BR0308644A - Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos - Google Patents

Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos

Info

Publication number
BR0308644A
BR0308644A BR0308644-5A BR0308644A BR0308644A BR 0308644 A BR0308644 A BR 0308644A BR 0308644 A BR0308644 A BR 0308644A BR 0308644 A BR0308644 A BR 0308644A
Authority
BR
Brazil
Prior art keywords
deoxo
aza
methylhomoerythromromine
pseudopolymorph
isostructural pseudopolymorphs
Prior art date
Application number
BR0308644-5A
Other languages
English (en)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominik Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Original Assignee
Pliva Istrazivacki Inst D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O
Publication of BR0308644A publication Critical patent/BR0308644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Instructional Devices (AREA)
  • Finger-Pressure Massage (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)

Abstract

"PSEUDOPOLIMORFOS ISOESTRUTURAIS DE 9-DEOXO-9A-AZA-9A-METIL-9A-HOMOERITROMICINA A E SEUS USOS". Os pseudopolimorfos isoestrutural substancialmente puro de 9-deoxo-9a-aza-9a-metil-9a-homoeritromicina A tendo a fórmula I: onde S é um solvente orgânico que é pelo menos parcialmente miscível com água, x é 1, 1,25, 1,5 ou 2, y é 0, 0,5, ou 1, o pseudopolimorfo sendo caracterizado pelo grupo espacial monocíclico P21 e os parâmetros médios da unidade celular: comprimento do eixo cristal a = 15,5 - 17,0 A, b = 15,5 - 17,0 A, e c = 17,5 19,5 A, e os ângulos entre os eixos cristais de (<244>=<sym> 90<198> e <225> 106<198> - 112<198>. Em adição, esta descrição está direcionada aos processos para a preparação dos pseudopolimorfos isoestruturais substancialmente puro da fórmula I; as composições farmacêuticas contendo os pseudopolimorfos isoestruturais substancialmente puro da fórmula I; e ao método para tratamento de infecções bacterianas ou protozoárias, e as doenças inflamatórias relacionadas através da administração de uma composição farmacêutica contendo o pseudopolimorfo isoestrutural substancialmente puro da fórmula I.
BR0308644-5A 2002-03-18 2003-03-18 Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos BR0308644A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
BR0308644A true BR0308644A (pt) 2005-01-25

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308644-5A BR0308644A (pt) 2002-03-18 2003-03-18 Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos

Country Status (23)

