KR20140026328A - 사이클로스포린 유사체 - Google Patents
사이클로스포린 유사체 Download PDFInfo
- Publication number
- KR20140026328A KR20140026328A KR1020137012144A KR20137012144A KR20140026328A KR 20140026328 A KR20140026328 A KR 20140026328A KR 1020137012144 A KR1020137012144 A KR 1020137012144A KR 20137012144 A KR20137012144 A KR 20137012144A KR 20140026328 A KR20140026328 A KR 20140026328A
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- South Korea
- Prior art keywords
- compound
- chch
- isobutyl
- alkyl
- ocular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
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- Biotechnology (AREA)
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- Peptides Or Proteins (AREA)
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| US61/392,451 | 2010-10-12 | ||
| PCT/US2011/055788 WO2012051193A1 (en) | 2010-10-12 | 2011-10-11 | Cyclosporin analogs |
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| BR (1) | BR112013008749A2 (enExample) |
| CA (1) | CA2814191A1 (enExample) |
| IL (1) | IL225616A0 (enExample) |
| MX (1) | MX2013004062A (enExample) |
| RU (1) | RU2013120927A (enExample) |
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| US20100305047A1 (en) * | 2009-05-27 | 2010-12-02 | Allergan, Inc. | Cyclosporin derivatives for enhancing the growth of hair |
| AU2011342284C1 (en) * | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| WO2013181339A2 (en) * | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| WO2014138359A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Steroid antibiotic conjugates |
| TW201639873A (zh) | 2015-01-08 | 2016-11-16 | 歐樂根公司 | Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物 |
| CA3045944A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| US11523772B2 (en) | 2016-12-14 | 2022-12-13 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| CN115028681B (zh) * | 2022-08-11 | 2022-11-15 | 中国科学院微生物研究所 | 一种降解亲环素a的嵌合体化合物及其制备方法与应用 |
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| US4649047A (en) | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2762843B1 (fr) | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2772768B1 (fr) * | 1997-12-19 | 2000-01-14 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| ATE254630T1 (de) | 1998-06-12 | 2003-12-15 | Chem Ag C | Cyclosporine |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| CN100478025C (zh) * | 2005-03-25 | 2009-04-15 | 中国科学院上海药物研究所 | 一种环孢菌素a眼用微乳制剂及其制备方法 |
| CA2652662C (en) * | 2006-05-19 | 2015-11-03 | Scynexis, Inc. | Methods for the treatment and prevention of ocular disorders |
| CN101687013A (zh) * | 2007-05-04 | 2010-03-31 | 阿勒根公司 | 环孢菌素在治疗具有人工晶状体的患者中的用途 |
| US8716238B2 (en) | 2008-07-10 | 2014-05-06 | Allergan, Inc. | Cyclosporin derivatives for treating ocular and dermal diseases and conditions |
| US9217015B2 (en) * | 2010-07-16 | 2015-12-22 | S&T Global Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
| CN103153330B (zh) * | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
| AU2011316690C1 (en) | 2010-10-12 | 2017-01-19 | Allergan, Inc. | Cyclosporin analogs |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| MX350746B (es) | 2010-12-03 | 2017-09-14 | Hebei Kunxiangjishi Pharmaceutical Tech Co Ltd | Derivados de ciclosporina novedosos para el tratamiento y la prevención de una infección viral. |
-
2011
- 2011-10-11 EP EP11770984.0A patent/EP2627663B1/en not_active Not-in-force
- 2011-10-11 CN CN201180059696XA patent/CN103261212A/zh active Pending
- 2011-10-11 JP JP2013533941A patent/JP5805773B2/ja not_active Expired - Fee Related
- 2011-10-11 KR KR1020137012144A patent/KR20140026328A/ko not_active Withdrawn
- 2011-10-11 WO PCT/US2011/055788 patent/WO2012051193A1/en not_active Ceased
- 2011-10-11 US US13/270,929 patent/US9175042B2/en active Active
- 2011-10-11 BR BR112013008749A patent/BR112013008749A2/pt not_active IP Right Cessation
- 2011-10-11 RU RU2013120927/04A patent/RU2013120927A/ru not_active Application Discontinuation
- 2011-10-11 CA CA2814191A patent/CA2814191A1/en not_active Abandoned
- 2011-10-11 MX MX2013004062A patent/MX2013004062A/es unknown
- 2011-10-11 AU AU2011316689A patent/AU2011316689B2/en not_active Ceased
-
2013
- 2013-04-07 IL IL225616A patent/IL225616A0/en unknown
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2015
- 2015-10-02 US US14/873,908 patent/US9561259B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120135939A1 (en) | 2012-05-31 |
| US9561259B2 (en) | 2017-02-07 |
| BR112013008749A2 (pt) | 2019-09-24 |
| US9175042B2 (en) | 2015-11-03 |
| CA2814191A1 (en) | 2012-04-19 |
| CN103261212A (zh) | 2013-08-21 |
| JP2013544786A (ja) | 2013-12-19 |
| US20160022765A1 (en) | 2016-01-28 |
| AU2011316689B2 (en) | 2016-07-14 |
| EP2627663B1 (en) | 2018-02-21 |
| EP2627663A1 (en) | 2013-08-21 |
| JP5805773B2 (ja) | 2015-11-10 |
| IL225616A0 (en) | 2013-06-27 |
| WO2012051193A1 (en) | 2012-04-19 |
| RU2013120927A (ru) | 2014-11-20 |
| MX2013004062A (es) | 2013-07-22 |
| AU2011316689A1 (en) | 2013-05-02 |
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