NO20044341L - Isostrukturelle pseudopolymorfer av 9-deokso-9a-aza-9a-metyl-9a-homoerytromycin - Google Patents

Isostrukturelle pseudopolymorfer av 9-deokso-9a-aza-9a-metyl-9a-homoerytromycin

Info

Publication number
NO20044341L
NO20044341L NO20044341A NO20044341A NO20044341L NO 20044341 L NO20044341 L NO 20044341L NO 20044341 A NO20044341 A NO 20044341A NO 20044341 A NO20044341 A NO 20044341A NO 20044341 L NO20044341 L NO 20044341L
Authority
NO
Norway
Prior art keywords
homoerythromycin
deoxo
aza
methyl
pseudopolymorph
Prior art date
Application number
NO20044341A
Other languages
English (en)
Inventor
Mladen Vinkovic
Mikjenko Dumic
Original Assignee
Pliva Istrazivacki Inst Doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst Doo filed Critical Pliva Istrazivacki Inst Doo
Publication of NO20044341L publication Critical patent/NO20044341L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)

Abstract

Hovedsakelig, ren isostrukturelle pseudopolymorfer av 9-de-okso-9a-aza-9a-metyl-9a-homoertyromycin A med formelen I: hvor S er et organisk løsemiddel som er i det minste delvis blandbar med vann, x er 1, 1.25, 1.5 eller 2, y er 0, 0.5 eller 1, pseudopolymorfen er kjennetegnet ved den monokliniske romgruppen P 2i og gjenomsnittlige enhetscelleparametere omfattende: krystallakselengder på a = 15.5-17.0 Å, b= 15.5-17.0 Å og c = 17.5-19.5 A, og vinkler mellom krystallaksene på a = y = 90. og P = 106°-112°. I tillegg er denne avsløring rettet mot fremgangsmåte for fremstilling av de hovedsakelig, rene isostrukturelle pseudopolymorfen av formel I, farmasøytiske preparater inneholdende hovedsakelig rene isostrukturelle pseudopolymorfer av formel I, og en fremgangsmåte for behandling av bakterie og protosoninfeksjoner og inflammasjonsrelaterte sykdommer ved administrering av et farmasøytisk preparat inneholdende de hovedsakelig, rene isostrukturelle pseudopolymorfer av formel I.
NO20044341A 2002-03-18 2004-10-13 Isostrukturelle pseudopolymorfer av 9-deokso-9a-aza-9a-metyl-9a-homoerytromycin NO20044341L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
NO20044341L true NO20044341L (no) 2004-11-23

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044341A NO20044341L (no) 2002-03-18 2004-10-13 Isostrukturelle pseudopolymorfer av 9-deokso-9a-aza-9a-metyl-9a-homoerytromycin

Country Status (23)

