AU2008226067B2 - Sequence based engineering and optimization of single chain antibodies - Google Patents

Sequence based engineering and optimization of single chain antibodies Download PDF

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Publication number
AU2008226067B2
AU2008226067B2 AU2008226067A AU2008226067A AU2008226067B2 AU 2008226067 B2 AU2008226067 B2 AU 2008226067B2 AU 2008226067 A AU2008226067 A AU 2008226067A AU 2008226067 A AU2008226067 A AU 2008226067A AU 2008226067 B2 AU2008226067 B2 AU 2008226067B2
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AU
Australia
Prior art keywords
amino acid
database
scfv
sequences
antibody
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008226067A
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English (en)
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AU2008226067A1 (en
Inventor
Leonardo Borras
David Urech
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esbatech a Novartis Co LLC
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Esbatech An Alcon Biomedical Research Unit LLC
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Application filed by Esbatech An Alcon Biomedical Research Unit LLC filed Critical Esbatech An Alcon Biomedical Research Unit LLC
Publication of AU2008226067A1 publication Critical patent/AU2008226067A1/en
Assigned to ESBATECH, AN ALCON BIOMEDICAL RESEARCH UNIT LLC reassignment ESBATECH, AN ALCON BIOMEDICAL RESEARCH UNIT LLC Amend patent request/document other than specification (104) Assignors: ESBATECH AG
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2008226067A 2007-03-12 2008-03-12 Sequence based engineering and optimization of single chain antibodies Ceased AU2008226067B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90636507P 2007-03-12 2007-03-12
US60/906,365 2007-03-12
PCT/EP2008/001958 WO2008110348A1 (en) 2007-03-12 2008-03-12 Sequence based engineering and optimization of single chain antibodies

Publications (2)

Publication Number Publication Date
AU2008226067A1 AU2008226067A1 (en) 2008-09-18
AU2008226067B2 true AU2008226067B2 (en) 2012-11-08

Family

ID=39586970

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008226067A Ceased AU2008226067B2 (en) 2007-03-12 2008-03-12 Sequence based engineering and optimization of single chain antibodies

Country Status (11)

Country Link
US (2) US8280711B2 (enExample)
EP (2) EP3202786A3 (enExample)
JP (1) JP5622397B2 (enExample)
CN (2) CN103275216B (enExample)
AU (1) AU2008226067B2 (enExample)
CA (1) CA2680564C (enExample)
IL (1) IL200710A (enExample)
IN (1) IN2009DN05758A (enExample)
NZ (1) NZ579594A (enExample)
RU (2) RU2009137582A (enExample)
WO (1) WO2008110348A1 (enExample)

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Also Published As

Publication number Publication date
EP2118138A1 (en) 2009-11-18
NZ579594A (en) 2012-03-30
IL200710A (en) 2014-07-31
IN2009DN05758A (enExample) 2015-07-24
CN103275216B (zh) 2015-05-06
US9938336B2 (en) 2018-04-10
EP3202786A3 (en) 2017-10-11
RU2009137582A (ru) 2011-04-20
CA2680564C (en) 2018-05-01
CN103275216A (zh) 2013-09-04
EP3202786A2 (en) 2017-08-09
US20100137150A1 (en) 2010-06-03
CN101668771A (zh) 2010-03-10
CN101668771B (zh) 2013-08-21
JP2010523077A (ja) 2010-07-15
WO2008110348A1 (en) 2008-09-18
AU2008226067A1 (en) 2008-09-18
HK1138602A1 (en) 2010-08-27
JP5622397B2 (ja) 2014-11-12
CA2680564A1 (en) 2008-09-18
IL200710A0 (en) 2010-05-17
RU2014127308A (ru) 2016-02-10
US8280711B2 (en) 2012-10-02
US20130053259A1 (en) 2013-02-28

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