RU2009137582A - Инженерия и оптимизация одноцепочечных антител на основе последовательности - Google Patents

Инженерия и оптимизация одноцепочечных антител на основе последовательности Download PDF

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Publication number
RU2009137582A
RU2009137582A RU2009137582/10A RU2009137582A RU2009137582A RU 2009137582 A RU2009137582 A RU 2009137582A RU 2009137582/10 A RU2009137582/10 A RU 2009137582/10A RU 2009137582 A RU2009137582 A RU 2009137582A RU 2009137582 A RU2009137582 A RU 2009137582A
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RU
Russia
Prior art keywords
database
amino acid
acid sequences
scfv
frame positions
Prior art date
Application number
RU2009137582/10A
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English (en)
Russian (ru)
Inventor
Дэвид УРЕХ (CH)
Дэвид УРЕХ
Леонардо БОРРАС (CH)
Леонардо БОРРАС
Original Assignee
Эсбатек Аг (Ch)
Эсбатек Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эсбатек Аг (Ch), Эсбатек Аг filed Critical Эсбатек Аг (Ch)
Publication of RU2009137582A publication Critical patent/RU2009137582A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
RU2009137582/10A 2007-03-12 2008-03-12 Инженерия и оптимизация одноцепочечных антител на основе последовательности RU2009137582A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90636507P 2007-03-12 2007-03-12
US60/906,365 2007-03-12

Related Child Applications (1)

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RU2014127308A Division RU2014127308A (ru) 2007-03-12 2014-07-03 Инженерия и оптимизация одноцепочечных антител на основе последовательности

Publications (1)

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RU2009137582A true RU2009137582A (ru) 2011-04-20

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RU2009137582/10A RU2009137582A (ru) 2007-03-12 2008-03-12 Инженерия и оптимизация одноцепочечных антител на основе последовательности
RU2014127308A RU2014127308A (ru) 2007-03-12 2014-07-03 Инженерия и оптимизация одноцепочечных антител на основе последовательности

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RU2014127308A RU2014127308A (ru) 2007-03-12 2014-07-03 Инженерия и оптимизация одноцепочечных антител на основе последовательности

Country Status (11)

Country Link
US (2) US8280711B2 (enExample)
EP (2) EP3202786A3 (enExample)
JP (1) JP5622397B2 (enExample)
CN (2) CN103275216B (enExample)
AU (1) AU2008226067B2 (enExample)
CA (1) CA2680564C (enExample)
IL (1) IL200710A (enExample)
IN (1) IN2009DN05758A (enExample)
NZ (1) NZ579594A (enExample)
RU (2) RU2009137582A (enExample)
WO (1) WO2008110348A1 (enExample)

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Also Published As

Publication number Publication date
EP2118138A1 (en) 2009-11-18
NZ579594A (en) 2012-03-30
IL200710A (en) 2014-07-31
IN2009DN05758A (enExample) 2015-07-24
CN103275216B (zh) 2015-05-06
US9938336B2 (en) 2018-04-10
EP3202786A3 (en) 2017-10-11
CA2680564C (en) 2018-05-01
CN103275216A (zh) 2013-09-04
EP3202786A2 (en) 2017-08-09
US20100137150A1 (en) 2010-06-03
CN101668771A (zh) 2010-03-10
CN101668771B (zh) 2013-08-21
JP2010523077A (ja) 2010-07-15
WO2008110348A1 (en) 2008-09-18
AU2008226067B2 (en) 2012-11-08
AU2008226067A1 (en) 2008-09-18
HK1138602A1 (en) 2010-08-27
JP5622397B2 (ja) 2014-11-12
CA2680564A1 (en) 2008-09-18
IL200710A0 (en) 2010-05-17
RU2014127308A (ru) 2016-02-10
US8280711B2 (en) 2012-10-02
US20130053259A1 (en) 2013-02-28

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