Country Link
US (1) US7569549B2 (no)
EP (2) EP1627883A1 (no)
JP (1) JP2005529082A (no)
KR (1) KR20050002872A (no)
CN (1) CN1642966A (no)
AT (1) ATE440104T1 (no)
AU (1) AU2003215779A1 (no)
BG (1) BG108874A (no)
BR (1) BR0308644A (no)
CA (1) CA2479211A1 (no)
DE (1) DE60328872D1 (no)
EA (1) EA200401217A1 (no)
ES (1) ES2331733T3 (no)
HR (2) HRP20020231A2 (no)
IL (1) IL163836A0 (no)
IS (1) IS7449A (no)
MX (1) MXPA04009009A (no)
NO (1) NO20044341L (no)
NZ (1) NZ535477A (no)
PL (1) PL372468A1 (no)
RS (1) RS82504A (no)
TN (1) TNSN04166A1 (no)
WO (1) WO2003077830A2 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
WO2005009447A1 (en) * 2003-07-24 2005-02-03 Pliva - Research And Development Ltd. Single dose fast dissolving azithromycin
CA2547774A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
RU2006119453A (ru) * 2003-12-04 2007-12-20 Пфайзер Продактс Инк. (Us) Получение посредством основанных на применении жидкостей способов лекарственные формы азитромицина с большим количеством частиц
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5686587A (en) 1993-05-19 1997-11-11 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) * 1998-11-30 2003-12-04 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
DE60029589T2 (de) * 1999-06-29 2007-07-19 Sandoz Ag Verfahren zur herstellung von azithromycin
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
IL150564A0 (en) * 2000-01-04 2003-02-12 Teva Pharma Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
AU2000270425A1 (en) * 2000-07-25 2002-02-13 Instituto De Investigacion En Quimica Aplicada S.C Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydr oxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-ona and obtaining a new form of 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin
ATE306491T1 (de) * 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
WO2002042315A2 (en) * 2000-11-27 2002-05-30 Biochemie S.A. Macrolide solvates
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
KR100574153B1 (ko) 2001-05-22 2006-04-25 화이자 프로덕츠 인코포레이티드 아지트로마이신의 결정형
BR0215193A (pt) * 2001-12-21 2004-11-16 Pfizer Prod Inc Formulações de azitromicina diretamente compressìveis
BR0215175A (pt) 2001-12-21 2004-12-28 Pfizer Prod Inc Métodos para a granulação úmida de azitromicina
CN1646104A (zh) 2002-02-01 2005-07-27 辉瑞产品公司 阿齐霉素的干颗粒制剂
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
US7569549B2 (en) 2009-08-04
MXPA04009009A (es) 2005-06-17
WO2003077830A3 (en) 2004-05-13
US20040014951A1 (en) 2004-01-22
ATE440104T1 (de) 2009-09-15
IL163836A0 (en) 2005-12-18
WO2003077830A2 (en) 2003-09-25
EP1627883A1 (en) 2006-02-22
BR0308644A (pt) 2005-01-25
CA2479211A1 (en) 2003-09-25
IS7449A (is) 2004-09-16
ES2331733T3 (es) 2010-01-14
NZ535477A (en) 2006-11-30
EP1485393B1 (en) 2009-08-19
AU2003215779A1 (en) 2003-09-29
CN1642966A (zh) 2005-07-20
DE60328872D1 (en) 2009-10-01
PL372468A1 (en) 2005-07-25
EP1485393A2 (en) 2004-12-15
HRP20040858A2 (en) 2005-06-30
TNSN04166A1 (en) 2007-03-12
EA200401217A1 (ru) 2005-02-24
BG108874A (en) 2005-12-30
RS82504A (en) 2006-12-15
JP2005529082A (ja) 2005-09-29
KR20050002872A (ko) 2005-01-10
HRP20020231A2 (en) 2003-12-31

Similar Documents

Publication Publication Date Title
NO20044341L (no) Isostrukturelle pseudopolymorfer av 9-deokso-9a-aza-9a-metyl-9a-homoerytromycin
WO2003097598A8 (fr) Composé comprenant un antagonisme du récepteur de pdg2
WO2003006425A3 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
DK1558579T3 (da) N-alkyl-4-methylenamino-3-hydroxy-2-pyridoner som antimikrobialer
MXPA03008755A (es) Derivados de 2-amino-propanol.
NO2012012I2 (no) Pasireotide (som diaspartat salt). Det kjemiske navnet er cyclo[(4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-)
NO20062292L (no) Fremgangsmate for behandling av transplantasjonsavstoting
BR0014274A (pt) Composições de intercalação de catodo, métodos de produção e baterias de lìtio recarregáveis contendo as mesmas
AU3196900A (en) Preventives/remedies for interstitial pneumonia and pulmonary fibrosis
CY1110000T1 (el) Ενωσεις οκταϋδροβενζιμιδαζολονης ως αναλγητικα
EP1457550A3 (en) Composition for removing residues from the microstructure of an object
AU2001236606A1 (en) 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa
NO331012B1 (no) N-sulfonyl-4-metylenamino-3-hydroksy-2-pyridoner som antimikrobielle midler
WO2005020293A3 (en) Highly conducting and transparent thin films formed from new fluorinated derivatives of 3,4-ethylenedioxythiophene
BR0111780A (pt) Agente herbicida
WO2002085291A3 (en) Nociceptin analogs
WO2003053971A8 (en) Pyridoquinoxaline antivirals
SE9904765D0 (sv) Pharmaceutically-useful compounds
CA2336129A1 (en) Ectoparasiticide agents
IL190024A0 (en) Stabilized protease composition
BR0109946A (pt) Derivados de eritromicina substituìda em 6-o tendo tolerância gastrointestinal
PT1204659E (pt) Benzofuranos serotoninergicos
NO20055097L (no) Krystallinske N-formyl-hydroksylaminforbindelser
WO2002094186A3 (en) Urazole compounds useful as anti-inflammatory agents
TW200503675A (en) Combination of phenylcarboxamides with blockers of the Ikr channel and their use for the treatment of atrial arrhythmias