RU2013106514A - Способы лечения нарушений желудочно-кишечного тракта независимо от потребления пищи - Google Patents
Способы лечения нарушений желудочно-кишечного тракта независимо от потребления пищи Download PDFInfo
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Abstract
1. Фармацевтическая композиция для лечения нарушения желудочно-кишечного тракта у пациента, где композиция содержит:(a) первую твердую частицу, где указанная первая твердая частица содержит декслансопразол и первое энтеросолюбильное покрытие, причем первое энтеросолюбильное покрытие высвобождает декслансопразол из твердой частицы при pH от приблизительно 5,0 до приблизительно 5,5; и(b) вторую твердую частицу, где указанная вторая твердая частица содержит декслансопразол и второе энтеросолюбильное покрытие, причем второе энтеросолюбильное покрытие высвобождает декслансопразол из твердой частицы при pH от приблизительно 6,2 до приблизительно 6,8;в которой первая твердая частица содержит от приблизительно 15 вес.% до приблизительно 50 вес.% фармацевтической композиции и вторая твердая частица содержит от приблизительно 50 вес.% до приблизительно 85 вес.% фармацевтической композиции; и,дополнительно, где указанную фармацевтическую композицию можно вводить пациенту независимо от приема пищи.2. Композиция по п.1, в которой первое энтеросолюбильное покрытие имеет рН приблизительно 5,5.3. Композиция по п.2, в которой первое энтеросолюбильное покрытие содержит дисперсию сополимера метакриловой кислоты.4. Композиция по п.1, в которой второе энтеросолюбильное покрытие имеет рН приблизительно 6,75.5. Композиция по п.4, в которой второе энтеросолюбильное покрытие содержит смесь сополимера метакриловой кислоты типа B и сополимера метакриловой кислоты типа A в отношении 3:1.6. Композиция по п.1, в которой первая твердая частица содержит защитный слой между активным агентом и первым энтеросолюбильным покрытием.7. Композиция по п.1, в кото�
Claims (15)
1. Фармацевтическая композиция для лечения нарушения желудочно-кишечного тракта у пациента, где композиция содержит:
(a) первую твердую частицу, где указанная первая твердая частица содержит декслансопразол и первое энтеросолюбильное покрытие, причем первое энтеросолюбильное покрытие высвобождает декслансопразол из твердой частицы при pH от приблизительно 5,0 до приблизительно 5,5; и
(b) вторую твердую частицу, где указанная вторая твердая частица содержит декслансопразол и второе энтеросолюбильное покрытие, причем второе энтеросолюбильное покрытие высвобождает декслансопразол из твердой частицы при pH от приблизительно 6,2 до приблизительно 6,8;
в которой первая твердая частица содержит от приблизительно 15 вес.% до приблизительно 50 вес.% фармацевтической композиции и вторая твердая частица содержит от приблизительно 50 вес.% до приблизительно 85 вес.% фармацевтической композиции; и,
дополнительно, где указанную фармацевтическую композицию можно вводить пациенту независимо от приема пищи.
2. Композиция по п.1, в которой первое энтеросолюбильное покрытие имеет рН приблизительно 5,5.
3. Композиция по п.2, в которой первое энтеросолюбильное покрытие содержит дисперсию сополимера метакриловой кислоты.
4. Композиция по п.1, в которой второе энтеросолюбильное покрытие имеет рН приблизительно 6,75.
5. Композиция по п.4, в которой второе энтеросолюбильное покрытие содержит смесь сополимера метакриловой кислоты типа B и сополимера метакриловой кислоты типа A в отношении 3:1.
6. Композиция по п.1, в которой первая твердая частица содержит защитный слой между активным агентом и первым энтеросолюбильным покрытием.
7. Композиция по п.1, в которой вторая твердая частица содержит защитный слой между активным агентом и вторым энтеросолюбильным покрытием.
8. Композиция по пп.6 или 7, в которой защитный слой представляет собой сахарозу, гипромеллозу, неэнтеросолюбильное покрытие или любую их комбинацию.
9. Композиция по п.8, в которой неэнтеросолюбильное покрытие представляет собой гидроксипропилцеллюлозу.
10. Композиция по п.1, в которой первая твердая частица содержит приблизительно 25% фармацевтической композиции и вторая твердая частица содержит приблизительно 75% фармацевтической композиции.
11. Композиция по п.1, в которой первая твердая частица представляет собой гранулу.
12. Композиция по п.1, в которой вторая твердая частица представляет собой гранулу.
13. Композиция по п.1, в которой фармацевтическая композиция представляет собой таблетку или капсулу.
14. Композиция по п.1, в которой нарушение жедудочно-кишечного тракта представляет собой изжогу, воспалительную болезнь кишечника, болезнь Крона, синдром раздраженного кишечника, язвенный колит, пептическую язву, стрессовую язву, кровоточащую пептическую язву, дуоденальную язву, инфекционный энтерит, колит, дивертикулит, повышенную кислотность желудка, диспепсию, гастропарез, синдром Золлингера-Эллисона, гастроэзофагеальную рефлюксную болезнь, заболевание, вызванное Helicobacter pylori, синдром укороченной кишки, гиперсекреторные состояния, связанные с системным мастоцитозом или базофильным лейкозом, или гипергистаминемией, или комбинации любых из вышеупомянутых нарушений.
