RU2012121591A - Способ получения органических соединений - Google Patents
Способ получения органических соединений Download PDFInfo
- Publication number
- RU2012121591A RU2012121591A RU2012121591/04A RU2012121591A RU2012121591A RU 2012121591 A RU2012121591 A RU 2012121591A RU 2012121591/04 A RU2012121591/04 A RU 2012121591/04A RU 2012121591 A RU2012121591 A RU 2012121591A RU 2012121591 A RU2012121591 A RU 2012121591A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- alkoxy
- halogen
- formula
- group
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract 4
- 150000002894 organic compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 150000003839 salts Chemical class 0.000 claims abstract 26
- 229910052736 halogen Inorganic materials 0.000 claims abstract 22
- 150000002367 halogens Chemical group 0.000 claims abstract 22
- 125000001424 substituent group Chemical group 0.000 claims abstract 20
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 11
- 239000001257 hydrogen Substances 0.000 claims abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 11
- 229910052782 aluminium Inorganic materials 0.000 claims abstract 6
- 150000001412 amines Chemical class 0.000 claims abstract 6
- -1 aluminum halide Chemical class 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims 28
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 17
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 150000004820 halides Chemical class 0.000 claims 10
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 150000001540 azides Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 5
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 5
- YNLAOSYQHBDIKW-UHFFFAOYSA-M diethylaluminium chloride Chemical compound CC[Al](Cl)CC YNLAOSYQHBDIKW-UHFFFAOYSA-M 0.000 claims 4
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 3
- 229910017604 nitric acid Inorganic materials 0.000 claims 3
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 2
- DQGZQAJIHKWEIU-UHFFFAOYSA-N azido(diethyl)alumane Chemical group [N-]=[N+]=[N-].CC[Al+]CC DQGZQAJIHKWEIU-UHFFFAOYSA-N 0.000 claims 2
- 229910052796 boron Inorganic materials 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- MWMPSUHRZSGXIO-UHFFFAOYSA-N azido(dimethyl)alumane Chemical compound C[Al+]C.[N-]=[N+]=[N-] MWMPSUHRZSGXIO-UHFFFAOYSA-N 0.000 claims 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 claims 1
- JGHYBJVUQGTEEB-UHFFFAOYSA-M dimethylalumanylium;chloride Chemical compound C[Al](C)Cl JGHYBJVUQGTEEB-UHFFFAOYSA-M 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 1
- 229960004699 valsartan Drugs 0.000 claims 1
- FAKSURHLJDDKJL-UHFFFAOYSA-N CCCCC(N(Cc(cc1)ccc1-c1ccccc1C1NNC(C2CCCC2)NN1)C(C(O)=O)=C(C)C)=O Chemical compound CCCCC(N(Cc(cc1)ccc1-c1ccccc1C1NNC(C2CCCC2)NN1)C(C(O)=O)=C(C)C)=O FAKSURHLJDDKJL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09174264.3 | 2009-10-27 | ||
| EP09174264A EP2316821A1 (en) | 2009-10-27 | 2009-10-27 | Process for the manufacture of organic compounds |
| PCT/EP2010/066041 WO2011051213A1 (en) | 2009-10-27 | 2010-10-25 | Process for the manufacture of organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012121591A true RU2012121591A (ru) | 2013-12-10 |
Family
ID=41716392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012121591/04A RU2012121591A (ru) | 2009-10-27 | 2010-10-25 | Способ получения органических соединений |
Country Status (24)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102321038B (zh) * | 2011-07-11 | 2014-03-26 | 安徽省虹升生物科技有限公司 | 一种改进的制备缬沙坦方法 |
| FR2981077B1 (fr) * | 2011-10-11 | 2013-11-01 | Michelin Soc Tech | Methode pour preparer un melange maitre d'elastomere dienique et de silice |
| CN109641856B (zh) * | 2016-09-02 | 2022-09-30 | 南京诺瑞特医药科技有限公司 | 缬沙坦二钠盐的晶型 |
| CN110078640B (zh) * | 2019-03-29 | 2022-04-05 | 浙江美诺华药物化学有限公司 | 一种缬沙坦中间体的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874867A (en) | 1987-05-22 | 1989-10-17 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| JPH04297466A (ja) | 1990-06-22 | 1992-10-21 | Nippon Shinyaku Co Ltd | テトラゾール誘導体及び医薬 |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| GB0222056D0 (en) | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| ITMI20032267A1 (it) * | 2003-11-21 | 2005-05-22 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procdimento per la preparzione di valsartan e suoi intermedi |
| HRP20030965A2 (en) * | 2003-11-24 | 2005-08-31 | Belupo - Lijekovi I Kozmetika D.D. | Process for production of (s)-n-pentanoyl-n-[[2'-( |
| US20060281801A1 (en) * | 2005-04-19 | 2006-12-14 | Ashok Kumar | Process for the preparation of valsartan and its intermediates |
| CA2619955A1 (en) * | 2005-08-22 | 2007-03-22 | Alembic Limited | Process for preparing valsartan |
| US7880015B2 (en) * | 2006-07-03 | 2011-02-01 | Aurobindo Pharma Ltd. | Process for the preparation of angiotensin II antagonist |
| CN101450917B (zh) * | 2007-12-06 | 2012-07-11 | 浙江海正药业股份有限公司 | 缬沙坦的合成方法 |
| US7943794B2 (en) * | 2008-02-13 | 2011-05-17 | Ranbaxy Laboratories Limited | Processes for the preparation of intermediates of valsartan |
-
2009
- 2009-10-27 EP EP09174264A patent/EP2316821A1/en not_active Ceased
-
2010
- 2010-10-25 CN CN2010800487722A patent/CN102596899A/zh active Pending
- 2010-10-25 EP EP10768497A patent/EP2493848A1/en not_active Withdrawn
- 2010-10-25 MX MX2012005025A patent/MX2012005025A/es not_active Application Discontinuation
- 2010-10-25 PH PH1/2012/500677A patent/PH12012500677A1/en unknown
- 2010-10-25 RU RU2012121591/04A patent/RU2012121591A/ru not_active Application Discontinuation
- 2010-10-25 KR KR1020127010679A patent/KR20120098652A/ko not_active Withdrawn
- 2010-10-25 PE PE2012000559A patent/PE20121501A1/es not_active Application Discontinuation
- 2010-10-25 IN IN3032DEN2012 patent/IN2012DN03032A/en unknown
- 2010-10-25 AU AU2010311636A patent/AU2010311636B2/en not_active Expired - Fee Related
- 2010-10-25 JP JP2012535763A patent/JP2013508436A/ja active Pending
- 2010-10-25 NZ NZ599218A patent/NZ599218A/en not_active IP Right Cessation
- 2010-10-25 AR ARP100103910A patent/AR079104A1/es not_active Application Discontinuation
- 2010-10-25 BR BR112012009815A patent/BR112012009815A2/pt not_active IP Right Cessation
- 2010-10-25 US US13/504,333 patent/US20120238761A1/en not_active Abandoned
- 2010-10-25 CA CA2777031A patent/CA2777031A1/en not_active Abandoned
- 2010-10-25 WO PCT/EP2010/066041 patent/WO2011051213A1/en not_active Ceased
- 2010-10-26 TW TW099136578A patent/TW201124389A/zh unknown
-
2012
- 2012-04-03 TN TNP2012000154A patent/TN2012000154A1/en unknown
- 2012-04-04 ZA ZA2012/02490A patent/ZA201202490B/en unknown
- 2012-04-05 IL IL219111A patent/IL219111A0/en unknown
- 2012-04-26 MA MA34806A patent/MA33692B1/fr unknown
- 2012-04-26 EC ECSP12011833 patent/ECSP12011833A/es unknown
- 2012-04-26 CL CL2012001081A patent/CL2012001081A1/es unknown
