RU2005102094A - Ингибиторы каспазы и их применение - Google Patents
Ингибиторы каспазы и их применение Download PDFInfo
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- RU2005102094A RU2005102094A RU2005102094/04A RU2005102094A RU2005102094A RU 2005102094 A RU2005102094 A RU 2005102094A RU 2005102094/04 A RU2005102094/04 A RU 2005102094/04A RU 2005102094 A RU2005102094 A RU 2005102094A RU 2005102094 A RU2005102094 A RU 2005102094A
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- compound according
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- 102000011727 Caspases Human genes 0.000 title claims 2
- 108010076667 Caspases Proteins 0.000 title claims 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 39
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 206010052779 Transplant rejections Diseases 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 210000004351 coronary vessel Anatomy 0.000 claims 5
- 238000009169 immunotherapy Methods 0.000 claims 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- -1 trifluorophenoxy Chemical group 0.000 claims 4
- 208000020084 Bone disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 210000000278 spinal cord Anatomy 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010055128 Autoimmune neutropenia Diseases 0.000 claims 2
- 208000004429 Bacillary Dysentery Diseases 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 206010019773 Hepatitis G Diseases 0.000 claims 2
- 206010019755 Hepatitis chronic active Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
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- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
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- 206010040047 Sepsis Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
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- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
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- 230000002757 inflammatory effect Effects 0.000 claims 2
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- 201000008482 osteoarthritis Diseases 0.000 claims 2
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- 230000002062 proliferating effect Effects 0.000 claims 2
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- 208000035473 Communicable disease Diseases 0.000 claims 1
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- 208000001490 Dengue Diseases 0.000 claims 1
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- 206010014596 Encephalitis Japanese B Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102100039898 Interleukin-18 Human genes 0.000 claims 1
- 201000005807 Japanese encephalitis Diseases 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 claims 1
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- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 150000001414 amino alcohols Chemical class 0.000 claims 1
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- 239000010836 blood and blood product Substances 0.000 claims 1
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- 125000006239 protecting group Chemical group 0.000 claims 1
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- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
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- 125000004360 trifluorophenyl group Chemical group 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39259202P | 2002-06-28 | 2002-06-28 | |
| US60/392,592 | 2002-06-28 | ||
| US43507302P | 2002-12-20 | 2002-12-20 | |
| US60/435,073 | 2002-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005102094A true RU2005102094A (ru) | 2006-02-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005102094/04A RU2005102094A (ru) | 2002-06-28 | 2003-06-27 | Ингибиторы каспазы и их применение |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7553852B2 (enExample) |
| EP (1) | EP1539701A1 (enExample) |
| JP (2) | JP4616643B2 (enExample) |
| KR (1) | KR20050013260A (enExample) |
| CN (1) | CN100503572C (enExample) |
| AR (1) | AR040350A1 (enExample) |
| AU (1) | AU2003248758A1 (enExample) |
| BR (1) | BR0312232A (enExample) |
