RU2003102365A - Композиции на основе антибиотика хонолона пролонгированного действия и способ их получения - Google Patents
Композиции на основе антибиотика хонолона пролонгированного действия и способ их полученияInfo
- Publication number
- RU2003102365A RU2003102365A RU2003102365/15A RU2003102365A RU2003102365A RU 2003102365 A RU2003102365 A RU 2003102365A RU 2003102365/15 A RU2003102365/15 A RU 2003102365/15A RU 2003102365 A RU2003102365 A RU 2003102365A RU 2003102365 A RU2003102365 A RU 2003102365A
- Authority
- RU
- Russia
- Prior art keywords
- composition according
- mixture
- derivatives
- active substance
- quinolone antibiotic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 25
- 229940064005 Antibiotic throat preparations Drugs 0.000 title 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 title 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 title 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 title 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 title 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940079866 intestinal antibiotics Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 title 1
- 239000003306 quinoline derived antiinfective agent Substances 0.000 claims 7
- 239000000126 substance Substances 0.000 claims 6
- VUKAUDKDFVSVFT-UHFFFAOYSA-N 2-[6-[4,5-bis(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)-6-methoxyoxan-3-yl]oxy-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Chemical group COC1C(OC)C(OC2C(C(O)C(OC)C(CO)O2)O)C(COC)OC1OC1C(COCC(C)O)OC(OC)C(OCC(C)O)C1OCC(C)O VUKAUDKDFVSVFT-UHFFFAOYSA-N 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 239000004605 External Lubricant Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000004610 Internal Lubricant Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N Ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 1
- 229960001229 Ciprofloxacin Hydrochloride Drugs 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 229960003405 ciprofloxacin Drugs 0.000 claims 1
- DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin HCl Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 claims 1
- 239000002360 explosive Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000002035 prolonged Effects 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2(1H)-one Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
Claims (12)
1. Оральная матричная композиция антибиотика, содержащая активное вещество хинолон, отличающаяся тем, что она выделяет 80% активного вещества как в 0,1 N соляной кислоте, так и в ацетатном буфере при рН 4,5 в тесте с использованием лопастного способа согласно USP XXIV при 50 оборотах в минуту при температуре 37°С в течение от 1 до 4 ч.
2. Оральная композиция, содержащая антибиотик хинолон, отличающаяся тем, что она содержит смесь из a) гелеобразующего полимера с вязкостью от 5 до 400 спз, измеренной в виде 2%-ного водного раствора при температуре 20°С, и b) смеси, по крайней мере, двух производных антибиотика хинолона.
3. Оральная композиция, содержащая антибиотик хинолон, отличающаяся тем, что она содержит смесь из а) набухающего в воде полимера и с) смеси, по крайней мере, двух производных антибиотика хинолона.
4. Композиция по пп.1-3, отличающаяся тем, что в качестве смеси двух производных антибиотика хинолона она содержит смесь соли со свободным основанием.
5. Композиция по пп.1-4, отличающаяся тем, что в качестве смеси двух производных антибиотика хинолона она содержит смесь двух солей.
6. Композиция по пп.1-5, отличающаяся тем, что антибиотиком хинолона является ципрофлоксацин.
7. Композиция по пп.1-6, отличающаяся тем, что двумя производными являются ципрофлоксацина-гидрохлорид и ципрофлоксацин-бетаин.
8. Композиция по пп.1-7, отличающаяся тем, что гелеобразующим полимером является гидроксипропилметилцеллюлоза с вязкостью максимально 75 спз, измеренная в виде 2%-ного водного раствора при температуре 20°С.
9. Композиция по пп.1-8, отличающаяся тем, что гидроксипропилметилцеллюлоза демонстрирует вязкость максимально 50 спз, измеренную в виде 2%-ного водного раствора при температуре 20°С.
10. Композиция по пп.1-9, отличающаяся тем, что композиция является комбинационным препаратом, содержащим часть с интенсивным выделением (ИВ-часть) и часть с пролонгированным действием (РВ-часть).
11. Композиция по пп.1-10, отличающаяся тем, что на одну массовую часть гидроксипропилметилцеллюлозы она содержит 2-20 мас.ч. смеси активного вещества.
12. Способ получения композиции по пп.1-11, по которому часть активного вещества смешивают со взрывчатым веществом, гранулируют, и смешивают с внешней смазкой и внутренней смазкой (ИВ-часть), и другую часть активного вещества смешивают с кислотой и гидроксипропилметилцеллюлозой, гранулируют и смешивают с внешней смазкой и внутренней смазкой (РВ-часть), и (ИВ)- и (РВ)-часть таблетируют с получением комбинационных таблеток и полученные таблетки лакируют.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031043.5 | 2000-06-26 | ||
| DE10031043A DE10031043A1 (de) | 2000-06-26 | 2000-06-26 | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003102365A true RU2003102365A (ru) | 2004-05-27 |
| RU2332204C2 RU2332204C2 (ru) | 2008-08-27 |
Family
ID=7646816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003102365/15A RU2332204C2 (ru) | 2000-06-26 | 2001-06-13 | Композиции на основе антибиотика хинолона пролонгированного действия и способ их получения |
Country Status (41)
| Country | Link |
|---|---|
| US (3) | US7709022B2 (ru) |
| EP (1) | EP1296685B1 (ru) |
| JP (1) | JP4958373B2 (ru) |
| KR (1) | KR100939617B1 (ru) |
| CN (1) | CN1273138C (ru) |
| AR (1) | AR029688A1 (ru) |
| AT (1) | ATE355062T1 (ru) |
| AU (1) | AU2001270573A1 (ru) |
| BG (1) | BG65914B1 (ru) |
| BR (1) | BRPI0111911B8 (ru) |
| CA (1) | CA2414271C (ru) |
| CU (1) | CU23264B7 (ru) |
| CY (1) | CY1107574T1 (ru) |
| CZ (1) | CZ301812B6 (ru) |
| DE (2) | DE10031043A1 (ru) |
| DK (1) | DK1296685T3 (ru) |
| DO (1) | DOP2001000199A (ru) |
| EE (1) | EE04992B1 (ru) |
| ES (1) | ES2282270T3 (ru) |
| GT (1) | GT200100126A (ru) |
| HK (1) | HK1058479A1 (ru) |
| HN (1) | HN2001000132A (ru) |
| HR (1) | HRP20030050B1 (ru) |
| HU (1) | HU229806B1 (ru) |
| IL (2) | IL153333A0 (ru) |
| MA (1) | MA25761A1 (ru) |
| MX (1) | MXPA02012727A (ru) |
| MY (1) | MY140994A (ru) |
| NO (1) | NO325415B1 (ru) |
| NZ (1) | NZ523352A (ru) |
| PE (1) | PE20020207A1 (ru) |
| PL (1) | PL203710B1 (ru) |
| PT (1) | PT1296685E (ru) |
| RU (1) | RU2332204C2 (ru) |
| SI (1) | SI1296685T1 (ru) |
| SK (1) | SK287384B6 (ru) |
| SV (1) | SV2002000505A (ru) |
| TW (1) | TWI279232B (ru) |
| UA (1) | UA83616C2 (ru) |
| WO (1) | WO2002000219A1 (ru) |
| ZA (1) | ZA200210350B (ru) |
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| US20080206329A1 (en) * | 2004-12-03 | 2008-08-28 | Sanjay Verma | Modified Release Ciprofloxacin Compositions |
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| EP2116264B1 (en) | 2006-12-26 | 2017-09-27 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
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2000
- 2000-06-26 DE DE10031043A patent/DE10031043A1/de not_active Ceased
-
2001
- 2001-06-13 DE DE50112123T patent/DE50112123D1/de not_active Expired - Lifetime
- 2001-06-13 WO PCT/EP2001/006695 patent/WO2002000219A1/de active IP Right Grant
- 2001-06-13 AT AT01949412T patent/ATE355062T1/de active
- 2001-06-13 CN CNB018118283A patent/CN1273138C/zh not_active Expired - Lifetime
- 2001-06-13 EE EEP200200707A patent/EE04992B1/xx unknown
- 2001-06-13 AU AU2001270573A patent/AU2001270573A1/en not_active Abandoned
- 2001-06-13 US US10/311,913 patent/US7709022B2/en not_active Expired - Fee Related
- 2001-06-13 RU RU2003102365/15A patent/RU2332204C2/ru active
- 2001-06-13 BR BRPI0111911A patent/BRPI0111911B8/pt not_active IP Right Cessation
- 2001-06-13 PT PT01949412T patent/PT1296685E/pt unknown
- 2001-06-13 EP EP01949412A patent/EP1296685B1/de not_active Expired - Lifetime
- 2001-06-13 JP JP2002505001A patent/JP4958373B2/ja not_active Expired - Lifetime
- 2001-06-13 SI SI200130710T patent/SI1296685T1/sl unknown
- 2001-06-13 ES ES01949412T patent/ES2282270T3/es not_active Expired - Lifetime
- 2001-06-13 CZ CZ20024216A patent/CZ301812B6/cs not_active IP Right Cessation
- 2001-06-13 CA CA002414271A patent/CA2414271C/en not_active Expired - Lifetime
- 2001-06-13 DK DK01949412T patent/DK1296685T3/da active
- 2001-06-13 MX MXPA02012727A patent/MXPA02012727A/es active IP Right Grant
- 2001-06-13 SK SK1821-2002A patent/SK287384B6/sk not_active IP Right Cessation
- 2001-06-13 HU HU0300953A patent/HU229806B1/hu unknown
- 2001-06-13 NZ NZ523352A patent/NZ523352A/en not_active IP Right Cessation
- 2001-06-13 KR KR1020027017634A patent/KR100939617B1/ko active IP Right Grant
- 2001-06-13 IL IL15333301A patent/IL153333A0/xx unknown
- 2001-06-13 PL PL360632A patent/PL203710B1/pl unknown
- 2001-06-13 UA UA2003010650A patent/UA83616C2/ru unknown
- 2001-06-25 HN HN2001000132A patent/HN2001000132A/es unknown
- 2001-06-25 MY MYPI20012975A patent/MY140994A/en unknown
- 2001-06-25 SV SV2001000505A patent/SV2002000505A/es active IP Right Grant
- 2001-06-26 TW TW090115340A patent/TWI279232B/zh not_active IP Right Cessation
- 2001-06-26 AR ARP010103034A patent/AR029688A1/es not_active Application Discontinuation
- 2001-06-26 PE PE2001000618A patent/PE20020207A1/es active IP Right Grant
- 2001-06-26 GT GT200100126A patent/GT200100126A/es unknown
- 2001-06-26 DO DO2001000199A patent/DOP2001000199A/es unknown
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2002
- 2002-12-09 IL IL153333A patent/IL153333A/en active IP Right Grant
- 2002-12-11 BG BG107372A patent/BG65914B1/bg unknown
- 2002-12-20 NO NO20026160A patent/NO325415B1/no not_active IP Right Cessation
- 2002-12-20 ZA ZA200210350A patent/ZA200210350B/en unknown
- 2002-12-24 CU CU20020333A patent/CU23264B7/es unknown
- 2002-12-26 MA MA26979A patent/MA25761A1/fr unknown
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2003
- 2003-01-24 HR HR20030050A patent/HRP20030050B1/xx not_active IP Right Cessation
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2004
- 2004-02-23 HK HK04101286A patent/HK1058479A1/xx not_active IP Right Cessation
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2006
- 2006-11-16 US US11/560,594 patent/US7780986B2/en not_active Expired - Fee Related
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2007
- 2007-04-04 CY CY20071100478T patent/CY1107574T1/el unknown
- 2007-06-14 US US11/762,831 patent/US8187632B2/en not_active Expired - Fee Related
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