KR840005097A - 비닐 카르복실산 유도체의 제조방법 - Google Patents

비닐 카르복실산 유도체의 제조방법 Download PDF

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KR840005097A
KR840005097A KR1019830002573A KR830002573A KR840005097A KR 840005097 A KR840005097 A KR 840005097A KR 1019830002573 A KR1019830002573 A KR 1019830002573A KR 830002573 A KR830002573 A KR 830002573A KR 840005097 A KR840005097 A KR 840005097A
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pyridyl
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신지 테라오 (외 1)
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구라바야시 이꾸시로
다께다야꾸힝 고오교 가부시끼 가이샤
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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Abstract

내용 없음

Description

비닐 카르복실산 유도체의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 일반식
    (식중 R1은 피리딜기이고 R2는 저급알콕시기, 저급알킬기, 할로겐 원자, 트리플루오로메틸기, 저급 알케닐기 또는 메틸렌 디옥시기를 임의로 가질 수 있는 페닐기, 티에닐기, 푸릴기, 나프틸기, 벤조티에닐기 또는 피리딜기이다)의 혼합물을 일반식
    (식중 R3는 수소원자 또는 저급알킬기이고 n은 0∼6의 정수이며 X는 할로겐원자이다)의 화합물과 반응시킴을 특징으로 하는 일반식
    (식중, Rl,R2,R3및 n은 상기와 같다)의 화합물의 제조방법.
  2. 제1항에 있어서, 반응이 염기 존재하에 수행되는 방법.
  3. 제2항에 있어서, 염기가 n-부틸리튬, 소듐하이드라이드 또는 포타슘 3차 부톡시드인 방법.
  4. 제1항에 있어서, 반응이 용매 존재하에 수행되는 방법.
  5. 제4항에 있어서, 용매가 에테르, 테트라히드로푸란, 디메틸포름아이드, 디메틸술폭시드 또는 이들 둘 이상의 혼합용매인 방법.
  6. 제1항에 있어서, 반응이 -10℃∼50℃의 온도에서 수행되는 방법.
  7. 일반식
    (식중R1은 피리딜기이고 R2는 저급알콕시기, 저급알킬기, 할로겐원자, 트리플루오로메틸기, 저급알케닐기, 또는 메틸렌 디옥시기를 임의로 가질수 있는 페닐기, 티에닐기, 푸릴기, 나프틸기, 벤조티에닐기또는 피리딜기 이며 Z는 할로겐원자 이다)의 화합물을 일반식
    [식중 Y1은 황원자 또는 일반식( R4는 수소원자 또는 아세틸기를 나타내고 m은 0또는 1이다)의 기이고, n은 0~6의정수이며, R3는 수소원자 또는 저급알킬기 이다)의화합물과 반응 시킴을 특징으로 하는 일반식
    (식중 R1,R2,R3,n 및 Y1은 상기와 같다)의 화합물의 제조방법.
  8. 제7항에 있어서, 반응이 염기 존재하는 수행되는 방법.
  9. 제8항에 있어서, 염기가 소듐하이드라이드, 포타슘 3차 부톡시드, 탄산칼륨, 소듐메톡시드인 방법.
  10. 제7항에 있어서, 반응이 용매 존재하에 수행되는 방법.
  11. 제10항에 있어서, 용매가 에테르, 테트라히드로푸란, 디메틸포름아미드, 디메틸술폭시드 또는 이들둘 이상의 혼합용매인 방법.
  12. 제7항에 있어서 , 반응이 -10°C~60°C의 온도에서 수행되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002573A 1982-06-14 1983-06-09 비닐 카르복실산 유도체의 제조방법 KR900006400B1 (ko)

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Application Number Priority Date Filing Date Title
KR1019900011203A KR900006683B1 (ko) 1982-06-14 1990-07-23 비닐 카르복실산 유도체의 제조방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP102488/82 1982-06-14
JP57102488A JPS58219162A (ja) 1982-06-14 1982-06-14 置換ビニルカルボン酸誘導体およびその製造法
JP102488 1982-06-14
JP21175382A JPH0244467B2 (ja) 1982-12-01 1982-12-01 Chikanbinirukarubonsanjudotainoseizoho
JP211753/82 1982-12-01
JP211753 1986-09-10

