RU2013120927A - Аналоги циклоспорина - Google Patents
Аналоги циклоспорина Download PDFInfo
- Publication number
- RU2013120927A RU2013120927A RU2013120927/04A RU2013120927A RU2013120927A RU 2013120927 A RU2013120927 A RU 2013120927A RU 2013120927/04 A RU2013120927/04 A RU 2013120927/04A RU 2013120927 A RU2013120927 A RU 2013120927A RU 2013120927 A RU2013120927 A RU 2013120927A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- chch
- isobutyl
- alkyl
- compound
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract 7
- 150000001875 compounds Chemical class 0.000 claims abstract 24
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims abstract 12
- 101150065749 Churc1 gene Proteins 0.000 claims abstract 12
- 102100038239 Protein Churchill Human genes 0.000 claims abstract 12
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract 11
- -1 2-hydroxyisobutyl Chemical group 0.000 claims abstract 9
- 229930105110 Cyclosporin A Natural products 0.000 claims abstract 6
- 108010036949 Cyclosporine Proteins 0.000 claims abstract 6
- 229960001265 ciclosporin Drugs 0.000 claims abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 4
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract 2
- 125000005842 heteroatom Chemical group 0.000 claims abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 239000001301 oxygen Substances 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 2
- 206010023332 keratitis Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 210000004087 cornea Anatomy 0.000 claims 2
- 201000010666 keratoconjunctivitis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 206010003645 Atopy Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000009299 Benign Mucous Membrane Pemphigoid Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 206010072139 Ocular rosacea Diseases 0.000 claims 1
- 201000002154 Pterygium Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000016807 X-linked intellectual disability-macrocephaly-macroorchidism syndrome Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims 1
- 208000010217 blepharitis Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 206010015907 eye allergy Diseases 0.000 claims 1
- 208000027993 eye symptom Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 210000004175 meibomian gland Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000015200 ocular cicatricial pemphigoid Diseases 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39245110P | 2010-10-12 | 2010-10-12 | |
| US61/392,451 | 2010-10-12 | ||
| PCT/US2011/055788 WO2012051193A1 (en) | 2010-10-12 | 2011-10-11 | Cyclosporin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013120927A true RU2013120927A (ru) | 2014-11-20 |
Family
ID=44883796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013120927/04A RU2013120927A (ru) | 2010-10-12 | 2011-10-11 | Аналоги циклоспорина |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9175042B2 (enExample) |
| EP (1) | EP2627663B1 (enExample) |
| JP (1) | JP5805773B2 (enExample) |
| KR (1) | KR20140026328A (enExample) |
| CN (1) | CN103261212A (enExample) |
| AU (1) | AU2011316689B2 (enExample) |
| BR (1) | BR112013008749A2 (enExample) |
| CA (1) | CA2814191A1 (enExample) |
| IL (1) | IL225616A0 (enExample) |
| MX (1) | MX2013004062A (enExample) |
| RU (1) | RU2013120927A (enExample) |
| WO (1) | WO2012051193A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010138422A1 (en) * | 2009-05-27 | 2010-12-02 | Allergan, Inc. | Cyclosporin derivatives for enhancing the growth of hair |
| JP6144627B2 (ja) * | 2010-12-15 | 2017-06-07 | コントラヴィア ファーマシューティカルズ、インク． | アミノ酸１および３で修飾されたシクロスポリン類似体分子 |
| EP2855508B1 (en) | 2012-06-01 | 2018-02-14 | Allergan, Inc. | Cyclosporin a analogs |
| CN105025929A (zh) | 2013-03-08 | 2015-11-04 | 阿勒根公司 | 环孢菌素a-类固醇缀合物 |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112255A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| CN115028681B (zh) * | 2022-08-11 | 2022-11-15 | 中国科学院微生物研究所 | 一种降解亲环素a的嵌合体化合物及其制备方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649047A (en) | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2762843B1 (fr) | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2772768B1 (fr) * | 1997-12-19 | 2000-01-14 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| ES2212583T3 (es) | 1998-06-12 | 2004-07-16 | C-Chem Ag | Nuevas ciclosporinas. |
| US6254860B1 (en) * | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| CN100478025C (zh) * | 2005-03-25 | 2009-04-15 | 中国科学院上海药物研究所 | 一种环孢菌素a眼用微乳制剂及其制备方法 |
| ATE502633T1 (de) * | 2006-05-19 | 2011-04-15 | Scynexis Inc | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen |
| CA2686234A1 (en) | 2007-05-04 | 2008-11-13 | Allergan, Inc. | Use of cyclosporines in the treatment of patients with intraocular lenses |
| AU2009268549B2 (en) | 2008-07-10 | 2015-07-16 | Allergan, Inc. | Cyclosporin derivatives for treating ocular and dermal diseases and conditions |
| WO2012009715A2 (en) * | 2010-07-16 | 2012-01-19 | S&T Global Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| WO2012021796A2 (en) | 2010-08-12 | 2012-02-16 | S&T Global, Inc. | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
| RU2013119869A (ru) | 2010-10-12 | 2014-11-20 | Аллерган, Инк. | Аналоги циклоспорина |
| JP6093307B2 (ja) * | 2010-12-03 | 2017-03-08 | エス アンド ティー グローバル インク． | ウイルス感染の治療および予防のための新規シクロスポリン誘導体 |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
-
2011
- 2011-10-11 US US13/270,929 patent/US9175042B2/en active Active
- 2011-10-11 CN CN201180059696XA patent/CN103261212A/zh active Pending
- 2011-10-11 EP EP11770984.0A patent/EP2627663B1/en not_active Not-in-force
- 2011-10-11 CA CA2814191A patent/CA2814191A1/en not_active Abandoned
- 2011-10-11 AU AU2011316689A patent/AU2011316689B2/en not_active Ceased
- 2011-10-11 KR KR1020137012144A patent/KR20140026328A/ko not_active Withdrawn
- 2011-10-11 BR BR112013008749A patent/BR112013008749A2/pt not_active IP Right Cessation
- 2011-10-11 MX MX2013004062A patent/MX2013004062A/es unknown
- 2011-10-11 JP JP2013533941A patent/JP5805773B2/ja not_active Expired - Fee Related
- 2011-10-11 WO PCT/US2011/055788 patent/WO2012051193A1/en not_active Ceased
- 2011-10-11 RU RU2013120927/04A patent/RU2013120927A/ru not_active Application Discontinuation
-
2013
- 2013-04-07 IL IL225616A patent/IL225616A0/en unknown
-
2015
- 2015-10-02 US US14/873,908 patent/US9561259B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013544786A (ja) | 2013-12-19 |
| AU2011316689B2 (en) | 2016-07-14 |
| US9175042B2 (en) | 2015-11-03 |
| MX2013004062A (es) | 2013-07-22 |
| JP5805773B2 (ja) | 2015-11-10 |
| US20120135939A1 (en) | 2012-05-31 |
| BR112013008749A2 (pt) | 2019-09-24 |
| CN103261212A (zh) | 2013-08-21 |
| US20160022765A1 (en) | 2016-01-28 |
| CA2814191A1 (en) | 2012-04-19 |
| IL225616A0 (en) | 2013-06-27 |
| EP2627663B1 (en) | 2018-02-21 |
| US9561259B2 (en) | 2017-02-07 |
| EP2627663A1 (en) | 2013-08-21 |
| WO2012051193A1 (en) | 2012-04-19 |
| KR20140026328A (ko) | 2014-03-05 |
| AU2011316689A1 (en) | 2013-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20141013 |