15. Способ лечения нарушения желудочно-кишечного тракта у пациента, нуждающегося в этом лечении, включающий стадии:
введение указанному пациенту фармацевтической композиции по п.1, где указанную фармацевтическую композицию можно вводить пациенту независимо от приема пищи.
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US99875407P | 2007-10-12 | 2007-10-12 | |
US60/998,754 | 2007-10-12 | ||
US12/249,258 US8173158B2 (en) | 2007-10-12 | 2008-10-10 | Methods of treating gastrointestinal disorders independent of the intake of food |
US12/249,258 | 2008-10-10 |
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RU2010119041/15A Division RU2010119041A (ru) | 2007-10-12 | 2008-10-10 | Способы лечения нарушений желудочно-кишечного тракта, независимого от потребления пищи |
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RU2010119041/15A RU2010119041A (ru) | 2007-10-12 | 2008-10-10 | Способы лечения нарушений желудочно-кишечного тракта, независимого от потребления пищи |
RU2013106514/15A RU2013106514A (ru) | 2007-10-12 | 2008-10-10 | Способы лечения нарушений желудочно-кишечного тракта независимо от потребления пищи |
RU2014112070/15A RU2563993C1 (ru) | 2007-10-12 | 2014-03-28 | Способы лечения нарушений желудочно-кишечного тракта независимо от потребления пищи |
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US (1) | US8173158B2 (ru) |
EP (1) | EP2203068A4 (ru) |
JP (2) | JP5629581B2 (ru) |
KR (3) | KR20170097787A (ru) |
CN (2) | CN104069088A (ru) |
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BR (1) | BRPI0818286A2 (ru) |
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CO (1) | CO6260019A2 (ru) |
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WO2013111149A1 (en) * | 2011-12-21 | 2013-08-01 | Hetero Research Foundation | Controlled release solid oral compositions of dexlansoprazole |
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CN112168965A (zh) * | 2019-07-05 | 2021-01-05 | 中国科学院生物物理研究所 | SRCAP ATPase激动剂在肠道干细胞自我更新受抑介导的疾病治疗中的应用 |
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- 2008-10-10 KR KR1020157013260A patent/KR20150084013A/ko active Application Filing
- 2008-10-10 CN CN201410289597.6A patent/CN104069088A/zh active Pending
- 2008-10-10 MY MYPI20101591 patent/MY153062A/en unknown
- 2008-10-10 RU RU2010119041/15A patent/RU2010119041A/ru not_active Application Discontinuation
- 2008-10-10 EP EP08837108A patent/EP2203068A4/en not_active Ceased
- 2008-10-10 US US12/249,258 patent/US8173158B2/en active Active
- 2008-10-10 JP JP2010529082A patent/JP5629581B2/ja active Active
- 2008-10-10 KR KR1020107010478A patent/KR20100116165A/ko active Search and Examination
- 2008-10-10 BR BRPI0818286-8A patent/BRPI0818286A2/pt not_active Application Discontinuation
- 2008-10-10 CN CN2008801191827A patent/CN102014638A/zh active Pending
- 2008-10-10 CA CA2702356A patent/CA2702356C/en active Active
- 2008-10-10 WO PCT/US2008/079520 patent/WO2009049160A1/en active Application Filing
- 2008-10-10 AU AU2008310735A patent/AU2008310735B2/en active Active
- 2008-10-10 RU RU2013106514/15A patent/RU2013106514A/ru not_active Application Discontinuation
- 2008-10-10 MX MX2010003917A patent/MX2010003917A/es active IP Right Grant
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EP2203068A4 (en) | 2012-08-22 |
IL204886B (en) | 2018-02-28 |
HK1202441A1 (en) | 2015-10-02 |
JP5629581B2 (ja) | 2014-11-19 |
JP2014012692A (ja) | 2014-01-23 |
WO2009049160A1 (en) | 2009-04-16 |
MY153062A (en) | 2014-12-31 |
AU2008310735A1 (en) | 2009-04-16 |
US8173158B2 (en) | 2012-05-08 |
JP2011500595A (ja) | 2011-01-06 |
KR20100116165A (ko) | 2010-10-29 |
AU2008310735B2 (en) | 2013-09-12 |
BRPI0818286A2 (pt) | 2020-08-11 |
RU2010119041A (ru) | 2011-11-20 |
EP2203068A1 (en) | 2010-07-07 |
CO6260019A2 (es) | 2011-03-22 |
IL204886A0 (en) | 2010-11-30 |
CA2702356C (en) | 2014-02-11 |
RU2563993C1 (ru) | 2015-09-27 |
KR20170097787A (ko) | 2017-08-28 |
MX2010003917A (es) | 2012-09-28 |
US20090098199A1 (en) | 2009-04-16 |
CN104069088A (zh) | 2014-10-01 |
SG185296A1 (en) | 2012-11-29 |
KR20150084013A (ko) | 2015-07-21 |
CA2702356A1 (en) | 2009-04-16 |
CN102014638A (zh) | 2011-04-13 |
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