KR840009096A - 이치환 폴리에틸렌 이민의 제조방법 - Google Patents
이치환 폴리에틸렌 이민의 제조방법 Download PDFInfo
- Publication number
- KR840009096A KR840009096A KR1019840001935A KR840001935A KR840009096A KR 840009096 A KR840009096 A KR 840009096A KR 1019840001935 A KR1019840001935 A KR 1019840001935A KR 840001935 A KR840001935 A KR 840001935A KR 840009096 A KR840009096 A KR 840009096A
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- formula
- group
- atom
- optionally
- Prior art date
Links
- 229920002873 Polyethylenimine Polymers 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 3
- 239000004215 Carbon black (E152) Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229930195733 hydrocarbon Natural products 0.000 claims 2
- 150000002430 hydrocarbons Chemical class 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- -1 polymethylene Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 일반식(Ⅱ)의 폴리메틸렌 아민을 다음 일반식(Ⅲ)의 할로겐화 유도체와 축합시키거나 다음 일반식(Ⅳ)의 폴리메틸렌 이민을 다음 일반식(Ⅴ)의 할로겐화 유도체와 축합시켜 필요하다면, 그렇게 얻어진 다음 일반식(Ⅰ)의 유도체를 적당한 산으로 처리하여 상응하는 부가염들을 얻게함을 특징으로 하는 다음 일반식(Ⅰ)의 이치환 폴리에틸렌 이민 및 생리학적으로 내성을 가진 산부가염의 제조방법.Cl-R (Ⅴ)상기식에서 A는 임의로 하나 또는 두개의 이중 결합 및 임의로 하나 또는 그 이상의 히드록시 그룹으로 치환된 3내지 5탄소 원자를 갖는 직쇄 또는 측쇄 탄화수소아를 나타내고, n는 0또는 1또는 2의 정수를 나타내고, Z는 산소원자 또는 그룹을 나타내며, 그리고 R는 a,COR´식의 담을 나타내고 여기서 R´는 임의로 산소 또는 황원자 또는 이중 결합을 가지며 그리고 페닐엠로 임의 치환되는 (즉 그 자체는 하나 또는 그 이상의 할로겐 원자 또는 1내지 5탄소 원자를 `는 알콕시로 또는 m은 1,2 또는 3을 나타내는 -0.CH)2m-0-표로 임의 치환된다) 1내지 6탄소원자를 갖는 직쇄 또는 측쇄 탄화수소기를 나타내며, 페닐기(하나 또는 그 이상의 할로겐 원자, 1내지 5탄소원자를 갖는 하나 또는 그 이상의 알콕시기, 또는 m는 1,2 또는 3을 나타내는 -0(CH2)m-0-기로 임의 치환된다), 또는식의 기를 나타내며, (여기서 R1및 R2는 같거나 다르며 각각 할로겐 원자 또는 1내지 6탄소원자를 갖는 알킬기를 나타내거나 R1및 R2는 예를들어 피롤리디닐, 피페리디노 또는 몸포리노 기와 같이 질소원자와 함께 산소원자를 임의로 함유하는 6원형 또는 6원형 헤테로 고리기와 결합한 것임), 또는 b) -SO2R˝식의 기를 나타내며 여기서 R˝는 직쇄 또는 측쇄인 1내지 3탄소원자를 갖는 알킬기 또는 페닐기를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8305904 | 1983-04-12 | ||
| FR8305904A FR2544315B1 (fr) | 1983-04-12 | 1983-04-12 | Polymethylene imines disubstituees, leurs procedes de preparation, et les compositions pharmaceutiques les renfermant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840009096A true KR840009096A (ko) | 1984-12-24 |
Family
ID=9287737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840001935A KR840009096A (ko) | 1983-04-12 | 1984-04-12 | 이치환 폴리에틸렌 이민의 제조방법 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4593026A (ko) |
| EP (1) | EP0122855B1 (ko) |
| JP (1) | JPS59196888A (ko) |
| KR (1) | KR840009096A (ko) |
| AT (1) | ATE28871T1 (ko) |
| AU (1) | AU560621B2 (ko) |
| CA (1) | CA1227204A (ko) |
| DE (1) | DE3465306D1 (ko) |
| DK (1) | DK185984A (ko) |
| ES (1) | ES531572A0 (ko) |
| FR (1) | FR2544315B1 (ko) |
| GR (1) | GR81936B (ko) |
| IL (1) | IL71503A (ko) |
| NO (1) | NO159018C (ko) |
| NZ (1) | NZ207820A (ko) |
| OA (1) | OA07703A (ko) |
| PH (1) | PH19660A (ko) |
| PT (1) | PT78410B (ko) |
| ZA (1) | ZA842686B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9024617D0 (en) * | 1989-12-05 | 1991-01-02 | Ici Plc | Heterocyclic compounds |