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KR840005097A true KR840005097A (ko) 1984-11-03
KR900006400B1 KR900006400B1 (ko) 1990-08-30

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AU (1) AU553529B2 (ko)
CA (1) CA1196642A (ko)
DE (1) DE3373467D1 (ko)
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US4518602A (en) * 1982-10-07 1985-05-21 Takeda Chemical Industries, Ltd. Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
US4563446A (en) * 1983-07-27 1986-01-07 Takeda Chemical Industries, Ltd. Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
DE3431004A1 (de) * 1984-08-23 1986-03-06 Hoechst Ag, 6230 Frankfurt Neue 3-pyridylverbindungen und verfahren zu ihrer herstellung
EP0239306B1 (en) 1986-03-27 1993-06-02 Merck Frosst Canada Inc. Tetrahydrocarbazole esters
NO890046L (no) * 1988-01-20 1989-07-21 Bayer Ag Disubstituerte pyridiner.
US5470982A (en) * 1988-01-20 1995-11-28 Bayer Aktiengesellschaft Disubstituted pyridines
AU2992089A (en) * 1988-02-22 1989-08-24 Takeda Chemical Industries Ltd. Acrylic acid morpholides, their production and use
HU205075B (en) * 1988-04-04 1992-03-30 Takeda Chemical Industries Ltd Process for producing substituted vinyl pyridines
GB8814639D0 (en) * 1988-06-20 1988-07-27 Ici Plc Heterocyclic tertiary alcohol derivatives
DE3932403A1 (de) * 1989-05-12 1991-04-11 Thomae Gmbh Dr K Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5506227A (en) * 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
AU4730996A (en) * 1995-02-22 1996-09-11 Takeda Chemical Industries Ltd. Use of vinyl carboxylic acid compounds for the treatment or prevention of transient ischaemic attacks
EP1073640B1 (en) * 1998-04-23 2005-04-13 Takeda Pharmaceutical Company Limited Naphthalene derivatives, their production and use
US7232837B2 (en) * 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
MXPA04000891A (es) * 2001-07-30 2004-05-21 Novo Nordisk As Nuevos derivados de acido vinilcarboxilico y su uso como antidiabeticos.

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US4186202A (en) * 1974-11-21 1980-01-29 Astra Lakemedel Aktiebolag Phenyl-pyridylamine derivatives
CA1134828A (en) * 1978-12-28 1982-11-02 Tadao Tanouchi Pyridine derivatives
GB2068950A (en) * 1980-02-06 1981-08-19 Pfizer Ltd Pyridine Derivatives
CA1250844A (en) * 1981-06-22 1989-03-07 Neville Ford Substituted imidazo¬1,5-a|pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application
US4518602A (en) * 1982-10-07 1985-05-21 Takeda Chemical Industries, Ltd. Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
US4563446A (en) * 1983-07-27 1986-01-07 Takeda Chemical Industries, Ltd. Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines

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ES523199A0 (es) 1985-02-16
DK158306B (da) 1990-04-30
US4727078A (en) 1988-02-23
PT76865A (en) 1983-07-01
NO162155B (no) 1989-08-07
EP0098690B1 (en) 1987-09-09
DK265783D0 (da) 1983-06-10
PT76865B (en) 1986-02-27
NO162155C (no) 1989-11-15
ES8503330A1 (es) 1985-02-16
DE3373467D1 (en) 1987-10-15
IL68957A0 (en) 1983-10-31
GR78283B (ko) 1984-09-26
KR900006400B1 (ko) 1990-08-30
HU188911B (en) 1986-05-28
AU1548383A (en) 1984-12-20
CA1196642A (en) 1985-11-12
FI832113L (fi) 1983-12-15
IE831338L (en) 1983-12-14
FI832113A0 (fi) 1983-06-13
FI79099B (fi) 1989-07-31
NO832137L (no) 1983-12-15
FI79099C (fi) 1989-11-10
EP0098690A3 (en) 1984-11-14
US4760068A (en) 1988-07-26
IE55359B1 (en) 1990-08-29
AU553529B2 (en) 1986-07-17
DK158306C (da) 1990-10-08
DK265783A (da) 1983-12-15
EP0098690A2 (en) 1984-01-18

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