JP2009153527A5 - - Google Patents
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- Publication number
- JP2009153527A5 JP2009153527A5 JP2009092502A JP2009092502A JP2009153527A5 JP 2009153527 A5 JP2009153527 A5 JP 2009153527A5 JP 2009092502 A JP2009092502 A JP 2009092502A JP 2009092502 A JP2009092502 A JP 2009092502A JP 2009153527 A5 JP2009153527 A5 JP 2009153527A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hybrid
- hybrid antibody
- antibody fragment
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 92
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 92
- 238000000034 method Methods 0.000 claims 28
- 238000004519 manufacturing process Methods 0.000 claims 20
- 241000894007 species Species 0.000 claims 12
- 210000004602 germ cell Anatomy 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33659101P | 2001-12-03 | 2001-12-03 | |
| US60/336,591 | 2001-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Division JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012056050A Division JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009153527A JP2009153527A (ja) | 2009-07-16 |
| JP2009153527A5 true JP2009153527A5 (enExample) | 2010-11-11 |
| JP5054058B2 JP5054058B2 (ja) | 2012-10-24 |
Family
ID=23316785
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Expired - Fee Related JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
| JP2009092502A Expired - Fee Related JP5054058B2 (ja) | 2001-12-03 | 2009-04-06 | ハイブリッド抗体 |
| JP2012056050A Withdrawn JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Expired - Fee Related JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012056050A Withdrawn JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7399594B2 (enExample) |
| EP (2) | EP1461428B1 (enExample) |
| JP (3) | JP4723810B2 (enExample) |
| AT (1) | ATE550352T1 (enExample) |
| AU (1) | AU2002359568B2 (enExample) |
| CA (1) | CA2468744C (enExample) |
| CY (1) | CY1112843T1 (enExample) |
| DK (1) | DK1461428T3 (enExample) |
| ES (1) | ES2384100T3 (enExample) |
| PT (1) | PT1461428E (enExample) |
| SI (1) | SI1461428T1 (enExample) |
| WO (1) | WO2003048321A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7393648B2 (en) * | 2001-12-03 | 2008-07-01 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
| CA2491669A1 (en) * | 2002-07-04 | 2004-01-15 | Oncomab Gmbh | Neoplasm specific antibodies and uses thereof |
| GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| KR101073590B1 (ko) * | 2003-07-15 | 2011-10-14 | 메디뮨 리미티드 | Ｉｌ-13에 대한 인간 항체 분자 |
| JP2007534307A (ja) * | 2003-11-07 | 2007-11-29 | キュラジェン コーポレイション | 分泌性白血球プロテアーゼインヒビターに対する抗体 |
| DE10353175A1 (de) * | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
| EP1531162A1 (en) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
| AU2004297616B2 (en) | 2003-12-04 | 2008-12-18 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| CA2550155C (en) * | 2003-12-15 | 2015-03-17 | Dendreon Corporation | Hla-dr-specific antibodies, compositions and methods |
| EP1735615A4 (en) * | 2004-03-31 | 2009-12-02 | Centocor Ortho Biotech Inc | METHOD AND DEVICE FOR THE ANALYSIS AND GENERATION OF AMINO ACID AND NUCLEIC ACID SEQUENCES FOR HUMAN ANTIBODIES |
| WO2005111081A2 (en) * | 2004-05-10 | 2005-11-24 | Egea Biosciences, Llc | Immunoglobulin-like variable chain binding polypeptides and methods of use |
| GB0414886D0 (en) * | 2004-07-02 | 2004-08-04 | Neutec Pharma Plc | Treatment of bacterial infections |
| CA2611519A1 (en) | 2005-06-17 | 2006-12-28 | Tolerx, Inc. | Ilt3 binding molecules and uses therefor |
| FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| WO2008094176A2 (en) * | 2006-06-19 | 2008-08-07 | Tolerx, Inc. | Ilt3 binding molecules and uses therefor |
| AU2008333131B2 (en) | 2007-12-07 | 2013-10-24 | Merck Serono S/A | Humanized antibody molecules specific for IL-31 |
| EP3211010A1 (en) * | 2007-12-21 | 2017-08-30 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (il-4r) - 173 |
| CA2708074A1 (en) * | 2007-12-21 | 2009-07-02 | National Research Council Of Canada | Non-aggregating human vh domains |
