RO84586B - Procedeu pentru prepararea unor derivati de piranona - Google Patents

Procedeu pentru prepararea unor derivati de piranona

Info

Publication number
RO84586B
RO84586B RO108190A RO10819080A RO84586B RO 84586 B RO84586 B RO 84586B RO 108190 A RO108190 A RO 108190A RO 10819080 A RO10819080 A RO 10819080A RO 84586 B RO84586 B RO 84586B
Authority
RO
Romania
Prior art keywords
hydrogen
alkyl
general formula
preparing
phenyl
Prior art date
Application number
RO108190A
Other languages
English (en)
Other versions
RO84586A (ro
Inventor
Barry Peter Clark
William James Ross
Alec Todd
Original Assignee
Lilly Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Limited filed Critical Lilly Industries Limited
Publication of RO84586A publication Critical patent/RO84586A/ro
Publication of RO84586B publication Critical patent/RO84586B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Prezenta inventie se refera la un procedeu pentru prepararea unor derivati de piranona cu formula generala I:(vezi form. in desc.)în care R1 reprezinta un radical COOR5 în care R5 este hidrogen sau un radical alchil cu 1....8 atomi de carbon, R2 este un radical fenil sau naftil eventual substituiti cu unul sau mai multi substituenti alesi dintre halogen sau alchil cu 1....6 atomi de carbon R3 este un atom de hidrogen sau halogen cu conditia ca atunci cînd R3 este hidrogen R4 este hidrogen si R1 este COOT5, R5 sa fie hidrogen metil sau etil iar R2 sa nu fie fenil compusi care prezinta proprietati farmacologice, caracterizat prin aceea ca un compus cu formula generala II: (vezi form. in desc.) se supune reactiei cu un acid mineral de preferinta acid sulfuric sau clorhidric la o temperatura cuprinsa între 0.....100 degree C, urmata eventual de conversia grupei COOR5 în COOH.
RO108190A 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona RO84586B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7912062 1979-04-05

Publications (2)

Publication Number Publication Date
RO84586A RO84586A (ro) 1984-07-17
RO84586B true RO84586B (ro) 1984-09-30

Family

ID=10504371

Family Applications (3)

Application Number Title Priority Date Filing Date
RO108190A RO84586B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO80100748A RO80248A (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO108192A RO84583B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO80100748A RO80248A (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona
RO108192A RO84583B (ro) 1979-04-05 1980-04-05 Procedeu pentru prepararea unor derivati de piranona

Country Status (32)

Country Link
US (3) US4304728A (ro)
JP (1) JPS55133375A (ro)
AR (4) AR224149A1 (ro)
AT (1) AT371456B (ro)
AU (1) AU536369B2 (ro)
BE (1) BE882643A (ro)
CA (1) CA1142526A (ro)
CH (1) CH645370A5 (ro)
CS (4) CS222198B2 (ro)
DD (1) DD150001A5 (ro)
DE (1) DE3012584A1 (ro)
DK (1) DK142080A (ro)
ES (1) ES8104267A1 (ro)
FI (1) FI801019A (ro)
FR (2) FR2453169A1 (ro)
GB (2) GB2047698B (ro)
GR (1) GR67747B (ro)
HU (1) HU182115B (ro)
IE (1) IE49658B1 (ro)
IL (1) IL59747A (ro)
IT (1) IT1143085B (ro)
LU (1) LU82335A1 (ro)
NL (1) NL8002024A (ro)
NZ (1) NZ193344A (ro)
PH (1) PH16517A (ro)
PL (4) PL123699B1 (ro)
PT (1) PT71049A (ro)
RO (3) RO84586B (ro)
SE (1) SE8002514L (ro)
SU (1) SU1083909A3 (ro)
YU (1) YU91980A (ro)
ZA (1) ZA801978B (ro)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644071A (en) * 1984-07-11 1987-02-17 G. D. Searle & Co. Aralkoxy and aryloxyalkoxy kojic acid derivatives
DK59688A (da) * 1987-03-20 1988-09-21 Hoffmann La Roche Styrylketoner
EP0897924B1 (en) * 1996-04-26 2001-10-31 Daiichi Pharmaceutical Co., Ltd. Process for the preparation of tetrahydro-indolizines
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
PE20011333A1 (es) * 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
US20030027847A1 (en) * 2000-06-16 2003-02-06 Walker Michael A. HIV integrase inhibitors
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
US8252938B2 (en) 2009-06-08 2012-08-28 Dow Agrosciences, Llc. Process for the preparation of 6-(aryl)-4-aminopicolinates
US8598086B2 (en) 2009-06-08 2013-12-03 Dow Agrosciences, Llc. 3-halo-(arly)-4-iminotetrahydropicolinates and their use as herbicides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065290A (en) * 1975-07-03 1977-12-27 Eli Lilly And Company Herbicidal β-phenyl-4-piperidinones
US4060533A (en) * 1976-06-25 1977-11-29 Sandoz, Inc. Pyranone carboxamides

Also Published As

Publication number Publication date
ES490121A0 (es) 1981-04-01
GB2047698A (en) 1980-12-03
ES8104267A1 (es) 1981-04-01
AR224149A1 (es) 1981-10-30
RO84583A (ro) 1984-07-17
AR226126A1 (es) 1982-05-31
BE882643A (fr) 1980-10-03
ATA181980A (de) 1982-11-15
YU91980A (en) 1983-02-28
ZA801978B (en) 1981-09-30
FR2493147A1 (fr) 1982-05-07
AT371456B (de) 1983-06-27
PL123813B1 (en) 1982-11-30
IT8048347A0 (it) 1980-04-04
RO84583B (ro) 1984-09-30
AU5703280A (en) 1980-10-09
NL8002024A (nl) 1980-10-07
US4304728A (en) 1981-12-08
FI801019A (fi) 1980-10-06
RO84586A (ro) 1984-07-17
GB2047698B (en) 1983-10-19
IL59747A0 (en) 1980-06-30
GB8312569D0 (en) 1983-06-08
PL123812B1 (en) 1982-11-30
AR226127A1 (es) 1982-05-31
DK142080A (da) 1980-10-06
FR2453169B1 (ro) 1985-03-08
PL123811B1 (en) 1982-11-30
SE8002514L (sv) 1980-10-06
FR2493147B1 (ro) 1985-02-15
GB2123813A (en) 1984-02-08
HU182115B (en) 1983-12-28
IE49658B1 (en) 1985-11-13
PT71049A (en) 1980-05-01
JPS55133375A (en) 1980-10-17
GR67747B (ro) 1981-09-16
RO80248A (ro) 1982-12-06
PH16517A (en) 1983-11-08
US4448787A (en) 1984-05-15
PL223228A1 (ro) 1981-01-30
CS222199B2 (en) 1983-05-27
IE800670L (en) 1980-10-05
CA1142526A (en) 1983-03-08
DD150001A5 (de) 1981-08-12
CS222197B2 (en) 1983-05-27
SU1083909A3 (ru) 1984-03-30
AR224318A1 (es) 1981-11-13
DE3012584A1 (de) 1980-10-16
CS222186B2 (en) 1983-05-27
AU536369B2 (en) 1984-05-03
CS222198B2 (en) 1983-05-27
FR2453169A1 (fr) 1980-10-31
PL123699B1 (en) 1982-11-30
US4471129A (en) 1984-09-11
NZ193344A (en) 1983-06-14
IT1143085B (it) 1986-10-22
IL59747A (en) 1983-12-30
GB2123813B (en) 1984-07-18
LU82335A1 (fr) 1981-12-02
CH645370A5 (fr) 1984-09-28

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