RU2005120390A - Способ получения макролидного соединения - Google Patents
Способ получения макролидного соединения Download PDFInfo
- Publication number
- RU2005120390A RU2005120390A RU2005120390/13A RU2005120390A RU2005120390A RU 2005120390 A RU2005120390 A RU 2005120390A RU 2005120390/13 A RU2005120390/13 A RU 2005120390/13A RU 2005120390 A RU2005120390 A RU 2005120390A RU 2005120390 A RU2005120390 A RU 2005120390A
- Authority
- RU
- Russia
- Prior art keywords
- strain
- macrolide compound
- ferm
- represented
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 12
- 239000003120 macrolide antibiotic agent Substances 0.000 title claims 12
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 238000000034 method Methods 0.000 claims 4
- 241001134635 Micromonosporaceae Species 0.000 claims 2
- 241000235575 Mortierella Species 0.000 claims 2
- 241001558147 Mortierella sp. Species 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 2
- 241000187180 Streptomyces sp. Species 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 1
- 238000011426 transformation method Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (7)
1. Способ получения макролидного соединения 11107D, представленного формулой (II)
где макролидное соединение 11107D получают из макролидного соединения 11107В, представленного формулой (I)
способом биологического превращения, который предусматривает следующие процессы (А) и (В):
(А) процесс инкубирования макролидного соединения 11107В, представленного формулой (I), в присутствии штамма, имеющего способность проведения вышеупомянутого биологического превращения и принадлежащего к роду Mortierella, роду Streptomyces или семейству Micromonosporaceae, или получения его культивируемого мицелия; и
(В) процесс сбора макролидного соединения 11107D, представленного формулой (II), из инкубируемого раствора, полученного в стадии (А).
2. Способ получения по п. 1, где штаммом, принадлежащим к роду Mortierella, является штамм Mortierella sp. F-1529 (FERM BP-8547) или штамм F-1530 (Ferm BP-8548).
3. Способ получения по п. 1, где штаммом, принадлежащим к роду Streptomyces, является штамм Streptomyces sp. AB-1704 (FERM BP-8551), штамм А-1544 (FERM BP-8446) или штамм А-1545 (FERM BP-8447).
4. Способ получения по п. 1, где штаммом, принадлежащим к семейству Micromonosporaceae, является штамм АВ-1896 (FERM BP-8550).
5. Штамм Streptomyces sp. AB-1704 (FERM BP-8551), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
6. Штамм Mortierella sp. F-1529 (FERM BP-8547) или штамм F-1530 (Ferm BP-8548), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
7. Штамм АВ-1896 (FERM BP-8550), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002-346796 | 2002-11-29 | ||
| JP2002346796 | 2002-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005120390A true RU2005120390A (ru) | 2006-01-27 |
| RU2330069C2 RU2330069C2 (ru) | 2008-07-27 |
Family
ID=32462862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005120390/13A RU2330069C2 (ru) | 2002-11-29 | 2003-11-27 | Способ получения макролидного соединения и штаммы streptomyces sp., mortierella sp. и micromonosporaceae |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7745198B2 (ru) |
| EP (1) | EP1580278A4 (ru) |
| JP (1) | JP4439401B2 (ru) |
| KR (1) | KR20050086873A (ru) |
| CN (1) | CN1717493A (ru) |
| AU (1) | AU2003284469B2 (ru) |
| BR (1) | BR0316746A (ru) |
| CA (1) | CA2507641A1 (ru) |
| MX (1) | MXPA05005672A (ru) |
| NO (1) | NO20052568L (ru) |
| NZ (1) | NZ540103A (ru) |
| RU (1) | RU2330069C2 (ru) |
| WO (1) | WO2004050890A1 (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI334866B (en) * | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| US7932083B2 (en) | 2003-11-27 | 2011-04-26 | Mercian Corporation | DNA participating in hydroxylation of macrolide compound |
| US8008049B2 (en) * | 2004-07-20 | 2011-08-30 | Eisai R&D Management Co., Ltd. | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| CN101282967B (zh) | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
| AU2007285215A1 (en) * | 2006-08-14 | 2008-02-21 | Eisai R & D Management Co., Ltd. | Stable lyophilized preparation |
| NZ575828A (en) * | 2007-01-29 | 2011-04-29 | Eisai R&D Man Co Ltd | Solid of macrolide compound, method for production thereof, and pharmaceutical composition comprising the same |
| CN111825733A (zh) * | 2013-04-04 | 2020-10-27 | 哈佛大学的校长及成员们 | 大环内酯及其制备和使用方法 |
| WO2015175594A1 (en) | 2014-05-15 | 2015-11-19 | Eisai R&D Management Co., Ltd. | Pladienolide pyridine compounds and methods of use |
| US10633407B2 (en) | 2014-10-08 | 2020-04-28 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
| US10640528B2 (en) | 2015-03-25 | 2020-05-05 | President And Fellows Of Havard College | Macrolides with modified desosamine sugars and uses thereof |
| EP3344780B1 (en) | 2015-09-01 | 2021-06-23 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic sf3b1 mutants |
| US10745387B2 (en) | 2015-11-18 | 2020-08-18 | Eisai R&D Management Co., Ltd. | Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof |
| WO2018170129A1 (en) | 2017-03-15 | 2018-09-20 | Eisai Co., Ltd | Spliceosome mutations and uses thereof |
| MX2020004179A (es) | 2017-10-31 | 2020-08-03 | Eisai R&D Man Co Ltd | Combinacion que comprende al menos un modulador de espliceosomas y al menos un inhibidor elegido de inhibidores de bcl2, bcl2/bclxl y bclxl, y metodos de uso. |
| TW201945351A (zh) | 2018-04-09 | 2019-12-01 | 日商衛材R&D企管股份有限公司 | 特定普拉二烯內酯化合物及其使用方法 |
| CN117285502A (zh) | 2018-04-12 | 2023-12-26 | 卫材R&D管理有限公司 | 作为用于治疗癌症的剪接体靶向剂的普拉二烯内酯衍生物 |
| KR20210016406A (ko) | 2018-06-01 | 2021-02-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 스플라이싱 조정제를 사용하는 방법 |
| KR20230104204A (ko) | 2020-11-04 | 2023-07-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 골수이형성 증후군(mds)에 대한 바이오마커 및 이를 사용하는 방법 |
| CN114478257A (zh) * | 2021-12-29 | 2022-05-13 | 福建省山河药业有限公司 | 一种抗肿瘤霉菌酸类化合物及其制备方法、应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04352783A (ja) * | 1991-05-27 | 1992-12-07 | Taisho Pharmaceut Co Ltd | １２員環マクロライド系化合物 |
| AU5179800A (en) | 1999-06-03 | 2000-12-28 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Mycolactone and related compounds, compositions and methods of use |
| AU2001278155A1 (en) | 2000-08-03 | 2002-02-18 | Kosan Biosciences, Inc. | Fermentation and purification of mycolactones |
| TWI312681B (en) * | 2001-02-01 | 2009-08-01 | Novel physiologically active substance | |
| TWI233361B (en) | 2001-04-13 | 2005-06-01 | Gen Hospital Corp | Methods of preventing UVB-induced skin damage |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| US7256178B2 (en) * | 2002-07-31 | 2007-08-14 | Eisai Co., Ltd. | Physiologically active substances |
| CN101282967B (zh) | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
-
2003
- 2003-11-27 MX MXPA05005672A patent/MXPA05005672A/es active IP Right Grant
- 2003-11-27 US US10/532,412 patent/US7745198B2/en not_active Expired - Fee Related
- 2003-11-27 AU AU2003284469A patent/AU2003284469B2/en not_active Ceased