| CA (1) | CA2493646A1 (enExample) |
| IL (1) | IL165986A0 (enExample) |
| MX (1) | MXPA05000069A (enExample) |
| NO (1) | NO20050851L (enExample) |
| NZ (1) | NZ537807A (enExample) |
| PE (1) | PE20040728A1 (enExample) |
| PL (1) | PL374598A1 (enExample) |
| RU (1) | RU2005102094A (enExample) |
| TW (1) | TW200404783A (enExample) |
| UY (1) | UY27872A1 (enExample) |
| WO (1) | WO2004002961A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2846274C2 (ru) * | 2022-01-04 | 2025-09-03 | Инново Терапьютикс Инк. | Новые соединения, производные изоиндолинона, в качестве ингибиторов каспазы |
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| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| BR0312232A (pt) | 2002-06-28 | 2005-05-10 | Vertex Pharma | Inibidores de caspases e seus usos |
| JP4675628B2 (ja) * | 2002-12-20 | 2011-04-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | ４−オキソ−３−（１−オキソ−１ｈ−イソキノリン−２−イルアセチルアミノ）−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用 |
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| CA2559303C (en) | 2004-03-12 | 2013-09-10 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| CN102362867A (zh) | 2004-05-15 | 2012-02-29 | 沃泰克斯药物股份有限公司 | 使用ice抑制剂治疗癫痫发作 |
| EP1778221A2 (en) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
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| EP1796660B1 (en) | 2004-09-17 | 2016-11-23 | BioMAS Ltd. | Use of ammonium trichloro(dioxyethylene-o,o')tellurate (as101) for the inhibition of interleukin-1beta-converting enzyme |
| CN101098855B (zh) * | 2004-11-24 | 2012-06-06 | 沃泰克斯药物股份有限公司 | 3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
| CA2593005A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof |
| EP1898940A4 (en) * | 2005-06-07 | 2010-05-26 | Univ Pennsylvania | Alpha2beta1 / GPIa IIA INTEGRIN INHIBITORS |
| US8987306B2 (en) * | 2005-06-07 | 2015-03-24 | The Trustees Of The University Of Pennsylvania | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold |
| JP2009502922A (ja) * | 2005-07-28 | 2009-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤プロドラッグ |
| WO2007027742A2 (en) * | 2005-08-31 | 2007-03-08 | The Trustees Of The University Of Pennsylvania | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS |
| WO2008016973A1 (en) | 2006-08-01 | 2008-02-07 | Families Of Spinal Muscular Atrophy | 2,4-diaminoquinazolines for spinal muscular atrophy |
| ATE523493T1 (de) * | 2006-09-11 | 2011-09-15 | Organon Nv | 2-(1-oxo-1h-isochinolin-2-yl) acetamid-derivate |
| WO2008073388A2 (en) * | 2006-12-11 | 2008-06-19 | Mutual Pharmaceutical Company, Inc. | Alfuzosin formulations, methods of making and methods of use |
| US20100092556A1 (en) * | 2006-12-11 | 2010-04-15 | Kristin Arnold | Alfuzosin formulations, methods of making, and methods of use |
| FR2923160B1 (fr) | 2007-11-02 | 2013-07-26 | Pasteur Institut | Composes destines a prevenir ou traiter une infection virale. |
| EP2635906A4 (en) | 2010-11-05 | 2014-04-02 | Univ Brandeis | Ice inhibiting compounds and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| CA2862084C (en) | 2012-01-26 | 2021-05-11 | Ptc Therapeutics, Inc. | 1h-isochromen-1-one derivatives and compositions thereof for treating spinal muscular atrophy |
| WO2015175381A1 (en) | 2014-05-12 | 2015-11-19 | Conatus Pharmaceuticals, Inc. | Treatment of the complications of chronic liver disease with caspase inhibitors |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
| EP3935042B1 (en) * | 2019-03-07 | 2024-08-28 | NOBO Medicine Inc. | Caspase inhibitors and methods of use thereof |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
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| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| DD232699A1 (de) * | 1983-11-18 | 1986-02-05 | Adw Ddr | Verfahren zur herstellung von chinazolin-4-on-3-alkansaeuren und deren estern |
| FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
| US5714484A (en) | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
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| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
