RS50083B - N-/2-hidroksi-3-(1-piperidinil) propoksi/piridin-1-oksid- 3-karbo ksimidoil hlorid i njegova upotreba u tretiranju insulinske rezistencije - Google Patents
N-/2-hidroksi-3-(1-piperidinil) propoksi/piridin-1-oksid- 3-karbo ksimidoil hlorid i njegova upotreba u tretiranju insulinske rezistencijeInfo
- Publication number
- RS50083B RS50083B YUP-603/01A YUP60301A RS50083B RS 50083 B RS50083 B RS 50083B YU P60301 A YUP60301 A YU P60301A RS 50083 B RS50083 B RS 50083B
- Authority
- RS
- Serbia
- Prior art keywords
- piperidinyl
- propoxy
- pyridine
- hydroxy
- oxide
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 title 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 title 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
N-{2-hidroksi-3-(1-piperidinil)-propoksi}-piridin-1-oksid-3-karboksiimidoil hlorid, njegovi stereoizomeri, i adicione soli sa kiselinama. Prijava sadrži još 3 patentna zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9900475A HUP9900475D0 (en) | 1999-02-26 | 1999-02-26 | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
Publications (2)
Publication Number | Publication Date |
---|---|
YU60301A YU60301A (sh) | 2004-05-12 |
RS50083B true RS50083B (sr) | 2009-01-22 |
Family
ID=90014224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-603/01A RS50083B (sr) | 1999-02-26 | 2000-02-24 | N-/2-hidroksi-3-(1-piperidinil) propoksi/piridin-1-oksid- 3-karbo ksimidoil hlorid i njegova upotreba u tretiranju insulinske rezistencije |
Country Status (27)
Country | Link |
---|---|
US (1) | US6649628B1 (sr) |
EP (1) | EP1163224B1 (sr) |
JP (1) | JP4689838B2 (sr) |
KR (1) | KR100676124B1 (sr) |
AT (1) | ATE237590T1 (sr) |
AU (1) | AU779096B2 (sr) |
BG (1) | BG65178B1 (sr) |
BR (1) | BR0008969A (sr) |
CA (1) | CA2360451C (sr) |
CZ (1) | CZ297386B6 (sr) |
DE (1) | DE60002187T2 (sr) |
DK (1) | DK1163224T3 (sr) |
EE (1) | EE04961B1 (sr) |
ES (1) | ES2193055T3 (sr) |
HR (1) | HRP20010584B1 (sr) |
HU (1) | HUP9900475D0 (sr) |
IL (2) | IL144866A0 (sr) |
NO (1) | NO319793B1 (sr) |
PL (1) | PL197692B1 (sr) |
PT (1) | PT1163224E (sr) |
RS (1) | RS50083B (sr) |
RU (1) | RU2250901C2 (sr) |
SI (1) | SI1163224T1 (sr) |
SK (1) | SK287063B6 (sr) |
UA (1) | UA72495C2 (sr) |
WO (1) | WO2000050403A1 (sr) |
ZA (1) | ZA200106488B (sr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
IL162941A0 (en) | 2002-01-11 | 2005-11-20 | Biorex Kutato Fejlesztoe Kft | Carboxamidine derivatives and their use in the treatment of vascular diseases |
HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
US20080227813A1 (en) * | 2006-09-26 | 2008-09-18 | Jack Raymond Barber | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
CA2728363C (en) | 2008-06-26 | 2019-02-19 | Orphazyme Aps | Use of hsp70 as a regulator of enzymatic activity |
JP2010150243A (ja) * | 2008-11-18 | 2010-07-08 | Santen Pharmaceut Co Ltd | ピリジン−3−カルバルデヒドo−(ピペリジン−1−イル−プロピル)−オキシム誘導体を有効成分として含有する網脈絡膜変性疾患の治療剤 |
ES2753169T3 (es) | 2010-11-30 | 2020-04-07 | Orphazyme As | Procedimientos para aumentar la actividad intracelular de Hsp70 |
HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
EP2892540B1 (en) * | 2012-09-06 | 2018-07-25 | Mcpharma Biotech Inc. | Treatment of diarrhea and post-weaning diarrhea with resistant potato starch |
DK2896269T4 (da) | 2012-09-14 | 2020-08-31 | Saint Gobain | Rude med et elektrisk forbindelseselement |