- 2003-11-27 RU RU2005120390/13A patent/RU2330069C2/ru not_active IP Right Cessation
- 2003-11-27 EP EP03775924A patent/EP1580278A4/en not_active Withdrawn
- 2003-11-27 KR KR1020057009524A patent/KR20050086873A/ko not_active Application Discontinuation
- 2003-11-27 CA CA002507641A patent/CA2507641A1/en not_active Abandoned
- 2003-11-27 NZ NZ540103A patent/NZ540103A/en unknown
- 2003-11-27 JP JP2004556846A patent/JP4439401B2/ja not_active Expired - Fee Related
- 2003-11-27 WO PCT/JP2003/015170 patent/WO2004050890A1/ja active Application Filing
- 2003-11-27 CN CNA2003801044327A patent/CN1717493A/zh active Pending
- 2003-11-27 BR BR0316746-1A patent/BR0316746A/pt not_active IP Right Cessation
-
2005
- 2005-05-27 NO NO20052568A patent/NO20052568L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ540103A (en) | 2007-05-31 |
| AU2003284469B2 (en) | 2008-02-21 |
| JP4439401B2 (ja) | 2010-03-24 |
| EP1580278A4 (en) | 2010-08-25 |
| AU2003284469A1 (en) | 2004-06-23 |
| NO20052568L (no) | 2005-06-29 |
| US20060141589A1 (en) | 2006-06-29 |
| EP1580278A1 (en) | 2005-09-28 |
| BR0316746A (pt) | 2005-10-18 |
| CA2507641A1 (en) | 2004-06-17 |
| NO20052568D0 (no) | 2005-05-27 |
| WO2004050890A1 (ja) | 2004-06-17 |
| JPWO2004050890A1 (ja) | 2006-03-30 |
| MXPA05005672A (es) | 2005-08-16 |
| RU2330069C2 (ru) | 2008-07-27 |
| KR20050086873A (ko) | 2005-08-30 |
| CN1717493A (zh) | 2006-01-04 |
| US7745198B2 (en) | 2010-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005120390A (ru) | Способ получения макролидного соединения | |
| BR0207287A (pt) | Glicosamina e método de fabricação de glicosamina a partir de biomassa microbiana | |
| HUP0300556A2 (hu) | Oldószermentes extrakciós eljárás | |
| DK149095B (da) | Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k | |
| NO991863L (no) | Nye bakteriestammer og bruken derav i fermenteringsprosesser for 2-keto-L-gulonsyreproduksjon | |
| HUP0300073A2 (en) | Method of purifying a fermentation broth | |
| CA1319636C (en) | Process for the production of macrolide compounds | |
| JP2001275656A (ja) | ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法 | |
| CN1085250C (zh) | 制备HMG－CoA还原酶抑制剂及其中间体的酶促羟基化方法 | |
| RU2004114667A (ru) | Гидроксилирование компактина до правастатина с помощью micromonospora | |
| WO2005003141A3 (en) | An improved process for the preparation of cefditoren | |
| EE200200460A (et) | Meetod tuntud tetrasooli derivaadi sünteesiks | |
| DE60225004D1 (de) | Verfahren zur Herstellung von Glutathion | |
| TW200745341A (en) | A method for preparing cercosporamide | |
| RU2003102446A (ru) | Новые полициклические ксантоны и их применение | |
| RU2006133740A (ru) | Полусинтетический способ получения десерпидина | |
| Kirschner et al. | Cladobotryum semicirculare sp. nov.(Hyphomycetes) from commercially grown Ganoderma tsugae in Taiwan and other Basidiomycota in Cuba | |
| JPH0722513B2 (ja) | ビスホモ―γ―リノレン酸及びこれを含有する脂質の製造方法 | |
| DK0456986T3 (da) | Varmeresistent beta-galactosyltransferase, fremtillingsfremgangsmåde herfor og anvendelse heraf | |
| JP4439079B2 (ja) | プラバスタチンの製造方法 | |
| EP1167534A3 (en) | Process for the preparation of optically active 1,2-diols by cultivating microorganisms | |
| HUP0303472A2 (hu) | Eljárások pantotenát fokozott termelésére | |
| JPS56140888A (en) | Preparation of limiting enzyme | |
| JP2005000144A (ja) | コンパクチンをプラバスタチンに転換できるストレプトミセス種ｃｊｐｖ９７５６５２及びそれを利用したプラバスタチンの製造法 | |
| JPH0984591A (ja) | カロテノイド硫酸エステルおよびその製造方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20101128 |