ATE332908T1 - Substituierte 9a-n-(n' 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a - Google Patents

Substituierte 9a-n-(n' 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a

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Publication number
ATE332908T1
ATE332908T1 AT03773875T AT03773875T ATE332908T1 AT E332908 T1 ATE332908 T1 AT E332908T1 AT 03773875 T AT03773875 T AT 03773875T AT 03773875 T AT03773875 T AT 03773875T AT E332908 T1 ATE332908 T1 AT E332908T1
Authority
AT
Austria
Prior art keywords
deoxo
aza
homoerithromycin
hydro
sulfonyl
Prior art date
Application number
AT03773875T
Other languages
English (en)
Inventor
Nedjeljko Kujundzic
Krajacic Mirjana Bukvic
Karmen Brajsa
Original Assignee
Pliva Istrazivacki Inst D D O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D D O filed Critical Pliva Istrazivacki Inst D D O
Application granted granted Critical
Publication of ATE332908T1 publication Critical patent/ATE332908T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT03773875T 2002-11-11 2003-11-10 Substituierte 9a-n-(n' 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a ATE332908T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20020885A HRP20020885B1 (en) 2002-11-11 2002-11-11 SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A

Publications (1)

Publication Number Publication Date
ATE332908T1 true ATE332908T1 (de) 2006-08-15

Family

ID=32310061

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03773875T ATE332908T1 (de) 2002-11-11 2003-11-10 Substituierte 9a-n-(n' 4- (sulfonyl)phenylcarbamoyl) derivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a und 5-0- desosaminyl-9-deoxo-9-di-hydro-9a-aza-9a- homoerithronolide a

Country Status (13)

Country Link
US (1) US7365056B2 (de)
EP (1) EP1575969B1 (de)
JP (1) JP2006507315A (de)
AT (1) ATE332908T1 (de)
AU (1) AU2003282256A1 (de)
CL (1) CL2003002294A1 (de)
CY (1) CY1106193T1 (de)
DE (1) DE60306807T2 (de)
DK (1) DK1575969T3 (de)
ES (1) ES2268446T3 (de)
HR (1) HRP20020885B1 (de)
PT (1) PT1575969E (de)
WO (1) WO2004043985A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
EP1841437B1 (de) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
CN104119413B (zh) * 2014-07-29 2016-08-24 华中农业大学 一种土拉霉素残留标示物的合成方法

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FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
US5124482A (en) * 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) * 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) * 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) * 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5248793A (en) * 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP931480B1 (en) 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
SI1148049T1 (en) * 1995-07-17 2005-02-28 Warner-Lambert Company Crystalline R-(R*,R*)$-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4- (phenylamino)carbonyl -1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
WO1997035590A1 (en) 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
NO319194B1 (no) 2002-11-14 2005-06-27 Pronova Biocare As Lipase-katalysert forestringsfremgangsmate av marine oljer
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de

Also Published As

Publication number Publication date
DE60306807D1 (de) 2006-08-24
CL2003002294A1 (es) 2005-01-28
JP2006507315A (ja) 2006-03-02
HRP20020885A2 (en) 2005-04-30
HRP20020885B1 (en) 2007-05-31
CY1106193T1 (el) 2011-06-08
ES2268446T3 (es) 2007-03-16
AU2003282256A1 (en) 2004-06-03
US20060084795A1 (en) 2006-04-20
US7365056B2 (en) 2008-04-29
WO2004043985A1 (en) 2004-05-27
DE60306807T2 (de) 2007-01-18
PT1575969E (pt) 2006-10-31
EP1575969B1 (de) 2006-07-12
DK1575969T3 (da) 2006-10-30
EP1575969A1 (de) 2005-09-21

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