RU2005120390A - Способ получения макролидного соединения - Google Patents
Способ получения макролидного соединения Download PDFInfo
- Publication number
- RU2005120390A RU2005120390A RU2005120390/13A RU2005120390A RU2005120390A RU 2005120390 A RU2005120390 A RU 2005120390A RU 2005120390/13 A RU2005120390/13 A RU 2005120390/13A RU 2005120390 A RU2005120390 A RU 2005120390A RU 2005120390 A RU2005120390 A RU 2005120390A
- Authority
- RU
- Russia
- Prior art keywords
- strain
- macrolide compound
- ferm
- represented
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 12
- 239000003120 macrolide antibiotic agent Substances 0.000 title claims 12
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 238000000034 method Methods 0.000 claims 4
- 241001134635 Micromonosporaceae Species 0.000 claims 2
- 241000235575 Mortierella Species 0.000 claims 2
- 241001558147 Mortierella sp. Species 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 2
- 241000187180 Streptomyces sp. Species 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 1
- 238000011426 transformation method Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (7)
1. Способ получения макролидного соединения 11107D, представленного формулой (II)
где макролидное соединение 11107D получают из макролидного соединения 11107В, представленного формулой (I)
способом биологического превращения, который предусматривает следующие процессы (А) и (В):
(А) процесс инкубирования макролидного соединения 11107В, представленного формулой (I), в присутствии штамма, имеющего способность проведения вышеупомянутого биологического превращения и принадлежащего к роду Mortierella, роду Streptomyces или семейству Micromonosporaceae, или получения его культивируемого мицелия; и
(В) процесс сбора макролидного соединения 11107D, представленного формулой (II), из инкубируемого раствора, полученного в стадии (А).
2. Способ получения по п. 1, где штаммом, принадлежащим к роду Mortierella, является штамм Mortierella sp. F-1529 (FERM BP-8547) или штамм F-1530 (Ferm BP-8548).
3. Способ получения по п. 1, где штаммом, принадлежащим к роду Streptomyces, является штамм Streptomyces sp. AB-1704 (FERM BP-8551), штамм А-1544 (FERM BP-8446) или штамм А-1545 (FERM BP-8447).
4. Способ получения по п. 1, где штаммом, принадлежащим к семейству Micromonosporaceae, является штамм АВ-1896 (FERM BP-8550).
5. Штамм Streptomyces sp. AB-1704 (FERM BP-8551), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
6. Штамм Mortierella sp. F-1529 (FERM BP-8547) или штамм F-1530 (Ferm BP-8548), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
7. Штамм АВ-1896 (FERM BP-8550), имеющий способность превращения макролидного соединения 11107В, представленного формулой (I), в макролидное соединение 11107D, представленное формулой (II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002346796 | 2002-11-29 | ||
| JP2002-346796 | 2002-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005120390A true RU2005120390A (ru) | 2006-01-27 |
| RU2330069C2 RU2330069C2 (ru) | 2008-07-27 |
Family
ID=32462862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005120390/13A RU2330069C2 (ru) | 2002-11-29 | 2003-11-27 | Способ получения макролидного соединения и штаммы streptomyces sp., mortierella sp. и micromonosporaceae |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7745198B2 (ru) |
| EP (1) | EP1580278A4 (ru) |
| JP (1) | JP4439401B2 (ru) |
| KR (1) | KR20050086873A (ru) |
| CN (1) | CN1717493A (ru) |
| AU (1) | AU2003284469B2 (ru) |
| BR (1) | BR0316746A (ru) |
| CA (1) | CA2507641A1 (ru) |
| MX (1) | MXPA05005672A (ru) |
| NO (1) | NO20052568L (ru) |
| NZ (1) | NZ540103A (ru) |
| RU (1) | RU2330069C2 (ru) |
| WO (1) | WO2004050890A1 (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI334866B (en) * | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| CA2546614A1 (en) | 2003-11-27 | 2005-06-09 | Mercian Corporation | Dna participating in hydroxylation of macrolide compound |
| AU2005265443B2 (en) * | 2004-07-20 | 2008-09-04 | Eisai R & D Management Co., Ltd | DNA coding for polypeptide participating in biosynthesis of pladienolide |
| TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
| CN101282967B (zh) * | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
| US20090325978A1 (en) * | 2006-08-14 | 2009-12-31 | Katsumi Onai | Stable lyophilized preparation |
| US7790887B2 (en) * | 2007-01-29 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same |
| MX2015014026A (es) | 2013-04-04 | 2016-08-03 | Harvard College | Macrolidos y metodos para su preparacion y uso. |
| SI3143016T1 (sl) | 2014-05-15 | 2019-04-30 | Eisai R&D Management Co., Ltd. | Spojine pladienolid piridina in postopki uporabe |
| JP2017531663A (ja) | 2014-10-08 | 2017-10-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | １４員ケトライドならびにそれらの調製および使用の方法 |
| JP2018509452A (ja) | 2015-03-25 | 2018-04-05 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 修飾デソサミン糖をもつマクロライドおよびその使用 |
| US10889866B2 (en) | 2015-09-01 | 2021-01-12 | Eisai R&D Management Co., Ltd. | Splice variants associated with neomorphic SF3B1 mutants |
| RU2021102393A (ru) | 2015-11-18 | 2021-03-17 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Твердые формы пладиенолидпиридиновых соединений и способы их применения |
| WO2018170129A1 (en) | 2017-03-15 | 2018-09-20 | Eisai Co., Ltd | Spliceosome mutations and uses thereof |
| KR20200083532A (ko) | 2017-10-31 | 2020-07-08 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 적어도 1종의 스플라이세오솜 조정제, 및 bcl2 억제제, bcl2/bclxl 억제제 및 bclxl 억제제로부터 선택된 적어도 1종의 억제제를 포함하는 조합물 및 사용 방법 |
| BR112020020792A2 (pt) | 2018-04-09 | 2021-01-12 | Eisai R&D Management Co., Ltd. | Certos compostos de pladienolida e métodos de uso |
| SG11202009907XA (en) | 2018-04-12 | 2020-11-27 | Eisai R&D Man Co Ltd | Pladienolide derivatives as spliceosome targeting agents for treating cancer |
| EP3801523A2 (en) | 2018-06-01 | 2021-04-14 | Eisai R&D Management Co., Ltd. | Methods of using splicing modulators |
| TW202233187A (zh) | 2020-11-04 | 2022-09-01 | 日商衛材R&D企管股份有限公司 | 骨髓發育不良症候群（ｍｄｓ）之生物標記物及其使用方法 |
| CN114478257A (zh) * | 2021-12-29 | 2022-05-13 | 福建省山河药业有限公司 | 一种抗肿瘤霉菌酸类化合物及其制备方法、应用 |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04352783A (ja) | 1991-05-27 | 1992-12-07 | Taisho Pharmaceut Co Ltd | １２員環マクロライド系化合物 |
| EP1192147A1 (en) | 1999-06-03 | 2002-04-03 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Mycolactone and related compounds, compositions and methods of use |
| US6562602B2 (en) | 2000-08-03 | 2003-05-13 | Kosan Biosciences, Inc. | Fermentation and purification of mycolactones |
| TWI311558B (en) * | 2001-02-01 | 2009-07-01 | Mercian Corporatio | Novel physiologically active substance |
| TWI233361B (en) * | 2001-04-13 | 2005-06-01 | Gen Hospital Corp | Methods of preventing UVB-induced skin damage |
| TWI334866B (en) | 2002-05-29 | 2010-12-21 | Mercian Corp | Novel physiologically active substances |
| CN1671856B (zh) * | 2002-07-31 | 2010-05-12 | 卫材R&D管理株式会社 | 生理活性物质 |
| CN101282967B (zh) * | 2005-10-13 | 2011-01-26 | 卫材R&D管理有限公司 | 普拉二烯内酯b和普拉二烯内酯d的全合成 |
-
2003
- 2003-11-27 NZ NZ540103A patent/NZ540103A/en unknown
- 2003-11-27 RU RU2005120390/13A patent/RU2330069C2/ru not_active IP Right Cessation
- 2003-11-27 CN CNA2003801044327A patent/CN1717493A/zh active Pending
- 2003-11-27 CA CA002507641A patent/CA2507641A1/en not_active Abandoned
- 2003-11-27 WO PCT/JP2003/015170 patent/WO2004050890A1/ja active Application Filing
- 2003-11-27 EP EP03775924A patent/EP1580278A4/en not_active Withdrawn
- 2003-11-27 MX MXPA05005672A patent/MXPA05005672A/es active IP Right Grant
- 2003-11-27 KR KR1020057009524A patent/KR20050086873A/ko not_active Application Discontinuation
- 2003-11-27 BR BR0316746-1A patent/BR0316746A/pt not_active IP Right Cessation
- 2003-11-27 US US10/532,412 patent/US7745198B2/en not_active Expired - Fee Related
- 2003-11-27 AU AU2003284469A patent/AU2003284469B2/en not_active Ceased
- 2003-11-27 JP JP2004556846A patent/JP4439401B2/ja not_active Expired - Fee Related
-
2005
- 2005-05-27 NO NO20052568A patent/NO20052568L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050086873A (ko) | 2005-08-30 |
| NO20052568L (no) | 2005-06-29 |
| CN1717493A (zh) | 2006-01-04 |
| CA2507641A1 (en) | 2004-06-17 |
| WO2004050890A1 (ja) | 2004-06-17 |
| EP1580278A1 (en) | 2005-09-28 |
| MXPA05005672A (es) | 2005-08-16 |
| NO20052568D0 (no) | 2005-05-27 |
| RU2330069C2 (ru) | 2008-07-27 |
| AU2003284469B2 (en) | 2008-02-21 |
| AU2003284469A1 (en) | 2004-06-23 |
| NZ540103A (en) | 2007-05-31 |
| JP4439401B2 (ja) | 2010-03-24 |
| JPWO2004050890A1 (ja) | 2006-03-30 |
| BR0316746A (pt) | 2005-10-18 |
| EP1580278A4 (en) | 2010-08-25 |
| US20060141589A1 (en) | 2006-06-29 |
| US7745198B2 (en) | 2010-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20101128 |