17/013,165 patent/US12372515B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2848043A1 (en) | 2013-03-21 |
| US20180313822A1 (en) | 2018-11-01 |
| BR112014005746A2 (pt) | 2017-03-28 |
| CN108619572A (zh) | 2018-10-09 |
| AU2016203930A1 (en) | 2016-09-08 |
| KR20140072883A (ko) | 2014-06-13 |
| US20210123906A1 (en) | 2021-04-29 |
| IL231449A0 (en) | 2014-04-30 |
| JP2014531204A (ja) | 2014-11-27 |
| US12372515B2 (en) | 2025-07-29 |
| WO2013040078A2 (en) | 2013-03-21 |
| HK1200483A1 (en) | 2015-08-07 |
| DK2756073T3 (da) | 2021-03-22 |
| EP2756073A2 (en) | 2014-07-23 |
| CA2848043C (en) | 2022-07-12 |
| EP2756073B1 (en) | 2020-12-30 |
| EP2756073A4 (en) | 2015-05-06 |
| WO2013040078A3 (en) | 2013-05-10 |
| US20130190210A1 (en) | 2013-07-25 |
| JP2018171065A (ja) | 2018-11-08 |
| AU2012308715A1 (en) | 2014-04-24 |
| CN103946374A (zh) | 2014-07-23 |
| CA3157246A1 (en) | 2013-03-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014113641A (ru) | Сконструированные ткани для применения в исследованиях in vitro, их массивы и способы их изготовления | |
| Mondrinos et al. | Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture | |
| Amano et al. | Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays | |
| Ren et al. | Soft ring‐shaped cellu‐robots with simultaneous locomotion in batches | |
| JP6510033B2 (ja) | 三次元複合細胞凝集体モデル並びにその製造方法及び応用 | |
| JP5725560B2 (ja) | 細胞シートを利用した細胞評価システム及びその利用方法 | |
| Massai et al. | Bioreactors as engineering support to treat cardiac muscle and vascular disease | |
| EP3426769B1 (en) | Double tubular structures | |
| CN109082406B (zh) | 一种基于微流控芯片的三维类脑发育模型的构建方法 | |
| JP2016039806A (ja) | サイトカイン産生細胞シートとその利用方法 | |
| RU2015100977A (ru) | Спроектированные трехмерные конструкты соединительной ткани и способы изготовления таких конструктов | |
| Wei et al. | Organs-on-chips and its applications | |
| WO2014039938A1 (en) | Spherical multicellular aggregates with endogenous extracellular matrix | |
| US11066633B2 (en) | Systems and methods for producing micro-engineered models of the human cervix | |
| Wang et al. | A 3D construct of the intestinal canal with wrinkle morphology on a centrifugation configuring microfluidic chip | |
| Tang et al. | Heart-on-a-chip using human iPSC-derived cardiomyocytes with an integrated vascular endothelial layer based on a culture patch as a potential platform for drug evaluation | |
| WO2016052472A1 (ja) | 三次元細胞集合体の作製方法 | |
| US20250304896A1 (en) | Native Extracellular Matrix-Derived Membrane Inserts for Organs-On-Chips, Multilayer Microfluidics Microdevices, Bioreactors, Tissue Culture Inserts, and Two-Dimensional and Three-Dimensional Cell Culture Systems | |
| Jiang et al. | Microfluidic-based biomimetic models for life science research | |
| CN118599661A (zh) | 一种用于细胞三维共培养的微流控仿生芯片及其应用 | |
| JP2015192640A (ja) | 培養容器及びそれを利用した複数の積層細胞シートの作製方法 | |
| EP3187580B1 (en) | Artificial peritoneal tissue and method for producing same | |
| Hu et al. | Engineering Cardiobundles with Dynamic Microenvironmental Control as Advanced Cardiac Modeling for Heart‐on‐a‐Chip | |
| CN103146642A (zh) | 一种定向诱导间充质干细胞分化的方法 | |
| WO2013120613A1 (en) | Micro fluidic system for simulating in vivo-equivalent cell barriers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170905 |