| WO2009131605A2 (en) * | 2008-01-28 | 2009-10-29 | Thomas Jefferson University | Fusion partner cell line for preparation of hybrid cells expressing human antibodies |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| JP2012508022A (ja) * | 2008-11-06 | 2012-04-05 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 減少した免疫原性を有する操作された抗体および作製方法 |
| US8569460B2 (en) * | 2009-03-25 | 2013-10-29 | Vet Therapeutics, Inc. | Antibody constant domain regions and uses thereof |
| US9616120B2 (en) * | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
| BR112012022342A2 (pt) * | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais dirigidos a cd52 |
| AU2011268110B2 (en) | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| CN102251013A (zh) * | 2011-02-22 | 2011-11-23 | 北京市肿瘤防治研究所 | 一个识别肿瘤起始细胞的抗体和抗原及其应用 |
| JP6392764B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
| HRP20182129T1 (hr) * | 2012-10-12 | 2019-02-08 | Adc Therapeutics Sa | Konjugati protutijelo - pirolobenzodiazepin |
| HUE045435T2 (hu) | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pirrolobenzodiazepinek és konjugátumaik |
| RU2680267C2 (ru) | 2013-03-15 | 2019-02-19 | Мемориал Слоан Кеттеринг Кэнсер Сентер | Высокоаффинные антитела к gd2 |
| US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| KR20200032243A (ko) | 2017-02-08 | 2020-03-25 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
| SI3612537T1 (sl) | 2017-04-18 | 2022-10-28 | Medimmune Limited | Konjugati pirolobenzodiazepina |
| EP3612234B1 (en) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Combination therapy with an anti-axl antibody-drug conjugate |
| KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
| CN111065638B (zh) | 2017-08-18 | 2021-04-09 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂䓬缀合物 |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| IL286326B2 (en) | 2019-03-15 | 2025-10-01 | Medimmune Ltd | Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470925A (en) * | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5643756A (en) | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
| US5723287A (en) | 1992-09-22 | 1998-03-03 | Medical Research Council | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| GB9416721D0 (en) | 1994-08-18 | 1994-10-12 | Short Brothers Plc | A bias yarn assembly forming device |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| CA2249320C (en) * | 1996-03-20 | 2008-12-23 | Immunomedics, Inc. | Glycosylated humanized b-cell specific antibodies |
| US5908925A (en) * | 1996-06-27 | 1999-06-01 | Exocell, Inc. | Genetically engineered immunoglobulins with specificity for glycated albumin |
| US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7117096B2 (en) * | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| US7321026B2 (en) * | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| JP2005512962A (ja) * | 2001-09-20 | 2005-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｐｄｇｆ抗体および設計抗体の産生方法 |
| US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
-
2002
- 2002-12-03 ES ES02794114T patent/ES2384100T3/es not_active Expired - Lifetime
- 2002-12-03 AT AT02794114T patent/ATE550352T1/de active
- 2002-12-03 DK DK02794114.5T patent/DK1461428T3/da active
- 2002-12-03 WO PCT/US2002/038450 patent/WO2003048321A2/en not_active Ceased
- 2002-12-03 AU AU2002359568A patent/AU2002359568B2/en not_active Ceased
- 2002-12-03 SI SI200230983T patent/SI1461428T1/sl unknown
- 2002-12-03 EP EP02794114A patent/EP1461428B1/en not_active Expired - Lifetime
- 2002-12-03 JP JP2003549500A patent/JP4723810B2/ja not_active Expired - Fee Related
- 2002-12-03 PT PT02794114T patent/PT1461428E/pt unknown
- 2002-12-03 EP EP10178484A patent/EP2298817A1/en not_active Withdrawn
- 2002-12-03 CA CA2468744A patent/CA2468744C/en not_active Expired - Fee Related
- 2002-12-03 US US10/308,817 patent/US7399594B2/en not_active Expired - Lifetime
-
2009
- 2009-04-06 JP JP2009092502A patent/JP5054058B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-13 JP JP2012056050A patent/JP2012144551A/ja not_active Withdrawn
- 2012-06-07 CY CY20121100520T patent/CY1112843T1/el unknown
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