RO82739B - Procedeu pentru prepararea unor derivati de fluoerena - Google Patents

Procedeu pentru prepararea unor derivati de fluoerena

Info

Publication number
RO82739B
RO82739B RO104045A RO10404581A RO82739B RO 82739 B RO82739 B RO 82739B RO 104045 A RO104045 A RO 104045A RO 10404581 A RO10404581 A RO 10404581A RO 82739 B RO82739 B RO 82739B
Authority
RO
Romania
Prior art keywords
derivatives
fluoerene
preparing
carbamoylfluorene
permeation
Prior art date
Application number
RO104045A
Other languages
English (en)
Other versions
RO82739A (ro
Inventor
Edward Ralph Lavagnino
Andrew Joseph Pike
Jack Beuford Campbell
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO82739A publication Critical patent/RO82739A/ro
Publication of RO82739B publication Critical patent/RO82739B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Inventia se refera la un procedeu pentru perpararea unor derivati de fluorena cu formula generala I: (vezi formula) în care R1 si R2 reprezinta un atom de hidrogen sau un radical alchil C1....C6 prin reactia dintre 9-carbamoilfluorena si acrilonitril în prezenta unei baze, de preferinta hidroxid de benziltrimetilamoniu, în medi de solvent organic ales dintre dioxan si tetrahidrofuran la temperaturi cuprinse între 0 si 100 degree C de preferinta între 35 si 75 degree C.
RO104045A 1980-04-17 1981-04-16 Procedeu pentru prepararea unor derivati de fluoerena RO82739B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/141,229 US4282170A (en) 1980-04-17 1980-04-17 9-Carbamoyl-9-(2-cyanoethyl)fluorenes

Publications (2)

Publication Number Publication Date
RO82739A RO82739A (ro) 1984-01-14
RO82739B true RO82739B (ro) 1984-01-30

Family

ID=22494758

Family Applications (1)

Application Number Title Priority Date Filing Date
RO104045A RO82739B (ro) 1980-04-17 1981-04-16 Procedeu pentru prepararea unor derivati de fluoerena

Country Status (26)

Country Link
US (1) US4282170A (ro)
EP (1) EP0038676B1 (ro)
JP (2) JPS574954A (ro)
KR (1) KR840001071B1 (ro)
AR (1) AR228596A1 (ro)
AT (1) ATE9897T1 (ro)
AU (1) AU543345B2 (ro)
BG (1) BG35464A3 (ro)
CA (1) CA1172646A (ro)
CS (1) CS225833B2 (ro)
DD (1) DD158395A5 (ro)
DE (1) DE3166679D1 (ro)
DK (1) DK172181A (ro)
ES (1) ES501339A0 (ro)
FI (1) FI75337C (ro)
GB (1) GB2074161B (ro)
GR (1) GR73824B (ro)
IE (1) IE51221B1 (ro)
IL (1) IL62669A (ro)
NZ (1) NZ196814A (ro)
PH (1) PH15857A (ro)
PL (1) PL131122B1 (ro)
PT (1) PT72854B (ro)
RO (1) RO82739B (ro)
SU (1) SU1297724A3 (ro)
ZA (1) ZA812482B (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
FI844067A7 (fi) * 1983-10-19 1985-04-20 Lilly Co Eli Menetelmä 9-karbamoyylifluoreeni-johdannaisten valmistamiseksi.
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
US4842420A (en) * 1987-12-14 1989-06-27 Mobil Oil Corporation Variable-width draw tape for thermoplastic bags
US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
PL328094A1 (en) * 1996-01-16 1999-01-04 Bristol Myers Squibb Co Conformingly restricted aromatic inhibitors triglycerides carrying chromosome protein and method of obtaining such inhibitors
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
CN100463249C (zh) * 2006-01-24 2009-02-18 吉林大学 电化学沉积制备有机发光薄膜的方法及在发光器件中的应用
US7520124B2 (en) * 2006-09-12 2009-04-21 United Technologies Corporation Asymmetric serrated nozzle for exhaust noise reduction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2280058A (en) * 1942-04-21 Cyanoethylation of carbocycijc
CH407092A (de) 1962-12-21 1966-02-15 Boehringer & Soehne Gmbh Verfahren zur Herstellung basischer Fluoren-Derivate
US3325544A (en) * 1965-06-10 1967-06-13 Upjohn Co 9-(2-amino-1-methylethyl) fluoren-9-ol and salts thereof
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
JPH0149701B2 (ro) 1989-10-25
EP0038676A1 (en) 1981-10-28
EP0038676B1 (en) 1984-10-17
ZA812482B (en) 1982-11-24
CA1172646A (en) 1984-08-14
KR840001071B1 (ko) 1984-07-31
FI811176L (fi) 1981-10-18
PT72854A (en) 1981-05-01
ATE9897T1 (de) 1984-11-15
PH15857A (en) 1983-04-13
BG35464A3 (en) 1984-04-15
KR830005110A (ko) 1983-07-23
US4282170A (en) 1981-08-04
JPH0153267B2 (ro) 1989-11-13
CS225833B2 (en) 1984-02-13
IE810873L (en) 1981-10-17
SU1297724A3 (ru) 1987-03-15
GB2074161A (en) 1981-10-28
DK172181A (da) 1981-10-18
RO82739A (ro) 1984-01-14
PL131122B1 (en) 1984-10-31
DD158395A5 (de) 1983-01-12
GR73824B (ro) 1984-05-03
ES8302632A1 (es) 1983-01-16
GB2074161B (en) 1984-03-14
PL230714A1 (ro) 1982-08-02
ES501339A0 (es) 1983-01-16
IL62669A (en) 1984-06-29
NZ196814A (en) 1984-07-06
FI75337C (fi) 1988-06-09
JPH01125363A (ja) 1989-05-17
AR228596A1 (es) 1983-03-30
PT72854B (en) 1982-03-30
AU6961181A (en) 1981-10-22
JPS574954A (en) 1982-01-11
AU543345B2 (en) 1985-04-18
IL62669A0 (en) 1981-06-29
FI75337B (fi) 1988-02-29
IE51221B1 (en) 1986-11-12
DE3166679D1 (en) 1984-11-22

