JP4723810B2 - ハイブリッド抗体 - Google Patents

ハイブリッド抗体 Download PDF

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Publication number
JP4723810B2
JP4723810B2 JP2003549500A JP2003549500A JP4723810B2 JP 4723810 B2 JP4723810 B2 JP 4723810B2 JP 2003549500 A JP2003549500 A JP 2003549500A JP 2003549500 A JP2003549500 A JP 2003549500A JP 4723810 B2 JP4723810 B2 JP 4723810B2
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Japan
Prior art keywords
antibody
sequence
sequences
framework
homology
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Japanese (ja)
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JP2005511706A (ja
Inventor
ラッセル ロサー，
ダヤン ウー，
Original Assignee
アレクシオン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003549500A 2001-12-03 2002-12-03 ハイブリッド抗体 Expired - Fee Related JP4723810B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33659101P 2001-12-03 2001-12-03
US60/336,591 2001-12-03
PCT/US2002/038450 WO2003048321A2 (en) 2001-12-03 2002-12-03 Hybrid antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009092502A Division JP5054058B2 (ja) 2001-12-03 2009-04-06 ハイブリッド抗体

Publications (2)

Publication Number Publication Date
JP2005511706A JP2005511706A (ja) 2005-04-28
JP4723810B2 true JP4723810B2 (ja) 2011-07-13

Family

ID=23316785

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003549500A Expired - Fee Related JP4723810B2 (ja) 2001-12-03 2002-12-03 ハイブリッド抗体
JP2009092502A Expired - Fee Related JP5054058B2 (ja) 2001-12-03 2009-04-06 ハイブリッド抗体
JP2012056050A Withdrawn JP2012144551A (ja) 2001-12-03 2012-03-13 ハイブリッド抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009092502A Expired - Fee Related JP5054058B2 (ja) 2001-12-03 2009-04-06 ハイブリッド抗体
JP2012056050A Withdrawn JP2012144551A (ja) 2001-12-03 2012-03-13 ハイブリッド抗体

Country Status (12)

Country Link
US (1) US7399594B2 (enExample)
EP (2) EP1461428B1 (enExample)
JP (3) JP4723810B2 (enExample)
AT (1) ATE550352T1 (enExample)
AU (1) AU2002359568B2 (enExample)
CA (1) CA2468744C (enExample)
CY (1) CY1112843T1 (enExample)
DK (1) DK1461428T3 (enExample)
ES (1) ES2384100T3 (enExample)
PT (1) PT1461428E (enExample)
SI (1) SI1461428T1 (enExample)
WO (1) WO2003048321A2 (enExample)

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DE10353175A1 (de) * 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
EP1531162A1 (en) 2003-11-14 2005-05-18 Heinz Vollmers Adenocarcinoma specific antibody SAM-6, and uses thereof
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CA2550155C (en) * 2003-12-15 2015-03-17 Dendreon Corporation Hla-dr-specific antibodies, compositions and methods
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AU2008333131B2 (en) 2007-12-07 2013-10-24 Merck Serono S/A Humanized antibody molecules specific for IL-31
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WO2009131605A2 (en) * 2008-01-28 2009-10-29 Thomas Jefferson University Fusion partner cell line for preparation of hybrid cells expressing human antibodies
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
JP2012508022A (ja) * 2008-11-06 2012-04-05 アレクシオン ファーマシューティカルズ， インコーポレイテッド 減少した免疫原性を有する操作された抗体および作製方法
US8569460B2 (en) * 2009-03-25 2013-10-29 Vet Therapeutics, Inc. Antibody constant domain regions and uses thereof
US9616120B2 (en) * 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
BR112012022342A2 (pt) * 2010-03-04 2017-02-14 Vet Therapeutics Inc anticorpos monoclonais dirigidos a cd52
AU2011268110B2 (en) 2010-06-19 2016-05-19 Memorial Sloan-Kettering Cancer Center Anti-GD2 antibodies
CN102251013A (zh) * 2011-02-22 2011-11-23 北京市肿瘤防治研究所 一个识别肿瘤起始细胞的抗体和抗原及其应用
JP6392764B2 (ja) 2012-10-12 2018-09-19 エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ ピロロベンゾジアゼピン−抗体結合体
HRP20182129T1 (hr) * 2012-10-12 2019-02-08 Adc Therapeutics Sa Konjugati protutijelo - pirolobenzodiazepin
HUE045435T2 (hu) 2012-10-12 2019-12-30 Medimmune Ltd Pirrolobenzodiazepinek és konjugátumaik
RU2680267C2 (ru) 2013-03-15 2019-02-19 Мемориал Слоан Кеттеринг Кэнсер Сентер Высокоаффинные антитела к gd2
US9950078B2 (en) 2013-10-11 2018-04-24 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
KR20200032243A (ko) 2017-02-08 2020-03-25 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
SI3612537T1 (sl) 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (ko) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 항-cd19 adc의 투여를 위한 투약량 체제
CN111065638B (zh) 2017-08-18 2021-04-09 麦迪穆有限责任公司 吡咯并苯并二氮杂䓬缀合物
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
IL286326B2 (en) 2019-03-15 2025-10-01 Medimmune Ltd Azatidobenzodiazepine dimers and conjugates containing them for use in the treatment of cancer

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Also Published As

Publication number Publication date
SI1461428T1 (sl) 2012-07-31
JP2009153527A (ja) 2009-07-16
US20030219861A1 (en) 2003-11-27
US7399594B2 (en) 2008-07-15
CA2468744A1 (en) 2003-06-12
EP1461428B1 (en) 2012-03-21
WO2003048321A2 (en) 2003-06-12
JP2012144551A (ja) 2012-08-02
ES2384100T3 (es) 2012-06-29
WO2003048321A3 (en) 2003-10-16
ATE550352T1 (de) 2012-04-15
EP2298817A1 (en) 2011-03-23
EP1461428A4 (en) 2005-05-25
CY1112843T1 (el) 2016-02-10
JP5054058B2 (ja) 2012-10-24
CA2468744C (en) 2013-05-14
DK1461428T3 (da) 2012-06-04
JP2005511706A (ja) 2005-04-28
PT1461428E (pt) 2012-05-29
AU2002359568A1 (en) 2003-06-17
EP1461428A2 (en) 2004-09-29
AU2002359568B2 (en) 2008-02-21

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