AU2011316689B2 - Cyclosporin analogs - Google Patents

Cyclosporin analogs

Info

Publication number
AU2011316689B2
AU2011316689B2 AU2011316689A AU2011316689A AU2011316689B2 AU 2011316689 B2 AU2011316689 B2 AU 2011316689B2 AU 2011316689 A AU2011316689 A AU 2011316689A AU 2011316689 A AU2011316689 A AU 2011316689A AU 2011316689 B2 AU2011316689 B2 AU 2011316689B2
Authority
AU
Australia
Prior art keywords
compound according
isobutyl
chch
cyclosporin
ocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011316689A
Other languages
English (en)
Other versions
AU2011316689A1 (en
Inventor
William Robert Carling
Michael E. Garst
Christopher S. Schaumburg
David Arthur Scowen
Michael E. Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2011316689A1 publication Critical patent/AU2011316689A1/en
Application granted granted Critical
Publication of AU2011316689B2 publication Critical patent/AU2011316689B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2011316689A 2010-10-12 2011-10-11 Cyclosporin analogs Ceased AU2011316689B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39245110P 2010-10-12 2010-10-12
US61/392,451 2010-10-12
PCT/US2011/055788 WO2012051193A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Publications (2)

Publication Number Publication Date
AU2011316689A1 AU2011316689A1 (en) 2013-05-02
AU2011316689B2 true AU2011316689B2 (en) 2016-07-14

Family

ID=44883796

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011316689A Ceased AU2011316689B2 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Country Status (12)

Country Link
US (2) US9175042B2 (enExample)
EP (1) EP2627663B1 (enExample)
JP (1) JP5805773B2 (enExample)
KR (1) KR20140026328A (enExample)
CN (1) CN103261212A (enExample)
AU (1) AU2011316689B2 (enExample)
BR (1) BR112013008749A2 (enExample)
CA (1) CA2814191A1 (enExample)
IL (1) IL225616A0 (enExample)
MX (1) MX2013004062A (enExample)
RU (1) RU2013120927A (enExample)
WO (1) WO2012051193A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010138422A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
JP6144627B2 (ja) * 2010-12-15 2017-06-07 コントラヴィア ファーマシューティカルズ、インク． アミノ酸１および３で修飾されたシクロスポリン類似体分子
EP2855508B1 (en) 2012-06-01 2018-02-14 Allergan, Inc. Cyclosporin a analogs
CN105025929A (zh) 2013-03-08 2015-11-04 阿勒根公司 环孢菌素a-类固醇缀合物
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
EP3551034A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018112255A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CN115028681B (zh) * 2022-08-11 2022-11-15 中国科学院微生物研究所 一种降解亲环素a的嵌合体化合物及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649047A (en) 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2772768B1 (fr) * 1997-12-19 2000-01-14 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
ES2212583T3 (es) 1998-06-12 2004-07-16 C-Chem Ag Nuevas ciclosporinas.
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
CN100478025C (zh) * 2005-03-25 2009-04-15 中国科学院上海药物研究所 一种环孢菌素a眼用微乳制剂及其制备方法
ATE502633T1 (de) * 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
CA2686234A1 (en) 2007-05-04 2008-11-13 Allergan, Inc. Use of cyclosporines in the treatment of patients with intraocular lenses
AU2009268549B2 (en) 2008-07-10 2015-07-16 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
WO2012009715A2 (en) * 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
RU2013119869A (ru) 2010-10-12 2014-11-20 Аллерган, Инк. Аналоги циклоспорина
JP6093307B2 (ja) * 2010-12-03 2017-03-08 エス アンド ティー グローバル インク． ウイルス感染の治療および予防のための新規シクロスポリン誘導体
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof

Also Published As

Publication number Publication date
RU2013120927A (ru) 2014-11-20
JP2013544786A (ja) 2013-12-19
US9175042B2 (en) 2015-11-03
MX2013004062A (es) 2013-07-22
JP5805773B2 (ja) 2015-11-10
US20120135939A1 (en) 2012-05-31
BR112013008749A2 (pt) 2019-09-24
CN103261212A (zh) 2013-08-21
US20160022765A1 (en) 2016-01-28
CA2814191A1 (en) 2012-04-19
IL225616A0 (en) 2013-06-27
EP2627663B1 (en) 2018-02-21
US9561259B2 (en) 2017-02-07
EP2627663A1 (en) 2013-08-21
WO2012051193A1 (en) 2012-04-19
KR20140026328A (ko) 2014-03-05
AU2011316689A1 (en) 2013-05-02

Similar Documents

Publication Publication Date Title
EP2627664B1 (en) Cyclosporin analogs
EP2627663B1 (en) Cyclosporin analogs
EP2855508B1 (en) Cyclosporin a analogs
EP3277704A1 (en) Cyclosporins modified on the mebmt sidechain by heterocyclic rings
CN107496902B (zh) 在氨基酸1和3位修改的环孢菌素类似分子
HK1188459A (en) Cyclosporin analogs
HK1189898A (en) Cyclosporin analogs
HK1208874B (en) Cyclosporin a analogs

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired