RO91184B - Procedeu pentru prepararea unor derivati de 2,2'-iminobisetanol - Google Patents
Procedeu pentru prepararea unor derivati de 2,2'-iminobisetanolInfo
- Publication number
- RO91184B RO91184B RO116496A RO11649684A RO91184B RO 91184 B RO91184 B RO 91184B RO 116496 A RO116496 A RO 116496A RO 11649684 A RO11649684 A RO 11649684A RO 91184 B RO91184 B RO 91184B
- Authority
- RO
- Romania
- Prior art keywords
- radical
- aryl
- amino
- alkyl
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 title 1
- -1 C1-6alkyloxy Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55808183A | 1983-12-05 | 1983-12-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO91184A RO91184A (ro) | 1987-07-30 |
| RO91184B true RO91184B (ro) | 1987-07-31 |
Family
ID=24228139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO116496A RO91184B (ro) | 1983-12-05 | 1984-12-03 | Procedeu pentru prepararea unor derivati de 2,2'-iminobisetanol |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0145067B1 (OSRAM) |
| JP (1) | JPS60132977A (OSRAM) |
| KR (1) | KR870000923B1 (OSRAM) |
| AR (1) | AR241414A1 (OSRAM) |
| AT (1) | ATE40361T1 (OSRAM) |
| AU (1) | AU573658B2 (OSRAM) |
| BG (1) | BG43866A3 (OSRAM) |
| CA (1) | CA1337429C (OSRAM) |
| CS (1) | CS250242B2 (OSRAM) |
| CY (1) | CY1609A (OSRAM) |
| DD (1) | DD235453A5 (OSRAM) |
| DE (1) | DE3476388D1 (OSRAM) |
| DK (2) | DK165112C (OSRAM) |
| DZ (1) | DZ712A1 (OSRAM) |
| ES (1) | ES8603870A1 (OSRAM) |
| FI (1) | FI82460C (OSRAM) |
| GR (1) | GR81098B (OSRAM) |
| HK (1) | HK52791A (OSRAM) |
| HU (1) | HU202219B (OSRAM) |
| IE (1) | IE57831B1 (OSRAM) |
| IL (1) | IL73706A (OSRAM) |
| MA (1) | MA20292A1 (OSRAM) |
| NO (2) | NO169839C (OSRAM) |
| NZ (1) | NZ210388A (OSRAM) |
| PH (1) | PH22432A (OSRAM) |
| PL (1) | PL146342B1 (OSRAM) |
| PT (1) | PT79609B (OSRAM) |
| RO (1) | RO91184B (OSRAM) |
| SG (1) | SG47091G (OSRAM) |
| SU (1) | SU1428199A3 (OSRAM) |
| ZA (1) | ZA849445B (OSRAM) |
| ZW (1) | ZW19784A1 (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337432C (en) * | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| JPH02103116U (OSRAM) * | 1989-02-01 | 1990-08-16 | ||
| JPH02218675A (ja) * | 1989-02-21 | 1990-08-31 | Nippon Kayaku Co Ltd | ６―フルオロクロモン―２―カルボン酸及びその製造法 |
| IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| HU226525B1 (en) * | 1993-08-19 | 2009-03-30 | Janssen Pharmaceutica Nv | Vasocontrictive dihydrobenzopyran derivatives, pharmaceutical compositions containing them and process for preparing them |
| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
| IL127379A0 (en) * | 1996-06-07 | 1999-10-28 | Procter & Gamble | Dihydrobenzopyran and related compounds useful as anti-inflammatory agents |
| KR20010033188A (ko) * | 1997-12-19 | 2001-04-25 | 조지 제이. 리코스 | 베타 3 아드레날린성수용체 작용물질로 유용한 카복실치환된 크로만 유도체 |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6713651B1 (en) | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6593497B1 (en) | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| DE60233140D1 (de) | 2001-05-02 | 2009-09-10 | Nitromed Inc | Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren |
| DE60217870T2 (de) | 2001-07-26 | 2007-11-15 | Merck Patent Gmbh | Verwendung von 2- 5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| EP1741712B1 (en) * | 2004-07-30 | 2011-06-15 | Torrent Pharmaceuticals Ltd | amorphous form of nebivolol hydrochloride and its preparation |
| ATE465157T1 (de) * | 2004-08-11 | 2010-05-15 | Hetero Drugs Ltd | Neues verfahren zur herstellung von nebivololzwischenprodukten |
| CN100341866C (zh) * | 2004-08-30 | 2007-10-10 | 中国科学院理化技术研究所 | α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法 |
| NZ560386A (en) | 2005-01-31 | 2009-12-24 | Mylan Lab Inc | Pharmaceutical composition comprising hydroxylated nebivolol |
| AP2672A (en) * | 2005-01-31 | 2013-05-23 | Mylan Lab Inc | Glucuronidate nebivoloi metabolites |
| WO2006084684A1 (de) * | 2005-02-11 | 2006-08-17 | Stada Arzneimittel Ag | Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer |
| AT502220A1 (de) * | 2005-07-19 | 2007-02-15 | Pharmacon Forschung & Beratung | Verfahren zur herstellung von nebivolol |
| RU2392277C2 (ru) * | 2005-12-28 | 2010-06-20 | Асино Фарма Аг | Способ получения рацемического небиволола |
| EP1803716B1 (en) * | 2005-12-28 | 2012-07-25 | Acino Pharma AG | A process for preparation of racemic nebivolol |
| US7560575B2 (en) * | 2005-12-28 | 2009-07-14 | Acino Pharma Ag | Process for preparation of racemic Nebivolol |