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| KR20000049047A (ko) | 1996-10-11 | 2000-07-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 술폰아미드 인터루킨-1β 전환 효소 억제제 |
| WO1998018781A2 (en) | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| ES2296625T3 (es) | 1999-05-07 | 2008-05-01 | Encysive Pharmaceuticals, Inc | Derivados del acido carboxilico que inhiben el enlace de las integrinas con sus receptores. |
| SI20876B (sl) | 1999-05-07 | 2009-08-31 | Texas Biotechnology Corp | Derivati propanojske kisline, ki inhibirajo vezavo integrinov na njihove receptorje |
| AR026748A1 (es) | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| AU2002348533A1 (en) * | 2001-10-09 | 2003-05-26 | Vertex Pharmaceuticals Incorporated | Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof |
| AU2003211052A1 (en) * | 2002-02-11 | 2003-09-04 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| AU2003225088A1 (en) | 2002-04-19 | 2003-11-03 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
| BR0312232A (pt) | 2002-06-28 | 2005-05-10 | Vertex Pharma | Inibidores de caspases e seus usos |
| JP4675628B2 (ja) | 2002-12-20 | 2011-04-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | ４−オキソ−３−（１−オキソ−１ｈ−イソキノリン−２−イルアセチルアミノ）−ペンタン酸のエステル誘導体およびアミド誘導体、ならびにカスパーゼインヒビターとしてのそれらの使用 |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| CN101098855B (zh) | 2004-11-24 | 2012-06-06 | 沃泰克斯药物股份有限公司 | 3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
-
2003
- 2003-06-27 BR BR0312232-8A patent/BR0312232A/pt not_active IP Right Cessation
- 2003-06-27 RU RU2005102094/04A patent/RU2005102094A/ru unknown
- 2003-06-27 NZ NZ537807A patent/NZ537807A/en unknown
- 2003-06-27 KR KR10-2004-7021300A patent/KR20050013260A/ko not_active Ceased
- 2003-06-27 AU AU2003248758A patent/AU2003248758A1/en not_active Abandoned
- 2003-06-27 PE PE2003000653A patent/PE20040728A1/es not_active Application Discontinuation
- 2003-06-27 US US10/609,147 patent/US7553852B2/en not_active Expired - Fee Related
- 2003-06-27 TW TW092117681A patent/TW200404783A/zh unknown
- 2003-06-27 AR ARP030102352A patent/AR040350A1/es unknown
- 2003-06-27 EP EP03762231A patent/EP1539701A1/en not_active Withdrawn
- 2003-06-27 JP JP2004518103A patent/JP4616643B2/ja not_active Expired - Fee Related
- 2003-06-27 CA CA002493646A patent/CA2493646A1/en not_active Abandoned
- 2003-06-27 MX MXPA05000069A patent/MXPA05000069A/es unknown
- 2003-06-27 IL IL16598603A patent/IL165986A0/xx unknown
- 2003-06-27 PL PL03374598A patent/PL374598A1/xx not_active Application Discontinuation
- 2003-06-27 WO PCT/US2003/020557 patent/WO2004002961A1/en not_active Ceased
- 2003-06-27 CN CNB038187930A patent/CN100503572C/zh not_active Expired - Fee Related
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2005
- 2005-02-17 NO NO20050851A patent/NO20050851L/no not_active Application Discontinuation
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2009
- 2009-05-12 US US12/464,380 patent/US8129381B2/en not_active Expired - Fee Related
-
2010
- 2010-02-04 JP JP2010023632A patent/JP2010143942A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2846274C2 (ru) * | 2022-01-04 | 2025-09-03 | Инново Терапьютикс Инк. | Новые соединения, производные изоиндолинона, в качестве ингибиторов каспазы |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1539701A1 (en) | 2005-06-15 |
| IL165986A0 (en) | 2006-01-15 |
| NZ537807A (en) | 2007-05-31 |
| JP2010143942A (ja) | 2010-07-01 |
| AR040350A1 (es) | 2005-03-30 |
| AU2003248758A1 (en) | 2004-01-19 |
| US20040072850A1 (en) | 2004-04-15 |
| CN1675184A (zh) | 2005-09-28 |
| JP2005533825A (ja) | 2005-11-10 |
| JP4616643B2 (ja) | 2011-01-19 |
| TW200404783A (en) | 2004-04-01 |
| US20090281128A1 (en) | 2009-11-12 |
| WO2004002961A1 (en) | 2004-01-08 |
| CN100503572C (zh) | 2009-06-24 |
| BR0312232A (pt) | 2005-05-10 |
| KR20050013260A (ko) | 2005-02-03 |
| UY27872A1 (es) | 2003-12-31 |
| NO20050851L (no) | 2005-03-29 |
| MXPA05000069A (es) | 2005-04-11 |
| PE20040728A1 (es) | 2004-10-23 |
| US8129381B2 (en) | 2012-03-06 |
| PL374598A1 (en) | 2005-10-31 |
| CA2493646A1 (en) | 2004-01-08 |
| US7553852B2 (en) | 2009-06-30 |
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