JP2009153527A5 - - Google Patents
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- Publication number
- JP2009153527A5 JP2009153527A5 JP2009092502A JP2009092502A JP2009153527A5 JP 2009153527 A5 JP2009153527 A5 JP 2009153527A5 JP 2009092502 A JP2009092502 A JP 2009092502A JP 2009092502 A JP2009092502 A JP 2009092502A JP 2009153527 A5 JP2009153527 A5 JP 2009153527A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- hybrid
- hybrid antibody
- antibody fragment
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 92
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 92
- 238000000034 method Methods 0.000 claims 28
- 238000004519 manufacturing process Methods 0.000 claims 20
- 241000894007 species Species 0.000 claims 12
- 210000004602 germ cell Anatomy 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33659101P | 2001-12-03 | 2001-12-03 | |
| US60/336,591 | 2001-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Division JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012056050A Division JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009153527A JP2009153527A (ja) | 2009-07-16 |
| JP2009153527A5 true JP2009153527A5 (enExample) | 2010-11-11 |
| JP5054058B2 JP5054058B2 (ja) | 2012-10-24 |
Family
ID=23316785
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Expired - Fee Related JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
| JP2009092502A Expired - Fee Related JP5054058B2 (ja) | 2001-12-03 | 2009-04-06 | ハイブリッド抗体 |
| JP2012056050A Withdrawn JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003549500A Expired - Fee Related JP4723810B2 (ja) | 2001-12-03 | 2002-12-03 | ハイブリッド抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012056050A Withdrawn JP2012144551A (ja) | 2001-12-03 | 2012-03-13 | ハイブリッド抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7399594B2 (enExample) |
| EP (2) | EP1461428B1 (enExample) |
| JP (3) | JP4723810B2 (enExample) |
| AT (1) | ATE550352T1 (enExample) |
| AU (1) | AU2002359568B2 (enExample) |
| CA (1) | CA2468744C (enExample) |
| CY (1) | CY1112843T1 (enExample) |
| DK (1) | DK1461428T3 (enExample) |
| ES (1) | ES2384100T3 (enExample) |
| PT (1) | PT1461428E (enExample) |
| SI (1) | SI1461428T1 (enExample) |
| WO (1) | WO2003048321A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7393648B2 (en) * | 2001-12-03 | 2008-07-01 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
| EP2322559A3 (en) * | 2002-07-04 | 2011-08-03 | Patrys Limited | Neoplasm specific antibodies and uses thereof |
| GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
| KR101073590B1 (ko) * | 2003-07-15 | 2011-10-14 | 메디뮨 리미티드 | Ｉｌ-13에 대한 인간 항체 분자 |
| CA2545756A1 (en) * | 2003-11-07 | 2005-05-26 | Curagen Corporation | Antibodies against secretoryleukocyte protease inhibitor |
| EP1531162A1 (en) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
| DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
| JP2007512846A (ja) * | 2003-12-04 | 2007-05-24 | ゼンコー・インコーポレイテッド | 増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物 |
| EP1711527A4 (en) * | 2003-12-15 | 2008-09-03 | Dendreon Corp | HLA-DR SPECIFIC ANTIBODIES, COMPOSITIONS AND METHODS |
| CA2562034A1 (en) * | 2004-03-31 | 2005-10-20 | Jin Lu | Method and apparatus for analyzing and generating human antibody amino acid and nucleic acid sequences |
| US20060263787A1 (en) * | 2004-05-10 | 2006-11-23 | Evans Glen A | Immunoglobulin-like variable chain binding polypeptides and methods of use |
| GB0414886D0 (en) * | 2004-07-02 | 2004-08-04 | Neutec Pharma Plc | Treatment of bacterial infections |
| ES2547463T3 (es) | 2005-06-17 | 2015-10-06 | Merck Sharp & Dohme Corp. | Moléculas de unión a ILT3 y usos de las mismas |
| FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| WO2008094176A2 (en) * | 2006-06-19 | 2008-08-07 | Tolerx, Inc. | Ilt3 binding molecules and uses therefor |
| SI2796466T1 (en) * | 2007-12-07 | 2018-01-31 | Zymogenetics, Inc. | Molecules of Humanized Specifics Specifiable for IL-31 |