Country Link
US (1) US7569549B2 (pt)
EP (2) EP1627883A1 (pt)
JP (1) JP2005529082A (pt)
KR (1) KR20050002872A (pt)
CN (1) CN1642966A (pt)
AT (1) ATE440104T1 (pt)
AU (1) AU2003215779A1 (pt)
BG (1) BG108874A (pt)
BR (1) BR0308644A (pt)
CA (1) CA2479211A1 (pt)
DE (1) DE60328872D1 (pt)
EA (1) EA200401217A1 (pt)
ES (1) ES2331733T3 (pt)
HR (2) HRP20020231A2 (pt)
IL (1) IL163836A0 (pt)
IS (1) IS7449A (pt)
MX (1) MXPA04009009A (pt)
NO (1) NO20044341L (pt)
NZ (1) NZ535477A (pt)
PL (1) PL372468A1 (pt)
RS (1) RS82504A (pt)
TN (1) TNSN04166A1 (pt)
WO (1) WO2003077830A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US7572773B2 (en) 2003-07-24 2009-08-11 Pliva Hrvatska D.O.O. Single dose fast dissolving azithromycin
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
SI1691787T1 (sl) * 2003-12-04 2008-10-31 Pfizer Prod Inc Postopek za pripravo farmacevtskih produktov iz več delcev
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
EP1691786A1 (en) 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ATE154806T1 (de) 1993-05-19 1997-07-15 Pfizer Zwischenprodukt für azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IL143376A0 (en) * 1998-11-30 2002-04-21 Teva Pharma Ethanolate of azithromycin, process for the manufacture, and pharmaceutical compositions thereof
DE60044515D1 (de) * 1999-06-29 2010-07-15 Sandoz Ag Azithromycinmonohydrat
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
ATE388159T1 (de) * 2000-01-04 2008-03-15 Teva Pharma Verfahren zur herstellung von azithromycin- dihydrat
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
CA2417353C (en) * 2000-07-25 2009-09-01 Laboratorio Silanes,S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-one, and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
JP2004506664A (ja) * 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
HU229488B1 (hu) 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
JP2005515212A (ja) 2001-12-21 2005-05-26 ファイザー・プロダクツ・インク アジスロマイシンの湿式造粒法
AU2002348884A1 (en) * 2001-12-21 2003-07-09 Pfizer Products Inc. Directly compressible formulations of azithromycin
KR100676025B1 (ko) 2002-02-01 2007-01-29 화이자 프로덕츠 인코포레이티드 아지쓰로마이신의 건조 과립화 제제
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
US20040014951A1 (en) 2004-01-22
CA2479211A1 (en) 2003-09-25
HRP20020231A2 (en) 2003-12-31
ES2331733T3 (es) 2010-01-14
HRP20040858A2 (en) 2005-06-30
TNSN04166A1 (en) 2007-03-12
IL163836A0 (en) 2005-12-18
JP2005529082A (ja) 2005-09-29
MXPA04009009A (es) 2005-06-17
ATE440104T1 (de) 2009-09-15
NZ535477A (en) 2006-11-30
DE60328872D1 (en) 2009-10-01
IS7449A (is) 2004-09-16
EP1627883A1 (en) 2006-02-22
NO20044341L (no) 2004-11-23
RS82504A (en) 2006-12-15
US7569549B2 (en) 2009-08-04
EP1485393B1 (en) 2009-08-19
AU2003215779A1 (en) 2003-09-29
WO2003077830A2 (en) 2003-09-25
EP1485393A2 (en) 2004-12-15
PL372468A1 (en) 2005-07-25
KR20050002872A (ko) 2005-01-10
WO2003077830A3 (en) 2004-05-13
EA200401217A1 (ru) 2005-02-24
CN1642966A (zh) 2005-07-20
BG108874A (en) 2005-12-30

Similar Documents

Publication Publication Date Title
BR0308644A (pt) Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos
BR0210205A (pt) Antiinfecciosos
IT1313610B1 (it) Processo per la preparazione di formulazioni acquose per uso oftalmico
BRPI0414062A (pt) uso de ciclosporinas midificadas para o tratamento de distúrbios por hcv
BR0113643A (pt) Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos
NO20044534L (no) Substituerte fenylacetamider og deres anvendelse som glukokinaseaktivatorer
NO20034661L (no) Nociceptin-analoger
NO20042112L (no) Anvendelse av glycosider av mono- og diacylglycerol som anti-inflammatoriske midler.
AU3196900A (en) Preventives/remedies for interstitial pneumonia and pulmonary fibrosis
EP2772254A3 (en) Novel Antibacterial Agents
CU23210A3 (es) NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS
NO331012B1 (no) N-sulfonyl-4-metylenamino-3-hydroksy-2-pyridoner som antimikrobielle midler
PT1368041E (pt) Composicao aquosa de anfotericina
BR0111780A (pt) Agente herbicida
WO2002085291A3 (en) Nociceptin analogs
WO2003053971A8 (en) Pyridoquinoxaline antivirals
SE9904765D0 (sv) Pharmaceutically-useful compounds
DK0866791T3 (da) Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
BR0109946A (pt) Derivados de eritromicina substituìda em 6-o tendo tolerância gastrointestinal
BRPI0415285A (pt) derivados de aminoalcanol
TW200503675A (en) Combination of phenylcarboxamides with blockers of the Ikr channel and their use for the treatment of atrial arrhythmias
WO2002057286A3 (en) 9-amino erythromycin derivatives with antibacterial activity
WO2005018577A3 (en) 11-deoxy-6,9-ether erythromycin compounds
ATE332908T1 (de) Substituierte 9a-n-(n&#39; 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a
SE9902269D0 (sv) Pharmaceutically active compounds

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]