| US7858812B2 (en) | 2006-01-18 | 2010-12-28 | Hetero Drugs Limited | Process for isolation of desired isomers of nebivolol intermediates |
| ITMI20061889A1 (it) | 2006-10-03 | 2008-04-04 | Zambon Spa | Processo di preparazione di nebivololo |
| PT2228374E (pt) | 2006-11-27 | 2013-09-04 | Zach System Spa | Formato de nebivolol |
| AU2008209264B2 (en) | 2007-01-22 | 2014-11-27 | Mylan Pharmaceuticals Ulc | Pharmaceutical compositions comprising nebivolol or a nebivolol analogue |
| CN101463024B (zh) | 2007-12-21 | 2011-06-08 | 上海现代制药股份有限公司 | 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法 |
| ITMI20080547A1 (it) * | 2008-03-31 | 2009-10-01 | Zach System Spa | Processo di preparazione di nebivololo |
| IT1392067B1 (it) * | 2008-10-31 | 2012-02-09 | Zach System Spa | Processo di preparazione di nebivololo |
| IT1395354B1 (it) | 2009-07-23 | 2012-09-14 | Zach System Spa | Processo di preparazione di nebivololo |
| DE102010005953A1 (de) | 2010-01-27 | 2011-07-28 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Nebivolol |
| IT1397962B1 (it) | 2010-02-11 | 2013-02-04 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| IT1402974B1 (it) | 2010-11-30 | 2013-09-27 | Menarini Int Operations Lu Sa | Processo per la preparazione del nebivololo. |
| ITRM20110418A1 (it) | 2011-08-02 | 2013-02-03 | Menarini Int Operations Lu Sa | Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo. |
| EP2907810A1 (en) | 2014-02-14 | 2015-08-19 | Corden Pharma International GmbH | A new method for producing nebivolol hydrochloride of high purity |
| ES2700973T3 (es) | 2014-02-14 | 2019-02-20 | Corden Pharma Int Gmbh | Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| EP3299364B1 (en) | 2015-05-19 | 2021-10-20 | Zhejiang Ausun Pharmaceutical Co., Ltd. | Nebivolol synthesis method and intermediate compound thereof |
| CN105085499B (zh) * | 2015-08-07 | 2018-09-25 | 上海现代制药海门有限公司 | 盐酸奈必洛尔中间体混合物的结晶分离方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1054655A (OSRAM) * | 1964-01-24 | |||
| US4313955A (en) * | 1980-10-14 | 1982-02-02 | Ciba-Geigy Corporation | 1,5-Bis(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols |
| GB8418472D0 (en) * | 1984-07-19 | 1984-08-22 | Beecham Group Plc | Compounds |
-
1984
- 1984-11-19 CA CA000468108A patent/CA1337429C/en not_active Expired - Fee Related
- 1984-11-21 PL PL1984250524A patent/PL146342B1/pl unknown
- 1984-11-22 DE DE8484201693T patent/DE3476388D1/de not_active Expired
- 1984-11-22 AT AT84201693T patent/ATE40361T1/de not_active IP Right Cessation
- 1984-11-22 EP EP84201693A patent/EP0145067B1/en not_active Expired
- 1984-11-26 KR KR1019840007404A patent/KR870000923B1/ko not_active Expired
- 1984-11-29 GR GR81098A patent/GR81098B/el unknown
- 1984-11-29 NZ NZ210388A patent/NZ210388A/en unknown
- 1984-11-30 JP JP59252038A patent/JPS60132977A/ja active Granted
- 1984-12-02 DZ DZ847346A patent/DZ712A1/fr active
- 1984-12-03 RO RO116496A patent/RO91184B/ro unknown
- 1984-12-03 IL IL73706A patent/IL73706A/xx not_active IP Right Cessation
- 1984-12-03 AR AR84298819A patent/AR241414A1/es active
- 1984-12-03 DD DD84270216A patent/DD235453A5/de not_active IP Right Cessation
- 1984-12-04 SU SU843826501A patent/SU1428199A3/ru active
- 1984-12-04 DK DK577084A patent/DK165112C/da not_active IP Right Cessation
- 1984-12-04 FI FI844777A patent/FI82460C/fi active IP Right Grant
- 1984-12-04 BG BG067765A patent/BG43866A3/xx unknown
- 1984-12-04 HU HU844482A patent/HU202219B/hu unknown
- 1984-12-04 ES ES538256A patent/ES8603870A1/es not_active Expired
- 1984-12-04 CS CS849320A patent/CS250242B2/cs unknown
- 1984-12-04 NO NO844845A patent/NO169839C/no not_active IP Right Cessation
- 1984-12-04 ZA ZA849445A patent/ZA849445B/xx unknown
- 1984-12-04 PT PT79609A patent/PT79609B/pt unknown
- 1984-12-04 MA MA20516A patent/MA20292A1/fr unknown
- 1984-12-04 ZW ZW197/84A patent/ZW19784A1/xx unknown
- 1984-12-04 PH PH31525A patent/PH22432A/en unknown
- 1984-12-04 IE IE3103/84A patent/IE57831B1/en not_active IP Right Cessation
- 1984-12-05 AU AU36326/84A patent/AU573658B2/en not_active Expired
-
1991
- 1991-06-18 SG SG47091A patent/SG47091G/en unknown
- 1991-07-11 HK HK527/91A patent/HK52791A/en not_active IP Right Cessation
-
1992
- 1992-01-31 DK DK011892A patent/DK165321C/da not_active IP Right Cessation
- 1992-04-03 CY CY1609A patent/CY1609A/xx unknown
-
2004
- 2004-11-26 NO NO2004007C patent/NO2004007I2/no unknown
Also Published As
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