RU2005119190A - Композиция, содержащая nadh/nadph - Google Patents
Композиция, содержащая nadh/nadph Download PDFInfo
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- RU2005119190A RU2005119190A RU2005119190/15A RU2005119190A RU2005119190A RU 2005119190 A RU2005119190 A RU 2005119190A RU 2005119190/15 A RU2005119190/15 A RU 2005119190/15A RU 2005119190 A RU2005119190 A RU 2005119190A RU 2005119190 A RU2005119190 A RU 2005119190A
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- composition according
- antioxidant
- oxygen
- composition
- insulating substance
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- 239000000203 mixture Substances 0.000 title claims 17
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 title claims 4
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 title claims 3
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 title claims 2
- 239000003963 antioxidant agent Substances 0.000 claims abstract 15
- 230000003078 antioxidant effect Effects 0.000 claims abstract 12
- 238000000034 method Methods 0.000 claims abstract 4
- 235000006708 antioxidants Nutrition 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- YPZRHBJKEMOYQH-UYBVJOGSSA-N FADH2 Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(NC(=O)NC2=O)=C2NC2=C1C=C(C)C(C)=C2 YPZRHBJKEMOYQH-UYBVJOGSSA-N 0.000 claims 2
- YTNIXZGTHTVJBW-SCRDCRAPSA-N FMNH2 Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2NC2=C1NC(=O)NC2=O YTNIXZGTHTVJBW-SCRDCRAPSA-N 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 239000008298 dragée Substances 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 239000011261 inert gas Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 108010074122 Ferredoxins Proteins 0.000 claims 1
- BOPGDPNILDQYTO-NNYOXOHSSA-L NADH(2-) Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-L 0.000 claims 1
- 229930002875 chlorophyll Natural products 0.000 claims 1
- 235000019804 chlorophyll Nutrition 0.000 claims 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical group C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 claims 1
- 239000011714 flavin adenine dinucleotide Substances 0.000 claims 1
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims 1
- 229940013640 flavin mononucleotide Drugs 0.000 claims 1
- 239000011768 flavin mononucleotide Substances 0.000 claims 1
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 claims 1
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 claims 1
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 230000010627 oxidative phosphorylation Effects 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 229930003802 tocotrienol Natural products 0.000 claims 1
- 239000011731 tocotrienol Substances 0.000 claims 1
- 235000019148 tocotrienols Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000003019 stabilising effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (16)
1. Композиция, отличающаяся тем, что она содержит, по меньшей мере, один изолированный оздоровительный антиоксидант А с редокспотенциалом менее -180 мВ, выбираемый из группы, состоящей из никотинамид-аденин-динуклеотида, восстановленного (NADH), никотинамид-аденин-динуклеотидфосфата, восстановленного (NADPH), флавинаденин-динуклеотида, восстановленного (FADH2), флавин-мононуклеотида, восстановленного FMNH2, FADH, и FMNH, и, по меньшей мере, один изолированный антиоксидант В, стабилизирующий антиоксидант А, со стандартным редокспотенциалом, который ниже стандартного редокспотенциала антиоксиданта А, причем антиоксидант В представляет собой хлорофилл и/или восстановленный ферредоксин.
2. Композиция по п.1, отличающаяся тем, что она содержит дополнительно вещество, изолирующее кислород.
3. Композиция по п.2, отличающаяся тем, что изолирующим кислород веществом является маслянистое вещество.
4. Композиция по п.3, отличающаяся тем, что изолирующим кислород веществом является маслянистое вещество с содержанием, по меньшей мере, одного дополнительного антиоксиданта С.
5. Композиция по п.4, отличающаяся тем, что изолирующее кислород вещество содержит витамин Е в качестве антиоксиданта С.
6. Композиция по п.5, отличающаяся тем, что витамин Е содержит токотриенол в качестве антиоксиданта С.
7. Композиция по любому из пп.1-6, отличающаяся тем, что антиоксиданта А и В применяются в соотношении от 10:1 до 1:10.
8. Композиция по п.7, отличающаяся тем, что антиоксиданты А и В применяются в соотношении от 3:1 до 1:3.
9. Композиция по п.1, отличающаяся тем, что она содержит дополнительно одно или несколько вспомогательных веществ.
10. Применение композиции по любому из пп.1-9 в качестве пищевой добавки.
11. Применение композиции по любому из пп.1-9 в качестве лекарственного средства.
12. Применение композиции по любому из пп.1-9 для получения средства, выбираемого из группы, состоящей из средства для повышения окислительного фосфорилирования, средства для повышения позновательных, умственных и двигательных способностей, средства для повышения способности печени к синтезу и выведению ядов, средства для лечения утомляемости, пассивности, нарушений либидо и потенции, депрессивных состояний, ослабления способности к обучению и концентрации внимания.
13. Композиция по п.1, отличающаяся тем, что она выпускается в виде таблеток, жидкости, капсул, драже, сиропа, лосьона, крема или порошка.
14. Способ получения композиции по любому из пп.1-9, отличающийся тем, что смешивают вместе антиоксиданты А и В и при необходимости изолирующее кислород вещество и при необходимости композицию перерабатывают в таблетки, жидкость, капсулы, драже, лосьон, крем или порошок.
15. Способ по п.14, отличающийся тем, что антиоксиданты А и В и при необходимости изолирующее кислород вещество смешивают между собой в атмосфере инертного газа.
16. Способ по п.14 или 15, отличающийся тем, что композиция перерабатывается в атмосфере инертного газа.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0173402A AT502435B1 (de) | 2002-11-19 | 2002-11-19 | Pharmazeutische zusammensetzung umfassend ein wasserstoffübertragendes coenzym und chlorophyll |
| ATA1734/2002 | 2002-11-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005119190A true RU2005119190A (ru) | 2005-11-20 |
| RU2338540C2 RU2338540C2 (ru) | 2008-11-20 |
Family
ID=32315086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005119190/15A RU2338540C2 (ru) | 2002-11-19 | 2003-11-19 | Композиция, содержащая nadh/nadph |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7255813B2 (ru) |
| EP (1) | EP1562613B1 (ru) |
| JP (2) | JP2006512320A (ru) |
| CN (1) | CN1713916A (ru) |
| AT (2) | AT502435B1 (ru) |
| AU (1) | AU2003287740A1 (ru) |
| CA (1) | CA2503860C (ru) |
| DE (1) | DE50309383D1 (ru) |
| DK (1) | DK1562613T3 (ru) |
| ES (1) | ES2302957T3 (ru) |
| HR (1) | HRP20050573B1 (ru) |
| NO (1) | NO333911B1 (ru) |
| PL (1) | PL214006B1 (ru) |
| PT (1) | PT1562613E (ru) |
| RS (1) | RS51606B (ru) |
| RU (1) | RU2338540C2 (ru) |
| SI (1) | SI1562613T1 (ru) |
| WO (1) | WO2004045626A1 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT502435B1 (de) * | 2002-11-19 | 2008-01-15 | Oekopharm Forschungs Und Entwi | Pharmazeutische zusammensetzung umfassend ein wasserstoffübertragendes coenzym und chlorophyll |
| JP5843448B2 (ja) * | 2011-02-08 | 2016-01-13 | 新日本製薬 株式会社 | 緑茶抽出液の製造方法、食品の製造方法、飲料の製造方法、洗浄剤の製造方法及び抗菌剤の製造方法 |
| JP6288757B2 (ja) * | 2013-08-23 | 2018-03-07 | 京都府公立大学法人 | 運動機能性向上剤 |
| CN104306390A (zh) * | 2014-10-23 | 2015-01-28 | 苏州人本药业有限公司 | 还原型辅酶ⅱ的用途 |
| JP6129395B1 (ja) * | 2016-10-29 | 2017-05-17 | 誠一 荒木 | ミトコンドリア活性化に起因した血管内皮細胞保護回復用還元型ビタミンｂ２製剤 |
| WO2018148930A1 (zh) * | 2017-02-17 | 2018-08-23 | 纯菁生物科技（美国）有限公司 | Nadh或者fadh2在癌症病人的营养干预上的应用 |
| CN107213159B (zh) * | 2017-06-05 | 2020-06-23 | 苏州人本药业有限公司 | Nadph在制备抗焦虑药物中的应用 |
| CN107213160B (zh) * | 2017-06-06 | 2020-07-24 | 重庆纳德福实业集团有限公司 | Nadph在拮抗药物致线粒体毒性中的应用 |
| CN109432181A (zh) * | 2018-12-19 | 2019-03-08 | 泓博元生命科技（深圳）有限公司 | 缓解抑郁症的组合物及其制备方法与应用 |
| CN109620863A (zh) * | 2018-12-19 | 2019-04-16 | 泓博元生命科技（深圳）有限公司 | 一种缓解抑郁症的组合物及其制备方法与应用 |
| CN110339179A (zh) * | 2019-05-29 | 2019-10-18 | 泓博元生命科技（深圳）有限公司 | 含nadh或nadph的软胶囊及其制备方法和应用 |
| CN112384080A (zh) * | 2019-06-04 | 2021-02-19 | 邦泰合盛生物科技（深圳）有限公司 | 辅酶膳食营养补充剂及其制备方法和应用 |
| CN110237089A (zh) * | 2019-06-19 | 2019-09-17 | 泓博元生命科技（深圳）有限公司 | Nadh和/或nmn防治男性勃起功能障碍的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3934369A (en) * | 1974-04-23 | 1976-01-27 | University Of Illinois Foundation | Vitro net bioxynthesis of chlorophyll and grana |
| JPS59216824A (ja) * | 1983-05-24 | 1984-12-06 | Yoshiro Shimura | 健康増進剤 |
| JPS60132987A (ja) * | 1983-12-22 | 1985-07-16 | Riken Vitamin Co Ltd | クロロフイル組成物 |
| JPS60221749A (ja) * | 1984-04-18 | 1985-11-06 | Mitsubishi Electric Corp | 光記録媒体 |
| JPS614798A (ja) * | 1984-06-19 | 1986-01-10 | 東亞合成株式会社 | 高度不飽和脂肪酸組成物 |
| JPS63237584A (ja) * | 1987-03-26 | 1988-10-04 | Mitsubishi Electric Corp | 光応答性スイツチ素子 |
| IL95393A0 (en) * | 1989-08-18 | 1991-06-30 | John Morris Co | Odor-masked and stabilized compositions for treating keratinous tissue,skin conditions,and promoting wound healing |
| US5760206A (en) * | 1992-12-11 | 1998-06-02 | E. I. Du Pont De Nemours And Company | Nucleotide sequence of soybean stearoyl-ACP desaturase gene |
| US5332727A (en) * | 1993-04-29 | 1994-07-26 | Birkmayer U.S.A. | Stable, ingestable and absorbable NADH and NADPH therapeutic compositions |
| CA2167104A1 (en) * | 1995-01-17 | 1996-07-18 | Joerg G.D. Birkmayer | Nadh and nadph therapeutic agents for nasal, sublingual, rectal and dermal administration |
| US5777190A (en) * | 1997-05-29 | 1998-07-07 | Battelle Memorial Institute | Method of controlled reduction of nitroaromatics by enzymatic reaction with oxygen sensitive nitroreductase enzymes |
| US6133227A (en) * | 1997-06-23 | 2000-10-17 | The Procter & Gamble Company | Enzymatic detergent compositions |
| JPH11292737A (ja) * | 1998-02-16 | 1999-10-26 | Shiseido Co Ltd | 免疫賦活剤 |
| US6124242A (en) * | 1998-06-26 | 2000-09-26 | Basf Aktiengesellschaft | Herbicidal compositions and processes based on ferrodoxin:NADP reductase inhibitors |
| RU2143212C1 (ru) * | 1998-07-29 | 1999-12-27 | Общество с ограниченной ответственностью "Фитолон" | Биологически активная добавка |
| JP2001061498A (ja) * | 1999-08-31 | 2001-03-13 | Oriental Yeast Co Ltd | 還元型補酵素溶液 |
| IT1318565B1 (it) * | 2000-06-09 | 2003-08-27 | World Pharma Tech Ltd | Integratore alimentare proenergetico a base di nadh octocosanolo evitamina e. |
| AT502435B1 (de) * | 2002-11-19 | 2008-01-15 | Oekopharm Forschungs Und Entwi | Pharmazeutische zusammensetzung umfassend ein wasserstoffübertragendes coenzym und chlorophyll |
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2002
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- 2003-11-19 JP JP2004552258A patent/JP2006512320A/ja active Pending
- 2003-11-19 EP EP03779534A patent/EP1562613B1/de not_active Expired - Lifetime
- 2003-11-19 PT PT03779534T patent/PT1562613E/pt unknown
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- 2003-11-19 RU RU2005119190/15A patent/RU2338540C2/ru active IP Right Revival
- 2003-11-19 DK DK03779534T patent/DK1562613T3/da active
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- 2003-11-19 DE DE50309383T patent/DE50309383D1/de not_active Expired - Lifetime
- 2003-11-19 RS YU20050376A patent/RS51606B/sr unknown
- 2003-11-19 SI SI200331205T patent/SI1562613T1/sl unknown
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- 2003-11-19 US US10/535,330 patent/US7255813B2/en not_active Expired - Lifetime
- 2003-11-19 CN CNA2003801035544A patent/CN1713916A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| PL377022A1 (pl) | 2006-01-23 |
| AT502435A1 (de) | 2007-03-15 |
| CN1713916A (zh) | 2005-12-28 |
| PL214006B1 (pl) | 2013-06-28 |
| HRP20050573B1 (hr) | 2013-10-11 |
| ES2302957T3 (es) | 2008-08-01 |
| NO333911B1 (no) | 2013-10-21 |
| NO20052839L (no) | 2005-06-10 |
| EP1562613B1 (de) | 2008-03-12 |
| PT1562613E (pt) | 2008-06-06 |
| US20060011891A1 (en) | 2006-01-19 |
| WO2004045626A1 (de) | 2004-06-03 |
| EP1562613A1 (de) | 2005-08-17 |
| JP2006512320A (ja) | 2006-04-13 |
| RS20050376A (en) | 2007-12-31 |
| RU2338540C2 (ru) | 2008-11-20 |
| JP2011144186A (ja) | 2011-07-28 |
| CA2503860C (en) | 2011-09-13 |
| AT502435B1 (de) | 2008-01-15 |
| SI1562613T1 (sl) | 2008-08-31 |
| DK1562613T3 (da) | 2008-07-14 |
| ATE388714T1 (de) | 2008-03-15 |
| RS51606B (sr) | 2011-08-31 |
| AU2003287740A1 (en) | 2004-06-15 |
| HRP20050573A2 (en) | 2006-07-31 |
| DE50309383D1 (de) | 2008-04-24 |
| CA2503860A1 (en) | 2004-06-03 |
| US7255813B2 (en) | 2007-08-14 |
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