RU2000119792A - Моносульфат азепептидного производного и содержащая его фармацевтическая композиция, ингибирующая вич-протеазу - Google Patents
Моносульфат азепептидного производного и содержащая его фармацевтическая композиция, ингибирующая вич-протеазуInfo
- Publication number
- RU2000119792A RU2000119792A RU2000119792/04A RU2000119792A RU2000119792A RU 2000119792 A RU2000119792 A RU 2000119792A RU 2000119792/04 A RU2000119792/04 A RU 2000119792/04A RU 2000119792 A RU2000119792 A RU 2000119792A RU 2000119792 A RU2000119792 A RU 2000119792A
- Authority
- RU
- Russia
- Prior art keywords
- proteasis
- azepeptida
- monosulphate
- derivative
- pharmaceutical composition
- Prior art date
Links
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 Salt bisulfate Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (1)
1. Соль-бисульфат, имеющая формулу
2. Лечебная форма, содержащая соль-бисульфат по п. 1 и фармацевтически приемлемый носитель.
2. Лечебная форма, содержащая соль-бисульфат по п. 1 и фармацевтически приемлемый носитель.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7196898P | 1998-01-20 | 1998-01-20 | |
| US60/071,968 | 1998-01-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2186070C2 RU2186070C2 (ru) | 2002-07-27 |
| RU2000119792A true RU2000119792A (ru) | 2002-08-10 |
Family
ID=22104737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000119792/04A RU2186070C2 (ru) | 1998-01-20 | 1998-12-22 | Моносульфат азапептидного производного и содержащая его фармацевтическая композиция, ингибирующая вич-протеазу |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US6087383A (ru) |
| EP (1) | EP1056722B1 (ru) |
| JP (2) | JP4860037B2 (ru) |
| KR (1) | KR100559283B1 (ru) |
| CN (1) | CN1116282C (ru) |
| AR (1) | AR014417A1 (ru) |
| AT (1) | ATE219057T1 (ru) |
| AU (1) | AU735875B2 (ru) |
| BG (1) | BG64774B1 (ru) |
| BR (1) | BR9814736A (ru) |
| CA (1) | CA2317736C (ru) |
| CO (1) | CO4970820A1 (ru) |
| CZ (1) | CZ293507B6 (ru) |
| DE (1) | DE69806067T2 (ru) |
| DK (1) | DK1056722T3 (ru) |
| EE (1) | EE04434B1 (ru) |
| EG (1) | EG23936A (ru) |
| ES (1) | ES2178300T3 (ru) |
| GE (1) | GEP20033026B (ru) |
| HK (2) | HK1033667A1 (ru) |
| HU (1) | HU227196B1 (ru) |
| IL (2) | IL137384A0 (ru) |
| LT (1) | LT4780B (ru) |
| LV (1) | LV12522B (ru) |
| MY (1) | MY114838A (ru) |
| NO (1) | NO315605B1 (ru) |
| NZ (1) | NZ504417A (ru) |
| PE (1) | PE20000185A1 (ru) |
| PL (1) | PL190744B1 (ru) |
| PT (1) | PT1056722E (ru) |
| RO (1) | RO118869B1 (ru) |
| RU (1) | RU2186070C2 (ru) |
| SK (1) | SK283975B6 (ru) |
| TR (1) | TR200001876T2 (ru) |
| TW (1) | TW531531B (ru) |
| UA (1) | UA59432C2 (ru) |
| UY (1) | UY25345A1 (ru) |
| WO (1) | WO1999036404A1 (ru) |
| ZA (1) | ZA9956B (ru) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960664B2 (en) | 2001-05-22 | 2005-11-01 | Pharmacia & Upjohn Company | Aza hydroxylated ethyl amine compounds |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| US7157561B2 (en) * | 2001-07-13 | 2007-01-02 | Roche Diagnostics Operations, Inc. | Methods of inhibiting transmission of a costimulatory signal of lymphocytes |
| ATE398455T1 (de) * | 2003-01-14 | 2008-07-15 | Gilead Sciences Inc | Zusammensetzungen und verfahren zur antiviralen kombinationstherapie |
| TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7829720B2 (en) * | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| CN1980666B (zh) * | 2004-05-04 | 2011-03-30 | 布里斯托尔-迈尔斯斯奎布公司 | 制备阿扎那韦硫酸氢盐的方法和新的形式 |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| US20050288343A1 (en) * | 2004-05-19 | 2005-12-29 | Andrew Rusowicz | Process of preparing substituted carbamates and intermediates thereof |
| TWI354569B (en) * | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7642049B2 (en) | 2006-06-30 | 2010-01-05 | Bristol-Myers Squibb Company | Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms |
| WO2008011117A2 (en) * | 2006-07-21 | 2008-01-24 | Gilead Sciences, Inc. | Antiviral protease inhibitors |
| BG66056B1 (bg) * | 2006-10-05 | 2010-12-30 | Красимир ДЕЧЕВ | Метод и инсталация за производство на трисезонна добавка към дизелово гориво |
| SI2003120T1 (sl) | 2007-06-12 | 2010-03-31 | Concert Pharmaceuticals Inc | Azapeptidni derivati kot inhibitorji hiv proteaze |
| CN101795674A (zh) * | 2007-06-22 | 2010-08-04 | 百时美施贵宝公司 | 含有阿扎那韦的压片组合物 |
| EP2178512B1 (en) * | 2007-06-22 | 2011-03-09 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
| PT2170292E (pt) * | 2007-06-22 | 2014-03-06 | Bristol Myers Squibb Holdings Ireland | Composições de comprimido contendo atazanavir |
| ATE499927T1 (de) * | 2007-06-22 | 2011-03-15 | Bristol Myers Squibb Co | Tablettierte atazanavirhaltige zusammensetzungen |
| CN101743004A (zh) * | 2007-06-29 | 2010-06-16 | 吉里德科学公司 | 治疗用组合物及其用途 |
| BRPI0813000A2 (pt) * | 2007-06-29 | 2014-12-23 | Gilead Sciences Inc | Composições terapêuticas e uso das mesmas |
| WO2009136365A1 (en) * | 2008-05-08 | 2009-11-12 | Ranbaxy Laboratories Limited | Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof |
| WO2010070611A1 (en) | 2008-12-18 | 2010-06-24 | Ranbaxy Laboratories Limited | Atazanavir formulations |
| US8552036B2 (en) | 2009-01-12 | 2013-10-08 | Hetero Research Foundation | Polymorph of atazanavir sulfate |
| JP2012528160A (ja) | 2009-05-27 | 2012-11-12 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｉｖプロテアーゼ阻害薬 |
| EP2272830A1 (en) | 2009-06-18 | 2011-01-12 | Esteve Química, S.A. | Preparation process of an antivirally heterocyclic azahexane derivative |
| WO2011027324A1 (en) | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Polymorphic forms of atazanavir sulfate |
| BR112012009857A8 (pt) | 2009-10-26 | 2023-04-11 | Merck Sharp & Dohme | Composições farmacêuticas sólidas contendo um inibidor de integrase |
| WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
| ES2969969T3 (es) | 2010-01-27 | 2024-05-23 | Viiv Healthcare Co | Combinaciones de dolutegravir y lamivudina para el tratamiento de la infección por VIH |
| EP2542527A2 (en) | 2010-03-01 | 2013-01-09 | Lupin Limited | Process for the preparation of atazanavir sulfate substantially free of diastereomers |
| WO2011127244A2 (en) | 2010-04-09 | 2011-10-13 | Bristol-Myers Squibb Company | ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT |
| US20130224294A1 (en) | 2010-09-28 | 2013-08-29 | Ratiopharm Gmbh | Dry processing of atazanavir |
| WO2013014633A1 (en) | 2011-07-27 | 2013-01-31 | Ranbaxy Laboratories Limited | Process for preparation of atazanavir or its bisulfate salt |
| US8461347B2 (en) | 2011-08-05 | 2013-06-11 | Scinopharm Taiwan, Ltd. | Process for preparing form A of atazanavir sulfate |
| EP2771332B1 (en) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS |
| WO2014030173A2 (en) * | 2012-08-24 | 2014-02-27 | Laurus Labs Private Limited | An improved process for the preparation of atazanavir bisulfate |
| WO2014036690A1 (zh) * | 2012-09-04 | 2014-03-13 | 上海迪赛诺化学制药有限公司 | 制备阿扎那韦硫酸氢盐a型结晶的方法 |
| WO2014125270A1 (en) | 2013-02-12 | 2014-08-21 | Cipla House | Process for preparing atazanavir sulphate |
| CN104250225A (zh) * | 2013-06-28 | 2014-12-31 | 上海威智医药科技有限公司 | 阿扎那韦磷酸盐及其制备和应用 |
| CN104250224A (zh) * | 2013-06-28 | 2014-12-31 | 上海威智医药科技有限公司 | 阿扎那韦富马酸盐及其制备和应用 |
| CN104250223B (zh) * | 2013-06-28 | 2017-04-12 | 上海威智医药科技有限公司 | 阿扎那韦氢溴酸盐及其制备和应用 |
| CN105859611A (zh) * | 2016-04-18 | 2016-08-17 | 上海现代制药海门有限公司 | 一种阿扎那韦硫酸氢盐a型结晶的制备方法 |
| CN109251165B (zh) * | 2018-10-02 | 2022-09-23 | 国药集团川抗制药有限公司 | 阿扎那韦达二4-氨基苯磺酸盐及其制备方法 |
| CN111349042B (zh) * | 2018-12-20 | 2023-07-14 | 陕西理工大学 | 一种阿扎那韦单晶及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849911A (en) * | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| TW409125B (en) * | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
-
1998
- 1998-12-21 US US09/217,538 patent/US6087383A/en not_active Expired - Lifetime
- 1998-12-22 CN CN98812741A patent/CN1116282C/zh not_active Expired - Lifetime
- 1998-12-22 EE EEP200000798A patent/EE04434B1/xx unknown
- 1998-12-22 EP EP98964878A patent/EP1056722B1/en not_active Expired - Lifetime
- 1998-12-22 RU RU2000119792/04A patent/RU2186070C2/ru active
- 1998-12-22 AU AU20101/99A patent/AU735875B2/en not_active Expired
- 1998-12-22 BR BR9814736-6A patent/BR9814736A/pt not_active Application Discontinuation
- 1998-12-22 KR KR1020007007885A patent/KR100559283B1/ko not_active IP Right Cessation
- 1998-12-22 UA UA2000084931A patent/UA59432C2/ru unknown
- 1998-12-22 JP JP2000540121A patent/JP4860037B2/ja not_active Expired - Lifetime
- 1998-12-22 NZ NZ504417A patent/NZ504417A/en not_active IP Right Cessation
- 1998-12-22 AT AT98964878T patent/ATE219057T1/de active
- 1998-12-22 WO PCT/US1998/027382 patent/WO1999036404A1/en active IP Right Grant
- 1998-12-22 CA CA002317736A patent/CA2317736C/en not_active Expired - Lifetime
- 1998-12-22 DE DE69806067T patent/DE69806067T2/de not_active Expired - Lifetime
- 1998-12-22 HU HU0101389A patent/HU227196B1/hu unknown
- 1998-12-22 ES ES98964878T patent/ES2178300T3/es not_active Expired - Lifetime
- 1998-12-22 PT PT98964878T patent/PT1056722E/pt unknown
- 1998-12-22 SK SK1062-2000A patent/SK283975B6/sk not_active IP Right Cessation
- 1998-12-22 RO ROA200000717A patent/RO118869B1/ro unknown
- 1998-12-22 GE GEAP19985466A patent/GEP20033026B/en unknown
- 1998-12-22 TR TR2000/01876T patent/TR200001876T2/xx unknown
- 1998-12-22 DK DK98964878T patent/DK1056722T3/da active
- 1998-12-22 IL IL13738498A patent/IL137384A0/xx active IP Right Grant
- 1998-12-22 CZ CZ20002564A patent/CZ293507B6/cs not_active IP Right Cessation
- 1998-12-22 PL PL342019A patent/PL190744B1/pl unknown
-
1999
- 1999-01-05 ZA ZA9900056A patent/ZA9956B/xx unknown
- 1999-01-05 MY MYPI99000020A patent/MY114838A/en unknown
- 1999-01-12 UY UY25345A patent/UY25345A1/es not_active Application Discontinuation
- 1999-01-15 TW TW088100623A patent/TW531531B/zh not_active IP Right Cessation
- 1999-01-17 EG EG5699A patent/EG23936A/xx active
- 1999-01-18 AR ARP990100179A patent/AR014417A1/es active IP Right Grant
- 1999-01-19 CO CO99002578A patent/CO4970820A1/es unknown
- 1999-01-20 PE PE1999000047A patent/PE20000185A1/es not_active IP Right Cessation
-
2000
- 2000-06-06 LV LVP-00-78A patent/LV12522B/en unknown
- 2000-07-14 LT LT2000067A patent/LT4780B/lt not_active IP Right Cessation
- 2000-07-17 BG BG104618A patent/BG64774B1/bg unknown
- 2000-07-19 NO NO20003692A patent/NO315605B1/no not_active IP Right Cessation
- 2000-07-19 IL IL137384A patent/IL137384A/en not_active IP Right Cessation
-
2001
- 2001-04-26 HK HK01103011A patent/HK1033667A1/xx not_active IP Right Cessation
- 2001-06-15 HK HK01104126A patent/HK1033458A1/xx not_active IP Right Cessation
-
2008
- 2008-12-17 JP JP2008321240A patent/JP2009102357A/ja not_active Withdrawn
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