Similar Documents

Publication Publication Date Title
RO82739B (ro) Procedeu pentru prepararea unor derivati de fluoerena
RO86363B (ro) Procedeu pentru prepararea unor derivati de metiltiopirimidina
KR860001104A (ko) 테트라히드로프탈이미드의 제조방법
RO94159B1 (ro) Procedeu pentru prepararea unor derivati de pirazolsulfonamida
RO81225B (ro) Procedeu pentru prepararea unor derivati ai acidului 6-beta-hidroxialchilpenicilanic
RO82369B (ro) Procedeu pentru prepararea unor derivati de 9-amino-dibenzopiran
KR870001177A (ko) 2,2,6,6-테트라알킬-4-피레리딜아민류의 제조방법
RO84096B (ro) Procedeu de preparare a unor derivati heterociclici
RO81944B (ro) Procedeu de preparare a unor imidodisulfamide
ES8405371A1 (es) Un procedimiento para la preparacion de derivados del indol.
RO72596B (ro) Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilic, tiazancarboxilic sau morfolincarboxilic
AR245695A1 (es) Procedimiento de preparacion del 5,6-dihidroxiindol o de su derivado 3-alquilado,intermediarios utilizados en dicho procedimiento y procedimiento para preparar dichos intermediarios.
KR880003965A (ko) 이노소오스 유도체, 그의 제조방법 및 용도
DE69001929D1 (de) Formungsverfahren.
RO92200B (ro) Procedeu pentru prepararea unor s-benzilcarbamati
KR880005100A (ko) N-치환된 피페라진논의 제조방법
RO84100B (ro) Procedeu pentru prepararea unor derivati de benzodiazepina
RO86858B (ro) Procedeu pentru prepararea unor derivati de acid -2-fenoxipropionic ai pentitelor
ES378034A1 (es) Un metodo para la produccion de un compuesto herbicida.
KR850003389A (ko) 신규의 벤조일우레아 유도체 및 이들중간물질의 제조방법
ES451292A1 (es) Un procedimiento para la preparacion de derivados de tieno- tiacina.
RO85278B (ro) Procedeu de preparare a unor derivati de 1, 2, 3-tiadiazol-5-il-uree
RO85385B (ro) Procedeu pentru prepararea unor derivati de tiazol
GB1479909A (en) 4-oxo-2-imidazolidinylideneureas
RO72834B (ro) Procedeu de obtinere a unor derivati ai acizilor (5-alchilureido-1, 3, 4-tiadiazol-2-il-sulfonil)-acetici