CN103275216A - 单链抗体的基于序列的工程改造和最优化 - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract
Description
Claims (14)
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CN105518461A (zh) * | 2013-09-06 | 2016-04-20 | 豪夫迈·罗氏有限公司 | 改进抗体稳定性的方法 |
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WO2009000098A2 (en) | 2007-06-25 | 2008-12-31 | Esbatech Ag | Sequence based engineering and optimization of single chain antibodies |
AU2009264567B2 (en) | 2008-06-25 | 2014-06-12 | Novartis Ag | Humanization of rabbit antibodies using a universal antibody framework |
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CN102143976B (zh) | 2008-06-25 | 2015-11-25 | 艾斯巴技术-诺华有限责任公司 | 抑制vegf的稳定和可溶的抗体 |
WO2009155723A2 (en) | 2008-06-25 | 2009-12-30 | Esbatech, An Alcon Biomedical Research Unit Llc | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα |
EP3385279B1 (en) | 2009-03-20 | 2020-02-26 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
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MX2012005864A (es) | 2009-11-20 | 2012-08-31 | Amgen Inc | Proteinas de enlace al antígeno anti-orai 1 y usos de las mismas. |
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UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
GB201310859D0 (en) * | 2013-06-18 | 2013-07-31 | Cambridge Entpr Ltd | Rational method for solubilising proteins |
MX2017003247A (es) | 2014-09-15 | 2017-11-30 | Amgen Inc | Proteina de union a antigenos, bi-especificos del receptor anti-cgrp/receptor pac1 y usos de las mismas. |
AU2016323440B2 (en) | 2015-09-15 | 2023-07-13 | Amgen Inc. | Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof |
US10822408B2 (en) | 2015-12-15 | 2020-11-03 | Amgen Inc. | PACAP antibodies and uses thereof |
US20230137351A1 (en) | 2016-11-14 | 2023-05-04 | Amgen Inc. | Bispecific or biparatopic antigen binding proteins and uses thereof |
JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
JP7339262B2 (ja) | 2018-01-12 | 2023-09-05 | アムジェン インコーポレイテッド | Pac1抗体及びその使用 |
CN112292394A (zh) * | 2018-06-08 | 2021-01-29 | 文塔纳医疗系统公司 | 用于改善的功能性和可制造性的通用或归一化抗体框架 |
WO2020243477A2 (en) | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
CA3143524A1 (en) | 2019-06-28 | 2020-12-30 | Amgen Inc. | Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins |
CA3160482A1 (en) | 2019-11-08 | 2021-05-14 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-igg molecules |
AU2020386005A1 (en) | 2019-11-19 | 2022-05-26 | Amgen Inc. | Novel multispecific antibody format |
CA3164129A1 (en) | 2019-12-20 | 2021-06-24 | Amgen Inc. | Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors |
JP2023538897A (ja) | 2020-08-20 | 2023-09-12 | アムジエン・インコーポレーテツド | Fab領域中に非標準的なジスルフィドを有する抗原結合タンパク質 |
JP2023544769A (ja) | 2020-10-07 | 2023-10-25 | アムジエン・インコーポレーテツド | 多重特異性抗体の構築のためのビルディングブロックの合理的選択 |
TW202233663A (zh) | 2020-11-10 | 2022-09-01 | 美商安進公司 | 多特異性抗原結合結構域之新穎的連接子 |
TW202246319A (zh) | 2021-02-12 | 2022-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 補體c3抗原結合蛋白 |
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JP2024515301A (ja) | 2021-04-20 | 2024-04-08 | アムジエン・インコーポレーテツド | 多重特異性及び一価のigg分子の会合における鎖対形成の静電ステアリングにおけるバランスのとれた電荷分布 |
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US9938336B2 (en) | 2018-04-10 |
CN103275216B (zh) | 2015-05-06 |
AU2008226067A1 (en) | 2008-09-18 |
WO2008110348A1 (en) | 2008-09-18 |
AU2008226067B2 (en) | 2012-11-08 |
RU2009137582A (ru) | 2011-04-20 |
IL200710A0 (en) | 2010-05-17 |
JP2010523077A (ja) | 2010-07-15 |
EP2118138A1 (en) | 2009-11-18 |
CA2680564A1 (en) | 2008-09-18 |
CN101668771A (zh) | 2010-03-10 |
JP5622397B2 (ja) | 2014-11-12 |
EP3202786A2 (en) | 2017-08-09 |
US8280711B2 (en) | 2012-10-02 |
HK1138602A1 (en) | 2010-08-27 |
US20100137150A1 (en) | 2010-06-03 |
NZ579594A (en) | 2012-03-30 |
RU2014127308A (ru) | 2016-02-10 |
EP3202786A3 (en) | 2017-10-11 |
IN2009DN05758A (zh) | 2015-07-24 |
CA2680564C (en) | 2018-05-01 |
US20130053259A1 (en) | 2013-02-28 |
IL200710A (en) | 2014-07-31 |
CN101668771B (zh) | 2013-08-21 |
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