WO2015015248A1 (en) * | 2013-07-30 | 2015-02-05 | Debreceni Egyetem 67% | The use of compounds showing heat shock protein (hsp) co-inducing properties to enhance the insulin sensitizing effect in the treatment of type 2 diabetes |
HUE054957T2 (hu) * | 2014-09-15 | 2021-10-28 | Orphazyme As | Arimoklomol készítése |
WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
ES2831764T3 (es) * | 2016-04-29 | 2021-06-09 | Orphazyme As | Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa |
US20200085812A1 (en) | 2017-05-24 | 2020-03-19 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
WO2019229078A1 (en) | 2018-05-28 | 2019-12-05 | Orphazyme A/S | Hsp70 protein levels in pbmc samples as biomarker for disease |
HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
WO2021116487A1 (en) | 2019-12-13 | 2021-06-17 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of niemann-pick c disease |
KR20230035586A (ko) | 2020-06-24 | 2023-03-14 | 켐팜 덴마크 에이/에스 | 고셔병을 치료하기 위한 아리모클로몰 |
WO2022106614A1 (en) * | 2020-11-19 | 2022-05-27 | Orphazyme A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
JP2024502304A (ja) | 2020-12-24 | 2024-01-18 | ゼブラ デンマーク エー/エス | Er型ミスセンス変異を有する患者におけるニーマンピック病c型の治療用アリモクロモル |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
HUT78138A (hu) * | 1995-12-22 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt | Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása |
UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
HU220971B1 (hu) * | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
-
1999
- 1999-02-26 HU HU9900475A patent/HUP9900475D0/hu unknown
-
2000
- 2000-02-24 KR KR1020017010932A patent/KR100676124B1/ko not_active IP Right Cessation
- 2000-02-24 IL IL14486600A patent/IL144866A0/xx active IP Right Grant
- 2000-02-24 CA CA2360451A patent/CA2360451C/en not_active Expired - Lifetime
- 2000-02-24 RU RU2001126126/04A patent/RU2250901C2/ru active
- 2000-02-24 AU AU31824/00A patent/AU779096B2/en not_active Expired
- 2000-02-24 RS YUP-603/01A patent/RS50083B/sr unknown
- 2000-02-24 UA UA2001085933A patent/UA72495C2/uk unknown
- 2000-02-24 JP JP2000600986A patent/JP4689838B2/ja not_active Expired - Lifetime
- 2000-02-24 PT PT00909542T patent/PT1163224E/pt unknown
- 2000-02-24 AT AT00909542T patent/ATE237590T1/de active
- 2000-02-24 SI SI200030080T patent/SI1163224T1/xx unknown
- 2000-02-24 US US09/913,263 patent/US6649628B1/en not_active Expired - Lifetime
- 2000-02-24 ES ES00909542T patent/ES2193055T3/es not_active Expired - Lifetime
- 2000-02-24 CZ CZ20013053A patent/CZ297386B6/cs not_active IP Right Cessation
- 2000-02-24 EE EEP200100447A patent/EE04961B1/xx not_active IP Right Cessation
- 2000-02-24 PL PL350915A patent/PL197692B1/pl unknown
- 2000-02-24 WO PCT/HU2000/000015 patent/WO2000050403A1/en active IP Right Grant
- 2000-02-24 SK SK1158-2001A patent/SK287063B6/sk not_active IP Right Cessation
- 2000-02-24 BR BR0008969-9A patent/BR0008969A/pt not_active IP Right Cessation
- 2000-02-24 DE DE60002187T patent/DE60002187T2/de not_active Expired - Lifetime
- 2000-02-24 EP EP00909542A patent/EP1163224B1/en not_active Expired - Lifetime
- 2000-02-24 DK DK00909542T patent/DK1163224T3/da active
-
2001
- 2001-08-07 ZA ZA200106488A patent/ZA200106488B/xx unknown
- 2001-08-07 HR HR20010584A patent/HRP20010584B1/xx not_active IP Right Cessation
- 2001-08-13 IL IL144866A patent/IL144866A/en not_active IP Right Cessation
- 2001-08-22 BG BG105837A patent/BG65178B1/bg unknown
- 2001-08-23 NO NO20014103A patent/NO319793B1/no not_active IP Right Cessation
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