AR079104A1 - Compuestos organicos, proceso de preparacion y uso de los mismos - Google Patents
Compuestos organicos, proceso de preparacion y uso de los mismosInfo
- Publication number
- AR079104A1 AR079104A1 ARP100103910A ARP100103910A AR079104A1 AR 079104 A1 AR079104 A1 AR 079104A1 AR P100103910 A ARP100103910 A AR P100103910A AR P100103910 A ARP100103910 A AR P100103910A AR 079104 A1 AR079104 A1 AR 079104A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- halo
- formula
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicacion 1: Un proceso para la elaboracion de un compuesto de la formula (4) o una sal del mismo, tal como una sal de amina del mismo: el cual comprende: hacer reaccionar un compuesto de la formula (3), o una sal del mismo en donde R es alquilo C1-7, compuestos de formulas (1) en donde R1 es hidrogeno, alquilo C1-7, alcoxilo C1-7, cicloalquilo C3-8, o arilo C6-10, cada uno insustituido o sustituido por uno o más, por ejemplo, hasta tres sustituyentes seleccionados a partir de halogeno, nitro, alquilo C1-7, halo-alquilo C1-7, alcoxilo C1-7-alquilo C1-7, alcoxilo C1-7, halo-alcoxilo C1-7, alcoxilo C1-7-alcoxilo C1-7, halo-alcoxilo C1-7-alcoxilo C1-7, alquilo C1-7-alcoxilo C1-7, halo-alquilo C1-7-alcoxilo C1-7; y R2, R3 y R4 son iguales o diferentes unos de otros, y son hidrogeno, halogeno, nitro, alquilo C1-7, alcoxilo C1-7, cicloalquilo C3-8, o arilo C6-10, cada uno insustituido o sustituido por uno o más, por ejemplo, hasta tres sustituyentes seleccionados a partir de halogeno, nitro, alquilo C1-7, halo-alquilo C1-7, alcoxilo C1-7-alquilo C1-7, alcoxilo C1-7, halo-alcoxilo C1-7, alcoxilo C1-7-alcoxilo C1-7, halo-alcoxilo C1-7-alcoxilo C1-7, alquilo C1-7-alcoxilo C1-7, halo-alquilo C1-7-alcoxilo C1-7; con un haluro de organoaluminio de la formula R5R6AIX o R5AIX2, en donde R5 y R6 son, independientemente uno del otro, alquilo C1-7, alquenilo C3-8, cicloalquilo C3-8, o arilo C6-10, de preferencia alquilo C1-7, y X es halogeno, para obtener el compuesto de la formula (4). Reivindicacion 13: Una sal de amina del compuesto de la formula (4). Reivindicacion 15: El uso de un haluro de organoaluminio de la formula R5R6AIX o R5AIX2, en donde R5 y R6 son, independientemente uno del otro, alquilo C1-7, alquenilo C3-8, cicloalquilo C3-8, o arilo C6-10, de preferencia alquilo C1-7, y X es halogeno, en un proceso para la elaboracion de valsartan, o una sal del mismo; o un compuesto de la formula (4), o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09174264A EP2316821A1 (en) | 2009-10-27 | 2009-10-27 | Process for the manufacture of organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079104A1 true AR079104A1 (es) | 2011-12-28 |
Family
ID=41716392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103910A AR079104A1 (es) | 2009-10-27 | 2010-10-25 | Compuestos organicos, proceso de preparacion y uso de los mismos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20120238761A1 (es) |
| EP (2) | EP2316821A1 (es) |
| JP (1) | JP2013508436A (es) |
| KR (1) | KR20120098652A (es) |
| CN (1) | CN102596899A (es) |
| AR (1) | AR079104A1 (es) |
| AU (1) | AU2010311636B2 (es) |
| BR (1) | BR112012009815A2 (es) |
| CA (1) | CA2777031A1 (es) |
| CL (1) | CL2012001081A1 (es) |
| CO (1) | CO6531487A2 (es) |
| EC (1) | ECSP12011833A (es) |
| IL (1) | IL219111A0 (es) |
| IN (1) | IN2012DN03032A (es) |
| MA (1) | MA33692B1 (es) |
| MX (1) | MX2012005025A (es) |
| NZ (1) | NZ599218A (es) |
| PE (1) | PE20121501A1 (es) |
| RU (1) | RU2012121591A (es) |
| TN (1) | TN2012000154A1 (es) |
| TW (1) | TW201124389A (es) |
| WO (1) | WO2011051213A1 (es) |
| ZA (1) | ZA201202490B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102321038B (zh) * | 2011-07-11 | 2014-03-26 | 安徽省虹升生物科技有限公司 | 一种改进的制备缬沙坦方法 |
| FR2981077B1 (fr) * | 2011-10-11 | 2013-11-01 | Michelin Soc Tech | Methode pour preparer un melange maitre d'elastomere dienique et de silice |
| WO2018040065A1 (zh) * | 2016-09-02 | 2018-03-08 | 诺瑞特国际药业股份有限公司 | 缬沙坦二钠盐的晶型 |