- 2012-04-26 CO CO12068973A patent/CO6531487A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2012DN03032A (cg-RX-API-DMAC7.html) | 2015-07-31 |
| KR20120098652A (ko) | 2012-09-05 |
| MX2012005025A (es) | 2012-06-08 |
| ECSP12011833A (es) | 2012-06-29 |
| JP2013508436A (ja) | 2013-03-07 |
| AU2010311636A1 (en) | 2012-05-03 |
| WO2011051213A1 (en) | 2011-05-05 |
| CA2777031A1 (en) | 2011-05-05 |
| AU2010311636B2 (en) | 2014-03-06 |
| MA33692B1 (fr) | 2012-10-01 |
| PH12012500677A1 (en) | 2012-10-29 |
| CO6531487A2 (es) | 2012-09-28 |
| NZ599218A (en) | 2014-02-28 |
| BR112012009815A2 (pt) | 2016-10-18 |
| IL219111A0 (en) | 2012-06-28 |
| EP2493848A1 (en) | 2012-09-05 |
| TW201124389A (en) | 2011-07-16 |
| ZA201202490B (en) | 2012-12-27 |
| PE20121501A1 (es) | 2012-11-15 |
| CN102596899A (zh) | 2012-07-18 |
| EP2316821A1 (en) | 2011-05-04 |
| TN2012000154A1 (en) | 2013-12-12 |
| US20120238761A1 (en) | 2012-09-20 |
| CL2012001081A1 (es) | 2013-06-14 |
| AR079104A1 (es) | 2011-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024105360A5 (cg-RX-API-DMAC7.html) | ||
| RU2012121591A (ru) | Способ получения органических соединений | |
| EA201070874A1 (ru) | Производные индол-2-карбоксамидов и азаиндол-2-карбоксамидов, замещённых силанильной группой, их получение и применение в терапии | |
| AR068359A1 (es) | Derivados de quinoleina sustituida, procesos para su preparacion e intermediarios de sintesis, una composicion fungicida que los comprende y un metodo para combatir o controlar hongos fitopatogenicos. | |
| WO2009122044A3 (fr) | Complexes de bore ou d'aluminium | |
| RU2012148386A (ru) | Способ получения 4-{4-[({[4-хлор-3-(трифторметил) фенил] амино}-карбонил) амино]-3-фторфенокси}-n-метилпиридин-2-карбоксамида, его солей и моногидрата | |
| RU2013107770A (ru) | Способ получения дронедарона | |
| UA86013C2 (ru) | Производные арилалкилкарбаматов, их получение и применение в лечении | |
| RU2013133144A (ru) | Цинкорганические комплексы, способы их получения и применение | |
| RU2010136738A (ru) | Ингибиторы для передачи сигнала брассиностероидов | |
| WO2010128313A3 (en) | Quaternary ammonium corrosion inhibitor | |
| RU2010136996A (ru) | Реакции сочетания, которые могут быть использованы при получении производных (1н-тетразол-5-ил)бифенила | |
| RU2014129937A (ru) | Способы и промежуточные соединения для получения фармацевтических агентов | |
| JP2020502244A5 (cg-RX-API-DMAC7.html) | ||
| PE20070792A1 (es) | Derivados lactama lactona como intermediarios en la sintesis de inhibidores de renina | |
| Yan et al. | Synthesis of sulfinamides via photocatalytic alkylation or arylation of sulfinylamine | |
| RU2012142172A (ru) | Азотсодержащее гетероциклическое соединение и способ его получения | |
| JP2005538088A5 (cg-RX-API-DMAC7.html) | ||
| RU2015111236A (ru) | Способ получения производного оксазола | |
| RU2018100967A (ru) | Способ получения азотсодержащего гетероциклического соединения и его промежуточного соединения | |
| RU2010115566A (ru) | Ускоренное восстановление амидов и сложных эфиров аминоборанами и добавками | |
| JP2019501877A5 (cg-RX-API-DMAC7.html) | ||
| RU2009143867A (ru) | Способы получения производных n-изобутил-n-(2-гидрокси-3-амино-4-фенилбутил)-пара-нитробензолсульфониламида | |
| JP2010111682A5 (cg-RX-API-DMAC7.html) | ||
| RU2015118752A (ru) | Катализатор и способ его синтеза |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150202 |