RU2005111243A - Производные тетрагидропиримидин-2-она и их применение - Google Patents
Производные тетрагидропиримидин-2-она и их применение Download PDFInfo
- Publication number
- RU2005111243A RU2005111243A RU2005111243/04A RU2005111243A RU2005111243A RU 2005111243 A RU2005111243 A RU 2005111243A RU 2005111243/04 A RU2005111243/04 A RU 2005111243/04A RU 2005111243 A RU2005111243 A RU 2005111243A RU 2005111243 A RU2005111243 A RU 2005111243A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/204—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/205—Heterocyclic compounds
- A23L27/2054—Heterocyclic compounds having nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
Claims (19)
2. Применение по п.1, в котором Y представляет собой гидрокси.
3. Применение по п.1, в котором Y представляет собой галогеналкил.
4. Применение по п.3, в котором Y представляет собой трифторметил.
5. Применение по любому из предшествующих пунктов, в котором Х представляет собой атом хлора.
6. Применение по п.1, где соединение выбрано из 1-(2'-гидроксифенил)-4-(3"-хлорфенил)-1,2,3,6-тетрагидропиримидин-2-она, 1-(2'-гидроксифенил)-4-(3"-метоксифенил)-1,2,3,6-тетрагидропиримидин-2-она, 1-(2'-трифторметилфенил)-4-(3"-нитрофенил)-1,2,3,6-тетрагидропиримидин-2-она и 1-(2'-гидроксифенил)-4-(3"-метилфенил)-1,2,3,6-тетрагидропиримидин-2-она.
7. Применение по п.1, где соединение представляет собой 1-(2'-гидроксифенил)-4-(3"-хлорфенил)-1,2,3,6-тетрагидропиримидин-2-он.
9. Композиция по п.8, в которой соединение формулы (V) является таким, как определено в любом из пп.2-7.
10. Композиция жидкости для полоскания рта, включающая соединение формулы (V):
в которой Х независимо выбран из нитро, галогена, алкила и алкокси; и Y независимо выбран из гидрокси и галогеналкила; при условии, что когда Y представляет собой гидроксил, Х не является нитро; для создания ощущения прохлады.
11. Композиция по п.10, в которой соединение формулы (V) является таким, как определено в любом из пп.2-7.
13. Композиция по п.12, в которой соединение формулы (V) является таким, как определено в любом из пп.2-7.
14. Композиция по п.12 или 13, где пищевым продуктом является напиток.
15. Композиция по п.12 или 13, где пищевым продуктом является мороженое.
16. Композиция по п.12 или 13, где пищевым продуктом является паста.
17. Композиция по п.12 или 13, где пищевым продуктом является кондитерское изделие.
18. Композиция по п.12, где соединение формулы (V) присутствует в количестве от 0,0001 до 3 вес.%.
19. Композиция по п.18, где соединение формулы (V) присутствует в количестве от 0,0003 до 0,1 вес.%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0221697.6A GB0221697D0 (en) | 2002-09-18 | 2002-09-18 | Novel compouds and their uses |
GB0221697.6 | 2002-09-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2005111243A true RU2005111243A (ru) | 2005-10-27 |
RU2334741C2 RU2334741C2 (ru) | 2008-09-27 |
Family
ID=9944340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005111243/04A RU2334741C2 (ru) | 2002-09-18 | 2003-08-26 | Производные тетрагидропиримидин-2-она и их применение |
Country Status (10)
Country | Link |
---|---|
US (2) | US7045624B2 (ru) |
EP (1) | EP1546114B1 (ru) |
JP (1) | JP4959939B2 (ru) |
CN (1) | CN100506800C (ru) |
AU (1) | AU2003266321A1 (ru) |
BR (1) | BR0314447A (ru) |
GB (1) | GB0221697D0 (ru) |
RU (1) | RU2334741C2 (ru) |
WO (1) | WO2004026840A1 (ru) |
ZA (1) | ZA200502122B (ru) |
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US3821221A (en) * | 1970-08-25 | 1974-06-28 | Delmar Chem | 1,2,3,6-tetrahydropyrimidine-2-one compounds and processes for makingthem |
JPH0887120A (ja) * | 1994-09-19 | 1996-04-02 | Fuji Electric Co Ltd | 電子写真用感光体 |
JP4558479B2 (ja) * | 2002-05-02 | 2010-10-06 | クラグモント ファーマスーティカルズ エルエルシー | 治療用1,2,3,6−テトラヒドロピリミジン−2−オン組成物及びそれを用いた方法 |
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- 2003-08-26 RU RU2005111243/04A patent/RU2334741C2/ru not_active IP Right Cessation
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BR0314447A (pt) | 2005-07-19 |
ZA200502122B (en) | 2006-05-31 |
EP1546114B1 (en) | 2015-09-30 |
CN100506800C (zh) | 2009-07-01 |
JP4959939B2 (ja) | 2012-06-27 |
JP2006512294A (ja) | 2006-04-13 |
US20060106217A1 (en) | 2006-05-18 |
GB0221697D0 (en) | 2002-10-30 |
WO2004026840A1 (en) | 2004-04-01 |
EP1546114A1 (en) | 2005-06-29 |
US20040067970A1 (en) | 2004-04-08 |
AU2003266321A1 (en) | 2004-04-08 |
RU2334741C2 (ru) | 2008-09-27 |
US7045624B2 (en) | 2006-05-16 |
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