RU2004108122A - Сверхразветвленный амилопектин для применения в способах хирургического или терапевтического лечения млекопитающих, или в диагностических методах, особенно для применения в качестве объемного плазмозаменителя - Google Patents
Сверхразветвленный амилопектин для применения в способах хирургического или терапевтического лечения млекопитающих, или в диагностических методах, особенно для применения в качестве объемного плазмозаменителя Download PDFInfo
- Publication number
- RU2004108122A RU2004108122A RU2004108122/15A RU2004108122A RU2004108122A RU 2004108122 A RU2004108122 A RU 2004108122A RU 2004108122/15 A RU2004108122/15 A RU 2004108122/15A RU 2004108122 A RU2004108122 A RU 2004108122A RU 2004108122 A RU2004108122 A RU 2004108122A
- Authority
- RU
- Russia
- Prior art keywords
- methods
- application
- amylopectin
- mol
- hyperbranched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/20—Amylose or amylopectin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B35/00—Preparation of derivatives of amylopectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (7)
1. Сверхразветвленный амилопектин со средней степенью разветвленности, выраженной в мол.% ангидроглюкозы, несущей точки разветвления, составляющей от более 10 до 25 мол.%, и средневзвешенной молекулярной массой ММ в интервале от 40000 до 800000 Д, и его производные, для применения в способах хирургического или терапевтического лечения человека или животного, или в диагностических методах.
2. Сверхразветвленный амилопектин по п.1 в качестве объемного плазмозаменителя.
3. Сверхразветвленный амилопектин по п.1 для улучшения микроциркуляции.
4. Сверхразветвленный амилопектин по п.1 для облегчения седиментации при выделении клеток в связи с лейкаферезом.
5. Сверхразветвленный амилопектин по п.1 для низкотемпературного хранения компонентов крови, таких как эритроцитов или гранулоцитов.
6. Сверхразветвленный амилопектин по любому из предшествующих пунктов, средняя степень разветвленности которого находится в интервале от 11 до 16 мол.%, а молекулярная масса имеет значение от 90000 до 300000 Д.
7. Сверхразветвленный амилопектин по любому из пп.1-5, средняя степень разветвленности которого находится в интервале от 13 до 16 мол.%, а молекулярная масса имеет значение от 120000 до 250000 Д.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10141099 | 2001-08-22 | ||
| DE10141099.9 | 2001-08-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004108122A true RU2004108122A (ru) | 2005-03-27 |
| RU2303984C2 RU2303984C2 (ru) | 2007-08-10 |
Family
ID=7696220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004108122/15A RU2303984C2 (ru) | 2001-08-22 | 2002-08-06 | Сверхразветвленный амилопектин для применения в способах хирургического или терапевтического лечения млекопитающих, или в диагностических методах, особенно для применения в качестве объемного плазмозаменителя |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7393841B2 (ru) |
| EP (1) | EP1421120B1 (ru) |
| JP (1) | JP2005501930A (ru) |
| KR (1) | KR100898528B1 (ru) |
| CN (1) | CN100390203C (ru) |
| AT (1) | ATE360651T1 (ru) |
| AU (1) | AU2002325398B2 (ru) |
| CA (1) | CA2456507C (ru) |
| DE (2) | DE10235954A1 (ru) |
| DK (1) | DK1421120T3 (ru) |
| ES (1) | ES2283585T3 (ru) |
| HK (1) | HK1068356A1 (ru) |
| HU (1) | HUP0401188A3 (ru) |
| MX (1) | MXPA04001606A (ru) |
| PL (1) | PL209763B1 (ru) |
| PT (1) | PT1421120E (ru) |
| RO (1) | RO122279B1 (ru) |
| RS (1) | RS51420B (ru) |
| RU (1) | RU2303984C2 (ru) |
| WO (1) | WO2003018639A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2840612B1 (fr) * | 2002-06-06 | 2005-05-06 | Roquette Freres | Polymeres solubles de glucose hautement branches et leur procede d'obtention |
| DE10237442B4 (de) * | 2002-08-16 | 2004-08-19 | Fresenius Kabi Deutschland Gmbh | Hochverzweigte, niedrig substituierte Stärkeprodukte |
| DE10256558A1 (de) * | 2002-12-04 | 2004-09-16 | Supramol Parenteral Colloids Gmbh | Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe |
| CZ20033424A3 (cs) * | 2003-12-16 | 2005-08-17 | Parenteral, A. S. | Náhražka krevní plazmy, výchozí produkt a způsob výroby výchozího produktu pro náhražku lidské krevní plazmy |
| FR2864088B1 (fr) * | 2003-12-19 | 2006-04-28 | Roquette Freres | Polymeres solubles de glucose hautement branches |
| ATE540996T1 (de) | 2005-06-06 | 2012-01-15 | Univ British Columbia | Polymerbasierter serumalbumin-ersatzstoff |
| EP1943908A1 (en) * | 2006-12-29 | 2008-07-16 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Novel slowly digestible storage carbohydrate |
| CA2791416C (en) | 2010-03-01 | 2018-05-15 | The University Of British Columbia | Derivatized hyperbranched polyglycerols |
