RU2001113268A - Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом с - Google Patents
Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом сInfo
- Publication number
- RU2001113268A RU2001113268A RU2001113268/04A RU2001113268A RU2001113268A RU 2001113268 A RU2001113268 A RU 2001113268A RU 2001113268/04 A RU2001113268/04 A RU 2001113268/04A RU 2001113268 A RU2001113268 A RU 2001113268A RU 2001113268 A RU2001113268 A RU 2001113268A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- arylalkyl
- alkynyl
- aryl
- alkenyl
- Prior art date
Links
- 108010047761 Interferon-alpha Proteins 0.000 title claims abstract 4
- 102000006992 Interferon-alpha Human genes 0.000 title claims abstract 4
- 208000006154 Chronic hepatitis C Diseases 0.000 title claims 2
- 208000005176 Hepatitis C Diseases 0.000 title claims 2
- 208000010710 hepatitis C virus infection Diseases 0.000 title claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 229960000329 ribavirin Drugs 0.000 title 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical group 0.000 claims 7
- 125000001589 carboacyl group Chemical group 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 4
- 101150065749 Churc1 gene Proteins 0.000 claims 4
- 102100038239 Protein Churchill Human genes 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 3
- 102000014150 Interferons Human genes 0.000 claims 3
- 230000000840 anti-viral effect Effects 0.000 claims 3
- 229940079322 interferon Drugs 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 2
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- 229940080296 2-naphthalenesulfonate Drugs 0.000 claims 1
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 208000020403 chronic hepatitis C virus infection Diseases 0.000 abstract 1
- 0 CC(C(*)Cc1c[n]c2c1cccc2)=O Chemical compound CC(C(*)Cc1c[n]c2c1cccc2)=O 0.000 description 2
- JVIMAGNYJQPHOX-LLVKDONJSA-N CC([C@@H](Cc1c[nH]c2c1cccc2)C=C)=O Chemical compound CC([C@@H](Cc1c[nH]c2c1cccc2)C=C)=O JVIMAGNYJQPHOX-LLVKDONJSA-N 0.000 description 1
- DSJKIXDMZZURCK-UHFFFAOYSA-N CCC(C(C)=O)N Chemical compound CCC(C(C)=O)N DSJKIXDMZZURCK-UHFFFAOYSA-N 0.000 description 1
- FNXUAOIIRXZFEE-UHFFFAOYSA-N CCC(C)CC(C(C)=N)C(C)=O Chemical compound CCC(C)CC(C(C)=N)C(C)=O FNXUAOIIRXZFEE-UHFFFAOYSA-N 0.000 description 1
- LHBSFMRWJFONTG-MRVPVSSYSA-N CC[C@H](CC1=CN=CC1=N)C(C)=O Chemical compound CC[C@H](CC1=CN=CC1=N)C(C)=O LHBSFMRWJFONTG-MRVPVSSYSA-N 0.000 description 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N Cc1cnc[nH]1 Chemical compound Cc1cnc[nH]1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17405998A | 1998-10-16 | 1998-10-16 | |
| US09/174,059 | 1998-10-16 | ||
| US09/348,534 | 1999-07-07 | ||
| US09/348,534 US6277830B1 (en) | 1998-10-16 | 1999-07-07 | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001113268A true RU2001113268A (ru) | 2003-09-27 |
Family
ID=26869824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001113268/04A RU2001113268A (ru) | 1998-10-16 | 1999-10-14 | Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом с |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1121369B1 (https=) |
| JP (1) | JP2002527522A (https=) |
| CN (1) | CN1330658A (https=) |
| AT (1) | ATE284408T1 (https=) |
| AU (1) | AU762395B2 (https=) |
| BR (1) | BR9915546A (https=) |
| CA (1) | CA2346447C (https=) |
| CZ (1) | CZ20011130A3 (https=) |
| DE (1) | DE69922529T2 (https=) |
| ES (1) | ES2229820T3 (https=) |
| HU (1) | HUP0200447A2 (https=) |
| ID (1) | ID29187A (https=) |
| IL (1) | IL142423A0 (https=) |
| NO (1) | NO20011789L (https=) |
| NZ (1) | NZ510811A (https=) |
| PL (1) | PL347268A1 (https=) |
| RU (1) | RU2001113268A (https=) |
| SK (1) | SK4742001A3 (https=) |
| TR (1) | TR200101085T2 (https=) |
| WO (1) | WO2000023454A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924270B2 (en) | 2000-04-20 | 2005-08-02 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| WO2004084796A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmasset Ltd. | Compounds for the treatment of flaviviridae infections |
| JP2007501806A (ja) * | 2003-08-13 | 2007-02-01 | ハワード ジェイ． スミス アンド アソシエイツ ピーティーワイ エルティーディー | ウィルス感染を治療する方法 |
| WO2005049065A2 (en) * | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections |
| JP2008540425A (ja) | 2005-05-02 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用 |
| WO2009028575A1 (ja) | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | 血液凝固第vii因子プロモーターの活性化剤及びその利用 |
| WO2009028573A1 (ja) | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | 血液凝固障害におけるリバビリンの利用 |
| WO2011151667A1 (en) | 2010-06-02 | 2011-12-08 | Adbula Kurkayev | Antiviral compositions |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| DE202012012955U1 (de) | 2011-10-21 | 2014-07-14 | Abbvie Inc. | Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| CA3033867A1 (en) | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| CN107513055B (zh) * | 2017-08-11 | 2018-06-22 | 广东昊邦医药健康有限责任公司 | 一种利巴韦林衍生化合物及其药物组合物 |
| CN117355311A (zh) | 2022-05-05 | 2024-01-05 | 阿卜杜拉·库尔卡耶夫 | 用于恢复生物体生理过程和细胞的药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1482736A (en) * | 1974-03-18 | 1977-08-10 | Icn Pharmaceuticals | 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives |
| US4544741A (en) * | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
| US4925930A (en) * | 1988-11-02 | 1990-05-15 | Nucleic Acid Research Institute | Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates |
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| WO1998021223A1 (en) * | 1996-11-12 | 1998-05-22 | Medivir Ab | Nucleosides |
-
1999
- 1999-10-14 TR TR2001/01085T patent/TR200101085T2/xx unknown
- 1999-10-14 BR BR9915546-0A patent/BR9915546A/pt not_active IP Right Cessation
- 1999-10-14 NZ NZ510811A patent/NZ510811A/xx unknown
- 1999-10-14 RU RU2001113268/04A patent/RU2001113268A/ru not_active Application Discontinuation
- 1999-10-14 ES ES99970662T patent/ES2229820T3/es not_active Expired - Lifetime
- 1999-10-14 EP EP99970662A patent/EP1121369B1/en not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011130A patent/CZ20011130A3/cs unknown
- 1999-10-14 HU HU0200447A patent/HUP0200447A2/hu unknown
- 1999-10-14 AT AT99970662T patent/ATE284408T1/de not_active IP Right Cessation
- 1999-10-14 DE DE69922529T patent/DE69922529T2/de not_active Expired - Fee Related
- 1999-10-14 ID IDW20010844A patent/ID29187A/id unknown
- 1999-10-14 AU AU11975/00A patent/AU762395B2/en not_active Ceased
- 1999-10-14 JP JP2000577180A patent/JP2002527522A/ja active Pending
- 1999-10-14 WO PCT/US1999/021448 patent/WO2000023454A1/en not_active Ceased
- 1999-10-14 IL IL14242399A patent/IL142423A0/xx unknown
- 1999-10-14 CN CN99814344A patent/CN1330658A/zh active Pending
- 1999-10-14 SK SK474-2001A patent/SK4742001A3/sk unknown
- 1999-10-14 CA CA002346447A patent/CA2346447C/en not_active Expired - Fee Related
- 1999-10-14 PL PL99347268A patent/PL347268A1/xx not_active Application Discontinuation
-
2001
- 2001-04-09 NO NO20011789A patent/NO20011789L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200101085T2 (tr) | 2001-08-21 |
| CA2346447A1 (en) | 2000-04-27 |
| SK4742001A3 (en) | 2001-11-06 |
| AU762395B2 (en) | 2003-06-26 |
| CZ20011130A3 (cs) | 2001-08-15 |
| CN1330658A (zh) | 2002-01-09 |
| WO2000023454A1 (en) | 2000-04-27 |
| NO20011789D0 (no) | 2001-04-09 |
| ATE284408T1 (de) | 2004-12-15 |
| CA2346447C (en) | 2006-01-31 |
| DE69922529T2 (de) | 2005-12-15 |
| IL142423A0 (en) | 2002-03-10 |
| ES2229820T3 (es) | 2005-04-16 |
| BR9915546A (pt) | 2001-08-14 |
| DE69922529D1 (de) | 2005-01-13 |
| HUP0200447A2 (en) | 2002-06-29 |
| ID29187A (id) | 2001-08-09 |
| EP1121369B1 (en) | 2004-12-08 |
| AU1197500A (en) | 2000-05-08 |
| JP2002527522A (ja) | 2002-08-27 |
| PL347268A1 (en) | 2002-03-25 |
| NZ510811A (en) | 2003-06-30 |
| EP1121369A1 (en) | 2001-08-08 |
| NO20011789L (no) | 2001-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20050516 |