| WO2009079793A1 (en) * | 2007-12-21 | 2009-07-02 | National Research Council Of Canada | Non-aggregating human vh domains |
| MX2010006735A (es) * | 2007-12-21 | 2010-09-30 | Medimmune Ltd | Miembros de union para receptor alfa de interleucina-4 (il-4ra) - 173. |
| US8557575B2 (en) * | 2008-01-28 | 2013-10-15 | Thomas Jefferson University | Fusion partner cell line for preparation of hybrid cells expressing human antibodies |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| US20110313134A1 (en) * | 2008-11-06 | 2011-12-22 | Alexion Pharmaceuticals, Inc. | Engineered antibodies with reduced immunogenicity and methods of making |
| WO2010110838A2 (en) * | 2009-03-25 | 2010-09-30 | Vet Therapeutics Inc. | Antibody constant domain regions and uses thereof |
| BR112012022338A2 (pt) * | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais direcionados a cd20 |
| EP2542258A4 (en) * | 2010-03-04 | 2013-08-21 | Vet Therapeutics Inc | ON CD52 MONOCLONAL ANTIBODIES |
| NZ603581A (en) | 2010-06-19 | 2015-05-29 | Sloan Kettering Inst Cancer | Anti-gd2 antibodies |
| CN102251013A (zh) * | 2011-02-22 | 2011-11-23 | 北京市肿瘤防治研究所 | 一个识别肿瘤起始细胞的抗体和抗原及其应用 |
| KR101995620B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
| DK2906298T3 (en) * | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| DK2839860T3 (da) | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| AU2014228772B2 (en) | 2013-03-15 | 2019-02-28 | Memorial Sloan Kettering Cancer Center | High affinity anti-GD2 antibodies |
| WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
| SMT202200490T1 (it) | 2017-04-18 | 2023-01-13 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
| SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CN113631560B (zh) | 2019-03-15 | 2025-02-18 | 麦迪穆有限责任公司 | 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470925A (en) * | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US5643756A (en) | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
| WO1994006920A1 (en) | 1992-09-22 | 1994-03-31 | Medical Research Council | Recombinant viruses displaying a nonviral polypeptide on their external surface |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| GB9416721D0 (en) | 1994-08-18 | 1994-10-12 | Short Brothers Plc | A bias yarn assembly forming device |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US6254868B1 (en) * | 1996-03-20 | 2001-07-03 | Immunomedics, Inc. | Glycosylated humanized B-cell specific antibodies |
| US5908925A (en) * | 1996-06-27 | 1999-06-01 | Exocell, Inc. | Genetically engineered immunoglobulins with specificity for glycated albumin |
| US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7117096B2 (en) * | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| JP2005512962A (ja) * | 2001-09-20 | 2005-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 抗ｐｄｇｆ抗体および設計抗体の産生方法 |
| US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
-
2002
- 2002-12-03 JP JP2003549500A patent/JP4723810B2/ja not_active Expired - Fee Related
- 2002-12-03 ES ES02794114T patent/ES2384100T3/es not_active Expired - Lifetime
- 2002-12-03 AU AU2002359568A patent/AU2002359568B2/en not_active Ceased
- 2002-12-03 CA CA2468744A patent/CA2468744C/en not_active Expired - Fee Related
- 2002-12-03 US US10/308,817 patent/US7399594B2/en not_active Expired - Lifetime
- 2002-12-03 DK DK02794114.5T patent/DK1461428T3/da active
- 2002-12-03 AT AT02794114T patent/ATE550352T1/de active
- 2002-12-03 PT PT02794114T patent/PT1461428E/pt unknown
- 2002-12-03 EP EP02794114A patent/EP1461428B1/en not_active Expired - Lifetime
- 2002-12-03 SI SI200230983T patent/SI1461428T1/sl unknown
- 2002-12-03 EP EP10178484A patent/EP2298817A1/en not_active Withdrawn
- 2002-12-03 WO PCT/US2002/038450 patent/WO2003048321A2/en not_active Ceased
-
2009
- 2009-04-06 JP JP2009092502A patent/JP5054058B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-13 JP JP2012056050A patent/JP2012144551A/ja not_active Withdrawn
- 2012-06-07 CY CY20121100520T patent/CY1112843T1/el unknown
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