| GB9008818D0 (en) * | 1990-04-19 | 1990-06-13 | Ici Plc | Amine derivatives |
| FR2667243B1 (fr) * | 1990-09-27 | 1994-11-04 | Adir | Utilisation de s derives de la triazine et de la pyrimidine pour l'obtention de medicaments reversant la resistance aux agents anticancereux et antimalariques. |
| FR2673627B1 (fr) * | 1991-03-07 | 1993-05-07 | Adir | Triazines et pyrimidines trisubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| AU676315B2 (en) * | 1993-06-30 | 1997-03-06 | Takeda Chemical Industries Ltd. | Stabilized solid pharmaceutical preparation and method of producing the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256513A (ko) * | 1968-10-02 | 1971-12-08 | ||
| FR2524467A1 (fr) * | 1982-03-30 | 1983-10-07 | Adir | Polymethylene-imines disubstituees, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
-
1983
- 1983-04-12 FR FR8305904A patent/FR2544315B1/fr not_active Expired
-
1984
- 1984-04-06 US US06/597,273 patent/US4593026A/en not_active Expired - Fee Related
- 1984-04-11 AT AT84400712T patent/ATE28871T1/de not_active IP Right Cessation
- 1984-04-11 PT PT78410A patent/PT78410B/pt unknown
- 1984-04-11 PH PH30532A patent/PH19660A/en unknown
- 1984-04-11 IL IL71503A patent/IL71503A/xx unknown
- 1984-04-11 AU AU26849/84A patent/AU560621B2/en not_active Ceased
- 1984-04-11 DK DK185984A patent/DK185984A/da not_active Application Discontinuation
- 1984-04-11 NO NO841451A patent/NO159018C/no unknown
- 1984-04-11 GR GR74366A patent/GR81936B/el unknown
- 1984-04-11 ZA ZA842686A patent/ZA842686B/xx unknown
- 1984-04-11 CA CA000451798A patent/CA1227204A/fr not_active Expired
- 1984-04-11 DE DE8484400712T patent/DE3465306D1/de not_active Expired
- 1984-04-11 EP EP84400712A patent/EP0122855B1/fr not_active Expired
- 1984-04-12 KR KR1019840001935A patent/KR840009096A/ko not_active Application Discontinuation
- 1984-04-12 OA OA58276A patent/OA07703A/xx unknown
- 1984-04-12 ES ES531572A patent/ES531572A0/es active Granted
- 1984-04-12 JP JP59073851A patent/JPS59196888A/ja active Pending
- 1984-04-12 NZ NZ207820A patent/NZ207820A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1227204A (fr) | 1987-09-22 |
| PT78410B (fr) | 1986-07-17 |
| ZA842686B (en) | 1985-02-27 |
| IL71503A0 (en) | 1984-07-31 |
| ES8603457A1 (es) | 1985-12-16 |
| PT78410A (fr) | 1984-05-01 |
| DK185984D0 (da) | 1984-04-11 |
| NO841451L (no) | 1984-10-15 |
| DE3465306D1 (en) | 1987-09-17 |
| NO159018C (no) | 1988-11-23 |
| JPS59196888A (ja) | 1984-11-08 |
| ES531572A0 (es) | 1985-12-16 |
| AU2684984A (en) | 1984-10-18 |
| FR2544315B1 (fr) | 1985-07-05 |
| GR81936B (ko) | 1984-12-12 |
| OA07703A (fr) | 1985-08-30 |
| AU560621B2 (en) | 1987-04-09 |
| ATE28871T1 (de) | 1987-08-15 |
| DK185984A (da) | 1984-10-13 |
| EP0122855A1 (fr) | 1984-10-24 |
| IL71503A (en) | 1987-11-30 |
| EP0122855B1 (fr) | 1987-08-12 |
| FR2544315A1 (fr) | 1984-10-19 |
| PH19660A (en) | 1986-06-09 |
| NZ207820A (en) | 1986-11-12 |
| US4593026A (en) | 1986-06-03 |
| NO159018B (no) | 1988-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |