RU2005113997A - Способы лечения послеоперационной боли введением антагониста фактора роста нервов и композиции, содержащие фактор роста нервов - Google Patents
Способы лечения послеоперационной боли введением антагониста фактора роста нервов и композиции, содержащие фактор роста нервов Download PDFInfo
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- RU2005113997A RU2005113997A RU2005113997/14A RU2005113997A RU2005113997A RU 2005113997 A RU2005113997 A RU 2005113997A RU 2005113997/14 A RU2005113997/14 A RU 2005113997/14A RU 2005113997 A RU2005113997 A RU 2005113997A RU 2005113997 A RU2005113997 A RU 2005113997A
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- ngf
- antagonist
- antibody
- growth factor
- postoperative pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Surgery (AREA)
- Mycology (AREA)
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- Rheumatology (AREA)
- Cell Biology (AREA)
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- Neurosurgery (AREA)
- Food Science & Technology (AREA)
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- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Способ лечения послеоперационной боли у индивидуума, включающий введение индивидууму эффективного количества антагониста фактора роста нервов (NGF), причем антагонист NGF отличается от иммуноадгезина TrkA.
2. Способ по п.1, где подавляется или облегчается боль в покое.
3. Способ по п.1, где подавляется или облегчается механически вызванная боль.
4. Способ по п.1, где антагонист NGF представляет собой антагонистическое антитело против NGF.
5. Способ по п.4, где антагонистическое антитело против NGF представляет собой человеческое антитело.
6. Способ по п.4, где антагонистическое антитело против NGF представляет собой гуманизированное антитело.
7. Способ по п.4, где антагонистическое антитело против NGF связывает человеческий NGF.
8. Способ по п.7, где антагонистическое антитело против NGF связывает человеческий NGF с аффинитетом связывания приблизительно 0,1 нМ или менее чем приблизительно 0,1 нМ.
9. Способ по п.1, где, кроме того, антагонист NGF отличается от антитела против NGF.
10. Способ по п.1, где антагонист NGF представляет собой ингибитор киназы, способный ингибировать нисходящую передачу сигналов киназы, связанную с активностью рецепторов NGF.
11. Способ по п.10, где ингибитор киназы представляет собой К252а.
12. Фармацевтическая композиция для лечения послеоперационной боли, содержащая фармацевтически эффективное количество антагонистического антитела против NGF и фармацевтически приемлемый носитель.
13. Набор для лечения послеоперационной боли, включающий антагонист NGF и инструкции по применению антагониста NGF для лечения послеоперационной боли, где антагонист NGF отличается от иммуноадгезина TrkA.
14. Набор по п.13, в котором, кроме того, антагонист NGF представляет собой антагонистическое антитело против NGF.
15. Набор по п.13, в котором, кроме того, антагонист NGF отличается от антитела против NGF.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41723702P | 2002-10-08 | 2002-10-08 | |
| US60/417,237 | 2002-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005113997A true RU2005113997A (ru) | 2005-10-27 |
| RU2338555C2 RU2338555C2 (ru) | 2008-11-20 |
Family
ID=32093988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005113997/14A RU2338555C2 (ru) | 2002-10-08 | 2003-10-08 | Способы лечения послеоперационной боли введением антагониста фактора роста нервов и композиции, содержащие фактор роста нервов |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7252822B2 (ru) |
| EP (1) | EP1556083B1 (ru) |
| JP (1) | JP4584713B2 (ru) |
| KR (1) | KR101080716B1 (ru) |
| CN (1) | CN1723039B (ru) |
| AT (1) | ATE497391T1 (ru) |
| AU (1) | AU2003285864C1 (ru) |
| BR (1) | BR0315164A (ru) |
| CA (1) | CA2501626A1 (ru) |
| DE (1) | DE60335957D1 (ru) |
| DK (1) | DK1556083T3 (ru) |
| ES (1) | ES2357948T3 (ru) |
| HK (1) | HK1074173A1 (ru) |
| IL (1) | IL167654A (ru) |
| MX (1) | MXPA05003502A (ru) |
| NO (1) | NO20052219L (ru) |
| NZ (1) | NZ539101A (ru) |
| PL (1) | PL211654B1 (ru) |
| PT (1) | PT1556083E (ru) |
| RU (1) | RU2338555C2 (ru) |
| SI (1) | SI1556083T1 (ru) |
| UA (1) | UA89610C2 (ru) |
| WO (1) | WO2004032870A2 (ru) |
| ZA (1) | ZA200502612B (ru) |
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