| CN110078640B (zh) * | 2019-03-29 | 2022-04-05 | 浙江美诺华药物化学有限公司 | 一种缬沙坦中间体的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874867A (en) | 1987-05-22 | 1989-10-17 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| JPH04297466A (ja) | 1990-06-22 | 1992-10-21 | Nippon Shinyaku Co Ltd | テトラゾール誘導体及び医薬 |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| GB0222056D0 (en) | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| ITMI20032267A1 (it) | 2003-11-21 | 2005-05-22 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procdimento per la preparzione di valsartan e suoi intermedi |
| HRP20030965A2 (en) * | 2003-11-24 | 2005-08-31 | Belupo - Lijekovi I Kozmetika D.D. | Process for production of (s)-n-pentanoyl-n-[[2'-( |
| EP1714963A1 (en) * | 2005-04-19 | 2006-10-25 | IPCA Laboratories Limited | Process for the Preparation of Valsartan and its Intermediates |
| ES2333169T3 (es) * | 2005-08-22 | 2010-02-17 | Alembic Limited | Procedimiento para la preparacion de valsartan. |
| WO2008004110A2 (en) * | 2006-07-03 | 2008-01-10 | Aurobindo Pharma Limited | Process for the preparation of the angiotensin ii antagonist valsartan |
| CN101450917B (zh) * | 2007-12-06 | 2012-07-11 | 浙江海正药业股份有限公司 | 缬沙坦的合成方法 |
| US7943794B2 (en) * | 2008-02-13 | 2011-05-17 | Ranbaxy Laboratories Limited | Processes for the preparation of intermediates of valsartan |
-
2009
- 2009-10-27 EP EP09174264A patent/EP2316821A1/en not_active Ceased
-
2010
- 2010-10-25 NZ NZ599218A patent/NZ599218A/en not_active IP Right Cessation
- 2010-10-25 CN CN2010800487722A patent/CN102596899A/zh active Pending
- 2010-10-25 BR BR112012009815A patent/BR112012009815A2/pt not_active IP Right Cessation
- 2010-10-25 WO PCT/EP2010/066041 patent/WO2011051213A1/en active Application Filing
- 2010-10-25 MX MX2012005025A patent/MX2012005025A/es not_active Application Discontinuation
- 2010-10-25 US US13/504,333 patent/US20120238761A1/en not_active Abandoned
- 2010-10-25 KR KR1020127010679A patent/KR20120098652A/ko not_active Application Discontinuation
- 2010-10-25 PE PE2012000559A patent/PE20121501A1/es not_active Application Discontinuation
- 2010-10-25 AR ARP100103910A patent/AR079104A1/es not_active Application Discontinuation
- 2010-10-25 CA CA2777031A patent/CA2777031A1/en not_active Abandoned
- 2010-10-25 RU RU2012121591/04A patent/RU2012121591A/ru not_active Application Discontinuation
- 2010-10-25 AU AU2010311636A patent/AU2010311636B2/en not_active Expired - Fee Related
- 2010-10-25 JP JP2012535763A patent/JP2013508436A/ja active Pending
- 2010-10-25 EP EP10768497A patent/EP2493848A1/en not_active Withdrawn
- 2010-10-25 IN IN3032DEN2012 patent/IN2012DN03032A/en unknown
- 2010-10-26 TW TW099136578A patent/TW201124389A/zh unknown
-
2012
- 2012-04-03 TN TNP2012000154A patent/TN2012000154A1/en unknown
- 2012-04-04 ZA ZA2012/02490A patent/ZA201202490B/en unknown
- 2012-04-05 IL IL219111A patent/IL219111A0/en unknown
- 2012-04-26 EC ECSP12011833 patent/ECSP12011833A/es unknown
- 2012-04-26 MA MA34806A patent/MA33692B1/fr unknown
- 2012-04-26 CO CO12068973A patent/CO6531487A2/es unknown
- 2012-04-26 CL CL2012001081A patent/CL2012001081A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TN2012000154A1 (en) | 2013-12-12 |
| PE20121501A1 (es) | 2012-11-15 |
| MX2012005025A (es) | 2012-06-08 |
| US20120238761A1 (en) | 2012-09-20 |
| MA33692B1 (fr) | 2012-10-01 |
| BR112012009815A2 (pt) | 2016-10-18 |
| AU2010311636A1 (en) | 2012-05-03 |
| ZA201202490B (en) | 2012-12-27 |
| IN2012DN03032A (es) | 2015-07-31 |
| WO2011051213A1 (en) | 2011-05-05 |
| CA2777031A1 (en) | 2011-05-05 |
| JP2013508436A (ja) | 2013-03-07 |
| ECSP12011833A (es) | 2012-06-29 |
| RU2012121591A (ru) | 2013-12-10 |
| AU2010311636B2 (en) | 2014-03-06 |
| KR20120098652A (ko) | 2012-09-05 |
| EP2316821A1 (en) | 2011-05-04 |
| NZ599218A (en) | 2014-02-28 |
| TW201124389A (en) | 2011-07-16 |
| CN102596899A (zh) | 2012-07-18 |
| CL2012001081A1 (es) | 2013-06-14 |
| CO6531487A2 (es) | 2012-09-28 |
| IL219111A0 (en) | 2012-06-28 |
| EP2493848A1 (en) | 2012-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |