RS82504A - Isostructural pseudopolymorphs of 9- deoxo-9a-aza-9a-methil- 9a- homoerythromycin a - Google Patents

Isostructural pseudopolymorphs of 9- deoxo-9a-aza-9a-methil- 9a- homoerythromycin a

Info

Publication number
RS82504A
RS82504A YU82504A YUP82504A RS82504A RS 82504 A RS82504 A RS 82504A YU 82504 A YU82504 A YU 82504A YU P82504 A YUP82504 A YU P82504A RS 82504 A RS82504 A RS 82504A
Authority
RS
Serbia
Prior art keywords
formula
substantially pure
isostructural pseudopolymorphs
deoxo
aza
Prior art date
Application number
YU82504A
Other languages
English (en)
Inventor
Miljenko Dumić
Marina Orešić
Aleksandar Danilovski
Zdravka Knežević
Dominik Cinčić
Katica Lazarić
Mladen Vinković
Ernest Meštrović
Alojz Dumbović
Gorjana Lazarevski
Darko Filić
Dejan-Krešimir Bućar
Original Assignee
PLIVA ISTRAŽIVAČKI INSTITUT d.o.o.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PLIVA ISTRAŽIVAČKI INSTITUT d.o.o. filed Critical PLIVA ISTRAŽIVAČKI INSTITUT d.o.o.
Publication of RS82504A publication Critical patent/RS82504A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)

Abstract

Stvarno čisti izostrukturni pseudopolimorfi 9-deoksi-9a-aza-9a-metil-9a-homoeritoromicina A koji imaju formulu I gde S je organski rastvarač koji je najmanje delimično mešljiv sa vodom, x je 1, 1,25, 1,5 ili 2, y je 0, 0,5 ili 1, poseudopolimorfi koji su okarakterisani kao monociklična prostorna grupa P21 i sa opsegom parametara ćelijske jedinice koji uključuju: dužine kristalnih osa od a=15,5-17,0 , b=15,5-17,0 i c=17,5-19,5 , i uglovima između kristalnih osa od α=-90° i á=106-112°. Dalje, ovo otkriće se odnosi na postupak za dobijanje stvarno čistih pseudopolimorfa formule I; farmaceutske kompozicije koje sadrže stvarno čiste izostrukturne pseudopolimorfe formule I; i na postupak za tretman bakterijskih i protozoičnih infekcija i oboljenja vezanih za zapaljenja sa uzimanjem farmaceutske kompozicije koja sadrži stvarno čiste izostrukturne pseudopolimorfe formule I.
YU82504A 2002-03-18 2003-03-18 Isostructural pseudopolymorphs of 9- deoxo-9a-aza-9a-methil- 9a- homoerythromycin a RS82504A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
RS82504A true RS82504A (en) 2006-12-15

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
YU82504A RS82504A (en) 2002-03-18 2003-03-18 Isostructural pseudopolymorphs of 9- deoxo-9a-aza-9a-methil- 9a- homoerythromycin a

Country Status (23)

Country Link
US (1) US7569549B2 (sr)
EP (2) EP1485393B1 (sr)
JP (1) JP2005529082A (sr)
KR (1) KR20050002872A (sr)
CN (1) CN1642966A (sr)
AT (1) ATE440104T1 (sr)
AU (1) AU2003215779A1 (sr)
BG (1) BG108874A (sr)
BR (1) BR0308644A (sr)
CA (1) CA2479211A1 (sr)
DE (1) DE60328872D1 (sr)
EA (1) EA200401217A1 (sr)
ES (1) ES2331733T3 (sr)
HR (2) HRP20020231A2 (sr)
IL (1) IL163836A0 (sr)
IS (1) IS7449A (sr)
MX (1) MXPA04009009A (sr)
NO (1) NO20044341L (sr)
NZ (1) NZ535477A (sr)
PL (1) PL372468A1 (sr)
RS (1) RS82504A (sr)
TN (1) TNSN04166A1 (sr)
WO (1) WO2003077830A2 (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
DE602004019288D1 (de) 2003-07-24 2009-03-19 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417360A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc método para a preparação de multiparticulados farmacêuticos
EP1691786A1 (en) 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
JP2007513146A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 液体系プロセスによるアジスロマイシンマルチパーティキュレート剤形
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
WO1994026758A1 (en) 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
EP1484062A1 (en) * 1998-11-30 2004-12-08 Teva Pharmaceutical Industries Limited Crystalline azithromycin, process for manufacture and pharmaceutical compositions thereof
JP4703924B2 (ja) * 1999-06-29 2011-06-15 サンド・アクチエンゲゼルシヤフト マクロライド
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
US6528492B1 (en) * 2000-07-25 2003-03-04 Instituto De Investigacion En Quimica Aplicada S.C. Single-step process for preparing 7, 16-deoxy-2-aza-10-0-cladinosil-12-0-desosaminil-4, 5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1) hexadeca-1(2)-en-ona and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
EP1313749B1 (en) * 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
US6949519B2 (en) 2000-11-27 2005-09-27 Sandoz Ag Macrolide solvates
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) * 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
EP1455758A1 (en) * 2001-12-21 2004-09-15 Pfizer Products Inc. Directly compressible formulations of azithromycin
WO2003053399A2 (en) 2001-12-21 2003-07-03 Pfizer Products Inc. Methods for wet granulating azithromycin
BR0307331A (pt) 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
HRP20040858A2 (en) 2005-06-30
KR20050002872A (ko) 2005-01-10
BR0308644A (pt) 2005-01-25
EP1485393B1 (en) 2009-08-19
IS7449A (is) 2004-09-16
EA200401217A1 (ru) 2005-02-24
EP1485393A2 (en) 2004-12-15
AU2003215779A1 (en) 2003-09-29
TNSN04166A1 (en) 2007-03-12
US20040014951A1 (en) 2004-01-22
ES2331733T3 (es) 2010-01-14
MXPA04009009A (es) 2005-06-17
PL372468A1 (en) 2005-07-25
IL163836A0 (en) 2005-12-18
WO2003077830A2 (en) 2003-09-25
ATE440104T1 (de) 2009-09-15
DE60328872D1 (en) 2009-10-01
NZ535477A (en) 2006-11-30
US7569549B2 (en) 2009-08-04
CA2479211A1 (en) 2003-09-25
JP2005529082A (ja) 2005-09-29
NO20044341L (no) 2004-11-23
CN1642966A (zh) 2005-07-20
WO2003077830A3 (en) 2004-05-13
EP1627883A1 (en) 2006-02-22
BG108874A (en) 2005-12-30
HRP20020231A2 (en) 2003-12-31

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