| KR20190064653A (ko) * | 2010-06-17 | 2019-06-10 | 가부시기가이샤하야시바라 | 풀루란 함유 분말과 그 제조방법 및 용도 |
| AR095937A1 (es) * | 2013-04-05 | 2015-11-25 | Acraf | Potenciador de la solubilidad en agua a base de glucógeno |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA928215A (en) | 1969-08-08 | 1973-06-12 | M. Brake Jon | Process for the cryogenic preservation of blood and erythrocytes and products produced thereby |
| US4125492A (en) | 1974-05-31 | 1978-11-14 | Pedro Cuatrecasas | Affinity chromatography of vibrio cholerae enterotoxin-ganglioside polysaccharide and the biological effects of ganglioside-containing soluble polymers |
| US4111199A (en) * | 1977-03-31 | 1978-09-05 | Isaac Djerassi | Method of collecting transfusable granulocytes by gravity leukopheresis |
| DE3029307A1 (de) | 1980-08-01 | 1982-03-04 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Haemoglobin enthaltendes blutersatzmittel |
| US4454161A (en) * | 1981-02-07 | 1984-06-12 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of branching enzyme, and a method for improving the qualities of food products therewith |
| DE3313600A1 (de) * | 1983-04-14 | 1984-10-18 | Laevosan-Gesellschaft mbH & Co. KG, Linz | Plasmastreckmittel auf staerkebasis und verfahren zu ihrer herstellung |
| NL8902128A (nl) * | 1989-08-23 | 1991-03-18 | Avebe Coop Verkoop Prod | Vertakkingsenzym en gebruik daarvan. |
| JP2896580B2 (ja) | 1989-08-25 | 1999-05-31 | チッソ株式会社 | アミロース―リゾチームハイブリッドと活性化糖およびその製造法 |
| DE19628705A1 (de) | 1996-07-08 | 1998-01-15 | Fresenius Ag | Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe |
| FR2783838B1 (fr) | 1998-09-25 | 2000-12-01 | Roquette Freres | Procede de preparation d'un melange d'enzymes de branchement de l'amidon extraites d'algues |
| AT409928B (de) | 1999-08-10 | 2002-12-27 | Tulln Zuckerforschung Gmbh | Plasmaexpander, blutverdünnungsmittel und kryoprotektor, hergestellt unter verwendung von amylopektin-kartoffelstärke |
| JP2001294601A (ja) * | 2000-04-11 | 2001-10-23 | Akita Prefecture | 高度分岐澱粉と該高度分岐澱粉の製造方法 |
| DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
-
2002
- 2002-08-06 ES ES02758435T patent/ES2283585T3/es not_active Expired - Lifetime
- 2002-08-06 PT PT02758435T patent/PT1421120E/pt unknown
- 2002-08-06 JP JP2003523498A patent/JP2005501930A/ja active Pending
- 2002-08-06 RU RU2004108122/15A patent/RU2303984C2/ru not_active IP Right Cessation
- 2002-08-06 AU AU2002325398A patent/AU2002325398B2/en not_active Ceased
- 2002-08-06 MX MXPA04001606A patent/MXPA04001606A/es active IP Right Grant
- 2002-08-06 AT AT02758435T patent/ATE360651T1/de active
- 2002-08-06 DE DE10235954A patent/DE10235954A1/de not_active Withdrawn
- 2002-08-06 WO PCT/EP2002/008757 patent/WO2003018639A1/de active IP Right Grant
- 2002-08-06 EP EP02758435A patent/EP1421120B1/de not_active Expired - Lifetime
- 2002-08-06 HU HU0401188A patent/HUP0401188A3/hu unknown
- 2002-08-06 DK DK02758435T patent/DK1421120T3/da active
- 2002-08-06 PL PL369363A patent/PL209763B1/pl not_active IP Right Cessation
- 2002-08-06 US US10/486,943 patent/US7393841B2/en not_active Expired - Fee Related
- 2002-08-06 RO ROA200400154A patent/RO122279B1/ro unknown
- 2002-08-06 KR KR10-2004-7002536A patent/KR100898528B1/ko not_active IP Right Cessation
- 2002-08-06 DE DE50210039T patent/DE50210039D1/de not_active Expired - Lifetime
- 2002-08-06 CN CNB028163540A patent/CN100390203C/zh not_active Expired - Fee Related
- 2002-08-06 CA CA2456507A patent/CA2456507C/en not_active Expired - Fee Related
- 2002-08-06 RS YUP-147/04A patent/RS51420B/en unknown
-
2005
- 2005-01-17 HK HK05100431A patent/HK1068356A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2456507A1 (en) | 2003-03-06 |
| EP1421120B1 (de) | 2007-04-25 |
| KR100898528B1 (ko) | 2009-05-20 |
| PL369363A1 (en) | 2005-04-18 |
| ATE360651T1 (de) | 2007-05-15 |
| RO122279B1 (ro) | 2009-03-30 |
| KR20040052215A (ko) | 2004-06-22 |
| RS51420B (en) | 2011-02-28 |
| HUP0401188A2 (hu) | 2004-09-28 |
| DE50210039D1 (de) | 2007-06-06 |
| US20040157207A1 (en) | 2004-08-12 |
| CN100390203C (zh) | 2008-05-28 |
| PL209763B1 (pl) | 2011-10-31 |
| RS14704A (en) | 2007-02-05 |
| CN1545522A (zh) | 2004-11-10 |
| CA2456507C (en) | 2011-05-03 |
| AU2002325398B2 (en) | 2008-02-28 |
| WO2003018639A1 (de) | 2003-03-06 |
| HK1068356A1 (en) | 2005-04-29 |
| HUP0401188A3 (en) | 2012-09-28 |
| JP2005501930A (ja) | 2005-01-20 |
| US7393841B2 (en) | 2008-07-01 |
| RU2303984C2 (ru) | 2007-08-10 |
| PT1421120E (pt) | 2007-08-03 |
| DK1421120T3 (da) | 2007-09-17 |
| EP1421120A1 (de) | 2004-05-26 |
| DE10235954A1 (de) | 2003-03-06 |
| MXPA04001606A (es) | 2005-03-07 |
| ES2283585T3 (es) | 2007-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20130807 |