DK1575969T3 - Substituerede 9a-N-(N'-4(sulfonyl)phenylcarbamoyl)-derivater af 9 deoxo-9-dihydro-9a-aza-9a-homoerithromycin A og 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolid A - Google Patents

Substituerede 9a-N-(N'-4(sulfonyl)phenylcarbamoyl)-derivater af 9 deoxo-9-dihydro-9a-aza-9a-homoerithromycin A og 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolid A

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Publication number
DK1575969T3
DK1575969T3 DK03773875T DK03773875T DK1575969T3 DK 1575969 T3 DK1575969 T3 DK 1575969T3 DK 03773875 T DK03773875 T DK 03773875T DK 03773875 T DK03773875 T DK 03773875T DK 1575969 T3 DK1575969 T3 DK 1575969T3
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DK
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Prior art keywords
deoxo
aza
dihydro
homoerithronolide
homoerithromycin
Prior art date
Application number
DK03773875T
Other languages
English (en)
Inventor
Nedjeljko Kujundzic
Krajacic Mirjana Bukvic
Karmen Brajsa
Original Assignee
Glaxosmithkline Zagreb
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Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
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Publication of DK1575969T3 publication Critical patent/DK1575969T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK03773875T 2002-11-11 2003-11-10 Substituerede 9a-N-(N'-4(sulfonyl)phenylcarbamoyl)-derivater af 9 deoxo-9-dihydro-9a-aza-9a-homoerithromycin A og 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolid A DK1575969T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20020885A HRP20020885B1 (en) 2002-11-11 2002-11-11 SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A

Publications (1)

Publication Number Publication Date
DK1575969T3 true DK1575969T3 (da) 2006-10-30

Family

ID=32310061

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03773875T DK1575969T3 (da) 2002-11-11 2003-11-10 Substituerede 9a-N-(N'-4(sulfonyl)phenylcarbamoyl)-derivater af 9 deoxo-9-dihydro-9a-aza-9a-homoerithromycin A og 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolid A

Country Status (13)

Country Link
US (1) US7365056B2 (da)
EP (1) EP1575969B1 (da)
JP (1) JP2006507315A (da)
AT (1) ATE332908T1 (da)
AU (1) AU2003282256A1 (da)
CL (1) CL2003002294A1 (da)
CY (1) CY1106193T1 (da)
DE (1) DE60306807T2 (da)
DK (1) DK1575969T3 (da)
ES (1) ES2268446T3 (da)
HR (1) HRP20020885B1 (da)
PT (1) PT1575969E (da)
WO (1) WO2004043985A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
DE602006006546D1 (de) * 2005-01-14 2009-06-10 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
CN104119413B (zh) * 2014-07-29 2016-08-24 华中农业大学 一种土拉霉素残留标示物的合成方法

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SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
BE892397A (nl) 1982-03-08 1982-07-01 Marchand Paul Wereldwijde draadloze telefonie voor 10 miljard abonnees
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
MX13723A (es) 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
US5149837A (en) * 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) * 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) * 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
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US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
IL128865A (en) * 1995-07-17 2006-04-10 Warner Lambert Co Atorostatin IV form crystals and its hydrates, methods of preparation and pharmaceutical preparations containing it
WO1997035590A1 (en) 1996-03-25 1997-10-02 Platt Chris E 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole
HRP990130B1 (en) 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
HRP20010146B1 (en) 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
NO319194B1 (no) 2002-11-14 2005-06-27 Pronova Biocare As Lipase-katalysert forestringsfremgangsmate av marine oljer
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de

Also Published As

Publication number Publication date
HRP20020885A2 (en) 2005-04-30
HRP20020885B1 (en) 2007-05-31
CL2003002294A1 (es) 2005-01-28
DE60306807D1 (de) 2006-08-24
US7365056B2 (en) 2008-04-29
EP1575969B1 (en) 2006-07-12
WO2004043985A1 (en) 2004-05-27
ES2268446T3 (es) 2007-03-16
PT1575969E (pt) 2006-10-31
ATE332908T1 (de) 2006-08-15
JP2006507315A (ja) 2006-03-02
CY1106193T1 (el) 2011-06-08
DE60306807T2 (de) 2007-01-18
US20060084795A1 (en) 2006-04-20
AU2003282256A1 (en) 2004-06-03
EP1575969A1 (en) 2005-09-21

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